Husson University is a private university located in Bangor, Maine, offering undergraduate and graduate degrees. Enrollment for the 2009-2010 academic year was over 3,500 students, with approximately 600 in graduate programs.Husson University is one of three universities in the Bangor area . With campuses in Westbrook and Presque Isle, it has the largest physical footprint of any private university in the state. Wikipedia.
Hofstetter B.,Ludwig Boltzmann Research Institute |
Gamsjaeger S.,Ludwig Boltzmann Research Institute |
Phipps R.J.,Warner Chilcott |
Phipps R.J.,Husson University |
And 4 more authors.
Journal of Bone and Mineral Research | Year: 2012
We used Raman and Fourier transform infrared microspectroscopy (FTIRM) analysis to examine the intrinsic bone material properties at actively bone-forming trabecular surfaces in iliac crest biopsies from women with postmenopausal osteoporosis (PMO) who were treated with either alendronate (ALN) or risedronate (RIS). At eight study sites, women were identified who had postmenopausal osteoporosis (PMO), were at least 5 years postmenopause, and had been on long-term therapy (either 3-5 years or >5 years) with daily or weekly ALN or RIS. Following standard tetracycline labeling, biopsies were collected from 102 women (33 treated with ALN for 3-5 years [ALN-3], 35 with ALN for >5 years [ALN-5], 26 with RIS for 3-5 years [RIS-3], and 8 with RIS for >5 years [RIS-5]) and were analyzed at anatomical areas of similar tissue age in bone-forming areas (within the fluorescent double labels). The following outcomes were monitored and reported: mineral to matrix ratio (corresponding to ash weight), relative proteoglycan content (regulating mineralization commencement), mineral maturity (indicative of the mineral crystallite chemistry and stoichiometry, and having a direct bearing on crystallite shape and size), and the ratio of two of the major enzymatic collagen cross-links (pyridinoline/divalent). In RIS-5 there was a significant decrease in the relative proteoglycan content (-5.83% compared to ALN-5), while in both RIS-3 and RIS-5 there was significantly lower mineral maturity/crystallinity (-6.78% and -13.68% versus ALN-3 and ALN-5, respectively), and pyridinoline/divalent collagen cross-link ratio (-23.09% and -41.85% versus ALN-3 and ALN-5, respectively). The results of the present study indicate that ALN and RIS exert differential effects on the intrinsic bone material properties at actively bone-forming trabecular surfaces. © 2012 American Society for Bone and Mineral Research.
Duque G.,University of Sydney |
Li W.,University of Sydney |
Adams M.,University of Sydney |
Xu S.,Procter and Gamble |
Phipps R.,Husson University
Osteoporosis International | Year: 2011
Aminobisphosphonates promote osteoblastogenesis while inhibiting adipogenesis in vitro. Their effect on adipogenesis in vivo remains unknown. In this study, we demonstrate that risedronate prevents marrow fat infiltration in postmenopausal women after 3 years of treatment. Introduction: Age-related bone loss is associated with high levels of adipogenesis within the bone marrow at the expense of osteoblast population. Bisphosphonates stimulate osteoblastogenesis while inhibiting adipogenesis in vitro. In the present study, we tested whether the effect of bisphosphonates on marrow adipogenesis in vitro is also seen in vivo. Methods: We analyzed transiliac bone biopsies from a randomized, placebo-controlled clinical trial that evaluated the effects of risedronate treatment 5 mg/day on vertebral and non-vertebral fractures in women with postmenopausal osteoporosis. Paired bone biopsies were obtained from a subset of patients at baseline and after treatment with placebo or risedronate for 3 years (n=14 per group). Biopsies were stained with toluidine blue and hematoxylin/eosin. Adipocyte volume/tissue volume (AV/TV), mean adipocyte number (AD #), and mean adipocyte diameter (AD diam) were quantified. Finally, expression levels of the adipogenesis transcription factor peroxisome proliferator activator gamma 2 (PPARγ2) within the bone marrow were quantified using immunohistochemistry. Results: In the placebo group, AV/TV, AD #, and AD diam significantly increased after 3 years (∼15%, <0.01). In contrast, AD diam remained unchanged and AV/TV and AD # were significantly reduced (∼20%) in the risedronate group at 3 years (<0.01). These changes were associated with a significant reduction in PPARγ2 expression in the bone marrow of risedronate-treated women. Conclusions: Risedronate reduces bone marrow fat in postmenopausal women. These findings are the first demonstration of an effect of bisphosphonates on marrow fat in humans in vivo. By regulating the amount of fat within the bone marrow, this effect may contribute to the beneficial effect of bisphosphonates on bone mass. © 2010 International Osteoporosis Foundation and National Osteoporosis Foundation.
Tucker L.A.,Brigham Young University |
Strong J.E.,Husson University |
LeCheminant J.D.,Brigham Young University |
Bailey B.W.,Brigham Young University
American Journal of Health Promotion | Year: 2015
Purpose. To determine the effect of two jumping programs on hip bone mineral density (BMD) in women. Design. Randomized controlled trial. Setting. Approximately 20 cities in the Mountain West. Subjects. Sixty premenopausal women, aged 25 to 50 years, completed the intervention. Intervention. Subjects were randomly assigned to a control group or one of two jumping groups. The Jump 10 group performed 10 jumps with 30 seconds rest between jumps, twice daily for 16 weeks, while the Jump 20 group performed the same protocol but with 20 jumps. Measures. Hip BMD was measured by using dual-energy x-ray absorptiometry. Analysis. Analysis of variance and covariance. Results. At 8 weeks, unadjusted percentage change in hip BMD was significantly different among groups (F=5.4, p=.0236). Specifically, compared with controls, the Jump 20 women had significantly greater gains in hip BMD and the Jump 10 women had marginally greater improvements. Following 16 weeks of jumping, differences between the Jump 10 and the Jump 20 groups compared with controls were significant (F = 4.2, p = .0444), especially after adjusting for the covariates (F = 7.3, p = .0092). Conclusion. After 16 weeks of high-impact jump training, hip BMD can be improved in premenopausal women by jumping 10 or 20 times, twice daily, with 30 seconds of rest between each jump, compared with controls. Copyright © 2015 by American Journal of Health Promotion, Inc.
Zhang T.,Husson University
European Journal of Pharmaceutical Sciences | Year: 2015
Atorvastatin is the most commonly used of all statins to lower cholesterol. Atorvastatin is extensively metabolized in both gut and liver to produce several active metabolites. The purpose of the present study is to develop a physiologically based pharmacokinetic (PBPK) model for atorvastatin and its two primary metabolites, 2-hydroxy-atorvastatin acid and atorvastatin lactone, using in vitro and in vivo data. The model was used to predict the pharmacokinetic profiles and drug-drug interaction (DDI) effect for atorvastatin and its metabolites in different DDI scenarios. The predictive performance of the model was assessed by comparing predicted results to observed data after coadministration of atorvastatin with different medications such as itraconazole, clarithromycin, cimetidine, rifampin and phenytoin. This population based PBPK model was able to describe the concentration-time profiles of atorvastatin and its two metabolites reasonably well in the absence or presence of those drugs at different dose regimens. The predicted maximum concentration (Cmax), area under the concentration-time curve (AUC) values and between-phase ratios were in good agreement with clinically observed data. The model has also revealed the importance of different metabolic pathways on the disposition of atorvastatin metabolites. This PBPK model can be utilized to assess the safety and efficacy of atorvastatin in the clinic. This study demonstrated the feasibility of applying PBPK approach to predict the DDI potential of drugs undergoing complex metabolism. © 2015 Elsevier Ltd. All rights reserved.
Herbert V.M.,Husson University
CIN - Computers Informatics Nursing | Year: 2016
Technology is increasing the complexity in the role of today’s nurse. Healthcare organizations are integrating more health information technologies and relying on the electronic health record for data collection, communication, and decision making. Nursing faculty need to prepare graduates for this environment and incorporate an academic electronic health record into a nursing curriculum to meet student-program outcomes. Although the need exists for student preparation, some nursing programs are struggling with implementation, whereas others have been successful. To better understand these complexities, this project was intended to identify current challenges and success strategies of effective academic electronic health record integration into nursing curricula. Using Rogers’ 1962 Diffusion of Innovation theory as a framework for technology adoption, a descriptive survey design was used to gain insights from deans and program directors of nursing schools involved with the national Health Informatics & Technology Scholars faculty development program or Cerner’s Academic Education Solution Consortium, working to integrate an academic electronic health record in their respective nursing schools. The participants’ experiences highlighted approaches used by these schools to integrate these technologies. Data from this project provide nursing education with effective strategies and potential challenges that should be addressed for successful academic electronic health record integration. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.