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Chen G.,Hukhou Municipal Central Hospital | Chen G.,Southern Medical University | Chen L.,Hukhou Municipal Central Hospital | Qin X.,Hukhou Municipal Central Hospital | And 3 more authors.
Clinical Laboratory | Year: 2015

Background: Systemic mastocytosis (SM) is a rare neoplasm. The symptoms of this disease vary among patients. The authors describe a rare case of SM with recurrent anaphylactic shock and multiple organ dysfunction failure. Methods: Hematologic investigation, bone marrow aspirate and biopsy, and cytogenetic analysis were performed. Results: The patient was rescued with positive treatment, administered on prednisolone and H1/H2-receptor blocking agents. Corticosteroid and IFN-α treatment have no significant effect on tumor burden, but no more anaphylactic shock occurred. Conclusions: Cladribine and imatinib are recommended to treat SM patients to obtain a better therapeutic effect. Maybe allogeneic hematopoietic stem cell transplantation is a cure for SM.

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