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He J.,Northwest University, China | Ma J.,Northwest University, China | Ma J.,Hunan Provincial Institute for Drug Control | Lai D.-W.,Peking University | And 2 more authors.
Natural Product Research

A new triterpenoid saponin, named esculentoside T (1), together with five known compounds (2-5), was isolated from the roots of Phytolacca acinosa. The structures of these compounds were elucidated on the basis of spectral data. © 2011 Taylor & Francis. Source

Lijun L.,Hunan Provincial Institute for Drug Control
Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation

Determined the easily oxidized substance of the injector based on GB15810-2001, and analyzed the source of uncertainty of the process of titration symmetrically, and valued the uncertainty of the result of data analysis. Source

Hu X.,Hunan Agricultural University | Hu X.,State Key Laboratory of Subhealth Intervention Technology | Wu G.-P.,Central South University | Zhang M.-H.,Shanghai JiaoTong University | And 8 more authors.
Analytical and Bioanalytical Chemistry

Clinical definition and appropriate management of anaphylaxis is a clinical challenge because there is large variability in presenting clinical signs and symptoms. Monitoring of the metabolic status of anaphylaxis may be helpful in understanding its pathophysiological processes and diagnosis. The purpose of this study was to conduct GC-MS serum metabolic profiling of anaphylaxis animal models and search for potential biomarkers of anaphylaxis. Thirtysix guinea pigs were randomly divided into an ovalbumin group (n012), a cattle albumin group (n012), and a control group (n012). The IgE level in the serum of the guinea pigs was evaluated by use of ELISA kits and the major metabolic changes in serum were detected by gas chromatography-mass spectrometry. Typical clinical symptoms appeared after the animals had been challenged with ovalbumin or cattle albumin. The IgE levels in serum of both model groups were significantly higher than those of the control group. Clustering trend of the three groups based on variables was observed and nine out of 858 metabolomic features were found to be significantly different between control group and model groups. Among the nine features, six features were tentatively identified as metabolites related to energy metabolism and signal transduction in anaphylaxis. In conclusion, GC-MS-based metabolic profiling analysis might be an effective auxiliary tool for investigation of anaphylaxis. © Springer-Verlag 2012. Source

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