Human Photosynthesis Study Center

Ciudad López Mateos, Mexico

Human Photosynthesis Study Center

Ciudad López Mateos, Mexico
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Aliev G.,International Biomedical | Aliev G.,Health Science University | Daza J.,Pontifical Xavierian University | Herrera A.S.,Human Photosynthesis Study Center | And 7 more authors.
CNS and Neurological Disorders - Drug Targets | Year: 2015

One of the biggest problems and challenges for the development of new drugs and treatment strategies against Alzheimer Disease (AD) is the crossing of target drugs into the blood brain barrier. The use of nanoparticles in drug delivery therapy holds much promise in targeting remote tissues, and as a result many studies have attempted to study the ultrastructural localization of nanoparticles in various tissues. However, there are currently no in vivo studies demonstrating the ultrastructural distribution of nanoparticles in the brain. The aim of this study was to address how intraperitoneal injection of silver nanoparticles in the brain leads to leaking on the inter-endothelial contact and luminal plasma membrane, thus elucidating the possibility of penetrating into the most affected areas in the Alzheimer brain (vascular endothelium, perivascular, neuronal and glial cells). Our results show that the silver nanoparticles reached the brain and were found in hippocampal areas, indicating that they can be conjugated and used to deliver the drugs into the cell cytoplasm of the damaged brain cells. The present study can be useful for the development of novel drug delivering therapy and useful in understanding the delivery, distribution and effects of silver nanoparticles in AD brain tissue at cellular and subcellular level. © 2015 Bentham Science Publishers.


Herrera A.S.,Human Photosynthesis Study Center | Esparza M.C.A.,Human Photosynthesis Study Center | Arias P.E.S.,Human Photosynthesis Study Center | Arias M.P.S.,Human Photosynthesis Study Center
Journal of Neurological Sciences | Year: 2012

Photosynthesis in plants is considered the most important chemical reaction in the world because is the first step in the food chain. The first clues of the process were detected by Lavoisier and others during the XVIII century, but the exact nature of the chemical reactions involved remain poorly understood. Moreover, dissociation of the water molecule constitutes the very first reaction of photosynthesis in plants, and was unsuspected, even unthinkable in human beings, until we found it in human retina in 1990s. The discovery of the amazing capacity of our body to makes the dissociation of the water molecule, breaks the paradigm: Plants and human beings have the same very first reaction as the origin of life. The impact in the field of molecular biology is huge; therefore the role of the water and glucose must be redefined, glucose is just a source of biomass, instead water is the real source of energy of the eukaryotic cell, and neuron cell is not an exception. The main source of energy of the CNS is the CSF and therefore the ventricles and subarachnoid space. Blood vessels are merely source of biomass. By the analogy with the process in plants, our discovery was named human photosynthesis. Human being begin to lose the capacity to split the water molecule at 26 years old, ca. 10 % each decade, and after fifties goes into free fall. Our research along these 23 years thought us that medical modulation of human photosynthesis has extraordinary therapeutic results in CNS ́s diseases.


Herrera A.S.,Human Photosynthesis Study Center | Leszek J.,Wroclaw Medical University | del Carmen Arias Esparza M.,Human Photosynthesis Study Center | Solis-Arias R.I.,Human Photosynthesis Study Center | And 2 more authors.
Journal of Bioanalysis and Biomedicine | Year: 2013

More than 100 years have passed by since the first description of AD by Alois Alzheimer; however the patients, presently; are dying in the same way in spite the technological advance. Our finding of the previously unknown capacity of the melanin's human body to split and reform the water molecule, appointed as human photosynthesis by its analogies with photosynthesis in plants; constitutes a disruptive advance in the knowledge because means that glucose is not a source of energy, instead it is a biomass source only. If really glucose were a source of energy, then diabetic patients should be able to fly. It is out of discussion that glucose is the ideal building block; our body even makes nucleic acids with it. But energy, (anything that makes a change) is astonishingly taken from water. AD is an energy problem, not a biomass trouble. In this speech we are presenting the concept, the basis and the amazing therapeutic results in Alzheimer's disease that the medical enhancement of Human Photosynthesis can give. Therefore the role of the CSF must be rethought due that water is so far the main source of energy of the CNS and the cerebral sulcus the best way to keep a close contact between neurons and water, therefore to the neuron cell water constitutes a source of energy that is easily affordable through the subarachnoid space and the ventricles. From now in ahead, the sacred role of glucose as source of energy is broken into small pieces. Human photosynthesis is a turning point in the understanding and treatment of the plague of the XXI century, the Alzheimer's Disease.


Solis-Herrera A.,Human Photosynthesis Study Center | Ashraf G.M.,King Abdulaziz University | Maria del Esparza C.A.,Human Photosynthesis Study Center | Arias R.I.S.,Human Photosynthesis Study Center | And 4 more authors.
Central Nervous System Agents in Medicinal Chemistry | Year: 2015

The chemical process initiated by QIAPI 1 has been deemed to be the most important biological reaction associated with human photosynthesis, and possibly neuroprotective effects under various inflammatory events. However, the detailed biological activities of QIAPI 1 as a melanin precursor are still unknown. In the present work, cytotoxicity test was done by MTT assay to determine cell viability of various cell lines (WI-38, A549, HS 683) like proliferation tests and its effect on cytokine production. Arsenic poisoning is an often-unrecognized cause of renal insufficiency. No prophylactic and/or therapeutic compounds have shown promising results against kidney diseases. The pathogenesis of Arsenicinduced nephropathy is not clear. Arsenic, as itself, does not degrade over time in the environment, and its accumulation may induce toxic effects. In this study, we also report the histological findings of the kidney in 3 groups of Wistar rats, a control group, a group exposed to arsenic in the water; and a group exposed to arsenic and treated with QIAPI 1 simultaneously. The findings of the current evidence indicates a potential therapeutic ability of QIAPI 1. © 2015 Bentham Science Publishers.


Herrera A.S.,Human Photosynthesis Study Center | Del C A Esparza M.,Human Photosynthesis Study Center | Ashraf G.M.,King Abdulaziz University | Zamyatnin A.A.,Moscow State University | And 2 more authors.
Central Nervous System Agents in Medicinal Chemistry | Year: 2015

Currently, cell biology is based on glucose as the main source of energy. Cellular bioenergetic pathways have become unnecessarily complex in their eagerness to explain that how the cell is able to generate and use energy from the oxidation of glucose, where mitochondria play an important role through oxidative phosphorylation. During a descriptive study about the three leading causes of blindness in the world, the ability of melanin to transform light energy into chemical energy through the dissociation of water molecule was unraveled. Initially, during 2 or 3 years; we tried to link together our findings with the widely accepted metabolic pathways already described in metabolic pathway databases, which have been developed to collect and organize the current knowledge on metabolism scattered across a multitude of scientific articles. However, firstly, the literature on metabolism is extensive but rarely conclusive evidence is available, and secondly, one would expect these databases to contain largely the same information, but the contrary is true. For the apparently well studied metabolic process Krebs cycle, which was described as early as 1937 and is found in nearly every biology and chemistry curriculum, there is a considerable disagreement between at least five databases. Of the nearly 7000 reactions contained jointly by these five databases, only 199 are described in the same way in all the five databases. Thus to try to integrate chemical energy from melanin with the supposedly well-known bioenergetic pathways is easier said than done; and the lack of consensus about metabolic network constitutes an insurmountable barrier. After years of unsuccessful results, we finally realized that the chemical energy released through the dissociation of water molecule by melanin represents over 90% of cell energy requirements. These findings reveal a new aspect of cell biology, as glucose and ATP have biological functions related mainly to biomass and not so much with energy. Our finding about the unexpected intrinsic property of melanin to transform photon energy into chemical energy through the dissociation of water molecule, a role performed supposedly only by chlorophyll in plants, seriously questions the sacrosanct role of glucose and thereby mitochondria as the primary source of energy and power for the cells. © 2015 Central Nervous System Agents in Medicinal Chemistry All Right reserved.

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