Zhu J.-Y.,Hubei University of Education
Journal of Craniofacial Surgery | Year: 2017
ABSTRACT: Due to the anatomic and functional complexity, reconstruction of the condylar process after mandibular tumor extirpation remains a surgical challenge. The aim of this study was to present the results and experience of condyle head reimplantation combined with vascularized free flap for mandibular reconstruction in our institution. In the current study, the authors evaluated the clinical features of condyle head reimplantation combined with vascularized free flap for mandibular reconstruction in 5 patients with benign mandibular intraosseous lesions from December 2013 to March 2015 in our institution. All patients showed nearly normal mouth opening, with minimal mandibular deviation and joint symptoms. The radiograph data showed that 4 patients had no obvious bone resorption of condyles while only 1 patient had prominent condyle resorption. All the condyles were cut above the condylar neck, with the biggest remaining condyle height being 2.8?cm and the smallest one being 1.1?cm. Moreover, the original vertical height of mandibular ramus was decreased by 2 to 3?mm during the surgery. In conclusion, this study revealed that combining the condyle reimplantation with vascularized free flap constitutes a reliable method in condylar reconstruction and a slight reduction of the vertical height of condyles may help to diminish unfavorable outcomes. © 2017 by Mutaz B. Habal, MD.
Zhang C.-Z.,Hubei University of Education
Biochemical and Biophysical Research Communications | Year: 2017
Recently, long noncoding RNAs (lncRNAs) have been reported to have crucial regulatory efficiency in human cancer biology. Long intergenic non-coding RNA 668 (LINC00668) was regarded as an oncogene in multiple cancers. However, the underlying molecular mechanism of LINC00668 in oral squamous cell carcinoma (OSCC) has not been studied. In this study, we first demonstrated that LINC00668 expression was up-regulated, which was correlated with tumor progression, and miR-297 down-regulated in OSCC tissues and cells. Importantly, LINC00668 expression was negatively correlated with miR-297 expression in OSCC tissues. Loss-of-function of LINC00668 revealed that LINC00668 functioned as a ceRNA for miR-297 to facilitate VEGFA expression, promoting OSCC progression. Furthermore, LINC00668 knockdown suppressed tumor growth and reduced the expression of proliferation antigen ki-67 in vivo. Finally, we confirmed that LINC00668 promoted OSCC activity through VEGFA signaling. In conclusion, these results suggest that LINC00668 promotes OSCC tumorigenesis via miR-297/VEGFA axis, which may provide a new target for the diagnosis and therapy of OSCC disease. © 2017 Elsevier Inc.
Fan X.,Hubei University of Education |
Fan X.,University of Glasgow |
Messenger C.,University of Glasgow |
Heng I.S.,University of Glasgow
Astrophysical Journal | Year: 2014
We present a general framework for incorporating astrophysical information into Bayesian parameter estimation techniques used by gravitational wave data analysis to facilitate multi-messenger astronomy. Since the progenitors of transient gravitational wave events, such as compact binary coalescences, are likely to be associated with a host galaxy, improvements to the source sky location estimates through the use of host galaxy information are explored. To demonstrate how host galaxy properties can be included, we simulate a population of compact binary coalescences and show that for ∼8.5% of simulations within 200 Mpc, the top 10 most likely galaxies account for a ∼50% of the total probability of hosting a gravitational wave source. The true gravitational wave source host galaxy is in the top 10 galaxy candidates ∼10% of the time. Furthermore, we show that by including host galaxy information, a better estimate of the inclination angle of a compact binary gravitational wave source can be obtained. We also demonstrate the flexibility of our method by incorporating the use of either the B or K band into our analysis. © 2014. The American Astronomical Society. All rights reserved.
Wang C.,Hubei University of Education
Applied Mechanics and Materials | Year: 2013
Composite thermal insulation material can be made from expanded and vitrified small balls and other inorganic insulation lightweight aggregate. According to the 'hydration, hardening' mechanism of inorganic gel material and material's thermal insulation mechanism, we can eliminate the heat convection of gas inside the holes by using foaming technology, and micro holes can reduce radiation heat transfer between the pore walls so as to further improve the thermal insulation properties of solid materials. © (2013) Trans Tech Publications, Switzerland.
Tong A.,Huazhong University of Science and Technology |
Tong A.,Hubei University of Education |
Zhou Y.,Huazhong University of Science and Technology |
Lu P.,Huazhong University of Science and Technology |
Lu P.,Wuhan Institute of Technology
Optics Express | Year: 2015
Using a fully classical model, we have studied sequential double ionization (SDI) of argon driven by elliptically polarized laser pulses at intensities well in the over-barrier ionization region. The results show that ion momentum distributions evolve from the two-band structure to the four-band, six-band structure and finally to the previously obtained four-band structure as the pulse duration increases. Our analysis shows that the evolution of these band structures originates from the pulse-durationdependent multiple ionization bursts of the second electron. These band structures unambiguously indicate the subcycle electron emission in SDI. © 2015 Optical Society of America.
Liang J.,Hubei University of Education
European Journal of Human Genetics | Year: 2016
The Msx1 transcription factor is involved in multiple epithelial-mesenchymal interactions during vertebrate embryogenesis. It has pleiotropic effects in several tissues. In humans, MSX1 variants have been related to tooth agenesis, orofacial clefting, and nail dysplasia. We correlate all MSX1 disease causing variants to phenotypic features to shed light on this hitherto unclear association. MSX1 truncations cause more severe phenotypes than in-frame variants. Mutations in the homeodomain always cause tooth agenesis with or without other phenotypes while mutations outside the homeodomain are mostly associated with non-syndromic orofacial clefts. Downstream effects can be further explored by the edgetic perturbation model. This information provides new insights for genetic diagnosis and for further functional analysis of MSX1 variants.European Journal of Human Genetics advance online publication, 6 July 2016; doi:10.1038/ejhg.2016.78. © 2016 Macmillan Publishers Limited
Wang T.,Hubei University of Education
ICIMA 2010 - 2010 2nd International Conference on Industrial Mechatronics and Automation | Year: 2010
In this paper, the author gives a personal view on the current development direction of smart home, and propos the "wisdom" of a smart home should be based on the biological intelligence, rather than a series of automated electrical equipments, and emphasizes that the central control computer system is the core part of the smart home, the control model of software is the heart part of Smart Home, the artificial intelligence applications for the smart home are the ultimate goal. © 2010 IEEE.
Hubei University of Education | Date: 2016-03-09
The present application provides indexing methods and systems for indexing spatial data objects of a data space, and methods and systems for performing an operation on an index of spatial data. One of the methods includes: associating each spatial data object with one of a plurality of separations according to a size of the respective spatial data object; and mapping each spatial data object to an index key based on the separation with which the spatial data object is associated. The methods and systems for performing an operation on an index of spatial data can facilitate efficient selection or manipulation of the spatial data objects.
Xia H.,Hubei University of Education
The International journal of oral & maxillofacial implants | Year: 2013
The aim of the present study was to investigate the stress distribution in the bone around a platform-switched implant with marginal bone loss. Finite element models of an implant-supported crown on a mandibular first molar were constructed and included an osseointegrated implant, a metal crown, and cancellous and cortical bone. Two kinds of abutments, conventional and platform-switched, were imported into the model. A variety of different levels of conical marginal bone resorption, from 0 to 2.0 mm in height and width, was created around the implant neck. The stresses generated in the peri-implant bone tissue were analyzed under 200 N of vertical or oblique loading. The location of stress concentration extended from the implant neck toward the apex in association with increases in bone resorption depth. In the bone-resorbed models, the platform-switched implant showed lower maximum equivalent stresses in the peri-implant bone than the conventional abutment. The difference between the two implant models decreased as bone resorption increased. Within the limitations of this study, the results suggest a biomechanical advantage for platform switching in a condition of marginal bone resorption, but this advantage may be weakened when bone resorption is dramatic. Additional animal or clinical studies are necessary to better clarify the effects of peri-implant bone defects on the biomechanical features of a platform-switched configuration.
Shue L.,Hubei University of Education
Biomatter | Year: 2012
Periodontal disease is characterized by the destruction of periodontal tissues. Various methods of regenerative periodontal therapy, including the use of barrier membranes, bone replacement grafts, growth factors and the combination of these procedures have been investigated. The development of biomaterials for tissue engineering has considerably improved the available treatment options above. They fall into two broad classes: ceramics and polymers. The available ceramic-based materials include calcium phosphate (eg, tricalcium phosphate and hydroxyapatite), calcium sulfate and bioactive glass. The bioactive glass bonds to the bone with the formation of a layer of carbonated hydroxyapatite in situ. The natural polymers include modified polysaccharides (eg, chitosan,) and polypeptides (collagen and gelatin). Synthetic polymers [eg, poly(glycolic acid), poly(L-lactic acid)] provide a platform for exhibiting the biomechanical properties of scaffolds in tissue engineering. The materials usually work as osteogenic, osteoconductive and osteoinductive scaffolds. Polymers are more widely used as a barrier material in guided tissue regeneration (GTR). They are shown to exclude epithelial downgrowth and allow periodontal ligament and alveolar bone cells to repopulate the defect. An attempt to overcome the problems related to a collapse of the barrier membrane in GTR or epithelial downgrowth is the use of a combination of barrier membranes and grafting materials. This article reviews various biomaterials including scaffolds and membranes used for periodontal treatment and their impacts on the experimental or clinical management of periodontal defect.