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Taichung, Taiwan

Yu W.-J.,Hung Kung University | Yu B.-C.,National Cheng Kung University | Yang F.-Y.,National Cheng Kung University | Chang C.-C.,Tainan University of Technology | And 2 more authors.
Journal of Food and Drug Analysis | Year: 2012

One of the major causes of the decline in semen quality appears to be the elevated levels of oxidative stress. Leaves of Toona Sinensis (TSL) have been used as a traditional medicine for treatment of certain male reproduction-related disorders in Chinese ancient medical books; however, the scientific data are limited. In the present study, human spermatozoa treated with hydrogen peroxide (H2O2) were used to investigate the protective function of TSL-6 under oxidative stress. The intracellular reactive oxygen species (ROS) levels of human spermatozoa were increased after 0.2 mmol/L H2O2 treatment and the elevated levels were diminished by TSL-6 dose dependently. The protection of TSL-6 against oxidative stress in human spermatozoa was further substantiated by increasing sperm motility assay including computer assisted sperm analysis (CASA), percentage of high MMP cells, ATP production, percentage of double strand DNA cells, and decreasing cell death. Our results suggested that TSL-6 improved functions of spermatozoa under oxidative stress via decreasing ROS level and cell death. In addition, TSL-6 increased sperm motility, MMP, ATP levels, and maintained the integrity of chromatin structure. TSL-6 is beneficial for human sperm and is potentially developed into functional foods for infertile men under oxidative stress. Source


Lin C.-H.,National Yang Ming University | Lin C.-H.,Hung Kung University | Chou L.-W.,National Yang Ming University | Wei S.-H.,National Yang Ming University | And 3 more authors.
Computer Methods and Programs in Biomedicine | Year: 2014

Background and objective: This study was designed to establish the validity and reliability of a new device that measures bilateral shoulder and elbow range of motion (ROM) and grip force performance in vivo. A further aim was to investigate the control of inter-limb grip force coordination during isometric force-maintenance tasks. Validity of the ROM and grip force measurements was examined using a validated clinical goniometer and standard weights. Subjects: Twenty-one healthy adults (six female, 15 male mean. ±. standard deviation age. = 23.05. ± 3.51) were recruited for this study. Design: All subjects were asked to perform tests to evaluate the validity and reliability of ROM, grip force maximum voluntary contraction (MVC) and coordination control measurements. Results: The ROM and grip force measurements were linearly correlated with criterion standards. For reliability testing, all of the intraclass correlation coefficient values were >0.99. The inter-limb grip force coordination control task showed that the force modulation timing during dominant-to-non-dominant hand transition was longer than the non-dominant-to-dominant hand transition (p< 0.05). Conclusions: These results demonstrate that this device is valid and reliable when used to measure shoulder and elbow ROM and grip force of both hands. Isometric force-maintenance tasks also indicated changes in inter-limb grip force control. © 2014 Elsevier Ireland Ltd. Source


Tsou C.-H.,Taipei Medical University Hospital | Tsou C.-H.,National Yang Ming University | Yu P.-Y.,Taipei Medical University Hospital | Tu P.-Y.,Taipei Medical University Hospital | And 3 more authors.
Chinese Journal of Physiology | Year: 2012

Cardiac and respiratory oscillations have been shown to interact with each other. This interaction could reflect autonomic nervous system functionality. Propofol-induced yawning during anesthesia induction seems to be associated with sympathetic activation. Presumptively, there is high linearity among interaction of different physiologic system behaviors. Recently, investigators used coherence analysis to quantify the existence and strength of linearity between system signals for study of cardio-respiratory interaction under different physiological conditions. In this investigation, we used a method of time-frequency coherence function to analyze ECG and respiration signals to investigate the linearity of cardio-respiratory dynamics in patients undergoing routine propofol induction procedures for elective surgery. In this prospective, observational clinical study, a total of 84 eligible patients were enrolled. The patients were categorized into yawning and no-yawning groups during propofol induction. During induction, both groups demonstrated significant reduction in high frequency coherence (coh-HF) with simultaneously significant increase in very low frequency coherence (coh-VLF) compared to the pre-induction period. As yawning occurred, the yawning group had more significant changes of cardio-respiratory coherences than the no-yawning group at coh-LF and coh-VLF bands. The yawning group also showed losses of linearity at high frequency band (coh-HF > 0.5) as compared to the pre-induction period, and also showed increases in linearity at low (coh-LF > 0.5) and very low (coh-VLF >0.5) frequency bands compared to the no-yawning group. Propofol-induced yawning alters cardio-respiratory dynamics with changes of linearity between cardio-vascular and respiratory system behaviors. © 2012 by The Chinese Physiological Society and Airiti Press Inc. Source


Huang J.-A.,Taichung Veterans General Hospital | Huang J.-A.,Hung Kung University | Weng R.-H.,Chia Nan University of Pharmacy and Science | Lai C.-S.,National Yunlin University of Science and Technology | Hu J.-S.,Fu Jen Catholic University
Evaluation and the Health Professions | Year: 2013

The purpose of this study was to explore the perceptual market orientation gaps between physician and patients and its impact on relationship quality and patient loyalty, and to verify the critical role of internal marketing on developing market orientation. Self-administered questionnaires were then employed to collect the data. We used a convenience sample of physicians and patients at a medical center in central Taiwan, and 90 usable questionnaires from physicians and 450 usable questionnaires from patients were returned. Hierarchical multiple regression analyses were used to validate the research hypotheses. Physicians' perceptual market orientation had a positive influence on physician-patient relationship quality, hospital-patient relationship quality, and patient loyalty, but the perceptual market orientation gap between physicians and their patients had a direct negative impact on these constructs. Finally, internal marketing was found to have an influence on relationship quality and patient loyalty through the mediation of market orientation. In order to enhance relationship quality and patient loyalty, hospital managers should focus their efforts on improving employees' market orientation and reducing patients' perceptual market orientation gap. In addition, internal marketing was found to be a useful pathway in developing market orientation. © The Author(s) 2012. Source


Wang L.-Y.,National Taiwan University | Wang L.-Y.,National Taiwan University Hospital | Luo H.-J.,National Taiwan University | Luo H.-J.,Hung Kung University | And 8 more authors.
Pediatric Pulmonology | Year: 2010

Oral feeding has been reported to compromise breathing among preterm infants with bronchopulmonary dysplasia (BPD) during hospitalization or shortly after discharge. However, limited information was available concerning whether preterminfants with BPD remain vulnerable to feeding and growth insufficiency after a longer term of follow-up. The purpose of this study was therefore to examine the effect of severity of BPD on pulse oxygen saturation (SpO 2) during feeding and growth in very low birth weight (VLBW) preterm infants during infancy. Seventy-two preterm infants with VLBW and 15 terminfants were prospectively examined their growth and SpO2 during feeding at 2, 4, and 6 months of corrected age. The severity of BPD was graded in VLBW infants according to the American National Institutes of Health consensus definition. In comparison to VLBW infants with mild BPD and terminfants, VLBW infants with severe BPD showed significantly lower mean levels of SpO 2 during feeding at 2-6 months corrected age (P<0.05). Those with severe BPD further exhibited higher rates of growth delay (weight<10th percentile) throughout the study period. Among VLBW infants, severe BPD had an adverse relation with subsequent weight measures after adjustment for medical and demographic confounding variables (β=-904 g, P=0.03). The consensus BPD definition is useful to identify those preterm infants who are at greater risk of feeding desaturation and growth delay during infancy and close monitoring of SpO2 during feeding should be advised. © 2010 Wiley-Liss, Inc. Source

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