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Changsha, China

Hunan Normal University , founded in 1938, is a higher education institution located in Changsha, Hunan Province, People's Republic of China. It has existed for 72 years. The University is a national 211 Project university, one of the country's 100 key universities in the 21st century that enjoy priority in obtaining national funds. Wikipedia.

Xiao L.,Hunan Normal University | Yeung E.S.,Iowa State University
Annual Review of Analytical Chemistry | Year: 2014

Imaging of plasmonic nanoparticles (PNP) with optical microscopy has aroused considerable attention in recent years. The unique localized surface plasmon resonance (LSPR) from metal nanoparticles facilitates the transduction of a chemical or physical stimulus into optical signals in a highly efficient way. It is therefore possible to perform chemical or biological assays at the single object level with the help of standard optical microscopes. Because the source of background noise from different samples is different, distinct imaging modalities have been developed to discern the signals of interest in complex surroundings. With these convenient yet powerful techniques, great improvements in chemical and biological assays have been demonstrated, and many interesting phenomena and dynamic processes have also been elucidated. Further development and application of optical imaging methods for plasmonic probes should lead to many exciting results in chemistry and biology in the future. © Copyright ©2014 by Annual Reviews. All rights reserved.

Liu Y.,Hunan Normal University
International journal of nanomedicine | Year: 2011

Smaller nanoparticles facilitate the delivery of DNA into cells through endocytosis and improve transfection efficiency. The aim of this study was to determine whether protamine sulfate-coated calcium phosphate (PS-CaP) could stabilize particle size and enhance transfection efficiency. pEGFP-C1 green fluorescence protein was employed as an indicator of transfection efficiency. Atomic force microscopy was used to evaluate the morphology and the size of the particles, and an MTT assay was introduced to detect cell viability and inhibition. The classical calcium phosphate method was used as the control. Atomic force microscopy images showed that the PS-CaP were much smaller than classical calcium phosphate particles. In 293 FT, HEK 293, and NIH 3T3 cells, the transfection efficiency of PS-CaP was higher than for the classical calcium phosphate particles. The difference in efficiencies implies that the smaller nanoparticles may promote the delivery of DNA into cells through endocytosis and could improve transfection efficiency. In addition, PS-CaP could be used to transfect HEK 293 cells after one week of storage at 4°C with a lesser extent of efficiency loss compared with classical calcium phosphate, indicating that protamine sulfate may increase the stability of calcium phosphate nanoparticles. The cell viability inhibition assay indicated that both nanoparticles show similar low cell toxicity. PS-CaP can be used as a better nonviral transfection vector compared with classical calcium phosphate.

Jenkins S.,Hunan Normal University
International Journal of Quantum Chemistry | Year: 2013

The need to make more quantitative use of the total electronic charge density distribution is demonstrated in this short perspective. This is framed in the perspective of the ground breaking early work of Bader and coworkers, along with mathematicians who captured the essential nature of a molecule in a suitably compact form in real space. We see that this simple form is the Poincaré-Hopf relation for molecules and clusters and the Euler-Hopf relation in solids. Thom's theory of elementary catastrophes combined with the Poincaré-Hopf relation provides the inspiration for the new quantum topology. An alternative use of the Poincaré-Hopf relation, molecular recognition, is discussed. Quantum topology is then used to create a topology phase diagram for both molecules and solids. The author adds their perspectives of the huge potential of the quantum topology approach by demonstrating the ease with which new theoretical ideas can be generated. © 2013 Wiley Periodicals, Inc.

Zhong X.-H.,Hunan Normal University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2010

The strong decay properties of the newly observed D(2550), D(2600), D(2750), and D(2760) are studied in a constituent quark model. It is predicted that the D(2760) and D(2750) seem to be two overlapping resonances. The D(2760) could be identified as the 1D33 with JP=3⊃-, while the D(2750) is most likely to be the high-mass mixed state |1D2′ H (JP=2⊃-) via the 1D21-1D23 mixing. The D(2600) favors the low-mass mixed state |(SD) 1L (JP=1⊃-) via the 1D13-2S13 mixing. The D(2550) as the 2S01 assignment bears controversies for its too-broad width given in experiments. © 2010 The American Physical Society.

Zhang A.,Hunan Normal University
Nuclear Physics B | Year: 2015

We investigate the thermal Casimir effect of a massless scalar field for two parallel plates moving in the equatorial orbit in Kerr space-time. Under the assumption that the typical cavity size is much smaller than the orbital radius, proposed by Sorge, we deduce the analytical expression of the renormalized free energy in this curved space-time. We also get the analytical representation for the renormalized internal energy, and find that there is a thermal correction to the Casimir energy, which depends on the proper temperature and the proper geometrical parameters of the plates. The asymptotic behavior of the Casimir free energy, entropy and internal energy at low temperature is also investigated. © 2015 The Author.

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