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Cremers B.,Saarland University | Clever Y.,Saarland University | Schaffner S.,Invatec Technology Center | Speck U.,Humbold University of Berlin | And 2 more authors.
Minerva Cardioangiologica | Year: 2010

Randomized clinical trials investigating the treatment of coronary in-stent restenosis with paclitaxel iopromide coated balloon catheters have shown favorable results. The aim of the present clinical investigation was to assess the efficacy of a novel paclitaxel urea coated angioplasty balloon in the treatment of coronary instent restenosis. A total of 26 restenotic bare metal stents in 23 patients with a lesion length of 22.8±11.1 mm and a reference vessel diameter of 2.64±0.31 mm were treated. Up to six months and including the six-month angiographic control, only one target lesion revascularization was necessary; in total, the rate of major adverse cardiovascular events until sixmonth follow-up was 4.3 %. In-stent late lumen loss was 0.07±0.37 nun, in-segment late lumen loss 0.02±0.50 mm. Binary restenosis was present in one patient (4.3%). The results of this first-in-human series with a paclitaxel urea coated balloon are comparable to paclitaxel iopromide coated balloon catheters. Randomized, controlled clinical trials are warranted to further evaluate this promising approach.


Wu Y.,Nanyang Technological University | Papper V.,Nanyang Technological University | Pokholenko O.,Nanyang Technological University | Kharlanov V.,Humbold University of Berlin | And 3 more authors.
Journal of Fluorescence | Year: 2015

4-N,N′-dimethylamino-4′-N′-stilbenemaleamic acid (DASMA), a unique molecular photochrome probe that exhibits solubility and retains trans-cis photoisomerisation in a wide range of organic solvents and aqueous pH environments, was prepared, purified and chemically characterised. Absorption, fluorescence excitation and emission spectra and constant-illumination fluorescence decay were measured in acetonitrile, dimethyl sulfoxide, ethanol, propylene carbonate, and aqueous glycerol mixtures. The pseudo-first-order fluorescence decay rates were found to be strongly dependent on the medium viscosity. In addition, the molecule exhibited the pH-dependent fluorescence and photoisomerisation kinetics. © 2015 Springer Science+Business Media.

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