Zhang H.-Y.,Zhejiang Center for Drug and Cosmetic Evaluation |
Jia F.,Zhejiang Center for Drug and Cosmetic Evaluation |
Qian J.,Zhejiang Center for Drug and Cosmetic Evaluation |
Lao Q.-C.,Hangzhou Hunter Biotechnology Inc. |
And 4 more authors.
Chinese Journal of New Drugs | Year: 2016
Objective: To evaluate and compare the myelosuppression and intestinal toxicity of vinorelbine bitartrate (VRL) injectable emulsion and VRL aqueous injection (NavelbineⓇ) using zebra fish model. Methods: Zebra fish embryos were separately administered with VRL injectable emulsion and VRL aqueous injection at different dosages. The numbers of erythrocyte and neutrophil, as well as enterocinesia function were evaluated to study the toxicity of the two dosage forms. Results: Both VRL injectable emulsion and VRL aqueous injection suppressed the production of erythrocyte and neutrophil in a dose-dependent manner. Compared with the VRL aqueous injection, VRL injectable emulsion had weaker inhibition effect on neutropenia at the same dose (P<0.001, P<0.01), while no obvious difference in erythropenia numbers was observed. Compared with 5% glucose injection, VRL aqueous injection obviously inhibited enterocinesia (P<0.01) in a dose-dependent manner. VRL injectable emulsion showed slight inhibition (4%~7%) of enterocinesia at the same dose, which had no significant difference with 5% glucose injection group. Conclusion: Compared with VRL aqueous injection, VRL injectable emulsion caused weaker myelosuppression and intestinal toxicity, which may indicate a promising advantage of fewer adverse effects in clinical practice. © 2016, Chinese Journal of New Drugs Co. Ltd. All right reserved.