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Noh D.-H.,The Korea Intellectual Property Office | Lee O.-H.,Kangwon National University | Cho J.H.,Hurum Central Research Institute | Hong H.-D.,Korea Food Research Institute | Kim K.-J.,University of Cincinnati
Food Science and Biotechnology | Year: 2013

Wine tannins are essential to the astringency and color stabilization of red wine through the formation of tannin conjugates. It is important to determine the concentration of tannins during wine aging and fermentation. The aim of this study was to establish a new method that allows for real-time analysis of tannin content in wine and eliminates inconvenient processes, such as calibrations and/or enzyme reactions. The Folin-Ciocalteau spectrophotometry (FCS) was used a positive control and compared it with new microelectrode biosensor cyclic voltammetry (MBCV) method. The new approach was established that not only allows for real-time tannin detection but is also economical and does not require the use of a specific enzyme. The results are reproducible and provide a precise measurement of tannin content. © 2013 The Korean Society of Food Science and Technology and Springer Science+Business Media Dordrecht.

Lee J.S.,Kangwon National University | Lee J.S.,National Institute of Biological Resources | Kim Y.-H.,Kangwon National University | Kim D.-B.,Kangwon National University | And 5 more authors.
Regulatory Toxicology and Pharmacology | Year: 2015

Codonopsis lanceolata is a perennial plant that has been used as a food and in traditional medicine for the treatment of cough, bronchitis, and inflammation in East Asia including Korea, Japan, and China. However, information regarding its toxicity is limited. Therefore, we performed a safety evaluation of aqueous C. lanceolata root extract (CLE) in Sprague-Dawley rats. Assessment of acute toxicity revealed that CLE did not influence mortality, clinical appearance, body weight gain, or necropsy findings at a dose of 5000mg/kg body weight. In the subchronic oral toxicity, data revealed that several significant alteration in food consumption, water consumption, protein excretion, WBCs levels, TGs, BUN levels, and the absolute and relative weights in the liver, spleen and lungs. However, these changes were transient and were not considered treatment related because they showed no apparent dose dependent. These results suggest that CLE (1250, 2500, and 5000mg/kgbody weight/day) administered orally does not cause acute or subchronic toxicity to male or female rats. The 50% lethal dose (LD50) of CLE was determined to be greater than 5000mg/kg. © 2015.

Lee J.S.,Kangwon National University | Kim K.-J.,University of Maryland University College | Kim Y.-H.,Kangwon National University | Kim D.-B.,Kangwon National University | And 5 more authors.
Nutrients | Year: 2014

Codonopsis lanceolata extract (CLE) has been used in traditional medicine in the Asian-Pacific region for the treatment of bronchitis, cough, and inflammation. However, it is still unclear whether obesity in mice can be altered by diet supplementation with CLE. To investigate whether CLE could have preventative effects on high fat diet (HFD)-induced obesity, male C57BL/6 mice were placed on either a normal chow diet, 60% HFD, or a HFD supplemented with CLE (60, 180, and 360 mg/kg/day) for 12 weeks. CLE decreased body weight and subcutaneous and visceral fat weights in HFD-induced obese mice. CLE group mice showed lower fat accumulation and a smaller adipocyte area in the adipose tissue compared with the HFD group mice. CLE group mice exhibited lower serum levels of triglycerides, total cholesterol, low density lipoprotein (LDL), glucose, and insulin compared with the HFD group mice. In addition, CLE decreased liver weight and lowered the increase in aspartate aminotransferase (AST) and alanine transaminase (ALT) levels in HFD-induced obese mice. These results indicate that CLE can inhibit the development of diet-induced obesity and hyperlipidemia in C57BL/6 mice. ©2014 by the authors; licensee MDPI, Basel, Switzerland.

Lee O.-H.,Kangwon National University | Kim J.H.,Kangwon National University | Kim Y.H.,Kangwon National University | Lee Y.J.,Kangwon National University | And 5 more authors.
Journal of the Korean Society of Food Science and Nutrition | Year: 2014

Cirsium setidens Nakai, a wild perennial, is widely consumed as a food and traditional medicine in Korea. In addition, diverse functionalities of C. setidens Nakai, including anti-inflammatory and antioxidant effects, have been reported. However, whether or not C. setidens Nakai and its major compound, pectolinarin have high nutritional value and functional properties remains unknown. This paper investigated the proximate compositions, mineral contents, hepatoprotective activities, hepatic fat accumulation inhibitory activities, and anti-inflammatory and anti-oxi-dant activities of C. setidens Nakai and its component parts, including of pectolinarin. The result showed that C. setidens Nakai and its major compounds have potential as a functional food material with natural antioxidant and anti-inflammatory activities.

Lee Y.J.,Kangwon National University | Kim D.B.,Kangwon National University | Cho J.-H.,Hurum Central Research Institute | Baik S.-O.,Hurum Central Research Institute | Lee O.-H.,Kangwon National University
Korean Journal of Food Science and Technology | Year: 2013

We aimed to provide the basic data for the development of a beverage using the juices from bioresources from Jeju. Our results show that pH and oBx of the bioresources ranged 2.0-6.5 and 3.3-16.8, respectively. Rubus coreanus Miquel juice had the highest total phenol content (47.3 mg gallic acid equivalent (GAE)/100 mL). Citrus sphaerocarpa juice showed higher rates of 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging (86.8%) than those of other juices. However, the oxygen radical absorbance capacity (ORAC) value (2,409.5 μM TE/mL) of Citrus sudachi Hort. ex Shirai juice was higher than those of other juices. A high correlation (R=0.7343) was observed between the pH and ORAC values for the 20 bioresources. Furthermore, a high correlation (R=0.8752) was found between the phenolic contents and DPPH radical scavenging for the 5 citrus fruits. These results suggest that the bioresources in Jeju could be used as natural antioxidants for the development of functional foods, including healthy beverages.

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