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Salvioli B.,Humanitas Clinical Institute IRCCS | Bazzocchi G.,Montecatone Rehabilitation Institute | Barbara G.,University of Bologna | Stanghellini V.,University of Bologna | And 4 more authors.
European Journal of Gastroenterology and Hepatology

Intestinal motor and sensory dysfunctions in traumatic complete or incomplete spinal cord injury (SCI) are frequent and result in altered mechanisms of defecation. The aim of this study is to investigate sigmoid compliance and perception in chronic SCI patients. Sigmoid responses to fixed-tension distentions were assessed using a tensostat in six patients (six men, 42±4 years) with chronic complete transection of the spinal cord (high-SCI; five tetraplegic C5-C7 and one paraplegic T4-T6) and impaired evacuation (i.e. constipation). A group of 10 healthy individuals (six men, 25±1 years) served as controls. SCI patients had higher sigmoid compliance at the highest distention level than the controls (10.3±2.4 vs. 5.1±0.8 ml/mmHg; P<0.05). Perception scores at first sensation were higher in SCI patients (2.3±0.7 vs. 1.1±0.1; P<0.05), but were not different at the highest distention levels (3.7±0.8 vs. 3±1; NS). The most commonly reported sensation by patients was distention/bloating and was referred less commonly to the hypogastrium compared with distention/bloating in controls. An increased sigmoid compliance can be detected in constipated SCI patients. The preservation of some degree of visceral sensations, although abnormally referred, could imply the occurrence of sensory input remodeling at the spinal level. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins. Source

Botea F.,University of Milan | Marconi M.,University of Milan | Lutman F.,Humanitas Clinical Institute IRCCS | Balzarini L.,Humanitas Clinical Institute IRCCS | And 3 more authors.
Updates in Surgery

Since the efficiency of percutaneous ablation techniques in treating colorectal liver metastases is dependent on tumor size, the aim of this study was to verify the accuracy of computed tomography or magnetic resonance in estimating the maximum diameter of colorectal liver metastases by comparing these findings with those of pathology in a series of patients who underwent liver resection. Radiological and pathological tumor measurements in 39 patients operated for 69 colorectal liver metastasis were recorded. The radiological measurement was performed by magnetic resonance in 40 tumors (23 cases) and by computed tomography in 29 tumors (16 patients). The mean difference between pathological and radiological sizes was 0.4 cm (p<0.001). Radiological size was smaller than pathological size in 60.9% of tumors, equal in 16% and bigger in 23% of tumors. The results indicated that radiology significantly underestimates the diameter of liver metastasis. To avoid on-site recurrence after percutaneous ablation therapies due to inaccurate radiological measurement, a radiological size of colorectal metastasis up to 2.5 cm should be considered as selection criteria for this treatment. © 2010 Springer-Verlag. Source

Mensi C.,Clinica Del Lavoro Luigi Devoto | Mensi C.,University of Milan | Termine L.,University of Milan | Garberi A.,University of Milan | And 5 more authors.

Pleural malignant mesothelioma is a locally invasive tumor that tends to progress due to direct extension of the tumor into the pulmonary parenchyma, the chest wall, the mediastinum, or the abdominal cavity via the diaphragm. In the later stages of the disease, distant metastases can occur. Metastases to the nervous system are rare, and clinical signs of nervous system involvement typically appear between 2 months and 6 years after the primary diagnosis. However, the case presented here manifested as neurological impairment without any respiratory symptoms. © Il Pensiero Scientifico Editore. Source

Magrini E.,Humanitas Clinical Institute IRCCS | Magrini E.,Italian National Cancer Institute | Szabo I.,University of Padua | Doni A.,Humanitas Clinical Institute IRCCS | And 3 more authors.

In addition to its role as neurotransmitter, serotonin (5-HT) is an important modulator of inflammation and immunity. Here, we report novel findings suggesting a 5-HT involvement in T cell migration. In particular, we show that 5-HT tunes the responsiveness of human T lymphocytes to the broadly expressed chemokine CXCL12 in transwell migration assays. By real-time PCR, western blot analysis and electrophysiological patch clamp experiments, we demonstrate that the type 3 5-HT receptor (5-HT 3) is functionally expressed in human primary T cells. In addition, specific 5-HT 3 receptor agonists selectively decrease T cell migration towards gradients of CXCL12 but not of inflammatory chemokines, such as CCL2 and CCL5. In transmigration experiments, 5-HT 3 receptor stimulation reverts the inhibitory effect of endothelial-bound CXCL12 on T cell migration. Our data suggest that the reduced T cell responsiveness to CXCL12 induced by 5-HT may occur to facilitate T cell extravasation and migration into inflamed tissues. © 2011 Magrini et al. Source

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