Chen G.,Hukhou Municipal Central Hospital |
Chen G.,Southern Medical University |
Chen L.,Hukhou Municipal Central Hospital |
Qin X.,Hukhou Municipal Central Hospital |
And 3 more authors.
Clinical Laboratory | Year: 2015
Background: Systemic mastocytosis (SM) is a rare neoplasm. The symptoms of this disease vary among patients. The authors describe a rare case of SM with recurrent anaphylactic shock and multiple organ dysfunction failure. Methods: Hematologic investigation, bone marrow aspirate and biopsy, and cytogenetic analysis were performed. Results: The patient was rescued with positive treatment, administered on prednisolone and H1/H2-receptor blocking agents. Corticosteroid and IFN-α treatment have no significant effect on tumor burden, but no more anaphylactic shock occurred. Conclusions: Cladribine and imatinib are recommended to treat SM patients to obtain a better therapeutic effect. Maybe allogeneic hematopoietic stem cell transplantation is a cure for SM. Source