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Yang X.,Hunan City University | Guan A.,Sinochem Group
Journal of Fluorine Chemistry | Year: 2014

Prostate cancer is one of leading causes of male deaths in Europe and US and is becoming a dramatically increasing malignancy in Asian countries including China. This disease is related to hormone malfunction linked with androgen receptor cell signaling. Targeting androgen receptor has been a major strategy for treating this disease. Among these treatments, small molecules such as flutamide, bicalutamide and newly FDA-approved MDV3100 are the mainstay of drugs in clinical use. Interestingly, all of them are fluorine-containing compounds, indicating a unique role of fluorine atom on treating this cancer. In this mini-review, we summarize the prostate cancer-related cell signaling, chemistry and mechanisms of action of these drugs, highlighting the importance of fluorine chemistry on treating prostate cancer. © 2014 Elsevier B.V.


Jin H.,Hunan City University | Wu Y.,Tufts University
International Journal of Digital Content Technology and its Applications | Year: 2011

Digital Rights Management (DRM) is an interdisciplinary and challenging research topic in recent years. VOD system becomes more and more popular due to its flexibility and convenience, but its program is prone to be copied and diffused illegally. Through researching on the VOD system and DRM technology, this paper incorporates and implements a scalable DRM system model in VOD, this model can expand DRM easily, and has good effect.


Huang W.-L.,Hunan City University | Cai J.-L.,Hangzhou Normal University
Acta Mechanica | Year: 2012

The conformal invariance and conserved quantity of Mei symmetry for a higher-order nonholonomic mechanical system are presented. Introducing an infinitesimal transformation group and infinitesimal generator vector, the definition of conformal invariance of Mei symmetry and the determining equation for the holonomic system which corresponds to a higher-order nonholonomic system are provided, and the relationship between Mei symmetry and conformal invariance of the system is discussed. The basis of restriction equations and additional restriction equations, the conformal invariance of weak and strong Mei symmetry for the higher-order nonholonomic mechanical system is constructed.With the aid of a structure equation that the gauge function satisfies, the system's corresponding conserved quantity is derived. Finally, an example is given to illustrate the application of the method and its result. © Springer-Verlag 2011.


Chen S.,Hunan City University
Journal of Computational and Theoretical Nanoscience | Year: 2011

A dendrimer nanostar is a tree-like highly branched polymer molecule. Dendrimer nanostars are synthesized from monomers with new branches added in discrete steps to form a tree-like architecture. They have some proven applications, and numerous potential applications. Let G is a connected graph with vertex set V and edge set E, the Hosoya index of a graph is defined as the total number of its matchings. We obtain exact formulas for calculating the Hosoya index of dendrimer nanostars. Copyright © 2011 American Scientific Publishers.


Long F.,Hunan City University
Nonlinear Analysis: Real World Applications | Year: 2012

In this paper, we study the problem of positive almost periodic solutions for the generalized Nicholson's blowflies model with a linear harvesting term and multiple time-varying delays. By applying the fixed point theorem and the Lyapunov functional method, we establish some criteria to ensure that the solutions of this model converge locally exponentially to a positive almost periodic solution. Moreover, we give an example to illustrate our main results. © 2011 Elsevier Ltd. All rights reserved.


Chen S.,Hunan City University
Journal of Combinatorial Optimization | Year: 2016

The Gutman index (also known as Schultz index of the second kind) of a graph G is defined as Gut(G)=∑u,v∈V(G)d(u)d(v)d(u,v). A graph G is called a cactus if each block of G is either an edge or a cycle. Denote by C(n,k) the set of connected cacti possessing n vertices and k cycles. In this paper, we give the first three smallest Gutman indices among graphs in C(n,k), the corresponding extremal graphs are characterized as well. © 2014, Springer Science+Business Media New York.


Zeng T.,Hunan City University
Match | Year: 2013

The Harary index is defined as the sum of reciprocal distances between all pairs of vertices in a nontrivial connected graph. All established results on Harary index mainly deal with bounds and extremal properties of Harary index. In this paper, we give a new sufficient condition, in terms of Harary index, for a connected bipartite graph to be Hamiltonian.


Zhou J.,Hunan City University
International Journal of Digital Content Technology and its Applications | Year: 2012

This paper applies Voronoi diagram into the localization of the wireless sensor network and proposes VBLS (Voronoi diagrams based localization scheme). This algorithm first sorts the received signal strength indicator (RSSI) from the anchor nodes by the order from high to low, computes Voronoi area of each anchor node by using UDG diagram and finally outputs the centroid of the intersection sets of all Voronoi as the localization results. The simulation results of the VBLS are compared with them of the range-free W-Centroid and Centroid. The simulation results indicate that if the anchor nodes are randomly placed, the localization error of VBLS is 18% and 13% lower than it of the Centroid and W-Centroid algorithm respectively; if the anchor nodes are placed uniformly, the localization error of VBLS is 7% lower than it of Centroid algorithm and is 2% higher than it of W-Centroid.


Wen T.,Hunan City University
Applied Mechanics and Materials | Year: 2012

The group eigenvalue method and fuzzy mathematics knowledge is used to assess the comprehensive evaluation of the service level for bus traffic. Analyzing the factors that influence the service level of bus traffic, it puts forward the evaluation index system of service level. In order to evaluate the service level for bus traffic, on the basis of defining remark grade, used the group eigenvalue method to decide the index weight. Then, the scientific and rationality of the evaluation method was detected by application example, according to the evaluation result, carried on the corresponding analysis. © (2012) Trans Tech Publications, Switzerland.


Wan X.-J.,Hunan City University
Transactions of Nonferrous Metals Society of China (English Edition) | Year: 2011

Porous Ti35Nb alloy with a porosity of 66 was made by a powder metallurgical method, and then it was treated by a standard treatment for activating the surface of Ti implant materials involving alkali and heat treatment. The alkali and heat treatment causes damages of the struts of the porous Ti35Nb in the form of reaction products layer, grain-pullout and cracks. Consequently, it leads to a significant degradation of the strength of the porous alloy. The effect of the alkali and heat treatment on the strength of the porous alloy was discussed. © 2011 The Nonferrous Metals Society of China.

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