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Anyang, South Korea

Kwak J.-H.,Chungbuk National University | Lee S.,Chung - Ang University | Park E.-S.,Chungbuk National University | In J.-K.,Chungbuk National University | And 9 more authors.
Archives of Pharmacal Research | Year: 2011

Obovatol derivatives were synthesized and evaluated for anti-platelet activity. Three derivatives (1, 2, 4i) displayed equipotent activity to obovatol in arachidonic acid-induced platelet aggregation. An initial SAR study revealed that the introduction of alkoxy group in B ring could enhance inhibitory activity. © 2011 The Pharmaceutical Society of Korea and Springer Netherlands. Source

Chae S.-H.,Seoul National University | Kim S.-I.,Nareso Co. | Yeon S.H.,Huons Co. | Perumalsamy H.,Seoul National University | Ahn Y.-J.,Seoul National University
Journal of Economic Entomology | Year: 2014

An assessment was made of the fumigant toxicity of 36 constituents from lemon balm oil (LBO) and summer savory oil (SSO) and another additional nine previously identified compounds of the oils, as well as of the control efficacy of four experimental spray formulations containing individual oils (0.5 and 0.1% sprays) and spinosad 10% suspension concentrate (SC) to females from B- and neonicotinoid-resistant Q-biotypes of Bemisia tabaci (Gennadius) (Homoptera: Aleyrodidae). Based on 24-h LC50 values, Q-biotype females (0.20 μg/cm3) were 40 times less susceptible to dichlorvos than B-biotype females (0.005 μg/cm3). Thymol (LC50, 0.35 μg/cm3) and carvacrol (0.56 μg/cm3) were the most toxic compounds toward Q-biotype females, followed by (1S)-( - )-borneol, α-terpineol, nerol, linalool, and carvone (1.06-1.38 μg/cm 3). The toxicity of these compounds was virtually identical toward both biotype females, indicating that the terpenoids and the insecticides (neonicotinoids and dichlorvos) do not share a common mode of action or elicit cross-resistance. The 0.5% spray of LBO, SSO, and spinosad 10% SC resulted in >90% mortality toward both biotype females. Global efforts to reduce the level of toxic synthetic insecticides in the agricultural environment justify further studies on LBO- and SSO-derived materials as potential contact-action fumigants for the control of B. tabaci populations. © 2014 Entomological Society of America. Source

The present invention relates to a method for preparing a purified extract of

Foundation University and Huons Co. | Date: 2013-01-22

Provided is an ophthalmic composition containing cyclosporine as an active ingredient and including polyethoxylated castor oil or polyethoxylated hydrogenated castor oil, and a method of preparing the same. Particularly, the ophthalmic composition is prepared as a nanoemulsion having a particle diameter of 100 nm or less simply by mixing and stirring an oil phase and an aqueous phase without using a high speed stirring or shearing machine, so that it is very physiochemically stable and storable for a long time. In addition, the ophthalmic composition causes no irritation to eyes.

Park S.H.,Chungbuk National University | Roh E.,Chungbuk National University | Kim H.S.,Huons Co. | Baek S.-I.,Chungbuk National University | And 5 more authors.
Biochemical and Biophysical Research Communications | Year: 2013

Lonicerae flos extract (HS-23) is a clinical candidate currently undergoing Phase I trial in lipopolysaccharide (LPS)-injected healthy human volunteers, but its molecular basis remains to be defined. Here, we investigated protective effects of HS-23 or its major constituents on Escherichia coli LPS-induced septic mortality in mice. Intravenous treatment with HS-23 rescued LPS-intoxicated C57BL/6J mice under septic conditions, and decreased the levels of cytokines such as tumor necrosis factor α (TNF-α), interleukin (IL)-1β and high-mobility group box-1 (HMGB-1) in the blood. Chlorogenic acid (CGA) and its isomers were assigned as major constituents of HS-23 in the protection against endotoxemia. As a molecular mechanism, HS-23 or CGA isomers inhibited endotoxin LPS-induced autophosphorylation of the IL-1 receptor-associated kinase 4 (IRAK-4) in mouse peritoneal macrophages as well as the kinase activity of IRAK-4 in cell-free reactions. HS-23 consequently suppressed downstream pathways critical for LPS-induced activation of nuclear factor (NF)-κB or activating protein 1 (AP-1) in the peritoneal macrophages. HS-23 also inhibited various toll-like receptor agonists-induced nitric oxide (NO) production, and down-regulated LPS-induced expression of NF-κB/AP-1-target inflammatory genes in the cells. Taken together, HS-23 or CGA isomers exhibited anti-inflammatory therapy against LPS-induced septic mortality in mice, at least in part, mediated through the inhibition of IRAK-4. © 2013 Elsevier Inc. All rights reserved. Source

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