Hungarian Food Safety Office

Budapest, Hungary

Hungarian Food Safety Office

Budapest, Hungary
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Yolci Omeroglu P.,Okan University | Ambrus A.,Hungarian Food Safety Office | Boyacioglu D.,Technical University of Istanbul
Food Analytical Methods | Year: 2013

Sample processing procedure should result in analytical portions that are representative of the analytical sample, even if 1-5 g portion are withdrawn from a large-size crops. Therefore, the efficiency of sample processing should be regularly tested during method validation and internal quality control studies. In the scope of this study, sample processing uncertainty was investigated by surface treatment of the cucumber, papaya, and jackfruit representing large-size crops with radio-labelled chlorpyrifos methyl. After homogenization in a chopper, five small and five large test portions were withdrawn from "statistically" well-mixed materials and their residue content was determined with liquid scintillation counter, which provided a quick and well reproducible mode of quantitative determination of residues. The efficiency of sample processing characterized with the sampling constant, changed between 0. 78 and 3. 01 kg with typical value of 1. 61 kg for processing at ambient temperature. Once the sampling constant was established, it was used to predict the uncertainty of sample processing for different test portion sizes. Uncertainty of sample processing at 30 g analytical portion varied between 4. 70 and 10. 55 %. Furthermore, addition of dry ice to papaya resulted in well-mixed samples as well as 50 % reduction in sampling constant value. © 2012 Springer Science+Business Media, LLC.


Omeroglu P.Y.,Okan University | Boyacioglu D.,Technical University of Istanbul | Ambrus A.,Hungarian Food Safety Office | Karaali A.,Yeditepe University | Saner S.,SK Group
Food Analytical Methods | Year: 2012

To facilitate the international food trade as well as to protect consumers from exposure to unacceptable pesticide residue levels, Codex Alimentarius Commission, European Union, and National Authorities set maximum residue limits for different food commodities. The control of pesticide residues at national and international level requires reliable and comparable analytical data that can be obtained by applying validated methods and implementing an effective internal quality control and quality assurance system in the testing laboratories. For the correct interpretation of the analytical results, measurement uncertainty should be estimated. Pesticide residue analysis includes two main steps: sampling performed outside of the laboratory and laboratory operations comprising of sample preparation, sample size reduction, sample processing, extraction, cleanup, and chromatographic determination. By taking into consideration the contribution of the individual steps to the overall uncertainty of the results, the analytical procedures can be optimized to fit for the purpose of the analysis with minimum cost. The scope of this paper is to review major steps of pesticide residue analysis in the light of current developments, to highlight the importance of identification and estimation of the uncertainties associated with the results, to describe suitable methods for their estimation, and to summarize the contribution of each step to the combined uncertainty. © 2012 Springer Science+Business Media, LLC.


Balayiannis G.,Benaki Phytopathological Institute | Karasali H.,Benaki Phytopathological Institute | Ambrus A.,Hungarian Food Safety Office
Bulletin of Environmental Contamination and Toxicology | Year: 2014

The extensive use of plant protection products in urban and rural pest control obliges to develop valid analytical methods for their successful and reliable quality control. An analytical procedure for the simultaneous determination of famoxadone and cymoxanil, by reversed phase high performance liquid chromatography based on the use of a monolithic C18 column has been developed and validated. The method involved the extraction of the active ingredients by sonication of the sample with acetonitrile and direct injection on a reversed phase liquid chromatographic system. The repeatability of the method expressed as relative standard deviation (%RSD), was lower than 1 % for both compounds. The limits of quantification for famoxadone and cymoxanil were 10 and 16 µg mL−1 respectively. The new method involves a considerable reduction in time for both sample preparation and analysis. The proposed analytical procedure is accurate and precise. © 2014 Springer Science+Business Media New York


Ambrus A.,Hungarian Food Safety Office | Zentai A.,Hungarian Food Safety Office | Sali J.,Hungarian Food Safety Office | Ficzere I.,Hungarian Food Safety Office
Accreditation and Quality Assurance | Year: 2011

Accurate analytical results with known uncertainty are required for the safety assessment of pesticides and testing the conformity of marketed food and feed with the maximum residue limits. The available information on various sources of errors was examined with special emphasis to those which may remain unaccounted for based on the current practice of many laboratories. The method validation typically covers the steps of the pesticide residue determination from the extraction of spiked samples to the instrumental determination, which contribute to only 10-40% of total variance of results. Though the variability of sampling, sample size reduction and sample processing may amount to the 60-90% of total variance, it generally remains unnoticed leading to wrong decisions. Another important source of gross error is the mismatch of the residues analysed and those included in the relevant residue definition. Procedures which may be applied for eliminating or reducing the errors are discussed. © 2010 Springer-Verlag.


Szeitz-Szabo M.,Hungarian Food Safety Office | Biro L.,NutriComp Nutrition and Health Co. | Biro Gy.,Hungarian Food Safety Office
Acta Alimentaria | Year: 2012

The authors' aim is to reveal the reflection of Hungarian political and economic transformation in the public health nutrition during the last two and a half decades. Results of the four representative, nationwide dietary surveys completed in this period have been analysed for macro-, micronutrient intakes and overweight/obesity. The food consumption-related vital statistics provided by Hungarian Central Statistical Office were also analysed and compared. There are certain signs of favourable improvements: slight decrease of energy intake in females, growing share of plant protein, less saturated, more polyunsaturated fatty acid intake, less sugar. These findings are in parallel with some positive general statistical issues: the extension of life expectancy, lesser acute myocardial infarction, atherosclerosis and stomach cancer mortality, more vegetables and fruit, lesser lard, more oil consumption. On the other hand, there are several detrimental nutritional issues that influence the health status of Hungarian population: still high energy, fat and cholesterol intake, low complex carbohydrates, too much sodium (salt), insufficiencies in some vitamin, macro- and microelements intake. The number of overweight/obese people takes up fairly high level. The surveys somewhat revealed the role of nutrition in the health status of population and now a particle of possibility for its improvement is available.


Ambrus A.,Hungarian Food Safety Office | Szeitzne-Szabo M.,Hungarian Food Safety Office | Zentai A.,Hungarian Food Safety Office | Sali J.,Hungarian Food Safety Office | Szabo I.J.,Hungarian Food Safety Office
Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment | Year: 2011

In view of the frequent occurrence of mycotoxins in cereals, a study was initiated to assess the exposure of the Hungarian adult population. Consumption data for 1360 individuals, based on a 3-day questionnaire, indicated that white bread accounted for the major intake of cereal-based products. Various cereal products were analysed for 16 mycotoxins by a LC/MS/MS multi-toxin method with LOD of 16 μgkg-1 and LOQ of 50 μgkg-1. Deoxynivalenol (DON) was most frequently detected, but no acetyl-deoxynivalenol was present in detectable concentrations. Consumer exposure was calculated with standard Monte Carlo probabilistic modelling and point estimates, taking into account bread consumption and DON contamination in independently taken wheat flour and wheat grain samples. Over 55% of cases the DON intake were below 15% of the provisional maximum tolerable daily intake (PMTDI) of 1 μg/(kg bw)/day. However, in 5-15% of cases, the intake from bread consumption alone exceeded the PMTDI. Wheat grain data led to the higher percentage. Intakes estimated from both data sets were at or below the acute reference dose (ARfD) of 8 μg/(kg bw)/day in 99.94-99.97% of cases. © 2011 Taylor & Francis.


Biro L.,NutriComp Nutrition and Health Co. | Szeitz-Szabo M.,Hungarian Food Safety Office | Biro G.,Hungarian Food Safety Office | Sali J.,Hungarian Food Safety Office
Acta Alimentaria | Year: 2011

The fourth countrywide nutrition survey was initiated and co-ordinated by the Hungarian Food Safety Office jointly to the yearly Household Budget Survey of Hungarian Central Statistical Office in 2009. The dietary assessment was performed by trained interviewers and skilled dieticians using a complex questionnaire system, containing three-day diary, short food frequency questionnaire and questions on taking of dietary supplements and on prevalence of food allergy. The data records were processed and the questionnaires were validated, the results obtained on the micronutrient intakes of the adult population are shown in this article. From fat soluble vitamins, the average daily intakes of vitamins A and D were lower than the national recommendations in case of both genders, meaning low intake for around 60% (in case of retinol) and 80-90% (in case of calciferols) of adults. The intakes of some water soluble vitamins belonging to B group, vitamin C and folates were low as well. Regarding the macroelements, the most important health problem on population level is the extremely high sodium load of the inhabitants, combined with unfavourable sodium/potassium ratio. The average daily calcium intake of every age and gender group was far below the recommended value. The average daily intake of iron was low for the 50% of adult females. The article also provides data on frequency of food supplement taking habits of inhabitants and of self-reported food allergy.


Szeitz-Szabo M.,Hungarian Food Safety Office | Biro L.,NutriComp Nutrition and Health Co. | Biro Gy.,Hungarian Food Safety Office | Sali J.,Hungarian Food Safety Office
Acta Alimentaria | Year: 2011

In 2009 Hungarian Food Safety Office (HFSO) performed a countrywide representative dietary survey to obtain food consumption data for quantitative food safety risk assessment utilizable in the field of public health nutrition as well. The consumption of foodstuffs, daily energy- and nutrient intakes, nutritional habits and dietary supplement usage of Hungarian population was assessed. The complex system has included three-day dietary record and a food consumption frequency questionnaire. Some anthropometric parameters were also self-recorded. According to the body mass index, a considerable proportion of both the 31-60 years old males (69%) and females (46%) were overweight or obese. The energy intake of the Hungarian adult population is slightly exceeds the recommendation. The intake of proteins is satisfactory in general. The average intake of total fats is very high (36.1-38.9 energy percent), and the fatty acid composition - mostly the ratio of n-6/n-3 fatty acids - is unfavourable, but the fatty acid pattern regarding saturated- (SFA), mono- (MUFA) and polyunsaturated (PUFA) fatty acid ratio shows favourable tendency. The proportion of complex carbohydrates within the intake of energy providing macronutrients is far lower than the optimal level, but it is a positive finding that added sugar intake is below the outmost recommendation. The average daily cholesterol intake is high (males: 469 mg, females: 335 mg), whilst the dietary fibre intake is lower than the recommended. The article provides data on alcohol, caffeine and fibre consumption, too.


PubMed | Hungarian Food Safety Office
Type: Comparative Study | Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment | Year: 2011

In view of the frequent occurrence of mycotoxins in cereals, a study was initiated to assess the exposure of the Hungarian adult population. Consumption data for 1360 individuals, based on a 3-day questionnaire, indicated that white bread accounted for the major intake of cereal-based products. Various cereal products were analysed for 16 mycotoxins by a LC/MS/MS multi-toxin method with LOD of 16 g kg and LOQ of 50 g kg. Deoxynivalenol (DON) was most frequently detected, but no acetyl-deoxynivalenol was present in detectable concentrations. Consumer exposure was calculated with standard Monte Carlo probabilistic modelling and point estimates, taking into account bread consumption and DON contamination in independently taken wheat flour and wheat grain samples. Over 55% of cases the DON intake were below 15% of the provisional maximum tolerable daily intake (PMTDI) of 1 g/(kg bw)/day. However, in 5-15% of cases, the intake from bread consumption alone exceeded the PMTDI. Wheat grain data led to the higher percentage. Intakes estimated from both data sets were at or below the acute reference dose (ARfD) of 8 g/(kg bw)/day in 99.94-99.97% of cases.


PubMed | Hungarian Food Safety Office
Type: Journal Article | Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment | Year: 2012

Poppy seed-containing foods are popular dishes in Hungary and some other Central European countries. The alkaloids of poppy are used in the production of medicines. Poppy seeds used as food may also contain considerable amounts of alkaloids, which raises the question of food safety. Morphine, codeine, thebaine and noscapine concentrations of poppy seed samples from the period 2001-2010 and consumption data from two Hungarian surveys, carried out in 2003 and 2009, were evaluated. Exposure calculations were made for morphine intake by both point estimate and probabilistic methods, and the uncertainty of the calculated values was estimated. The point estimate for the acute consumer exposure, calculated using the 97.5th percentiles of morphine concentration and of poppy seed consumption and taking into account the reduction of morphine content by processing, was 78.64g (kgbw)day for adults, and 116.90g (kgbw)day for children. Based on probabilistic estimations, the 97.5th and 99th percentile exposures ranged between 18.3-25.4 and 25.6-47.4g (kgbw)day for adults, and between 32.9 and 66.4g (kgbw)day for children, respectively. As a no observed effect level (NOEL) had not been established, the significance of exposure could not be assessed.

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