Human Performance and Exercise Biochemistry Laboratory

Bloomington, United States

Human Performance and Exercise Biochemistry Laboratory

Bloomington, United States
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The purpose of the present study was to evaluate the effects of PCSO-524, a marine oil lipid and n-3 LC PUFA blend, derived from New Zealand green- lipped mussel (Perna canaliculus), on markers of muscle damage and inflammation following muscle damaging exercise in untrained men.Thirty two untrained male subjects were randomly assigned to consume 1200mg/d of PCSO- 524 (a green-lipped mussel oil blend) or placebo for 26 d prior to muscle damaging exercise (downhill running), and continued for 96h following the muscle damaging exercise bout. Blood markers of muscle damage (skeletal muscle slow troponin I, sTnI; myoglobin, Mb; creatine kinase, CK), and inflammation (tumor necrosis factor, TNF-), and functional measures of muscle damage (delayed onset muscle soreness, DOMS; pressure pain threshold, PPT; knee extensor joint range of motion, ROM; isometric torque, MVC) were assessed pre- supplementation (baseline), and multiple time points post-supplementation (before and after muscle damaging exercise). At baseline and 24h following muscle damaging exercise peripheral fatigue was assessed via changes in potentiated quadriceps twitch force (Qtw,pot) from pre- to post-exhaustive cycling ergometer test in response to supra-maximal femoral nerve stimulation.Compared to placebo, supplementation with the green-lipped mussel oil blend significantly attenuated (p<0.05) sTnI and TNF- at 2, 24, 48, 72 and 96h., Mb at 24, 48, 72, 96h., and CK-MM at all-time points following muscle damaging exercise, significantly reduced (p<0.05) DOMS at 72 and 96h post-muscle damaging exercise, and resulted in significantly less strength loss (MVC) and provided a protective effect against joint ROM loss at 96h post- muscle damaging exercise. At 24h after muscle damaging exercise perceived pain was significantly greater (p<0.05) compared to baseline in the placebo group only. Following muscle damaging exercise Qtw,pot was significantly less (p<0.05) on the green-lipped mussel oil blend compared to placebo.Supplementation with a marine oil lipid and n-3 LC PUFA blend (PCSO-524), derived from the New Zealand green lipped mussel, may represent a useful therapeutic agent for attenuating muscle damage and inflammation following muscle damaging exercise.

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