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Wuhan, China

The Hubei University , colloquially known in Chinese as Huda was founded in 1931 and is as a key comprehensive university in Hubei Province, People's Republic of China. The University originated in 1931, starting from what was then Hubei Provincial College of Education. Established with approval from the national government, its first director was Huang Jianzhong. The College moved between locations and changed its name several times during its half-century of development. Since 1984, it has been Hubei University. Wikipedia.


Gong Y.,Hubei University
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2015

Crowdsourcing has become an increasingly attractive practice for companies to execute business processes in open contexts with on-demand workforce and higher level of flexibility. One of the challenges is the identification of the best-fit crowdsourcing participant from a group of online candidates. This paper presents a method of AHP-TOPSIS based on Grey Relation Analysis for estimating participants of a crowdsourcing task based on their online profiles and proposals. This method is tested by an experiment on a dataset of 348 completed IT service crowdsourcing tasks. An analysis on the matching between the test result and the actual selection result reveals the accuracy and efficiency of this method. Companies can use this method to facilitate the quality control at the beginning of crowdsourcing and keeps the selection of participants easy. This paper contributes to the design of a software agent for crowdsourcing platforms to automatically rank the participants of a task. © IFIP International Federation for Information Processing 2015.


Functional malignant pheochromocytoma is a rare tumor. Also, liver metastatic pheochromocytoma is deemed to be incurable because of its poor prognosis. Surgical debulking and removal of primary and metastases tumors, as well as radiosurgical or surgical treatment are recommended for patients. We treated a patient with multiple liver metastasis of functional malignant pheochromocytoma 4 years after the adrenal primary lesion was resected. The liver metastases were successfully removed by surgical resection. During the operation, the blood pressure increased quickly when the tumor was held between the fingers, reached the highest (201/110 mmHg), and then quickly declined to normal when the pressure was relieved. The patient is alive for more than 5 years after the operation. Thus, we believe that functional liver metastases of malignant pheochromocytoma may be curable by surgical resection with careful monitoring of anesthesia and blood pressure. Every effort should be taken to avoid direct stimulation of the tumor in the operation.


Gong X.,Hubei University | Padhi A.,Pennsylvania State University
Journal of Medical Virology | Year: 2011

The human cytomegalovirus (HCMV)-encoded chemokine receptor US28 is also a seven-transmembrane G-protein coupled receptor, whose signaling pathway is known for its involvement in host immune system evasion. HCMV infection can result in serious disease in immunocompromised individuals and is also linked to atherosclerosis and cardiovascular disease. Identifying amino acid residues that play a crucial role in successful viral adaptation in response to the host's immune defense is critical for effective drug design. In this study maximum likelihood-based codon substitution analyses were carried out to determine whether any codon of US28 has evolved adaptively. If the rate of nonsynonymous (dn) to the rate of synonymous (ds) nucleotide substitutions (ω=dn/ds) is greater than one, the codon is said to be under positive selection, indicating adaptive evolution. Although the overall ω for US28 gene was 0.154, indicating that most codon sites were subject to strong purifying selection, five codon sites are under strong positive selection. Three (E18D/L, D19A/E/G, and R267K/Q) of these positively selected sites are located in extracellular domains, the domains that play a crucial role for successful viral adaptation in response to the host's immune defense. The C-terminal (R329Q/W) and the fifth transmembrane domain (V190I), each have one positively selected site. These results suggest that relative to the extracellular domains, amino acid residues present in intracellular domains are more selectively constrained. A few amino acid residues in extracellular domains of US28 evolved more rapidly, presumably due to positive selection pressure resulting from ligand-binding and pathogen interactions of extracellular domains. © 2011 Wiley-Liss, Inc.


Naparus M.,Slovenian Academy of science and Arts | Naparus M.,Tular Cave Laboratory | Kuntner M.,Slovenian Academy of science and Arts | Kuntner M.,Smithsonian Institution | Kuntner M.,Hubei University
PLoS ONE | Year: 2012

Background: Although numerous studies model species distributions, these models are almost exclusively on single species, while studies of evolutionary lineages are preferred as they by definition study closely related species with shared history and ecology. Hermit spiders, genus Nephilengys, represent an ecologically important but relatively species-poor lineage with a globally allopatric distribution. Here, we model Nephilengys global habitat suitability based on known localities and four ecological parameters. Methodology/Principal Findings: We geo-referenced 751 localities for the four most studied Nephilengys species: N. cruentata (Africa, New World), N. livida (Madagascar), N. malabarensis (S-SE Asia), and N. papuana (Australasia). For each locality we overlaid four ecological parameters: elevation, annual mean temperature, annual mean precipitation, and land cover. We used linear backward regression within ArcGIS to select two best fit parameters per species model, and ModelBuilder to map areas of high, moderate and low habitat suitability for each species within its directional distribution. For Nephilengys cruentata suitable habitats are mid elevation tropics within Africa (natural range), a large part of Brazil and the Guianas (area of synanthropic spread), and even North Africa, Mediterranean, and Arabia. Nephilengys livida is confined to its known range with suitable habitats being mid-elevation natural and cultivated lands. Nephilengys malabarensis, however, ranges across the Equator throughout Asia where the model predicts many areas of high ecological suitability in the wet tropics. Its directional distribution suggests the species may potentially spread eastwards to New Guinea where the suitable areas of N. malabarensis largely surpass those of the native N. papuana, a species that prefers dry forests of Australian (sub)tropics. Conclusions: Our model is a customizable GIS tool intended to predict current and future potential distributions of globally distributed terrestrial lineages. Its predictive potential may be tested in foreseeing species distribution shifts due to habitat destruction and global climate change. © 2012 Nǎpǎruş, Kuntner.


Li J.,Wuhan University | Lei H.,Hubei University | Xu Y.,Wuhan University | Tao Z.-Z.,Wuhan University
PLoS ONE | Year: 2015

Telomerase activation has very important implications for head and neck squamous cell carcinoma (HNSCC), but the regulatory mechanisms of telomerase in HNSCC remain unclear. In our present study, we found that miR-512-5P was markedly downregulated in telomerase-positive HNSCC cell lines. Both in vitro and in vivo assays revealed that miR- 512-5P mimic attenuated HNSCC cell proliferation, and tumor growth in nude mice, which exerts its tumor suppressor function through elevated apoptosis, inhibition of the telomerase activity, decrease of telomere-binding proteins and shortening of telomere length by human telomerase reverse transcriptase (hTERT) downregulation. Furthermore, the dual-luciferase reporter gene assay results demonstrated that hTERT was a direct target of miR-512- 5P. We conclude that the frequently miR-512-5P overexpression can regulate hTERT and function as a tumor suppressor in HNSCC. Therefore, miR-512-5P may serve as a potential therapeutic agent for miR-based HNSCC therapy. Copyright: © 2015 Li et al.


Xiao Z.,Hubei University | Xiao Z.,University of Arizona | Strom R.G.,University of Arizona
Icarus | Year: 2012

The small crater populations (diameter smaller than 1. km) are widely used to date planetary surfaces. The reliability of small crater counts is tested by counting small craters at several young and old lunar surfaces, including Mare Nubium and craters Alphonsus, Tycho and Giordano Bruno. Based on high-resolution images from both the Lunar Reconnaissance Orbiter Camera and Kaguya Terrain Camera, small craters in two different diameter ranges are counted for each counting area. Large discrepancies exist in both the cumulative (absolute model ages) and relative plots for the two different size ranges of the same counting areas. The results indicate that dating planetary surfaces using small crater populations is highly unreliable because the contamination of secondaries may invalidate the results of small crater counts. A comparison of the size-frequency distributions of the small crater populations and impact ejected boulders around fresh lunar craters shows the same upturn as typical martian secondaries, which supports the argument that secondaries dominate the small crater populations on the Moon and Mars. Also, the size-frequency distributions of small rayed lunar and martian craters of probable primary origin are similar to that of the Population 2 craters on the inner Solar System bodies post-dating Late Heavy Bombardment. Dating planetary surfaces using the small crater populations requires the separation of primaries from secondaries which is extremely difficult. The results also show that other factors, such as different target properties and the subjective identification of impact craters by different crater counters, may also affect crater counting results. We suggest that dating planetary surfaces using small crater populations should be with highly cautious. © 2012 Elsevier Inc.


Zhong C.,Hubei University
Physical Chemistry Chemical Physics | Year: 2015

A D-A (donor-acceptor)-type chromophore may twist or flatten in its excited state to form a TICT (twisted intramolecular charge transfer) state or a PICT (planar intramolecular charge transfer) state, respectively. What is the driving force behind this twisting or planarization? Which geometry will occur for a certain D-A chromophore? To answer these questions, both fragment orbital interaction and excited state energy decomposition analyses were performed on several classical TICT/PICT molecules. Three driving forces were identified, namely, energy gap, hole-electron interactions, and excited state relaxation. The contributions of these driving forces in various types of molecules were analyzed to determine how the molecular structure affects them. The energy gap difference between the twisted and planar geometries was found to play a decisive role in most situations. Thus, evaluating the frontier orbital interactions between the donor and acceptor effectively predicts whether chromophores planarize or twist in the excited state. © 2015 the Owner Societies.


Yan X.,University of Missouri - Kansas City | Tian L.,University of Missouri - Kansas City | Tian L.,Hubei University | He M.,University of Missouri - Kansas City | And 2 more authors.
Nano Letters | Year: 2015

Earth-abundant, low-cost electrocatalysts with outstanding catalytic activity in the electrochemical hydrogen evolution reaction (HER) are critical in realizing the hydrogen economy to lift our future welfare and civilization. Here we report that excellent HER activity has been achieved with three-dimensional core/shell Co/Co3O4 nanosheets composed of a metallic cobalt core and an amorphous cobalt oxide shell. A benchmark HER current density of 10 mA cm-2 has been achieved at an overpotential of ∼90 mV in 1 M KOH. The excellent activity is enabled with the unique metal/oxide core/shell structure, which allows high electrical conductivity in the core and high catalytic activity on the shell. This finding may open a door to the design and fabrication of earth-abundant, low-cost metal oxide electrocatalysts with satisfactory hydrogen evolution reaction activities. © 2015 American Chemical Society.


Mao Q.,Hubei University
Energy Education Science and Technology Part A: Energy Science and Research | Year: 2014

This paper introduces the definition and classification of generalized inverse of a matrix, and then discusses the properties and solving of some important generalized inverses in detail. Through studying the properties and solving methods of these important generalized inverse matrices, the general solution and least square solution of system of linear equations are solved. © Sila Science. All Rights Reserved.


Pan F.,Hubei University | Wu X.,Wuhan University of Technology
Procedia Engineering | Year: 2011

The purpose of this thesis is to discuss the sustainable development of high-rise building in Chinese cities. As the construction climax of high-rise building has arrived in China, many constructed or constructing high-rise buildings are still in the state of environment-unfriendly, low standard and efficiency, high consumption and pollution, and featureless. This kind of development is not sustainable. The method used in this study is analysis of environment protection, safety, and efficiency of the high-rise building, which tend to solve these above problems and make a sustainable development. The paper suggests that it is necessary to establish the green high-rise building system, which to be composed of external environment, internal floorplan and Architectural Form. © 2011 Published by Elsevier Ltd.


Ma X.,Hubei University | Kim H.S.,Hanyang University
The Scientific World Journal | Year: 2014

The purpose of this paper is to give a foundation for providing a new soft algebraic tool in considering many problems containing uncertainties. In order to provide these new soft algebraic structures, we discuss a new soft set-(M, N)-soft intersection set, which is a generalization of soft intersection sets. We introduce the concepts of (M, N)-SI filters of BL-algebras and establish some characterizations. Especially, (M, N)-soft congruences in BL-algebras are concerned. © 2014 Xueling Ma and Hee Sik Kim.


Zhang C.,University of Wollongong | Yu R.,University of Wollongong | Zhou T.,University of Wollongong | Chen Z.,University of Wollongong | And 3 more authors.
Carbon | Year: 2014

In this work, a facile approach is reported to mass produce highly porous fibers constructed from silicon-carbon core-shell structures. The C-Si microfibers are prepared using a modified electrospinning deposition method (ESD), and subsequent calcination of the carbon shells. Benefited from the step of vacuum drying, the unnecessary solvent left in the precursor will volatilize, resulting in the uniform three-dimensional hierarchical microfibers constructed from silicon-carbon core-shell architectures. The uniform covering layers of carbon formed by decomposition of polymer contribute to the improvement of conductivity and alleviation of volume change. The pores in the microfibers are helpful for the diffusion of electrolyte. When evaluated as an anode material for lithium-ion batteries, the C-Si microfibers exhibit improved reversibility and cycling performance compared with the commercial Si nanoparticles. A high capacity of 860 mAh g-1 can be retained after 200 cycles at a current rate of 0.3 C. The rate capability of the C-Si microfibers is also improved. The special structure is believed to offer better structural stability upon prolonged cycling and to improve the conductivity of the material. This simple strategy using the modified ESD method could also be applied to prepare other porous energy materials. © 2014 Elsevier Ltd. All rights reserved.


Fang J.,Hawaii Pacific University | Zhang L.,Hubei University | Bazylinski D.A.,University of Nevada, Las Vegas
Trends in Microbiology | Year: 2010

The deep-sea piezosphere accounts for approximately 75% of the total ocean volume and hosts active and diverse biological communities. Evidence obtained thus far suggests that the microbial biomass present in the piezosphere is significant. Continued international interest in exploring the deep ocean provides impetus to increase our understanding of the deep-sea piezosphere and of the influence of piezophilic microbial communities on the global ocean environment and on biogeochemical cycling occurring in the deep sea. Here, we review the diversity, metabolic characteristics, geomicrobiology and biogeochemistry of the deep-sea piezophiles. © 2010 Elsevier Ltd.


Wang Q.,Hubei University | Zhan H.,Texas A&M University
Advances in Water Resources | Year: 2013

Radial reactive transport is investigated in an aquifer-aquitard system considering the important processes such as advection, radial and vertical dispersions for the aquifer, vertical advection and dispersion for the aquitards, and first-order biodegradation or radioactive decay. We solved the coupled governing equations of transport in the aquifer and the aquitards by honoring the continuity of concentration and mass flux across the aquifer-aquitard interfaces and recognizing the concentration variation along the aquifer thickness. This effort improved the averaged-approximation (AA) model, which dealt with radial dispersion in an aquifer-aquitard system by excluding the aquitard advection. To compare with our new solution, we expanded the AA model by including the aquitard advection. The expanded AA model considerably overestimated the mass in the upper aquitard when an upward advection existed there. The rates of mass change in the upper aquitard from the new solution and the AA model solution increased with time following sub-linear fashions. The times corresponding to the peak values of the residence time distributions for the AA model, the expanded AA model, and the new model were almost the same. The residence time distributions seemed to follow the Maxwell-Boltzmann distribution closely when plotting the time in logarithmic scale. In addition, we developed a finite-element COMSOL Multiphysics simulation of the problem, and found that the COMSOL solution agreed with the new solution well. © 2013 Elsevier Ltd.


Xu S.,Hubei University
RISTI - Revista Iberica de Sistemas e Tecnologias de Informacao | Year: 2016

In order to analyze application of virtual computer technology in digital library, the weight was topped offduring building of a digital library with the virtual computer technology. Earnings obtained by the digital library after application of the virtual computer technology were finally obtained. At last, it is concluded through AHP analysis that application of the virtual computer technology in the digital library can realize digitalization, dynamic development and diversification of resources, and can improve resource types and resource storage. Weights of resource information transfer, system improvement timeliness and system operation simplicity obtained by the algorithm are respectively 0.354, 0.325 and 0.331.


Zhigang P.,Hubei University
Acta Mathematica Scientia | Year: 2010

Let C'(α,β) be the class of functions f(z)=z+∑n=2∞anzn analytic in D = {z:|z|<1}, satisfying for some convex function g(z) with g(0)=g'(0) - 1 = 0 and for all z in D the condition |zf'(z)g(z)-1zf'(z)g(z)+(1-2α)|<βfor some α, β (0≤α<1, 0<β≤ 1). A sharp coefficient estimate, distortion theorems and radius of convexity are determined for the class C'(α,β). The results extend the work of C. Selvaraj. © 2010.


Feng P.,Hubei University
Procedia Engineering | Year: 2011

With the development of social, people have an increasing requirement for living environment. Green buildings and sustainable urban development are the urgent task in many Chinese cities. However, under the restriction of decisionmaking, planning, development and management, green buildings face the growing problem. The most prominent problem is not its economic rationality, but the lacking of moral foundation and technology combination. These three parts should be organic unity which composing the integrated concept of green buildings. © 2011 Published by Elsevier Ltd.


Wan L.,Hubei University
Advances in Engineering Materials and Applied Mechanics - Proceedings of the 5th International Conference on Machinery, Materials Science and Engineering Applications, MMSE 2015 | Year: 2016

The digital multi-channel temperature acquisition system is consisted of main controller, temperature gathering electric circuit, temperature display circuit, alarm circuit and keyboard control circuit. MCU AT89C51 is used as the controller and the data processor. The intelligent temperature sensor DS18B20 is used as the temperature detector. The LED digital display tube is used as the temperature display device. The hardware circuit is simple, and has the advantages of low cost, large measuring range, high measuring precision, displaying intuitive and easy to use. © 2016 Taylor & Francis Group, London.


You X.,Hubei University | Zheng Y.,Harbin Institute of Technology
Neurocomputing | Year: 2016

Calibrating roadside camera is essential and indispensable for intelligent traffic surveillance systems. Due to the characteristics of the traffic scenarios, the commonly used camera calibration methods based on calibration patterns are no longer suitable, since there are generally no calibration patterns (e.g., checkerboard) in traffic scenarios. In this paper, we propose an accurate and practical calibration method for roadside camera, where the vanishing point in the direction of traffic lane and the vertical vanishing point are employed that can be easily obtained from most traffic scenarios. By making full use of video information, the multiple observations of two vanishing points are available. Using these observations, we present a dynamic calibration method to correct camera parameters, where the least squares estimation is employed instead of closed-form computation. The experimental results on synthetic data show the accuracy and robustness to the noise of vanishing points; the experimental results on real traffic images demonstrate the effectiveness and practicability of the proposed calibration method. © 2016 Elsevier B.V.


Mao Y.,Hubei University | Ridd P.V.,James Cook University
Journal of Geophysical Research C: Oceans | Year: 2015

Accurate parameterization of spatially variable diffusivity in complex shelf regions such as the Great Barrier Reef (GBR) lagoon is an unresolved issue for hydrodynamic models. This leads to large uncertainties to the flushing time derived from them and to the evaluation of ecosystem resilience to terrestrially derived pollution. In fact, numerical hydrodynamic models and analytical cross-shore diffusion models have predicted very different flushing times for the GBR lagoon. Nevertheless, scarcity of in situ measurements used previously in the latter method prevents derivation of detailed diffusivity profiles. Here detailed cross-shore profiles of diffusivity were calculated explicitly in a closed form for the first time from the steady state transects of sea surface temperature for different sections of the GBR lagoon. We find that diffusivity remains relatively constant within the inner lagoon (< ∼20 km) where tidal current is weak, and increases linearly with sufficiently large tidal amplitude in reef-devoid regions, but increases dramatically where the reef matrixes start and fluctuates with reef size and density. The cross-shelf profile of steady state salinity calculated using the derived diffusivity values agrees well with field measurements. The calculated diffusivity values are also consistent with values derived from satellite-tracked drifters. Flushing time by offshore diffusion is of the order of 1 month, suggesting the important role of turbulent diffusion in flushing the lagoon, especially in reef-distributed regions. The results imply that previous very large residence times predicted by numerical hydrodynamic models may result from underestimation of diffusivity. Our findings can guide parameterization of diffusivity in hydrodynamic modeling. Key Points: The cross-shore profiles of diffusivity were calculated explicitly from SST Offshore turbulent diffusion plays an important role in flushing the lagoon Diffusivity increases significantly with the presence of reef matrix © 2015. American Geophysical Union. All Rights Reserved.


Tong J.-N.,Hubei University
Acta Geoscientica Sinica | Year: 2015

Marine Triassic sedimentation of east China occurred only in the Early-Middle Triassic time. The marine Lower-Middle Triassic successions not only are the depositional products in the sedimentary basins controlled by the regional tectonism but also represent the tectonic pattern and process of the Indosinian movement in the region. The Triassic strata of east China can be divided into two stratigraphic regions and six stratigraphic subregions. The stratigraphic sequences within each stratigraphic region can be unified into a uniform lithostratigraphic system according to the time attribute and lithofacies paleogeographic affiliation of the stratigraphic units, except for some specific geological bodies of quite distinctive lithofacies that can be separately named. The lithostratigraphic sequences can be well correlated on the basis of the integrated study of some characteristic paleontological and environmental events. The spatial and temporal variation of stratigraphic sequence indicates that the first episode or prologue of the Indosinian movement should have taken place in the late Early Triassic period, which resulted in the formation of a series of secondary marginal seas in the northern part of the Yangtze block due to its suturing with the North China block after that time, and the suture zone was finally closed in the late Middle Triassic. In the meantime, the southern margin of the Yangtze block became steepened to form a platform-slope-basin sedimentary system during the late Early Triassic with the compression of the Cathaysia block, and the deep basin was finally closed at the end of the Early Triassic, whereas united clastic sedimentary basins across the blocks occurred in the Middle Triassic. ©, 2015, Science Press. All right reserved.


Yu J.,Chongqing University of Posts and Telecommunications | Hu H.,Hubei University | Zhou S.,Chongqing University | Lin X.,Chongqing University
Automatica | Year: 2013

In this paper, the stability of multi-variable fractional order nonlinear dynamic system is investigated. We propose the definition of generalized Mittag-Leffler stability with multi-variable and introduce the fractional Lyapunov direct method with multi-variable. Meanwhile, a novel approach is suggested to study generalized Mittag-Leffler stability in multi-variable fractional order nonlinear dynamic systems. An interesting multi-variable fractional order Lotka-Volterra predator-prey model is used to illustrate the proposed method and its effectiveness. © 2013 Elsevier Ltd. All rights reserved.


Zhou M.-C.,Hubei University
Nonlinear Analysis: Real World Applications | Year: 2011

Based on the S-shaped power law logistic technology, we set up an economic growth model in this paper. The solution of the model is given via hypergeometric functions. We show that the dynamics of the model is asymptotically stable. And, it is found that the dynamics of the model is actually controlled by the power law logistic function through an ordinary logistic function, as a power function of the power law logistic. From the statistical point of view, in this paper, three different types of power law index means three different types of skewness, giving three different types of growth and diffusion patterns of technology. Then, we show some comparison results of different types of technology and of different initial levels of capital, and their effects on economic growth. A numerical example is also given in this paper to illustrate the effects. © 2010 Published by Elsevier Ltd. All rights reserved.


Huang Q.-A.,Hubei University | Liu M.,Georgia Institute of Technology
Electrochimica Acta | Year: 2015

A relatively high open circuit voltage (OCV) of 1.047 V at 600 °C was reported recently for a cell based on a BaZr0.1Ce0.7Y0.1Yb0.1O3-δ(BZCYYb)-NiO anode-supported thin SDC electrolyte, demonstrating a peak power density of 0.50 W/cm2. In this study, an equivalent circuit model was developed for interpreting the behavior of this SDC-based SOFC. The mechanism behind the high OCV and the corresponding high peak power density were elucidated via separating the polarization processes and the corresponding characteristic frequencies, especially those for oxygen ion diffusion through the interlayer at the anode/electrolyte interface. Theoretical analysis and data fitting based on the presented circuit model indicate that the inter-diffusion layer between Ni-BZCYYb and SDC effectively suppresses electronic conduction while maintaining the catalytic activity and ionic conductivity. More importantly, careful analysis of the characteristic frequencies offers a powerful approach to assigning a specific part of the impedance data (e.g., an impedance arc or loop) to the corresponding physicochemical process. Further, any sharp change in the characteristic frequency for a physicochemical process also reflects a change in the inherent nature of that process under the testing conditions. Once validated by more experimental results under a broader range of testing conditions, the presented equivalent circuit model, in turn, may be used to predict fuel cell performances and optimize the operating conditions. © 2014 Elsevier Ltd.


Deng S.,Hubei University
Proceedings of the 15th International Conference on Ground Penetrating Radar, GPR 2014 | Year: 2014

Yichang-Wanzhou railway with total length of 377 km was constructed in the mountain region presenting the most complex karst geological conditions in the world. Several collapses happened in its artificially trenched sections since this railway opened in the December of 2010. We proposed GPR technique for accurate location of karst cavities and tubes beneath the railway basement for grouting reinforcement. We used EKKO PRO with 100 MHz antenna equipment to detect totally 5.1 km long artificially trenched sections along this railway. Five rail-parallel GPR survey lines were deployed along the railway. We used spatial difference filtering and background removal to suppress flat-lying features and enhance dipping and hyperbolic diffraction features. The processed GPR profiles with effective exploring depth to 20 more meters revealed karst cavities and tubes very clearly. For data interpretation we used FDTD modeling for typical cluster of karst cavities, and the simulated GPR profile is similar to the one collected in field in both dynamic and kinematic characteristics. Next, a novel drilling technique, which do not require water while drilling, combined with borehole-televiewer measurement was used to test and verify GPR interpretation results, and thus proving the accuracy and correctness of GPR profile interpretations. © 2014 IEEE.


Yan M.,Wuhan University | Shen Y.,Wuhan University | Zhao L.,Hubei University | Li Z.,Wuhan University
Materials Research Bulletin | Year: 2011

In this study, the photochromic MoO3 powder with novel morphology has been synthesized via hydrothermal method, using ethylene diamine tetraacetice acid (EDTA) as organic inducing agent. The influence of EDTA on the morphology, structure and photochromic properties of MoO3 powder has been characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), as well as ultraviolet and visible spectroscopy (UV-vis) and color difference meter. When the molar ratio of EDTA/Mo6+ is 0.05:1, the EDTA-induced MoO3 powder is found to have 3D flower-like morphologies and excellent photochromic properties. Furthermore, the possible growth mechanism of the flower-like structure and the photochromic mechanism of MoO3 powder are also discussed in detail. © 2011 Elsevier Ltd. All rights reserved.


Peng Q.,Hubei University
Journal of Convergence Information Technology | Year: 2012

This paper presents a novel regional matching method with very fast performance, even though the stereo image has a great high resolution. Utilizing the property of affine invariance, some feature points in left image can be computed to become the matched points in right image. The relative disparity value between the matched points and feature points in right image imply the information about depth of region. For this reason, regional matching can be performed successfully with low cost of runtime. Also, the occlusive region can be recovered because this algorithm uses the geometric operation. The experimental results demonstrate that this algorithm match regions successfully for high resolution stereo images, and reduce the runtime within milliseconds.


Liao B.,Wuhan University | Liao B.,Hubei University | Xiao C.,Wuhan University | Jin L.,Wuhan University | Fu H.,City University of Hong Kong
CAD Computer Aided Design | Year: 2013

This paper proposes an efficient and Feature-preserving Locally Optimal Projection operator (FLOP) for geometry reconstruction. Our operator is bilateral weighted, taking both spatial and geometric feature information into consideration for feature-preserving approximation. We then present an accelerated FLOP operator based on the random sampling of the Kernel Density Estimate (KDE), which produces reconstruction results close to those generated using the complete point set data, to within a given accuracy. Additionally, we extend our approach to time-varying data reconstruction, called the Spatial-Temporal Locally Optimal Projection operator (STLOP), which efficiently generates temporally coherent and stable feature-preserving results. The experimental results show that the proposed algorithms are efficient and robust for feature-preserving geometry reconstruction on both static models and time-varying data sets. © 2013 Elsevier Ltd. All rights reserved.


Jin X.,Hubei University | Zhe H.,Hubei Cen Tronic Import and Export Co.
Journal of Convergence Information Technology | Year: 2012

Multi-agent systems (MAS) are one of the most important topics in distributed autonomous and decentralized systems. Usually multi-agent systems are used for software development of complex application systems. Unfortunately they tend to be complex systems their selves. The existing gap between analysis and design of multi-agent systems and their implementation lead to an increasing programming effort. In this paper, we propose a new methodology which tries to bridge the gap by integrating design and implementation to multi-agent systems. Our objective is to participate to the improvement of such software quality and productivity. We try to integrate some design rules and implementation in a unified case tools specifically conceived for MAS. The latter can help the designer to develop MAS more quickly and more easily, even if he/she does not have good experience in programming complex system. We first describe the steps of this methodology going from domain description phase until code generation via different phases: roles identification, task specification, ontology description, roles description, agents' structure and behavior definition. For each step we define the design process and the software tools to use. At last we propose a multi-agent based realtime demand responsive transport system. By computational experiments, we examine an effectiveness of the proposed method for the large real-time multi-agent based urban transport system.


Huang Z.B.,Hubei University | Lin H.Q.,Chinese University of Hong Kong | Arrigoni E.,University of Graz
Physical Review B - Condensed Matter and Materials Physics | Year: 2011

We study the hole binding energy and pairing correlations in the three-band Hubbard model coupled to an apical oxygen phonon, by exact diagonalization and constrained-path Monte Carlo simulations. In the physically relevant charge-transfer regime, we find that the hole binding energy is strongly enhanced by the electron-phonon interaction, which is due to a novel potential-energy-driven pairing mechanism involving reduction of both electronic potential energy and phonon related energy. The enhancement of hole binding energy, in combination with a phonon-induced increase of quasiparticle weight, leads to a dramatic enhancement of the long-range part of d-wave pairing correlations. Our results indicate that the apical oxygen phonon plays a significant role in the superconductivity of high-Tc cuprates. © 2011 American Physical Society.


Xiao H.,Hubei University
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2014

This paper divides the term meizhun into five homographs based on its morphemic structure and usage, and focuses on the modal adverb form that means maybe in English. Meizhun (maybe) generally appears in assertive sentences and can be used with auxiliary verbs, conjunctions, and other adverbs. Sentences with this term share the stylised frame of logical semantics. Its main textual functions are inference and definition, and the use of this term, which is derived from meizhun (uncertain/not sure), is now spreading rapidly among speakers of contemporary Chinese. © Springer International Publishing Switzerland 2014


SMSCs (synovial mesenchymal stem cells) isolated from TMJs (temporomandibular joints) were induced to proliferate and differentiate in vitro by bFGF (basic fibroblast growth factor) and explore the potential of SMSC differentiation into neuronal cells. In this study, the cultured SMSCs were derived from the TMJ synovial membrane of condylar hyperplasia patients and were amplified with the indicated concentration of FCS (fetal calf serum) and DMEM (Dulbecco's modified Eagle's medium) in vitro. bFGF (25 ng/ml) was applied to induced synovial cells differentiated into neuronal cells. Inverted microscopy, scanning electron microscopy, immunocytochemical and RT-PCR were used for checking the change of the induced cells. Morphology was mostly spindle; a small part was of a polygon. The undifferentiated SMSCs showed the fibroblast-like morphology; however, most of the differentiated cells were in the shape of a spindle and the rest were polygonal. Furthermore, being induced by bFGF, SMSCs can be found to be a unique long extension from the cell body under the scanning electron microscope. RT-PCR and immunocytochemical analysis was made to confirm nestin (neural stem cell marker) and NF-L (neurofilament-light or neurofilament 68-kDa mature nerve cell marker) expression in SMSCs. SMSCs can differentiate into neuronal cells when induced by bFGF. The bFGF-induced SMSCs not only changed into neural-like cells but also expressed specific markers.


Yang F.J.,Tohoku University | Yang F.J.,Hubei University | Sakuraba Y.,Tohoku University | Kokado S.,University of Shizuoka | And 3 more authors.
Physical Review B - Condensed Matter and Materials Physics | Year: 2012

The anisotropic magnetoresistance (AMR) effect was systematically investigated in epitaxially grown Co 2Fe xMn 1-xSi films against Fe composition x and the annealing temperature. A change of sign in the AMR ratio from negative to positive was clearly detected when x increased from 0.6 to 0.8. This sign reversal can reasonably be explained by the change in the dominant s-d scattering process from s →d to s →d caused by the creation of large d-states at the Fermi level, suggesting the disappearance of half-metallicity at x = 0.8. The variations in the remanent density of states in the half-metallic gap against annealing temperature are also discussed from the viewpoint of the AMR ratio on the basis of the s-d scattering model. © 2012 American Physical Society.


Zhou B.,Hubei University | Zhou B.,University of Hong Kong | Shen S.-Q.,University of Hong Kong
Physical Review B - Condensed Matter and Materials Physics | Year: 2011

In a recent work, it was demonstrated by means of numerical diagonalization that the Majorana end states can be localized at opposite ends of a sample of an ideal spinless p-wave superconductor with the strip geometry beyond the strict one-dimensional limit. Here, we reexamine this issue and study the topological quantum phase transition in the same system. We give the phase diagrams of the presence of Majorana end modes by using of Z2 topological index. It is found that the topological property of a strip geometry will change in an oscillatory way with respect of the sample width. © 2011 American Physical Society.


Yan S.-H.,Hubei University | Zhang X.-X.,CAS Wuhan Institute of Physics and Mathematics
Dianbo Kexue Xuebao/Chinese Journal of Radio Science | Year: 2010

Global navigation satellite system reflection (GNSS-R) technology has emerged as a remote sensing tool for soil moisture with great potential. In this paper we discuss the key technologies of soil moisture retrieving including Dobson semi-empirical electrical model, bi-static signal reflection model, and the soft-defined radio receiver. We also give the receiver calibration method by water reflection data. A field experiment to verify the effect of the retrieving method was carried out in Wuhan Botanical Garden of the Chinese Academy of Sciences. The experimental results show the agreement between the GNSS-R inferred bare surface soil moisture and the data collected by HH2 soil meter when the soil moisture is high. However low soil moisture will lead to more errors, which recommend more study to improve retrieving accuracy. ©2010 by Editorial Department of Chinese Journal of Radio Science.


Ling H.,Neijiang Normal University | Hong W.,Hubei University
Journal of Convergence Information Technology | Year: 2012

An ontology alignment is the expression of relations between different ontologies. Ontology alignment can solve the heterogeneity among ontologies, while category theory can shield this heterogeneity and provide uniform methodological framework for ontology integration. This paper applies category theory into the field of ontology alignment. Based on the features of geo-ontology, it redefines morphism to construct a more complex category, where objects are Geo-ontologies, morphism can not only express equal relation but also describe multi-semantic relations among geo-ontologies. Based on the definition given to and the features of morphism, this paper also defines ontology alignment and composing alignment, and elaborates ontology integration via pushout.


Wan N.,Texas State University | Zhan F.B.,Texas State University | Zhan F.B.,Hubei University | Lu Y.,Texas State University | Tiefenbacher J.P.,Texas State University
Health and Place | Year: 2012

This paper reports a study examining the association between colorectal cancer (CRC) survival and access to healthcare in Texas using data from the Texas cancer registry. We geo-referenced the data to the census tract level and used an enhanced 2-step floating catchment area method and factor analysis to estimate people's spatial and non-spatial access to healthcare. In addition, Cox proportional hazard regression was employed to assess the influence of different factors on CRC survival, and a spatial scan statistic was used to investigate the geographic disparity of CRC survival and the influence of access to healthcare. The analyses revealed that Hispanics, non-Hispanic blacks, and residents from several regions in Texas were more likely to die from CRC than others. Disadvantaged population groups based on factors rather than spatial access had an increased risk of CRC-specific mortality. Spatial access to oncologists has a significant association with CRC survival in non-urban areas but not in urban areas. Geographic disparities of CRC survival were largely influenced by factors rather than spatial access to healthcare. © 2011 Elsevier Ltd.


Tian L.,Wuhan University | Tian L.,Hubei University | Ye L.,Wuhan University | Liu J.,Wuhan University | Zan L.,Wuhan University
Catalysis Communications | Year: 2012

The CNTs-WO 3 hybrid nanostructures were fabricated by solvothermal synthesis. The morphologies, phase structures and optical properties of the nanostructures were investigated by TEM, XRD, UV-vis DRS and XPS respectively. The CNTs-WO 3 hybrid nanostructures exist higher photocatalytic activity than pure WO 3 nanosheets and the mechanical mixture of WO 3 and CNTs for the degradation of methyl blue (MB) under visible light. This is attributed to their large surface area, absorption enhancement in visible light region and effective separation of electrons and holes. The presence of radical scavengers such as KI, Fe 3 + and methanol in photocatalytic experiments demonstrates that photogenerated electrons are responsible for the photocatalytic degradation of MB on CNTs-WO 3. © 2011 Elsevier B.V. All rights reserved.


Du G.,University of Wollongong | Guo Z.,University of Wollongong | Wang S.,Hubei University | Zeng R.,University of Wollongong | And 2 more authors.
Chemical Communications | Year: 2010

Restacked MoS2 with enlarged c lattice parameter and surface area was prepared by exfoliation and restacking process, exhibiting high reversible lithium storage capacity and superior rate capability as anode material for lithium ion batteries. © 2010 The Royal Society of Chemistry.


To observe peripheral blood chromosome abnormality and microdeletions of the SRY and AZF genes on the Y chromosome in patients with chimera Klinefelter syndrome. We analyzed the cytogenetic karyotype of the peripheral blood chromosome in 1 infertile patient with mosaic karyotype Klinefelter syndrome and his parents. We identified 9 sequence tagged sites (STS) by multiplex PCR: sY84, sY86, sY127, sY129, sY134, sY254, sY255, sY242, and sY152. Meanwhile we detected the SRYgene and the microdeletion of AZF using ZFX/ZFY as the internal control gene. The karyotype of the patient was 46,XY (12%)/47,XXY (30%)/48,XXYY (56%)/49,XXXXY (2%). The karyotypes of his parents were normal. Consistency was found between the SRY gene and the chromosome gender in the patient and his parents. Y chromosome AZF microdeletion was observed in the patient. The deletion sites were sY86 and sY127, and the deletion type was AZFa + AZFb. AZF microdeletion of the Y chromosome exists in patients with Klinefelter syndrome. Chromosome karyotype and Y-chromosome AZF microdeletion are important criteria for the genetic diagnosis of Klinefelter syndrome.


Kuntner M.,Slovenian Academy of science and Arts | Gregoric M.,Slovenian Academy of science and Arts | Li D.,National University of Singapore | Li D.,Hubei University
Naturwissenschaften | Year: 2010

The architecture of vertical aerial orb webs may be affected by spider size and gravity or by the available web space, in addition to phylogenetic and/or developmental factors. Vertical orb web asymmetry measured by hub displacement has been shown to increase in bigger and heavier spiders; however, previous studies have mostly focused on adult and subadult spiders or on several size classes with measured size parameters but no mass. Both estimations are suboptimal because (1) adult orb web spiders may not invest heavily in optimal web construction, whereas juveniles do; (2) size class/developmental stage is difficult to estimate in the field and is thus subjective, and (3) mass scales differently to size and is therefore more important in predicting aerial foraging success due to gravity. We studied vertical web asymmetry in a giant orb web spider, Nephila pilipes, across a wide range of size classes/developmental stages and tested the hypothesis that vertical web asymmetry (measured as hub displacement) is affected by gravity. On a sample of 100 webs, we found that hubs were more displaced in heavier and larger juveniles and that spider mass explained vertical web asymmetry better than other measures of spider size (carapace and leg lengths, developmental stage). Quantifying web shape via the ladder index suggested that, unlike in other nephilid taxa, growing Nephila orbs do not become vertically elongated. We conclude that the ontogenetic pattern of progressive vertical web asymmetry in Nephila can be explained by optimal foraging due to gravity, to which the opposing selective force may be high web-building costs in the lower orb. Recent literature finds little support for alternative explanations of ontogenetic orb web allometry such as the size limitation hypothesis and the biogenetic law. © 2010 Springer-Verlag.


In this study, the overall property of fiber reinforced polymer (FRP) was researched. It is currently widely used in all areas, mainly in civil engineering. The huge need of this material drives the research of its mechanical property and corrosion mechanism. It is proven that the FRP can significantly strengthen the whole structure due to the support of fiber. And by applying osmosis hypothesis into the explanation of corrosion of FRP, we concluded that its corrosion rate is much slower than common materials, like steel. Generally, based on these conclusions, FRP is suitable for most of the facilities in civil engineering. © 2014 IFSA Publishing, S. L.


Liu X.,Hubei University
Applied Mechanics and Materials | Year: 2014

As the third Generation mobile communication technology develops quickly, all sorts of smartphone development platform are constantly launched, including Google's Android mobile phone, and the promising future of Android cannot be ignored. Allow for the situation, the design and implementation of the Video on Demand System based on Android has realistic significance. Our article mainly states the development of Android Video on Demand application, JAVA service application and network communication. Summarize the principle of VOD system and draw flow-process diagram of it. We develop VOD application using JAVA language on Android which is based on the flow-process diagram successfully. Finally, debugging the programming on a Google's Android mobile phone, finding the bugs existing in the program and modify the mistakes to improve the software. My paper concluded the framework of VOD system on Android and verified it's availability by realizing it on a Android cellphone to provide a model for future VOD system. © (2014) Trans Tech Publications, Switzerland.


Liu H.,Hubei University
Open Automation and Control Systems Journal | Year: 2014

We study the structure of cyclic codes of an arbitrary length n over the ring Fp + uFp + vFp, which is not a finite chain ring. We prove that the Gray image of a cyclic code over Fp + uFp + vFp is a 3-quasi-cyclic code over Fp. © Hualu Liu; Licensee Bentham Open.


Li J.,Hong Kong Polytechnic University | Li J.,Hubei University | Yan F.,Hong Kong Polytechnic University
ACS Applied Materials and Interfaces | Year: 2014

High-performance low-voltage flash memories based on organic floating-gate field-effect transistors are prepared by a solution process for the first time. Transistors with a high-mobility n-type polymer semiconductor, poly{[N,N ′-bis(2-octyldodecyl)naphthalene-1,4,5,8-bis(dicarboximide)-2, 6-diyl]-alt-5,5′-(2,2′-bithiophene)}, and a high-k polymer gate dielectric, poly(vinylidene fluoride-trifluoroethylene-chlorofluoroethylene) (k ≈ 60), are successfully fabricated on flexible substrates. A thin layer of Au nanoparticles is embedded in the gate dielectric, which can store injected charge from the channel and result in a memory effect. The organic memories demonstrate high carrier mobilities (>0.3 cm2/(V s)), low program/erase voltages (±6 V), little degradation after 105 program/erase cycles, and good retention after 105 s, which suggest great promise in the application of nonvolatile memories in flexible electronics. © 2014 American Chemical Society.


Du H.-N.,Hubei University
Current Protein and Peptide Science | Year: 2012

Myriad covalent post-translational modifications of histones have been demonstrated to play crucial roles in regulating gene transcription, gene repression, DNA damage and repair, and beyond. It has been long known that these modifications are often dynamic, such as histone ubiquitination and deubiquitination, and the processes through adding and/or removing these modified marks catalyzed by various classes of enzymes commonly influence many important physiological functions. In recent few years, studies on histone ubiquitination re-garners much attention arising from lots of new exciting findings emerged. Several important histone ubiquitination sites have been mapped in different organisms. In addition, the identification and characterization of numerous ubiquitin modifying enzymes, especially ligases and deubiquitinases, have facilitated the progress in understanding the roles of histone ubiquitination/deubiquitination events. Of particular interest, histone ubiquitination interplays with many other chromatin modifications, namely "crosstalk", which contributes to a variety of cellular events. In this review, I summarize the enzymes and factors involved in regulating the attachment and removal of ubiquitin from histones, and focus on what essential roles this modification plays. I also present new evidence that links histone ubiquitination with other histone modifications, which comprises an intricate crosstalk network. © 2012 Bentham Science Publishers.


Chen Z.-W.,Shanghai JiaoTong University | Liu B.,Hubei University | Tang N.-W.,Shanghai JiaoTong University | Xu Y.-H.,Shanghai JiaoTong University | And 6 more authors.
Nucleic Acids Research | Year: 2014

Human single-strand (ss) DNA binding proteins 1 (hSSB1) has been shown to participate in DNA damage response and maintenance of genome stability by regulating the initiation of ATM-dependent signaling. ATM phosphorylates hSSB1 and prevents hSSB1 from ubiquitin-proteasome-mediated degradation. However, the E3 ligase that targets hSSB1 for destruction is still unknown. Here, we report that hSSB1 is the bona fide substrate for an Fbxl5-containing SCF (Skp1-Cul1-F box) E3 ligase. Fbxl5 interacts with and targets hSSB1 for ubiquitination and degradation, which could be prevented by ATM-mediated hSSB1 T117 phosphorylation. Furthermore, cells overexpression of Fbxl5 abrogated the cellular response to DSBs, including activation of ATM and phosphorylation of ATM targets and exhibited increased radiosensitivity, chemosensitivity and defective checkpoint activation after genotoxic stress stimuli. Moreover, the protein levels of hSSB1 and Fbxl5 showed an inverse correlation in lung cancer cells lines and clinical lung cancer samples. Therefore, Fbxl5 may negatively modulate hSSB1 to regulate DNA damage response, implicating Fbxl5 as a novel, promising therapeutic target for lung cancers. © 2014 The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.


Hu B.Q.,Wuhan University | Hu B.Q.,Hubei University
Knowledge-Based Systems | Year: 2016

Three-way decisions on three-way decision spaces are based on fuzzy lattices, i.e. complete distributive lattices with involutive negators. However, now some popular structures, such as hesitant fuzzy sets and type-2 fuzzy sets, do not constitute fuzzy lattices. It limits applications of the theory of three-way decision spaces. So this paper attempts to generalize measurement on decision conclusion in three-way decision spaces from fuzzy lattices to partially ordered sets. First three-way decision spaces and three-way decisions are discussed based on general partially ordered sets. Then this paper points out that the collection of non-empty subset of [0, 1] and the family of hesitant fuzzy sets are both partially ordered sets. Finally this paper systematically discusses three-way decision spaces and three-way decisions based on hesitant fuzzy sets and interval-valued hesitant fuzzy sets and obtains many useful decision evaluation functions. © 2015 Elsevier B.V. All rights reserved.


Gong Y.,Hubei University
Information Systems Frontiers | Year: 2016

Crowdsourcing has become an increasingly attractive practice for companies to abstain on-demand workforce and higher level of flexibility in open contexts. While knowledge-intensive crowdsourcing is expected to be prosperous, most current crowdsourcing calls are still about general and low-priced tasks. An obstacle of conducing knowledge-intensive crowdsourcing is the lack of diversity of expertise and the small scale of crowd in isolated crowdsourcing marketplaces. In this paper, a network of crowdsourcing marketplaces is envisioned for efficient knowledge-intensive crowdsourcing and engagement of massive and diverse participants across different marketplaces. Based on an algorithm for estimating participants for knowledge-intensive crowdsourcing tasks, an experiment with 100 simulations indicates that conducting crowdsourcing tasks in a network of crowdsourcing marketplaces results in higher customer satisfaction than doing that in isolated marketplaces. This finding advocates the development of a network of crowdsourcing marketplaces to open up the potential of knowledge-intensive crowdsourcing. © 2016 Springer Science+Business Media New York


Guo Z.,University of Namur | Guo Z.,Hubei University | Liu W.,CAS Lanzhou Institute of Chemical Physics | Su B.-L.,University of Namur | Su B.-L.,Wuhan University of Technology
Journal of Colloid and Interface Science | Year: 2011

Nature is the creation of aesthetic functional systems, in which many natural materials have vagarious structures. Inspired from nature, such as lotus leaf, butterfly' wings, showing excellent superhydrophobicity, scientists have recently fabricated a lot of biomimetic superhydrophobic surfaces by virtue of various smart and easy routes. Whilst, many examples, such as lotus effect, clearly tell us that biomimicry is dissimilar to a simple copying or duplicating of biological structures. In this feature article, we review the recent studies in both natural superhydrophobic surfaces and biomimetic superhydrophobic surfaces, and highlight some of the recent advances in the last four years, including the various smart routes to construct rough surfaces, and a lot of chemical modifications which lead to superhydrophobicity. We also review their functions and applications to date. Finally, the promising routes from biomimetic superhydrophobic surfaces in the next are proposed. © 2010 Elsevier Inc.


Liang C.,Hubei University
Zhongguo zhen jiu = Chinese acupuncture & moxibustion | Year: 2010

To probe a better therapy for chronic persistent asthma. Thirty-six cases of chronic persistent asthma were randomly divided into a beat-sensitive moxibustion group (17 cases) and a western medication group (19 cases). In heat-sensitive moxibustion group, the sensitization points between Feishu (BL 13) and Geshu (BL 17) were selected with heat-sensitive moxibustion; in western medication group, Seretide inhalant was applied. The patients of both groups were continuously treated for 3 months and the therapeutic effects were evaluated by clinical symptom scores and pulmonary ventilation function test. After treatment, the effective rate of 88.2% (15/17) in heat-sensitive moxibustion group was superior to that of 47.4% (9/19) in western medication group (P < 0.05); the clinical symptom scores and pulmonary ventilation function were obviously improved in the two groups, and the heat-sensitive moxibustion group was superior to the western medication group (all P < 0.05). For chronic persistent bronchial asthma, heat-sensitive moxibustion can improve the clinical symptoms and the pulmonary ventilation function, and it is better than Seretide inhalant.


Wu D.,Hubei University | Long M.,Shanghai JiaoTong University
Surface and Coatings Technology | Year: 2011

While extending the application of TiO2 to substrates with low thermal resistance, enhanced visible-light activity of the self-cleaning TiO2-coated cotton fabrics has been realized by loading AgI particles. Several characterization tools, such as X-ray powder diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and UV-vis diffuse reflectance spectroscopy, were employed to study the phase structures, morphologies and optical properties of the samples. The photocatalytic properties of the prepared products were measured with the degradation of methyl orange at room temperature under visible light irradiation. In comparison with TiO2-cotton fabrics, the dramatic enhancement in the visible light photocatalytic performance of the AgI-TiO2-cotton fabrics could be attributed to AgI with narrow band gap and the effective electron-hole separations at the interfaces of the two semiconductors. The photocatalytic performances of the AgI-TiO2-cotton fabrics were maintained for the cycling experiments. In addition, based on the XRD patterns of the AgI-TiO2-cotton fabrics before and after reaction, AgI was stable in the composites under visible irradiation, indicating that AgI-TiO2-cotton fabrics could be used as stable and efficient visible-light-induced self-cleaning materials. © 2011 Elsevier B.V.


Wang Y.C.,Hubei University
Zhongguo zhen jiu = Chinese acupuncture & moxibustion | Year: 2010

OBJECTIVE: To explore the mechanism of electroacupuncture therapy on Parkinson's disease (PD). METHODS: Fifty Wistar rats were randomly divided into a normal group, a sham-operation group, a model group, a Fengfu-Taichong group and a Shuanggu Yitong group. PD model was duplicated by microinjection of 6-Hydroxyl-Dopamine into right corpora striata, and by microinjection of normal saline in sham-operation group. Rats in normal group, sham-operation group and model group were not treated. In Fengfu-Taichong group, the rats were treated by electroacupuncture at "Fengfu" (GV 16) and "Taichong" (LR 3) on the basis of the PD model, and by electroacupuncture at "Fengfu" (GV 16), "Taichong" (LR 3), "Guanyuan" (CV 4) and "Zusanli" (ST 36) in Shuanggu Yitong group, once daily for 2 weeks. GDNF and Ret expression were detected by immunohistochemistry and western blotting, respectively. RESULTS: The number of GDNF positive cells and the content of Ret receptor increased significantly in the two electroacupuncture groups compared with those in the other groups (all P < 0.01), and the expression of GDNF increased significantly in Shuanggu Yitong group compared with that in Fengfu-Taichong group (P < 0.01). CONCLUSION: Electroacupuncture can not only increase the expression of GDNF, but also enhance its effect. "Shuanggu Yitong" method is better than simple acupuncture at "Fengfu" (GV 16) and "Taichong" (LR 3) in increasing expression of GDNF.


Based on ZhangShi YiTong written by ZHANG Lu of Qing dynasty, and the record that external application of Baijiezi (seeds of Brassica Alba) for treating asthma of cold syndrome, retrospective study is conducted to modern literature of treating winter diseases in summer with acupoint sticking therapy for preventing and treating chronic cough and asthma. Learning from thoughts and methods of evidence-based medicine, and according to subject characteristics of TCM and acupuncture, acupoints and point-selecting discipline of prescription for preventing and treating chronic cough and asthma in summer with acupoint sticking are analyzed. The results show that the top ten common acupoints used for acupoint sticking therapy of treating winter diseases in summer are Feishu (BL 13), Dingchuan (EX-B 1), Xinshu (BL 15), Geshu (BL 17), Danzhong (CV 17), Shenshu (BL 23), Gaohuang (BL 43), Dazhui (GV 14), Pishu (BL 20), Tiantu (CV 22), most of which belong to the Bladder Meridian of Foot-Taiyang, Conception Vessel and Governor Vessel or extra-meridian points. It refers that the core acupoints of acupoint sticking therapy are Feishu (BL 13), Dingchuan (EX-B 1), Xinshu (BL 15), Geshu (BL 17), Danzhong (CV 17), and adjunct points can be selected by syndrome, disease different stage, disease or symptoms.


Tan X.,Hubei University
Energy Education Science and Technology Part A: Energy Science and Research | Year: 2014

With the wide application of web big data, in response to the Internet users are about the same theme of mass information effectively filter and extraction, this paper focus on this news mining and fusion of large scale usage data in web big data and proposes a document based on particle size of the news MGNF fusion algorithm, particle size document means that face now the newest microblog and short documents and traditional news dissemination documents, both document length although different, but as based on the calculation of grassroots journalism and communication mode. Through mining the different particle size of the document different views, we can find out the potential to be found for the information. The experimental results verify the effectiveness and energy cost efficiently of the proposed algorithm. © Sila Science. All Rights Reserved.


Tang H.T.,Hubei University
Zhongguo zhen jiu = Chinese acupuncture & moxibustion | Year: 2011

To observe the correlation relationship between acupuncture at Dicang (ST 4), Hegu (LI 4) and Houxi (SI 3) on the affected side of peripheral facial paralysis patients and activated areas in brain functional areas and central regulation mechanism of acupuncture at Hegu (LI 4) treatment. Eighteen cases with left peripheral facial paralysis were randomly divided into a Hegu group, a Dicang group and a Houxi group, 6 cases in each group. They were treated with electroacupuncture at left Dicang (ST 4), Hegu (LI 4) and Houxi (SI 3), respectively, and were examined with fMRI covering the whole brain at the same time. The fMRI data was analyzed by SPM software. It was found that the left precentral gyrus area and the left postcentral gyrus area were activated when electroacupuncture at left Hegu (LI 4), and the right precentral gyrus area and the bilateral postcentral gyrus area were activated when electroacupuncture at left Dicang (ST 4), and there was no activated area at precentral gyrus area and post central gyrus area when electroacupuncture at left Houxi (SI 3). The sensory importation information from Hegu (LI 4) and Dicang (ST 4) can converge and coincide in the brain and may influence each other.


Wan P.,Chinese Academy of Agricultural Sciences | Wan P.,Hubei Academy of Agricultural Science | Huang Y.,Hubei University | Wu H.,Hubei Academy of Agricultural Science | And 4 more authors.
PLoS ONE | Year: 2012

Transgenic crops producing insecticidal proteins from Bacillus thuringiensis (Bt) kill some key insect pests, but evolution of resistance by pests can reduce their efficacy. The main approach for delaying pest adaptation to Bt crops uses non-Bt host plants as "refuges" to increase survival of susceptible pests. To delay evolution of pest resistance to transgenic cotton producing Bt toxin Cry1Ac, the United States and some other countries have required refuges of non-Bt cotton, while farmers in China have relied on "natural" refuges of non-Bt host plants other than cotton. The "natural" refuge strategy focuses on cotton bollworm (Helicoverpa armigera), the primary target of Bt cotton in China that attacks many crops, but it does not apply to another major pest, pink bollworm (Pectinophora gossypiella), which feeds almost entirely on cotton in China. Here we report data showing field-evolved resistance to Cry1Ac by pink bollworm in the Yangtze River Valley of China. Laboratory bioassay data from 51 field-derived strains show that the susceptibility to Cry1Ac was significantly lower during 2008 to 2010 than 2005 to 2007. The percentage of field populations yielding one or more survivors at a diagnostic concentration of Cry1Ac increased from 0% in 2005-2007 to 56% in 2008-2010. However, the median survival at the diagnostic concentration was only 1.6% from 2008 to 2010 and failure of Bt cotton to control pink bollworm has not been reported in China. The early detection of resistance reported here may promote proactive countermeasures, such as a switch to transgenic cotton producing toxins distinct from Cry1A toxins, increased planting of non-Bt cotton, and integration of other management tactics together with Bt cotton. © 2012 Wan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Wang J.,University of Houston | Zhang K.-Y.,Daye Peoples Hospital | Liu S.-M.,Hubei University | Sen S.,University of Houston
Molecules | Year: 2014

MicroRNAs (miRNAs), the 17- to 25-nucleotide long noncoding RNAs that modulate the expression of mRNAs and proteins, have emerged as critical players in cancer initiation and progression processes. Deregulation of tissue miRNA expression levels associated with specific genetic alterations has been demonstrated in cancer, where miRNAs function either as oncogenes or as tumor-suppressor genes and are shed from cancer cells into circulation. The present review summarizes and evaluates recent advances in our understanding of the characteristics of tumor tissue miRNAs, circulating miRNAs, and the stability of miRNAs in tissues and their varying expression profiles in circulating tumor cells, and body fluids including blood plasma. These advances in knowledge have led to intense efforts towards discovery and validation of differentially expressing tumorassociated miRNAs as biomarkers and therapeutic targets of cancer. The development of tumor-specific miRNA signatures as cancer biomarkers detectable in malignant cells and body fluids should help with early detection and more effective therapeutic intervention for individual patients. © 2014 by the authors; licensee MDPI, Basel, Switzerland.


Wu S.,Hubei University
Zhongguo zhen jiu = Chinese acupuncture & moxibustion | Year: 2011

Based on the summarization of literatures on regulation of gastrointestinal electricity with acupuncture, the regulation effect of acupuncture, its influencing factors and its mechanism were analyzed in this article. It is found that the regulation effect can be influenced by many factors such as different acupuncture techniques, frequency, point selection, manipulations and the physical condition of the object. The effect of acupuncture appears great variety, which manifests as reinforced, inhibited or a kind of two-way regulation. And it is also held that the effect of acupuncture relies on the integrity of the nerve system. Nuclei, neurotransmitters, body fluid and gastrointestinal hormone also take part in the acupuncture effect. Therefore, studies on mechanism of acupuncture effect on gastrointestinal electricity should be strengthened in the future.


Zhuang L.,Fudan University | Zeng X.,Hubei University | Yang Z.,Fudan University | Meng Z.,Fudan University
PLoS ONE | Year: 2013

Background: The effect of interferon(IFN) in the management of hepatocellular carcinoma (HCC) remains controversial, and no clear recommendations have been proposed. Objectives: To evaluate the effect and safety of IFN for HCC. Methods: PubMed, OvidSP, and Cochrane Library were searched from their establishment date until August 30, 2012. Studies that met the inclusion criteria were systematically evaluated and then subjected to meta-analysis. Results: Thirteen randomized control trials (RCTs) involving 1344 patients were eligible for this study. When IFN was used as an adjuvant therapy for HCC patients after curative therapy, the meta-analysis showed that IFN reduced the 1-, 2-, 3-, 4-, and 5-year recurrence rates. Subgroup analysis showed that IFN reduced the 2-, 3-, 4-, and 5-year recurrence rates of hepatitis C viral (HCV)-related HCC. The effect of IFN for on hepatitis B virus(HBV)-related HCC patients could not be determined because of isufficient data. After surgical resection, adjuvant IFN therapy reduced the 4- and 5- recurrence rates. All studies reported that IFN could not improve the overall survival of HCV-realated HCC patients after curative therapies. Only one study showed that IFN was associated with better overall survival in HCC patients after curative therapy and subgroup of HCC patients after surgical resection. Thus, meta-analysis was not performed. Different treatment options were used as control to study the effect of IFN for intermediate and advanced HCC patients, thus meta-analysis was not appropriate. All included studies, except for one, reported that IFN treatment was well tolerated. Conclusions: After curative therapies, adjuvant IFN reduced the recurrence of HCC. IFN did not improve the survival of HCV-related HCC patients after curative therapy. Whether IFN is effective for intermediate and advanced HCC patients could not be determined because of insufficient data. The toxicity of IFN was acceptable. © 2013 Zhuang et al.


Hu S.,Hubei University | Cheng Q.,Wuhan University | Cheng Q.,York University | Wang L.,State University of New York at Buffalo | Xu D.,Wuhan University
Landscape and Urban Planning | Year: 2013

Characterizing the spatial distribution of urban land price is essential for improving urban planning and management, as well as for effectively modeling and predicting changes in urban land use. Previous studies have shown that in using conventional geostatistics methods to characterize the local structure of land price, there is controversy regarding the effectiveness of interpolation. In this paper, a recently developed Multifractal Inverse Distance Weighted (MIDW) interpolation method is applied to characterize the spatial structure of land price, and a spectrum analysis method (S- A) based on a fractal filtering technique is applied to separate the singularity from the background of land price distribution; these methods are applied to a study site in the city of Wuhan (China). It is shown that the MIDW interpolation method is a valid and effective alternative for characterizing land price distribution by comparison with ordinary IDW and Kriging methods. Based on deviation and parameters, the results of the MIDW method not only fit better with the surveyed values, but they also incorporate both the singularity and spatial association in data interpolation. The singularity of land price, which could be attributed to local special landscapes, such as the Yangtze River and East Lake, was successfully separated from its background by the S- A method. The background, which represents the overall spatial trend of land price distribution, was reclassified by the fractal concentration-area method. The derived singularity and background will better aid the decision-making process for urban planning. © 2012.


Chen Y.F.,Hubei University
Advanced Materials Research | Year: 2014

The merits of HVDC, such as long-distance power transmission, less line lose,ability to transmit high-power and so on,were introduced. The obstacles in development of HVDC,including failure of commutation,hazards of higher harmonics,limitations of transmission direction, problems of insulation and so on,were analyzed. The research progress both at home and abroad in development of HVDC were summarized. At last,research and application prospects of HVDC were prospected briefly. © (2014) Trans Tech Publications, Switzerland.


Liu F.X.,Hubei University
Zhonghua nan ke xue = National journal of andrology | Year: 2013

To explore the effect of seminal plasma lipoprotein (a) in abnormal semen liquefaction and its clinical significance. According to The WHO Laboratory Manual for the Examination and Processing of Human Semen, we conducted semen routine analyses of 101 patients with abnormal semen liquefaction and 26 normal healthy controls. We added chymotrypsin to the semen for 30 minutes of incubation at 37 degrees C. When there were filaments, we centrifuged the semen and obtained the upper seminal plasma to determine the level of lipoprotein (a). The level of lipoprotein (a) was significantly higher in the 101 patients ([526.2 +/- 243.5] mg/L) than in the 26 normal controls ([296.9 +/- 105.2] mg/L) (P < 0.01) . Lipoprotein (a) can inhibit fibrin dissolution, and delayed fibrin dissolution in semen liquefaction may be related to the increased level of seminal plasma lipoprotein (a). The seminal plasma lipoprotein (a) level should be taken into account in the clinical diagnosis of male infertility caused by abnormal semen liquefaction.


Zhang H.,Hubei Engineering University | Zhang L.,Hubei Engineering University | Shen H.,Hubei University
Signal Processing | Year: 2012

The spatial resolution of a hyperspectral image is often coarse because of the limitations of the imaging hardware. Super-resolution reconstruction (SRR) is a promising signal post-processing technique for hyperspectral image resolution enhancement. This paper proposes a maximum a posteriori (MAP) based multi-frame super-resolution algorithm for hyperspectral images. Principal component analysis (PCA) is utilized in both parts of the proposed algorithm: motion estimation and image reconstruction. A simultaneous motion estimation method with the first few principal components, which contain most of the information of a hyperspectral image, is proposed to reduce computational load and improve motion field accuracy. In the image reconstruction part, different image resolution enhancement techniques are applied to different groups of components, to reduce computational load and simultaneously remove noise. The proposed algorithm is tested on both synthetic images and real image sequences. The experimental results and comparative analyses verify the effectiveness of this algorithm. © 2012 Elsevier B.V. All rights reserved.


Branched-chain amino acid aminotransferase (BCAT) plays a key role in the biosynthesis of hydrophobic amino acids (such as leucine, isoleucine and valine), and its substrate spectrum has not been fully explored or exploited owing to the inescapable restrictions of previous assays, which were mainly based on following the formation/consumption of the specific branched-chain substrates rather than the common amino group donor/acceptor. In our study, detailed measurements were made using a novel coupled assay, employing (R)-hydroxyglutarate dehydrogenase from Acidaminococcus fermentans as an auxiliary enzyme, to provide accurate and reliable kinetic constants. We show that Escherichia coli BCAT can be used for asymmetric synthesis of a range of non-natural amino acids such as l-norleucine, l-norvaline and l-neopentylglycine and compare the kinetic results with the results of molecular modelling. A full two-substrate steady-state kinetic study for several substrates yields results consistent with a bi-bi ping-pong mechanism, and detailed analysis of the kinetic constants indicates that, for good 2-oxoacid substrates, release of 2-oxoglutarate is much slower than release of the product amino acid during the transamination reaction. The latter is in fact rate-limiting under conditions of substrate saturation. © 2013 FEBS.


Gan W.,Hubei University
Zhonghua nan ke xue = National journal of andrology | Year: 2011

To evaluate the efficacy and safety of Tolterodine Tartrate combined with the alpha-receptor blocker in the treatment of benign prostatic hyperplasia with detrusor overactivity (BPH-DO). A total of 113 patients with BPH-DO were randomly assigned to receive Tolterodine Tartrate combined with Cardura (Group A) and Cardura alone (Group B), both for 12 weeks. Then we recorded and compared their average 24 h urinary frequency, IPSS and QOL score, maximum urinary flow rate, residual urine volume and urinary retention times before and after the treatment. After the treatment, Group A showed significantly better improvement in the average 24 h urinary frequency and scores on IPSS and QOL than Group B. No significant differences were found between the two groups in the maximum urinary flow rate and residual urine volume. No acute urinary retention occurred in either group. The combined use of Tolterodine Tartrate and the alpha-receptor blocker can effectively relieve the symptoms of dysuria, urinary frequency and urinary urgency in patients with BPH-DO, with neither significant adverse effects on the maximum flow rate and residual urine volume nor increase in the incidence of acute urinary retention.


Zhao L.M.,Nanyang Technological University | Tang D.Y.,Nanyang Technological University | Liu D.,Hubei University
Applied Physics B: Lasers and Optics | Year: 2010

Ultrahigh-repetition-rate (over 100 GHz) boundsoliton pulses were experimentally generated in a fiber laser. Through incorporating a Loyt-type filter made of a piece of high birefringent fiber and an intracavity polarizer in a fiber laser, we found that not only ultrahigh-repetition-rate single-pulse soliton but also bound-soliton trains could be generated. Numerical simulations confirm the experimental observations. © Springer-Verlag 2010.


Wang Y.,Hubei University
IEEE Technology and Society Magazine | Year: 2013

Ying Wang shares his views on Information ethics in reuse of public sector information (PSI) in China. Ying Wang examines the ethical status of statements made on Chinese public sector web sites with respect to the reuse of PSI using a case analysis approach to gain insight into the ethical considerations and legal risks. PSI is considered to have significant economic potential for thee country. The China Information Office of the State Council has published a report from 2006 titled, Notice about Division of Tasks of Strengthening Development and Utilization of Information Resources, which emphasized on encouraging social forces to reuse government information with economic and social value; formulating administrative measures to regulate reuse of government information. All of these reports point to the explicit need to channel development of information resources.


Liu Q.,Hubei University | Jia X.,City University of Hong Kong | Zhou Y.,Huawei
Wireless Networks | Year: 2011

Directional antennas are widely used technologies for reducing signal interference and increasing spatial reuse. In this paper, we propose a topology control method for multi-channel multi-radio wireless mesh networks that use directional antennas. We are given a set of mesh routers installed in a region and some of them are gateway nodes that are connected to the Internet via wired lines. Each router has a traffic demand (Internet access traffic) generated from the end-users. The problem is how to adjust antenna orientations of radios and assign channels to them to construct a logical network topology, such that the minimum delivery ratio of traffic demands of routers is maximized. We first formulate the problem to an equivalent optimization problem with a clearer measurable metric, which is to minimize the largest interfering traffic of links in the network. We then propose a three-step solution to solve the problem. Firstly, we construct a set of routing trees, with the objective to balance the traffic among tree links. Secondly, we assign the radios of a node to the links it needs to serve, such that the total traffic load of the links that each radio serves is as balanced as possible. Thirdly, we do a fine-grained adjustment of antenna orientations and assign channels to them, such that the transmission area of each antenna will cover all the links it serves and the largest interfering traffic of links is minimized. © 2010 Springer Science+Business Media, LLC.


Liu Z.,Beijing Institute of Technology | Zeng X.,Hubei University
Advances in Mathematics of Communications | Year: 2016

The geometric structure of any relative one-weight code is determined, and by using this geometric structure, the support weight distribution of subcodes of any relative one-weight code is presented. An application of relative one-weight codes to the wire-tap channel of type II with multiple users is given, and certain kinds of relative one-weight codes all of whose nonzero codewords are minimal are determined. © 2016 AIMS.


Dan W.,CAS Institute of Geology and Geophysics | Dan W.,University of Chinese Academy of Sciences | Li X.-H.,CAS Institute of Geology and Geophysics | Li X.-H.,Hubei University | And 4 more authors.
Gondwana Research | Year: 2012

The Alxa Block is the westernmost part of the North China Craton (NCC). In the past, it has been considered to be part of the Archean NCC. However, formation and evolution of this block remain poorly understood, and this has hampered a broader understanding of the NCC. In this study we analyzed the in situ zircon U-Pb age and Hf-O isotopes for the two oldest rock units in the eastern Alxa Block, namely the Bayanwulashan and Diebusige Complexes. The Bayanwulashan Complex consists mainly of metamorphic rocks with mafic and felsic protoliths. SIMS U-Pb zircon dating results indicate that the primary magmatic ages of the mafic and felsic igneous rocks are ca. 2.34Ga and ca. 2.32-2.30Ga, respectively, and both sets of rocks were overprinted by two metamorphic events at ca. 1.89Ga and ca. 1.79Ga. Geochemical and zircon Hf-O isotopic data suggest that the ca. 2.34Ga amphibolites within the Bayanwulashan Complex are characteristically high in TiO 2 (up to 3.2%), Zr (up to 394ppm) and Ti/V (>30), resembling the basaltic rocks formed within continental rifts. The ca. 2.32-2.30Ga felsic rocks were generated by remelting of dominant meta-igneous rocks that have zircon Hf model ages of 2.92-2.81Ga. The Diebusige Complex is composed of amphibolites, mafic gneisses and paragneisses. It was intruded by granites dated at ca. 1.97-1.98Ga, and subjected to high grade metamorphic events at ca. 1.89Ga and ca. 1.79Ga. Re-examination of U-Pb ages for detrital and metamorphic zircons indicate that the depositional ages of protoliths of the Diebusige paragneisses may be considered to be between ca. 2.45 and 2.0Ga. These U-Pb zircon age data do not support the existence of exposed Archean rocks in the eastern Alxa Block, although the possibility of Archean rocks at deeper crustal levels cannot be ruled out entirely.The eastern Alxa Block contrasts to the neighboring Yinshan Block and Khondlite Belt, as well as the Trans-North China Orogen, in terms of the timing and evolution of magmatism and metamorphism. Thus, we conclude that the Alxa Block is a separated Paleoproterozoic terrane from the Western Block of the NCC, rather than the western extension of the Yinshan Block or part of the Khondalite Belt, as previously proposed. © 2011 International Association for Gondwana Research.


Li H.,Huazhong University of Science and Technology | Chen N.,Huazhong University of Science and Technology | Li L.,Hubei University
IEEE Transactions on Neural Networks and Learning Systems | Year: 2012

Elastic-net regularization is a successful approach in statistical modeling. It can avoid large variations which occur in estimating complex models. In this paper, elastic-net regularization is extended to a more general setting, the matrix recovery (matrix completion) setting. Based on a combination of the nuclear-norm minimization and the Frobenius-norm minimization, we consider the matrix elastic-net (MEN) regularization algorithm, which is an analog to the elastic-net regularization scheme from compressive sensing. Some properties of the estimator are characterized by the singular value shrinkage operator. We estimate the error bounds of the MEN regularization algorithm in the framework of statistical learning theory. We compute the learning rate by estimates of the Hilbert-Schmidt operators. In addition, an adaptive scheme for selecting the regularization parameter is presented. Numerical experiments demonstrate the superiority of the MEN regularization algorithm. © 2012 IEEE.


Liu Y.,Huazhong University of Science and Technology | Liu Y.,Wuhan Institute of Technology | Zhang X.,Hubei University | Su J.,Huazhong University of Science and Technology | And 3 more authors.
Optics Express | Year: 2014

A novel heterojunction ultraviolet (UV) photodetector of assembling Ag nanoparticles (NPs) onto ZnO nanowire (NW) arrays was fabricated via combination of chemical vapor deposition and thermal evaporation route. The fabricated composite Ag@ZnO NW arrays show blue-shift of UV peaks, suppression of the visible peaks, and obvious enhancements in absorption from ultraviolet to infrared region and photoluminescence (PL) emission at room-temperature. These phenomena are attributed to the Localized Surface Plasmon Resonance (LSPR) effect. Benefiting from absorption enhancement and surface heterojunctions, Ag@ZnO heterostructures show a photocurrent increment by 117%, a short response time of 80 ms and a recovery time of 3.27 s under 365 nm UV illumination of 0.24 mW/cm2. This research presented a simple route to obtain high performance UV photodetectors and would be of some benefit in optical-electron devices manufacture. © 2014 Optical Society of America.


Lim M.L.M.,National University of Singapore | Li D.,National University of Singapore | Li D.,Hubei University
PLoS ONE | Year: 2013

Animal colour signals used in intraspecies communications can generally be attributed to a composite effect of structural and pigmentary colours. Notably, the functional role of iridescent coloration that is 'purely' structural (i.e., absence of pigments) is poorly understood. Recent studies reveal that iridescent colorations can reliably indicate individual quality, but evidence of iridescence as a pure structural coloration indicative of male quality during contests and relating to an individual's resource-holding potential (RHP) is lacking. In age- and size-controlled pairwise male-male contests that escalate from visual displays of aggression to more costly physical fights, we demonstrate that the ultraviolet-green iridescence of Cosmophasis umbratica predicts individual persistence and relates to RHP. Contest initiating males exhibited significantly narrower carapace band separation (i.e., relative spectral positions of UV and green hues) than non-initiators. Asymmetries in carapace and abdomen brightness influenced overall contest duration and escalation. As losers retreated upon having reached their own persistence limits in contests that escalated to physical fights, losers with narrower carapace band separation were significantly more persistence. We propose that the carapace UV-green iridescence of C. umbratica predicts individual persistence and is indicative of a male's RHP. As the observed UV-green hues of C. umbratica are 'pure' optical products of a multilayer reflector system, we suggest that intrasexual variations in the optical properties of the scales' chitin-air-chitin microstructures are responsible for the observed differences in carapace band separations. © 2013 Lim, Li.


Xie Y.,Eastern Michigan University | Sha Z.,Hubei University | Bai Y.,CAS Institute of Botany
ISPRS Journal of Photogrammetry and Remote Sensing | Year: 2010

Large and growing archives of orbital imagery of the earth's surface collected over the past 40 years provide an important resource for documenting past and current land cover and environmental changes. However uses of these data are limited by the lack of coincident ground information with which either to establish discrete land cover classes or to assess the accuracy of their identification. Herein is proposed an easy-to-use model, the Tempo-Spatial Feature Evolution (T-SFE) model, designed to improve land cover classification using historical remotely sensed data and ground cover maps obtained at later times. This model intersects (1) a map of spectral classes (S-classes) of an initial time derived from the standard unsupervised ISODATA classifier with (2) a reference map of ground cover types (G-types) of a subsequent time to generate (3) a target map of overlaid patches of S-classes and G-types. This model employs the rules of Count Majority Evaluation, and Subtotal Area Evaluation that are formulated on the basis of spatial feature evolution over time to quantify spatial evolutions between the S-classes and G-types on the target map. This model then applies these quantities to assign G-types to S-classes to classify the historical images. The model is illustrated with the classification of grassland vegetation types for a basin in Inner Mongolia using 1985 Landsat TM data and 2004 vegetation map. The classification accuracy was assessed through two tests: a small set of ground sampling data in 1985, and an extracted vegetation map from the national vegetation cover data (NVCD) over the study area in 1988. Our results show that a 1985 image classification was achieved using this method with an overall accuracy of 80.6%. However, the classification accuracy depends on a proper calibration of several parameters used in the model. © 2009 International Society for Photogrammetry and Remote Sensing, Inc. (ISPRS).


Wang T.,Jiangxi Normal University | Chen S.,Jiangxi Normal University | Shao A.,Jiangxi Normal University | Gao M.,Jiangxi Normal University | And 3 more authors.
Organic Letters | Year: 2015

(Formula Presented) A direct oxidative cross-coupling between terminal alkynes and secondary phosphine oxides was developed. This approach provides an efficient way to construct alkynyl di(phenyl) phosphine oxides from basic materials, and in this process, the silver salts act as a key promoter. © 2014 American Chemical Society.


Shengli M.,Hubei University
Open Automation and Control Systems Journal | Year: 2015

In this paper, we researched the application of NS2 network simulation based on clustering algorithm. With the development of Internet, more and more information transferred by network. Thus the increasing of bandwidth cannot keep up with the demand of information transmission. The content distribution technique is a novel network technology that efficiently delivers the content to end user on behalf of origin web sites. It works by distributing content to the nearest server, so content will closer to users, and avoid congestion. In this paper, a simulation model of content delivery networks based on NS2 is put forward, and compared with C/S mode, we found that the system performance is more better than C/S. © Mao Shengli.


Xu J.,Hubei University
International Journal of Wavelets, Multiresolution and Information Processing | Year: 2014

Support vector machine regression (SVMR) is a regularized learning method in reproducing kernel Hilbert spaces with epsilon-insensitive loss function. Different from the previously known works on the generalization ability of SVMR with independent and identically distributed (i.i.d.) samples, in this paper, we consider the generalization ability of SVMR algorithm based on non-i.i.d. samples, uniformly ergodic Markov chain (u.e.M.c.) samples. We give an error analysis for SVMR algorithm based on u.e.M.c. samples and obtain the optimal learning rate for the SVMR algorithm based on u.e.M.c. samples. © 2014 World Scientific Publishing Company.


Xia L.,Renmin University of China | Gao J.,Renmin University of China | Liu Y.,Wuhan University | Wu K.,Hubei University
Tumor Biology | Year: 2013

Recently, many studies have been published to evaluate the correlation between the cytochrome P450 1A1 (CYP1A1) T3801C polymorphism and cervical neoplasia risk. However, the results remain inconclusive. To clarify this possible association, we conducted a systematic review and meta-analysis of published studies. Data were collected from the following electronic databases: PubMed, Embase, Ovid, ISI Web of Knowledge, Google Scholar, and Chinese Biomedical Database databases. The pooled odds ratio (OR) and its 95 % confidence interval (95 % CI) were used to assess the strength of this association. The pooled ORs were performed for the allele model (C vs. T), the homozygote model (CC vs. TT), the dominant model (CC/CT vs. TT), and the recessive model (CC vs. TT/CT), respectively. Finally, a total of 12 independent studies including a total of 3,724 subjects (1,912 cases/1,812 controls) were eligible for meta-analysis. Overall, there was a significant association between the CYP1A1 T3801C polymorphism and cervical neoplasia susceptibility (C vs. T, OR 1.32, 95 % CI 1.04-1.68, P = 0.02; CC vs. TT, OR 1.99, 95 % CI 1.19-3.35, P = 0.01; CC/CT vs. TT, OR 1.36, 95 % CI 1.02-1.81, P = 0.02; CC vs. TT/CT, OR 1.57, 95 % CI 1.23-2.02, P < 0.01). Meta-analysis of the ten studies on cervical cancer suggested a significant association between the CYP1A1 T3801C polymorphism and cervical cancer risk (C vs. T, OR 1.38, 95 % CI 1.05-1.82, P = 0.02; CC vs. TT, OR 2.06, 95 % CI 1.15-3.70, P = 0.02; CC/CT vs. TT, OR 1.45, 95 % CI 1.03-2.02, P = 0.03; CC vs. TT/CT, OR 1.56, 95 % CI 1.20-2.03, P < 0.01). In the stratified analysis by ethnicity, significant associations were also detected in some genetic models. This meta-analysis demonstrates a significant association between the CYP1A1 T3801C polymorphism and cervical neoplasia susceptibility. © 2012 International Society of Oncology and BioMarkers (ISOBM).


Zhang J.,Renmin University of China | Dong W.-G.,Renmin University of China | Lin J.,Hubei University
Medical Oncology | Year: 2011

Human selenium-binding protein 1 (SBP1) is known to play a key role in the development and progression of many cancers. The role of SBP1 expression in gastric carcinoma (GC) is far from being fully established. The aim of the present study was to evaluate the expression of SBP1 in GC and correlate the findings with several clinicopathological features and prognosis. Tissue samples from 65 patients treated by gastric resection for GC with clinical stage II and III were used. Each sample was matched with the corresponding nonneoplastic epithelia tissues removed during the same surgery. Reverse transcriptase- polymerase chain reaction, immunostaining and Western blot analyses were used to detect the expression of SBP1 at the mRNA and protein levels, respectively. The associations between SBP1 expressions and clinicopathological features were analyzed. Expressions of SBP1 at both mRNA and protein levels were significantly lower in GC than those in the corresponding nonneoplastic epithelia tissues (P = 0.000). SBP1-negative expression had a significant relationship with high clinical stage (P = 0.038). Prognosis of SBP1-negative patients was significantly poorer than that of SBP1-positive patients (P = 0.001), and multivariate analysis further confirmed that SBP1 was an independent prognostic factor (P = 0.004). Thus, down-regulation of SBP1 may play a key role in the tumorigenic process of human GC. The correlation of SBP1 reduction in GC with clinical stage and survival proposes a prognostic role in GC. © 2010 Springer Science+Business Media, LLC.


Feng J.,Shandong University | Ma P.,Shandong University | Yang H.,Hubei University | Lu L.,National University of Singapore
Electrochimica Acta | Year: 2013

The compatibility with graphitic anode has been one key problem in developing flame-retarding additives for lithium ion batteries. To understand the interactions between flame-retarding additives and graphitic anode, two phosphonate esters (dimethyl methylphosphonate DMMP and diethyl ethylphosphonate DEEP) are selected and characterized as flame retardant addtives. DEEP is reported as a flame-retarding additive for the first time. Their interactions with graphite anode are characterized via current-static charge-discharge, ex-situ XRD, FE-SEM and AC impedance. The results reveal that the two phosphonate esters demonstrate different reaction mechanisms with graphitic anode, which result in different anode compatibility. These findings may be useful for designing better flame-retarding additives for lithium ion batteries. © 2013 Elsevier Ltd. All rights reserved.


Zeng X.,Hubei University | Small D.P.,University of Western Ontario | Wan W.,University of Western Ontario
Carbohydrate Polymers | Year: 2011

Bacterial cellulose production by Acetobacter xylinum BPR 2001 was optimized using maple syrup as a carbon source. Twelve culture parameters were screened by the Plackett-Burman design and significant parameters were optimized by the response surface methodology using a three-level, four-factor Box-Behnken design. For fermentation in a rotary shaker, the optimal conditions for bacterial cellulose production were: maple syrup 30 g carbohydrate/l, (NH4)2SO4 3.3 g/l, KH2PO4 1 g/l, yeast extract 20 g/l, citric acid 1.6 g/l, trisodium citrate dehydrate 2.4 g/l, ethanol 0.5% (v/v), acetic acid 0.5 g/l, MgSO4· 7H2O 0.8 g/l, inoculum age 3 days, inoculum volume 6% (v/v), shaking speed 135 rpm, and incubation temperature 25 °C. Comparison of bacterial cellulose production with maple syrup or pure sugars showed maple syrup was a suitable carbon source. This was the first demonstration of conversion of maple syrup, a plentiful renewable resource, into bacterial cellulose, a nanobiomaterial ideal for many applications. © 2011 Elsevier Ltd. All rights reserved.


Yu T.L.,Xinyang Normal University | Lu X.,Hubei University
North-Western Journal of Zoology | Year: 2013

We studied male mate choice and mating success in Minshan's toads (Bufo gargarizans minshanicus) - a species in which female fecundity increases with body size, and the timeinvested in one mating is relatively long. Field data suggested that larger males had a mating advantage over smaller males, and that mating was size-assortative. We also tested sex recognition and mate choice in laboratory-based choice experiments. When a male B. g.minshanicus was allowed to choose between a male and a female of equal size, males did not discriminate between the sexes. When a male B. g. minshanicus was allowed to choose between a similar-sized gravid and non-gravid female, males preferably clasped the gravid female. When two different-sized gravid females were provided for males, the males did not discriminate females based on their body size. Although male B. g. minshanicus had an ability to distinguish between gravid and non-gravid females, under field conditions non-gravid female abundance is relatively low. Therefore, when the cost associated with making awrong choice is low, male Minshan's toads did not preferentially choose mates. © NwjZ, Oradea, Romania, 2013.


Objective: This study used a two-wave longitudinal research design to explore the role of individual strengths, including interpersonal strength, intellectual strength, and temperance strength, in affecting the mental health of stressed college students. Participants: A total of 404 stressed Chinese college students were screened to participate in this 12-month longitudinal study. Methods: At the beginning of the study (Time 1), students who had not experienced stressful events within the last 12 months were invited to assess their strengths, psychological well-being, and psychological symptoms. After 12 months (Time 2), 404 students who reported stressful experiences completed the scales again and were retained for the final analyses. Results: Academics-related stressors were the most endorsed life events among college students, whose states of mental health showed downward trends from Time 1 to Time 2. Three strengths had weak to modest correlations to mental health at both Time 1 and Time 2. Although the additional variances of mental health explained by the three strengths were very modest, the mediational roles of the strengths were identified. The perceived stress completely mediated the relationship between the strengths and the psychological symptoms and partly mediated the relationship between the strengths and psychological well-being. Conclusions: Individual strengths may function as a defense against perceived stress and are protective factors of mental health. These strengths maintain mental health by enhancing the psychological well-being and reducing the psychological symptoms of individuals. © 2016 Springer International Publishing Switzerland


Liu D.,Ohio State University | Xia F.,Hubei University
Remote Sensing Letters | Year: 2010

The advantages of object-based classification over the traditional pixel-based approach are well documented. However, the potential limitations of objectbased classification remain less explored. In this letter, we assess the advantages and limitations of an object-based approach to remote sensing image classification relative to a pixel-based approach. We first quantified the negative impacts of under-segmentation errors on the potential accuracy of object-based classification by developing a new segmentation accuracy measure. Then we evaluated the advantages and limitations of object-based classification by quantifying their overall effects relative to pixel-based classification, with respect to their classification units and features at multiple segmentation scales. The results based on a QuickBird satellite image indicate that (1) segmentation accuracies decrease with increasing segmentation scales and the negative impacts of under-segmentation errors become significantly large at large scales and (2) there are both advantages and limitations in using object-based classification, and their trade-off determines the overall effect of object-based classification, which is dependent on the segmentation scales.


Li Q.,Hubei University
Natural Hazards and Earth System Science | Year: 2013

The predictive analysis of natural disasters and their consequences is challenging because of uncertainties and incomplete data. The present article studies the use of variable fuzzy sets (VFS) and improved information diffusion method (IIDM) to construct a composite method. The proposed method aims to integrate multiple factors and quantification of uncertainties within a consistent system for catastrophic risk assessment. The fuzzy methodology is proposed in the area of flood disaster risk assessment to improve probability estimation. The purpose of the current study is to establish a fuzzy model to evaluate flood risk with incomplete data sets. The results of the example indicate that the methodology is effective and practical; thus, it has the potential to forecast the flood risk in flood risk management. © 2013 Author(s).


Wu S.,Stanford University | Wu S.,Hubei University | Chang E.,Stanford University | Cheng Z.,Stanford University
Current Organic Synthesis | Year: 2011

Bioluminescence refers to the emission of light from a living system in which photoproteins such as luciferase enzymes oxidize their substrates to produce light. Because of its high-sensitivity and low-toxicity, bioluminescence imaging (BLI) is particularly useful for in vitro assays and in vivo small animal imaging. It provides a powerful tool to study various important biological questions and processes including gene and protein expression, protein-protein interactions, protein-nucleic acid interactions, and cell signaling pathway functions. This review highlights some of the latest developments in the design and applications of molecular probes for BLI. © 2011 Bentham Science Publishers Ltd.


Qiu Q.,Hubei University
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2013

Taking "Apple" and "Red" as examples, and basing on the new description of lexical meaning structure, we hold that the lexical meaning structure was composed of three elements: referent meaning, attribute meaning and feature-value meaning. In the lexical meaning structures of different word-classes, overt and covert conditions of these three elements are different. According to the conditions, we can divide the lexical meaning structure into two sections, that is, indication meaning and implication meaning. A lexical meaning structure is composed of many minimum lexical meaning structures, and in a lexical meaning structure, all minimum lexical meaning structures share one indication meaning, so this lexical meaning structure is treated as a spherical structure of lexical meaning, and this indication meaning is regarded as the centre of the sphere, and implication meaning of this word is treated as outside of the center of the sphere. The spherical structure of lexical meaning is the foundation of the generation of syntactic structure, and the syntactic structure is the extending and intersecting of the spherical structure of lexical meaning. © 2013 Springer-Verlag.


Feng S.,Hubei University
Open Automation and Control Systems Journal | Year: 2015

The paper analyses the multiple kernel learning-based face recognition in pattern matching area. Based on the analysis of the basic theory of multiple kernel SVM, this thesis focuses on the multiple kernel SVM algorithm based on semi-infinite linear program (SILP), including SILP based on column generation (CG) and SILP based on chunking algorithm (CA). The two SILP improved algorithms are applied to several classification problems, including UCI binary classification problem datasets and multi-classification problem datasets. Furthermore, the two SILP improved algorithms are applied to the actual problems of face recognition. The experiment data shows that with the multiple kernel learning-based method, the performance of face recognition can be obviously improved. © Shan Feng.


Tu Z.,Henan University of Science and Technology | Zeng X.,Hubei University | Zeng X.,Chinese Academy of Sciences | Hu L.,Chinese Academy of Sciences
Finite Fields and their Applications | Year: 2014

In this paper, three classes of monomials and one class of trinomials over finite fields of even characteristic are proposed. They are proved to be complete permutation polynomials. © 2013 Elsevier Inc.


Zhang Y.,Hubei University
Proceedings - 2012 4th International Conference on Multimedia and Security, MINES 2012 | Year: 2012

This paper discussed the resource of the urban-rural income gap from the aspect of the productivity difference, and we reach the conclusion that the urban-rural income gap mainly resource from the difference in the total factor productivity, the speed of labor transfer, and the capital stock. From the data analysis, we can see the increase of the total factor productivity will help narrow the urban-rural income gap, and the distortions in capital allocation had the negative effect on narrowing the urban-rural income gap, and the transfer of rural surplus labor to urban significantly increased farmer's income. © 2012 IEEE.


Peng J.,Hubei University
Journal of Mathematical Chemistry | Year: 2014

Regression from high dimensional observation vectors is particularly difficult when training data is limited. Partial least squares (PLS) partly solves the high dimensional regression problem by projecting the data to latent variables space. The key issue in PLS is the computation of weight vector which describes the covariance between the responses and observations. For small-sample-size and high-dimensional regression problem, the covariance estimation is usually inaccurate and the correlated components in the predictors will distort the PLS weight. In this paper, we propose a sparse matrix transform (SMT) based PLS (SMT-PLS) method for high-dimensional spectroscopy regression. In SMT-PLS, the observation data is first decorrelated by SMT. Then, in the decorrelated data space, the PLS loading weight is computed by least squares regression. SMT technique provides an accurate data covariance estimation, which can overcome the effect of small-sample-size and benefit both the PLS weight computation and subsequent regression prediction. The proposed SMT-PLS method is compared, in terms of root mean square errors of prediction, to PLS, Power PLS and PLS with orthogonal scatter correction on four real spectroscopic data sets. Experimental results demonstrate the efficacy and effectiveness of our proposed method. © 2014 Springer International Publishing Switzerland.


Zhang X.,Tianjin University | Ordonez De Pablos P.,University of Oviedo | Wang X.,CAS Institute of Policy and Management | Wang W.,CAS Institute of Policy and Management | And 2 more authors.
Computers in Human Behavior | Year: 2014

Internet-based 3D social virtual world (SVW) is a special social media with 3D interface, open-ended, immersive, and collaborative nature, which has attracted interest among researchers and practitioners alike. This Chinese 3D SVW market developed for nearly 8 years, from 2005 to 2013. After the initiation stage (05-09), some new tendencies occurred in the maintenance stage (09-13). Some local SVWs (e.g.; HiPiHi) held advantages in attracting users in the early stage but failed in the maintenance stage, but other companies (e.g.; Uworld) attracted users' continuous adoption and commitment in long-term competition. Based on customer commitment theory and diffusion of innovation theory, we established a theoretical framework to explain how virtual world strategies impact on short-term and long-term customer commitment. Based on qualitative data (e.g.; longitude observation and third-party report), this research compares two major competitors' strategies in Chinese virtual world market (i.e.; HiPiHi and Uworld), and analyzes how their strategies succeeded or failed to attract users' long-term commitment. The findings suggest there is a "S-curve" for adoption rate of SVW users, and there is a "critical timeframe" for persuading users' continuous adoptions. Social virtual worlds should try to encourage users to reduce personalization and learning cost in the short-term, after which they can then change the "vicious circle" to "virtuous circle." © 2014 Elsevier Ltd. All rights reserved.


Cui W.,Huazhong University of Science and Technology | Cui W.,University of Sydney | Du F.,Huazhong University of Science and Technology | Zhao J.,Huazhong University of Science and Technology | And 4 more authors.
Carbon | Year: 2011

Silica-coated multi-walled carbon nanotubes (MWCNT@SiO2) were synthesized by a sol-gel method and then incorporated into an epoxy matrix. The less stiff silica intermediate shell on the MWCNTs not only alleviates the modulus mismatch between the stiff MWCNTs and the soft epoxy, but also improves the interaction between them. The thermal conductivities of the epoxy/MWCNT@SiO2 composites increase by 51% and 67% at low filler loadings of 0.5 wt.% and 1 wt.%, respectively. At the same time, the silica shell retains the high electrical resistivity of these composites. © 2010 Elsevier Ltd. All rights reserved.


Du X.,Wuhan University | Hu X.,Wuhan University | Hu X.,Hubei University | Wei J.,Wuhan University
Molecular Biology Reports | Year: 2014

High mobility group box 1 protein (HMGB1) plays an important role in myocardial ischemia and reperfusion (I/R) injury. Preconditioning of exendin-4 (Ex), a glucagon-like peptide-1 receptor agonist, has been reported to attenuate myocardial I/R injury. The current study investigated whether Ex postconditioning also attenuated myocardial I/R injury and the potential mechanisms. Anesthetized male rats were subjected to ischemia for 30 min and treated with Ex (5 μg/kg, i.v.) 5 min before reperfusion, in the absence and/or presence of exendin (9-39) (an antagonist of glucagon-like peptide-1 receptor, 5 μg/kg, i.v.), followed by reperfusion for 4 h. Lactate dehydrogenase (LDH), creatine kinase (CK), tumor necrosis factor-α, interleukin-6, and infarct size were measured. HMGB1 expression was assessed by immunoblotting. Postconditioning with Ex significantly decreased infarct size and levels of LDH and CK after 4 h reperfusion (all p < 0.05). Ex also significantly inhibited the increase in malondialdehyde level and decreased the level of superoxide dismutase (both p < 0.05). In addition, the increase in HMGB1 expression induced by I/R was significantly attenuated by Ex postconditioning. Administration of exendin (9-39) abolished the protective effect of Ex postconditioning (all p < 0.05). The present study suggests that Ex postconditioning may attenuate myocardial I/R injury, which may in turn be associated with inhibiting inflammation. © 2014 Springer Science+Business Media.


Du B.,Hubei University | Zhang L.,Wuhan University | Chen T.,Wuhan University | Wu K.,Wuhan University
International Journal of Fuzzy Systems | Year: 2012

Manifold learning methods have widely used in ordinary image processing domain. It has many advantages, depending on the different formulation of the manifold. Hyperspectral images are kind of images acquired by air-borne or space-born platforms. This paper introduces a novel manifold learning based dimension reduction (DR) method for hyperspectral classification. The purpose is to fully utilize the spectral and spatial information from hyperspectral images to get confidential landcover and land use class results. © 2012 TFSA.


Xu Y.,Hubei University
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2015

Underground water is different from surface water. Once contaminated, underground water is difficult to recover, so it is necessary to give priority to the prevention of the quality of underground water. High-density resistivity method is very important in the environmental engineering geophysical prospecting and it is widely used in mineral resources as well as monitoring the underground-water quality. In the experiment, multi-tools joint inversion is applied to build the model in order to increase the accuracy. In contrast with the pollution-free water model which is owned by the RES2DMOD, the inversion result of underground water quality with the high density resistivity method is useful to monitor the underground water quality, showing that different degree of water pollution depends on the position of abnormal and there is a more significant abnormal value in the vertical direction of the deep abnormal than that of the shallow abnormal, and high and low resistance pollution depends on the different value and forms of abnormal resistance. In conclusion, monitoring the underground water quality by the high density resistivity method is efficient. In the future research, it is necessary to accomplish more precise inversion models combining with field measurements to find out the optimal solution to monitor underwater quality. © 2015 SPIE.


Zhou D.,Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials | Tang B.,Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials | Lu X.-H.,Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials | Wei X.-L.,Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials | And 2 more authors.
Catalysis Communications | Year: 2014

Selective oxidation of alkenes with air to corresponding epoxides was performed over simple ion-exchanged Co-MOR and Co-5A. Among all transition metal ions-exchanged M-zeolites, both Co-MOR and Co-5A exhibited the highest activity at 363 K. Notably, for the epoxidation of styrene, α-pinene, α-methyl styrene and cyclooctene, Co-MOR obtained higher conversions than Co-5A, in agreement with the difference of pore sizes of both zeolitic materials. Recycling and control tests showed high durability of Co-MOR as a heterogeneous catalyst in our catalytic system. © 2013 Elsevier B.V.


Liu B.,Hubei University | Peng J.-X.,Huazhong University of Science and Technology
Tien Tzu Hsueh Pao/Acta Electronica Sinica | Year: 2011

In order to solve the problems that the image fusion method based on IHS transform can not preserve good spectral information and the image fusion method based on separable discrete wavelet transform is low in spatial resolution and block effect is exist in the fused image, a new multispectral image fusion method based on IHS transform and three channels nonseparable symmetrical wavelets is proposed. A construction method of the symmetrical filter bank relating to this kind of wavelet is presented. The multi-resolution decompositions of the intensity of the multispectral image and panchromatic image are performed in nonsubsampled mode using the filter bank constructed. The approximation images and the detail images of the multi-resolution pyramids are fused. The experiment results show that this method has good visual effect. The fusion performance outperforms the IHS fusion method, the fusion method based on DWT and the fusion method based on IHS-DWT in preserving spectral quality and high spatial resolution information.


The epidermal growth factor receptor (EGFR) is a promising therapeutic target in cancer, but its clinical value in breast cancer remains controversial. Our previous studies have found that quantitative analysis of biomarkers with quantum dot-based nanotechnology had better detection performance than conventional immunohistochemistry. The present study was undertaken to investigate the prognostic value of EGFR in breast cancer using quantum dot-based quantitative spectral analysis. EGFR expression in 65 breast cancer specimens was detected by immunohistochemistry and quantum dot-immunohistochemistry, and comparisons were made between the two methods. EGFR expression in tissue microarrays of 240 breast cancer patients was then detected by quantum dot-immunohistochemistry and spectral analysis. The prognostic value of EGFR immunofluorescence area (EGFR area) for five-year recurrence-free survival was investigated. The same antigen localization, high correlation of staining rates (r = 0.914), and high agreement of measurement (κ = 0.848) of EGFR expression in breast cancer were found by quantum dot-immunohistochemistry and immunohistochemistry. The EGFR area showed significant differences by tumor grade, lymph node status, HER2 status, and hormone receptor status (all P < 0.05). Patients in the large EGFR area (≥ 30.51) group had a significantly higher five-year recurrence rate (47.2% versus 27.4%, P = 0.002) and worse five-year recurrence-free survival (log-rank test, P = 0.0015) than those in the small EGFR area (<30.51) group. In the subgroups, EGFR area was an independent prognosticator in the HER2-positive and lymph node-positive subgroups. Quantum dot-based quantitative detection demonstrates the prognostic value of EGFR area in the HER2-positive and lymph node-positive subgroups of invasive breast cancer.


BACKGROUND: Biostimulation feedback treatment has been widely used for female stress urinary incontinence. The treatment principle is based on the electromyographic signal measured and the combination of biofeedback technique and electrotherapy technique. OBJECTIVE: To evaluate the effect of biofeedback electrical stimulation in treatment of female stress urinary incontinence. METHODS: Thirty female patients suffering from light or moderate stress urinary incontinence received biofeedback electrical stimulation for 4-8 weeks. The stimulation parameters were 60 Hz, 20-60 mA, 12-second feedback. The patients were instructed to contract pelvic floor muscle. The peak value of surface electromyography in pelvic floor muscular 2-second-rapid-contraction, mean value of pelvic floor muscular 10-second-contraction, mean value of the pelvic floor muscular 60-second-tolerance-contraction, and the rate of urine leakage were observed before and after treatment. RESULTS AND CONCLUSION: The peak value of surface electromyography in pelvic floor muscular 2-second-rapid-contraction, mean value of pelvic floor muscular 10-second-contraction, and mean value of the pelvic floor muscular 60-second-tolerance-contraction were significantly increased after treatment, compared with before treatment (P < 0.05). The rate of urine leakage was decreased obviously after treatment (P < 0.05). Biofeedback electrical stimulation can significantly increase surface electromyography value of pelvic floor muscles during contraction, and is an effective treatment for female stress urinary incontinence. © 2014, Journal of Clinical Rehabilitative Tissue Engineering Research. All Rights Reserved.


Yan S.Y.,Hubei University
Applied Mechanics and Materials | Year: 2014

Stock trading is a kind of modern economic movement in order to obtain high returns under risky investment activities. Stock value index only provides a tool for people with a measure of historical change of stock price. The paper presents a hybrid SAGA combined with dynamic penalty function algorithm is used to solve the model founded before. And also a more actual portfolio investment model, which is based on all requirements of the actual finical market such as no dividing stocks and all kinds of fees.The experiment results indicate that our algorithm has better searching ability and can avoid the occurring of earliness effectively. © (2014) Trans Tech Publications, Switzerland.


Mao Y.,Hubei University | Luick J.L.,South Australian Research And Development Institute
Journal of Geophysical Research: Oceans | Year: 2014

New mechanisms for stratification and upwelling in the southern Great Barrier Reef (GBR) are identified, and dynamic details of Capricorn Eddy, a transient feature located off the shelf at the southern extremity of the GBR, are revealed using the newly available surface current from High Frequency (HF) radar combined with other remote sensing and mooring data. The HF radar surface currents were used for tidal harmonic analysis and current-wind correlation analysis. These analyses, combined with Sea Surface Temperature (SST) data, mooring data, and altimetry-based geostrophic currents, enabled the effects of forcing from the large-scale oceanic currents (including the East Australian Current (EAC)), wind, and tides in a topographically complex flow regime to be separately identified. Within the indentation region where the width of the shelf abruptly narrows, current is strongly coupled with the EAC. Here strong residual flows, identified on current maps and SST images, fall into three patterns: southward flow, northwestward flow, and an eddy. Multiple data sets shed light on the prerequisite for the formation of the eddy, the reasons for its geometric variation, and its evolution with time. Intrusions of the eddy onto the shelf result in stratification characterized by a significant increase of surface temperature. Upwelling driven by wind or oceanic inflow is shown to cause stratification of previously well-mixed shelf water. The upwelling appears to be associated with equatorward-traveling coastal-trapped waves. The integrative method of analysis embodied here is applicable to other coastal regions with complex circulation. Key Points New mechanisms for stratification and upwelling in the SGBR are identified Detailed properties of the Capricorn Eddy are observed The integrative method is powerful in studying complex coastal circulation © 2014. American Geophysical Union. All Rights Reserved.


Wang G.,Hubei University
Applied Mechanics and Materials | Year: 2014

The article discusses the investigation of net gambling. In the world, according to different states have different attitude; the section concludes the illegality of net gambling. Initiation of investigation has two categories: automatic initiation and compelling initiation, we should choose the latter, but it should have exception. The specific countermeasures are collecting leads from citizens’ reports or the public security organs’ conduct. Then the public security organs should find out the truth of the case, arrest the suspects and obtain the evidence. When the investigations were concluded, the organs should remove it to procurator ate for examination, or quash the case, in accordance with the following elements: the facts, evidence and legality. At the last of the section, specific investigation countermeasures for different kinds of net gambling are discussed. © (2014) Trans Tech Publications, Switzerland.


Zhang F.,Hubei University
Applied Mechanics and Materials | Year: 2014

The air quantity of variable air volume system for the rooms and the total air quantity of the system changes with the change of room load. Combined with the system composition in the laboratory, the paper determines the control scheme of the variable air volume system, that is, indoor temperature-control, indoor positive pressure control, air distribution static pressure control, air-supply temperature control and new air volume control. The dotted lines with arrows mean the output signals from the control unit to actuator, and the solid lines with arrows represent the input signals from the actuator to the control unit. © (2014) Trans Tech Publications, Switzerland.


Kuntner M.,Slovenian Academy of science and Arts | Kuntner M.,Smithsonian Institution | Kuntner M.,Hubei University | Arnedo M.A.,University of Barcelona | And 4 more authors.
Molecular Phylogenetics and Evolution | Year: 2013

The pantropical orb web spider family Nephilidae is known for the most extreme sexual size dimorphism among terrestrial animals. Numerous studies have made Nephilidae, particularly Nephila, a model lineage in evolutionary research. However, a poorly understood phylogeny of this lineage, relying only on morphology, has prevented thorough evolutionary syntheses of nephilid biology. We here use three nuclear and five mitochondrial genes for 28 out of 40 nephilid species to provide a more robust nephilid phylogeny and infer clade ages in a fossil-calibrated Bayesian framework. We complement the molecular analyses with total evidence analysis including morphology. All analyses find strong support for nephilid monophyly and exclusivity and the monophyly of the genera Herennia and Clitaetra. The inferred phylogenetic structure within Nephilidae is novel and conflicts with morphological phylogeny and traditional taxonomy. Nephilengys species fall into two clades, one with Australasian species (true Nephilengys) as sister to Herennia, and another with Afrotropical species (Nephilingis Kuntner new genus) as sister to a clade containing Clitaetra plus most currently described Nephila. Surprisingly, Nephila is also diphyletic, with true Nephila containing N. pilipes+. N. constricta, and the second clade with all other species sister to Clitaetra; this ". Nephila" clade is further split into an Australasian clade that also contains the South American N. sexpunctata and the Eurasian N. clavata, and an African clade that also contains the Panamerican N. clavipes. An approximately unbiased test constraining the monophyly of Nephilengys, Nephila, and Nephilinae (Nephila, Nephilengys, Herennia), respectively, rejected Nephilengys monophyly, but not that of Nephila and Nephilinae. Further data are therefore necessary to robustly test these two new, but inconclusive findings, and also to further test the precise placement of Nephilidae within the Araneoidea. For divergence date estimation we set the minimum bound for the stems of Nephilidae at 40. Ma and of Nephila at 16. Ma to accommodate Palaeonephila from Baltic amber and Dominican Nephila species, respectively. We also calibrated and dated the phylogeny under three different interpretations of the enigmatic 165. Ma fossil Nephila jurassica, which we suspected based on morphology to be misplaced. We found that by treating N. jurassica as stem Nephila or nephilid the inferred clade ages were vastly older, and the mitochondrial substitution rates much slower than expected from other empirical spider data. This suggests that N. jurassica is not a Nephila nor a nephilid, but possibly a stem orbicularian. The estimated nephilid ancestral age (40-60. Ma) rejects a Gondwanan origin of the family as most of the southern continents were already split at that time. The origin of the family is equally likely to be African, Asian, or Australasian, with a global biogeographic history dominated by dispersal events. A reinterpretation of web architecture evolution suggests that a partially arboricolous, asymmetric orb web with a retreat, as exemplified by both groups of ". Nephilengys", is plesiomorphic in Nephilidae, that this architecture was modified into specialized arboricolous webs in Herennia and independently in Clitaetra, and that the web became aerial, gigantic, and golden independently in both ". Nephila" groups. The new topology questions previously hypothesized gradual evolution of female size from small to large, and rather suggests a more mosaic evolutionary pattern with independent female size increases from medium to giant in both ". Nephila" clades, and two reversals back to medium and small; combined with male size evolution, this pattern will help detect gross evolutionary events leading to extreme sexual size dimorphism, and its morphological and behavioral correlates. © 2013 Elsevier Inc.


Wang H.,Hubei University | Lhr H.,Helmholtz Center Potsdam | Ritter P.,Helmholtz Center Potsdam | Kervalishvili G.,Helmholtz Center Potsdam
Journal of Geophysical Research: Space Physics | Year: 2012

Based on two years of Subauroral Polarization Streams (SAPS) events detected by DMSP satellites in the dusk-premidnight sector, we have studied the temporal and spatial effects of SAPS on thermospheric quantities. The events are divided into two different MLT (magnetic local time) groups covered by F13 and F14/15. Concurrent CHAMP observations taken between-30° and +60° in longitude (-2 h and +4 h MLT) with respect to the SAPS detection location and within a time window of 1.5 h before and 3 h after the SAPS detection time are used for comparison. For the first time the spatial and temporal effects of SAPS are shown. SAPS have great influences on the zonal wind in all MLT bins (17-21 MLT) around the F13 MLT sector, with the largest effect appearing around 19 MLT, about 0-2 hours MLT after SAPS onset. SAPS have relatively little effect around 23-24 MLT, as deduced from F14/15 SAPS. For most cases the zonal wind peaks in the first orbit, concurrent with the SAPS onset. But around 19 MLT the zonal wind attains peak velocities about 1.5 h after the SAPS detection. This is claimed to be related to the longer persistence of SAPS events in this MLT sector than in other sectors. The background air density gets enhanced by SAPS with the most prominent variation occurring around 19 MLT. There are density bulges appearing around the SAPS latitude. The electron density trough gets deepened and attains the minimum in the first orbit after the SAPS onset. The largest depletion can also be found around 19 MLT. Both the eastward and westward Hall currents (electrojets) get strengthened right after SAPS onset. The zonal wind peaks 2-3 in latitudes equatorward of the eastward electrojet. © 2012 American Geophysical Union. All Rights Reserved.


Mo J.-Y.,Hubei University | Xu X.,CAS Institute of Vertebrate Paleontology and Paleoanthropology | Evans S.E.,University College London
Journal of Systematic Palaeontology | Year: 2012

The Late Cretaceous deposits of the Nanxiong Formation, southern China, have yielded some dinosaur bones and many eggs, but there has been little record of the associated fauna. A new locality in Jiangxi Province has recently produced a fossil lizard assemblage including two genera of herbivores and the partial skull and lower jaws of a terrestrial predator. The latter combines large size, the possession of a small number of recurved, well-separated marginal teeth, a blunt rostrum, and rounded cranial osteoderms. It resembles Estesia from the Late Cretaceous of Mongolia, but is distinct in its jaw morphology and the possession of cranial osteoderms. It is therefore placed in a new genus and species, Chianghsia nankangensis. Phylogenetic analysis groups Chianghsia unequivocally with the Platynota, the group to which living monitor lizards and extinct mosasaurs belong. Within Platynota, there is support for the attribution of Chianghsia to Monstersauria, the group that includes the living venomous Gila monster, Heloderma suspectum, and its fossil relatives. This is the first record of a large terrestrial predatory platynotan lizard from the Mesozoic of southern China. © 2012 The Natural History Museum.


Liang F.,Kanazawa Medical University | Liang F.,Hubei University | Koya D.,Kanazawa Medical University
Diabetes, Obesity and Metabolism | Year: 2010

Insulin resistance (IR) is closely associated with obesity, type 2 diabetes mellitus (T2DM), hypertension, polycystic ovary syndrome (PCOS), non-alcohol fatty liver diseases (NAFLD) and metabolic syndrome and is also a risk factor for serious diseases such as cardiovascular diseases. Pharmacological treatments available for IR are limited by drug adverse effects. Because acupuncture has been practiced for thousands of years in China, it has been increasingly used worldwide for IR-related diseases. This review analyses 234 English publications listed on the PubMed database between 1979 and 2009 on the effectiveness of acupuncture as a treatment for IR. These publications provide clinical evidence, although limited, in support of the effectiveness of acupuncture in IR. At this stage, well-designed, evidence-based clinical randomized controlled trial studies are therefore needed to confirm the effects of acupuncture on IR. Numerous experimental studies have demonstrated that acupuncture can correct various metabolic disorders such as hyperglycemia, overweight, hyperphagia, hyperlipidemia, inflammation, altered activity of the sympathetic nervous system and insulin signal defect, all of which contribute to the development of IR. In addition, acupuncture has the potential to improve insulin sensitivity. The evidence has revealed the mechanisms responsible for the beneficial effects of acupuncture, though further investigations are warranted. © 2010 Blackwell Publishing Ltd.


Shu S.,Hubei University | Li J.,Hua Zhong Normal University
Physical Review C - Nuclear Physics | Year: 2010

The Friedberg-Lee (FL) model is studied at finite temperature and density. The soliton solutions of the FL model in the deconfinement phase transition are solved and thoroughly discussed for certain boundary conditions. We indicate that the solitons before and after the deconfinement have different physical meanings: the soliton before deconfinement represents hadrons, while the soliton after the deconfinement represents the bound state of quarks which leads to a strongly interacting quark-gluon plasma phase. The corresponding phase diagram is given. © 2010 The American Physical Society.


Ma Z.M.,Shandong University | Hu B.Q.,Hubei University
Fuzzy Sets and Systems | Year: 2014

Filters play an important role in studying logical systems and the related algebraic structures. Various filters have been proposed in the literature. In this paper, we aim to develop a unifying definition for some specific filters called I-filters which provide us with a meaningful method to study these filters and corresponding logical algebras. In particular, trivial characterizations of I-filters, non-trivial characterizations of classes of I-filters, such as implicative, fantastic and Boolean filters, and characterizations of homologous logical algebras are obtained. Next, three new types of I-filters named divisible filters, strong and n-contractive filters in residuated lattices are introduced. Particularly, it is verified that n-fold implicative BL-algebras and n-contractive BL-algebras coincide. Finally, we investigate the relationships between these specific I-filters. It is shown that a filter is a fantastic filter if and only if it is both a divisible filter and a regular filter. © 2013 Elsevier B.V. All rights reserved.


Tang X.,Wuhan University | Tang X.,Hubei University | Liu Y.,Wuhan University | He Y.,Wuhan University | And 2 more authors.
Journal of Experimental Botany | Year: 2013

The roles of cell polarity and the first asymmetric cell division during early embryogenesis in apical-basal cell fate determination remain unclear. Previously, a novel Brassica napus microspore embryogenesis system was established, by which rape exine-dehisced microspores were induced by physical stress. Unlike traditional microspore culture, cell polarity and subsequent asymmetric division appeared in the exine-dehisced microspore, which finally developed into a typical embryo with a suspensor. Further studies indicated that polarity is critical for apical-basal cell fate determination and suspensor formation. However, the pattern of the first division was not only determined by cell polarity but was also regulated by the position of the ruptured exine. The first division could be equal or unequal, with its orientation essentially perpendicular to the polar axis. In both types of cell division, the two daughter cells could have different cell fates and give rise to an embryo with a suspensor, similar to zygotic apical-basal cell differentiation. The alignment of the two daughter cells is consistent with the orientation of the apical-basal axis of future embryonic development. Thus, the results revealed that exine dehiscing induces rape microspore polarization, and this polarity results in a different cell fate and fixes the apical-basal axis of embryogenesis, but is uncoupled from cell asymmetric division. The present study demonstrated the relationships among cell polarity, asymmetric cell division, and cell fate determination in early embryogenesis. © 2012 The Author. Published by Oxford University Press [on behalf of the Society for Experimental Biology]. All rights reserved.


Zhou D.W.,Hubei University
Zhonghua nan ke xue = National journal of andrology | Year: 2011

To investigate the effects of estrogen receptor alpha (ERa) and insulin-like growth factor 1 (IGF1) on the proliferation of prostatic smooth muscle cells (PSMCs) in vitro. The ERalpha shRNA expression frame was subcloned to the pGSadeno adenovirus vector by homologous recombination technology to construct the pGSaaeno-ERalpha vector. After the mouse PSMCs were transfected in vitro by pGSaaeno-ERalpha, the mRNA and protein expression levels of ERalpha were detected by RT-PCR and Western blot respectively. The expression of IGF1 in the ERa-reduced cells was determined by Western blot 6 hours after treatment with 17beta-estradiol (E2) at 10(-8) mol/L. The post-transfection activity of estrogen or exogenous IGF1 in the proliferation of PSMCs was evaluated by MTT chlormetric analysis. After treatment with E2, the proliferation of PSMCs and the expression of the IGF1 gene were significantly increased in the normal control group (P <0.05), but not obviously changed in the ERalpha-siRNA group (P> 0.05). And exogenous IGF1 failed to induce the proliferation of the ERalpha-reduced PSMCs. E2 induces the expression of IGF1 via ERalpha, and IGFl, with the interaction of ERalpha, promotes the proliferation of PSMCs.


Lu X.,CAS Xian Institute of Optics and Precision Mechanic | Wu H.,Hubei University | Yuan Y.,CAS Xian Institute of Optics and Precision Mechanic | Yan P.,CAS Xian Institute of Optics and Precision Mechanic | Li X.,CAS Xian Institute of Optics and Precision Mechanic
IEEE Transactions on Geoscience and Remote Sensing | Year: 2013

Hyperspectral unmixing is one of the most important techniques in analyzing hyperspectral images, which decomposes a mixed pixel into a collection of constituent materials weighted by their proportions. Recently, many sparse nonnegative matrix factorization (NMF) algorithms have achieved advanced performance for hyperspectral unmixing because they overcome the difficulty of absence of pure pixels and sufficiently utilize the sparse characteristic of the data. However, most existing sparse NMF algorithms for hyperspectral unmixing only consider the Euclidean structure of the hyperspectral data space. In fact, hyperspectral data are more likely to lie on a low-dimensional submanifold embedded in the high-dimensional ambient space. Thus, it is necessary to consider the intrinsic manifold structure for hyperspectral unmixing. In order to exploit the latent manifold structure of the data during the decomposition, manifold regularization is incorporated into sparsity-constrained NMF for unmixing in this paper. Since the additional manifold regularization term can keep the close link between the original image and the material abundance maps, the proposed approach leads to a more desired unmixing performance. The experimental results on synthetic and real hyperspectral data both illustrate the superiority of the proposed method compared with other state-of-the-art approaches. © 2012 IEEE.


Renewable energy power generation represented by wind power and photovoltaic power is intractable, which brings great challenge to safe operation of micro-grid. Designing energy storage system is an effective solution. This paper mainly researches how to obtain the energy storage capacity when the micro-grid is in island state, and put forward a method for determining the optimal storage capacity with probabilistic method based on statistics. According to the probability density function curve both the maximum charging and discharging power and the optimal capacity of energy storage system are calculated which can improve the economic benefit and renewable energy utilization. © (2014) Trans Tech Publications, Switzerland.


Feng Y.,University of Minnesota | Feng Y.,Hubei University | Zhang X.,University of Minnesota | Graves P.,New York Medical College | Zeng Y.,University of Minnesota
RNA | Year: 2012

Dicer cleaves double-stranded RNAs (dsRNAs) or precursor microRNAs (pre-miRNAs) to yield ∼22-nt RNA duplexes. The pre-miRNA structure requirement for human Dicer activity is incompletely understood. By large-scale in vitro dicing assays and mutagenesis studies, we showed that human Dicer cleaves most, although not all, of the 161 tested human pre-miRNAs efficiently. The stable association of RNAs with Dicer, as examined by gel shift assays, appears important but is not sufficient for cleavage. Human Dicer tolerates remarkable structural variation in its pre-miRNA substrates, although the dsRNA feature in the stem region and the 2-nt 3′-overhang structure in a pre-miRNA contribute to its binding and cleavage by Dicer, and a large terminal loop further enhances pre-miRNA cleavage. Dicer binding protects the terminal loop from digestion by S1 nuclease, suggesting that Dicer interacts directly with the terminal loop region. Copyright © 2012 RNA Society.


Chen H.,Nanchang University | Hu P.,Hubei University
IET Control Theory and Applications | Year: 2013

This article mainly studies the problem of the exponential stability for singular systems with two interval timevarying delays. By constructing a modified Lyapunov-Krasovskii functional (LKF) and utilising a convex polyhedron method to estimate the derivative of LKF, some new delay-dependent criteria can be established in terms of linear matrix inequalities. Compared with some existing literatures, the novelties in this study are that the needed decisive variables are fewer and the obtained delay-dependent stability criteria are less conservative. Finally, two illustrative numerical examples are given to show the effectiveness of the derived results. © The Institution of Engineering and Technology 2013.


Tian T.,Xiangtan University | Wang X.F.,Xiangtan University | Li W.,Hubei University
Solid State Communications | Year: 2013

As high-temperature structural materials, L12 intermetallic compounds have attracted the strong interest from both fundamental and industrial aspects. Understanding of elastic property is a basis for the complete investigations of mechanical behavior of L12 alloys. In an effort to explore the electronic origin of elastic properties of L12 intermetallics, we have performed a systematic study on elastic constants for single crystals, and Young's modulus, shear modulus, bulk modulus and Poisson's ratio for poly-crystals of 22 known Al3X and X3Al-type (X=transition or main group metal) intermetallics using the ab initio calculations. Based on the calculations of elastic constants and extreme (both positive and negative) Poisson's ratios, we found a pronounced correlation between the extreme Poisson's ratio and the elastic anisotropy, i.e., approximate 40% of the investigated L12 intermetallics exhibit intrinsic auxetic behavior. Furthermore, based on the distribution of bonding charge densities, we revealed that the ductility and extreme Poisson's ratios were attributable to the directionality of bonds of these alloys. Our findings provide a new method to predict mechanical behavior of intermetallics. © 2012 Elsevier Ltd.


He Y.,Hubei University | Yan X.,Nankai University
Science China Chemistry | Year: 2011

Mn-doped ZnS quantum dots /methyl violet nanohybrids were explored to develop a novel room temperature phosphorescence (RTP) sensor for the detection of DNA. Methyl violet (MV) as the electron acceptors was adsorbed on the surface of the quantum dots (QDs) to quench the RTP of the Mn-doped ZnS QDs through an electron-transfer process under excitation. The addition of DNA recovered the RTP signal of the Mn-doped ZnS QDs due to the binding of MV with DNA and the removal of MV from the surface of the Mn-doped ZnS QDs. Under the optimal conditions, the enhanced RTP intensity of the Mn-doped ZnS QDs/MV nanohybrids linearly increased with the concentration of DNA from 0.08 to 12 mg L -1 with the detection limit of 33.6 μg L-1. The relative standard deviation for eleven replicate detections of the reagent blank was 3.7%. The developed method was applied to the detection of DNA in spiked urine samples with recoveries of 96%-103% without interference from nonspecific fluorescence. © 2011 Science China Press and Springer-Verlag Berlin Heidelberg.


Yang B.,Chinese Peoples Liberation Army | Gao J.,Chinese Peoples Liberation Army | Rao Z.,Chinese Peoples Liberation Army | Shen Q.,Hubei University
Neoplasma | Year: 2013

The purpose of this study was to evaluate the association of expression level of α5β1-integrin and MMP-14 with clinicopathologic features and prognosis in colorectal cancer (CRC). The expressions of α5β1-integrin and MMP-14 in normal colorectal mucosa and CRC tissue were detected with immunohistochemistry. We estimated the five-year survival rate by the Kaplan-Meier method. The positive expressions rates of α5β1-integrin and MMP-14 in CRC tissue were 60.6% and 63.3% respectively, and there were significant differences on their positive expression rates between in CRC tissue and in normal colorectal mucosa(P<0.05). The expression rates of α5β1-integrin and MMP-14 in patients with poor histological differentiation, lymph node metastasis and high clinical staging were heightened. There was a significant difference (P<0.05) on the five-year survival rate for α5β1-integrin expression, which was 44.6% in positive groups and 75.5% in negative groups. And there was a significant difference (P<0.05) on the five-year survival rate for MMP-14 expression, which was 48.2% in positive group and 73.1% in negative group. The expression of α5β1-integrin and MMP-14 is correlated with the progression and metastasis of CRC, and α5β1-integrin and MMP-14 may be used as prognostic markers in CRC.


Yu J.,Wuhan University of Technology | Fan J.,Wuhan University of Technology | Zhao L.,Wuhan University of Technology | Zhao L.,Hubei University
Electrochimica Acta | Year: 2010

Dye-sensitized solar cells (DSSCs) are fabricated based on hollow anatase TiO2 (HA-TiO2) spheres synthesized by a chemically induced self-transformation (CIST) strategy using urea as a base catalyst, whose walls are composed of anatase nanocrystals and exhibit hierarchical porosity. TiO2 hollow structured materials not only have low density, high specific surface areas, and hierarchically porous structures, but also exhibit high light-collection efficiency and fast motion of charge carriers. Effects of calcination temperatures on the performance of HA-TiO2 solar cells are investigated and discussed. With increasing calcination temperatures, the light-electricity conversion efficiencies (η) increase. At 600 °C, HA-TiO2 cells reach the highest efficiency. The performances of HA-TiO2 cells are also compared with Degussa P-25 (P25) TiO2 nanoparticle cells at the same film thickness, and their optimal efficiencies at 600 °C are 4.82 and 4.35%, respectively. The enhanced performance of HA-TiO2 cells is due to their high surface area and hierarchically nanoporous structures when compared with the nonporous TiO2 nanoparticles (P25). © 2009 Elsevier Ltd. All rights reserved.


Lei J.,Hubei University
Advances in Engineering Materials and Applied Mechanics - Proceedings of the 5th International Conference on Machinery, Materials Science and Engineering Applications, MMSE 2015 | Year: 2016

Along with the development of the times, people demand for smart home is becoming more and more urgent. In the design of smart home, most people will first pay attention to the control of household appliances and the realization of the intelligent home appliances, but there are some other aspects that if transformed also will greatly enhance the intelligent degree of residence, such as the smart window. So, this paper tried to design a control system for smart window. The system has two main functions: automatic environment regulating function and automatic security protection function. The system uses a MCU, several kinds of sensors and signal processing circuit. According to the current actual situation, it can open windows or close windows by itself. © 2016 Taylor & Francis Group, London.


Yan S.,Hubei University
Advance Journal of Food Science and Technology | Year: 2015

The study established a BP neural network prediction model to test the effect of the application to predict the food safety Index. The GA was used to optimize the weights and thresholds of BP neural network. The theoretical analysis and experimental results prove that the BP neural network prediction is feasible for the food safety Index. The index prediction has some value in the field of food index forecast. © Maxwell Scientific Organization, 2015.


Wu H.X.,Hubei University
Advances in Engineering Materials and Applied Mechanics - Proceedings of the 5th International Conference on Machinery, Materials Science and Engineering Applications, MMSE 2015 | Year: 2016

The goods can be separated according to different materials by the automatic sorting system, it has the advantages of high efficiency, low cost etc., and PLC has the advantages of complete functions, versatility, high reliability, strong anti-interference ability, etc. The application of Siemens PLC in material sorting control system is introduced in this paper. Composition, control principle, control flow and control program were emphatically described, it meets the actual production requirements. The field experience shows the design of the system is reasonable, stable and reliable, and high automation. © 2016 Taylor & Francis Group, London.


You J.,Hubei University | Lu Q.,University of Houston
Supportive Care in Cancer | Year: 2014

Introduction: Social support has shown to improve adjustment among cancer survivors. However, it is unclear how health benefits of social support depend on the source of support, age, and gender. Chinese culture emphasizes relationship harmony and interdependence, providing a unique opportunity to address these questions. This study investigated how support from different sources was associated with adjustment to cancer and how the association was moderated by gender and age. Methods: Chinese cancer survivors (N = 238) from Beijing completed a questionnaire packet assessing support from different sources (e.g., family, friends, special others, society, and cancer organization) and adjustment (e.g., quality of life and positive and negative affect). Results: Perceived support from family was greater than support from other sources among Chinese cancer survivors. After controlling for support from other sources, greater support from family and society was associated with higher quality of life, more positive affect, and less negative affect. Support from family showed a stronger negative correlation with negative affect among males, and support from special others showed a stronger negative correlation with negative affect among females. Support from society had a stronger positive association with quality of life, and support from friends had a stronger negative association with quality of life among younger survivors than among older survivors. Conclusions: Findings highlight that health benefits of social support depend on the source of support, gender, and age among Chinese cancer survivors. The study has implications for delivering individualized healthcare services tailored to the preferences of cancer survivors based on their cultural backgrounds and demographic characteristics. © 2013 Springer-Verlag.


Wang X.,Wuhan University | Jiang T.,University of Pittsburgh | Ma F.,Hubei University
Journal of Information Science | Year: 2010

As a new-style computer-mediated communication system, the blog has been gaining popularity among various Web users. Blog communities come into being in the process of self-organized communication between bloggers and the community structures are reflected by the embedded social networks. This study research the communication patterns of scientist bloggers with the data from the largest Chinese-language scientific blog community specializing in computer and information sciences and technologies, i.e. the Csdn blog. The social network analysis of its blogroll link data suggests that the Csdn blog community is a small-world network. Many sub-communities exist in the blog community. The communication between the central and ordinary bloggers within the same sub-community is usually one-way and dense. The structure of the Csdn blog community indicates that distributed central actors are still important in the diffusion and communication of scientific knowledge. © 2010 The Author(s).


Yue X.L.,Hubei University
Genetics and molecular research : GMR | Year: 2012

The endangered marsh herb, Caldesia grandis, is native to China. We investigated the spatial structure of the genetic variation of three populations of C. grandis using RAPD markers and spatial autocorrelation analysis, based on the method of equal distance interval. A total of 157 individuals were sampled from four patches collected from the region of Hunan and Yunnan Provinces, China. Among the polymorphic bands generated by seven selective primers, polymorphic bands with frequencies ranging from 20 to 80% were used to calculate Moran's I spatial autocorrelation coefficient for each patch. We found significant spatial structure of genetic variation in the three patches in Bei Hai (BH) (patches BH-1 and BH-2) and Guai Hu (GH) (patch GH-1) populations of C. grandis (with significant positive autocorrelation within the short distance class). In contrast, the genetic variation in the Lang Pan Hu (LPH) population (patch LPH-1) was found to be randomly distributed. The different spatial distribution patterns may be attributed to environment differences. These results have implications for the conservation and management of this species, especially for sampling strategies for ex situ conservation.


Guo Z.,Hubei University | Guo Z.,CAS Lanzhou Institute of Chemical Physics | Liu W.,CAS Lanzhou Institute of Chemical Physics
Applied Physics Letters | Year: 2010

The promising formation mechanism of Ag nanoparticles on a Si wafer displaying superhydrophobicity, generated by means of a facile in situ galvanic cell route, is discussed. The results showed that the promising formation of Ag nanoparticles is based on a microelectrochemical redox reaction in which both the anodic process and the cathodic process occur simultaneously on the silicon substrate surface. This discovery could be of great importance in the design of other metal/semiconductor systems. © 2010 American Institute of Physics.


Dilek Y.,Miami University Ohio | Dilek Y.,Hubei University | Furnes H.,University of Bergen
Bulletin of the Geological Society of America | Year: 2011

Ophiolites, and discussions on their origin and significance in Earth's history, have been instrumental in the formulation, testing, and establishment of hypotheses and theories in earth sciences. The definition, tectonic origin, and emplacement mechanisms of ophiolites have been the subject of a dynamic and continually evolving concept since the nineteenth century. Here, we present a review of these ideas as well as a new classification of ophiolites, incorporating the diversity in their structural architecture and geochemical signatures that results from variations in petrological, geochemical, and tectonic processes during formation in different geodynamic settings. We define ophiolites as suites of temporally and spatially associated ultramafic to felsic rocks related to separate melting episodes and processes of magmatic differentiation in particular tectonic environments. Their geochemical characteristics, internal structure, and thickness vary with spreading rate, proximity to plumes or trenches, mantle temperature, mantle fertility, and the availability of fluids. Subduction-related ophiolites include suprasubduction-zone and volcanic-arc types, the evolution of which is governed by slab dehydration and accompanying metasomatism of the mantle, melting of the subducting sediments, and repeated episodes of partial melting of metasomatized peridotites. Subduction-unrelated ophiolites include continental-margin, mid-ocean-ridge (plume-proximal, plume-distal, and trench-distal), and plume-type (plume-proximal ridge and oceanic plateau) ophiolites that generally have mid-ocean-ridge basalt (MORB) compositions. Subduction-related lithosphere and ophiolites develop during the closure of ocean basins, whereas subduction-unrelated types evolve during rift drift and seafloor spreading. The peak times of ophiolite genesis and emplacement in Earth history coincided with collisional events leading to the construction of supercontinents, continental breakup, and plume-related supermagmatic events. Geochemical and tectonic fingerprinting of Phanerozoic ophiolites within the framework of this new ophiolite classification is an effective tool for identification of the geodynamic settings of oceanic crust formation in Earth history, and it can be extended into Precambrian greenstone belts in order to investigate the ways in which oceanic crust formed in the Archean. © 2011 Geological Society of America.


Meng Z.,China University of Mining and Technology | Meng Z.,China Three Gorges University | Li G.,Hubei University
Engineering Geology | Year: 2013

In order to investigate the permeability behavior of high rank coal during early depletion of CBM and its influencing factors, we collected 14 coal samples from Ordos Basin in northwest China and determined their air permeability under a varying effective stress of 2.5-20. MPa in laboratory. We used effective confining pressure to simulate effective stress. It turns out that high rank coal permeability is susceptible to effective stress. Permeability of coal samples declines exponentially with the rise of effective stress on the whole. When effective confining pressure variation ranges from 2.5. MPa to 10. MPa, permeability varies dramatically; when effective confining pressure rises to above 10. MPa, the curve of permeability decline gets gentle and the stress sensitivity becomes relatively weak. Coal permeability is also affected by coal moisture, maceral, fracturing and metamorphism degree. Permeability rises with the increase of vitrinite content and fracturing degree and decreases with the increase of moisture content. Permeability of wet and fractured coal samples is more sensitive to effective stress than dry intact ones and the irreversible permeability loss rate of fractured coal cores is significant, over 80%. Comparison of tests results of medium and low rank coal samples and high rank ones shows that, the stress sensitivity coefficient decreases with the increase of the maximum reflectance of vitrinite; if experiencing the same load-relief process, the irreversible permeability loss rate of low rank coal is less than that of medium and high rank coals. © 2013 Elsevier B.V.


Yuan Q.,Hunan University | Yuan Q.,University of Florida | Yuan Q.,Hubei University | Zhang Y.,University of Florida | And 8 more authors.
ACS Nano | Year: 2012

Herein a photon-manipulated mesoporous release system was constructed based on azobenzene-modified nucleic acids. In this system, the azobenzene- incorporated DNA double strands were immobilized at the pore mouth of mesoporous silica nanoparticles. The photoisomerization of azobenzene induced dehybridization/hybridization switch of complementary DNA, causing uncapping/capping of pore gates of mesoporous silica. This nanoplatform permits holding of guest molecules within the nanopores under visible light but releases them when light wavelength turns to the UV range. These DNA/mesoporous silica hybrid nanostructures were exploited as carriers for the cancer cell chemotherapy drug doxorubicin (DOX) due to its stimuli-responsive property as well as good biocompatibility via MTT assay. It is found that the drug release behavior is light-wavelength-sensitive. Switching of the light from visible to the UV range uncapped the pores, causing the release of DOX from the mesoporous silica nanospheres and an obvious cytotoxic effect on cancer cells. We envision that this photocontrolled drug release system could find potential applications in cancer therapy. © 2012 American Chemical Society.


Solidago canadensis, a clonal herb originally from North America (common name: Canada goldenrod), is an invasive species in many countries. We developed microsatellite primers for this species. Eleven polymorphic loci were generated and primers were designed. Polymorphism of these 11 loci was assessed in 35 plants from two populations (Wuhan and Shanghai) in China. The number of alleles per locus ranged from 3 to 14. The observed and expected heterozygosities varied from 0.0732 to 0.7391 and from 0.1177 to 0.8687, respectively. These microsatellite markers will be useful tools for studies of population genetics in the native and invasive range of this species.


Meng Z.,China University of Mining and Technology | Meng Z.,China Three Gorges University | Li G.,Hubei University | Xie X.,China University of Mining and Technology
Engineering Geology | Year: 2012

The risk assessment of floor water inrush is essential to assure the safe production in a coal pit. Floor aquifuge is the key factor controlling water inrush. Both the impermeability and the resistance to water pressure of an aquifuge vary with its lithology and structure features. With the increase of mudstone content, the permeability and resistance to water pressure of the floor drops. The dense tectonic fissures in floor will transform intact, blocky structure into very blocky or blocky/disturbed structure, lower the resistance to water pressure, increase the permeability of floor aquifuge, and thereby will raise the risk of water inrush. Considering the lithology and structure features, and based on a conventional water inrush coefficient, a coal floor water inrush risk assessment method is put forward. With Fangezhuang coal mine of China as a case study, the implementation of this method is elaborated. © 2012 Elsevier B.V.


Liu M.,Central China Normal University | Nie Y.,Central China Normal University | Yu J.,Hubei University
Shengtai Xuebao/ Acta Ecologica Sinica | Year: 2012

Soil infiltration is the basic hydrological process for water penetrating into the soil, and the amount of water infiltrating the soil surface directly affects the quantity of surface runoff and soil erosion, even the recharge of both soil and underground water. The initial soil water content is an important factor to soil infiltration, and its role in runoff controlling and soil erosion prevention has been taken into account by many researches. In this study, the double-ring infiltration method was used to quantitatively measure the infiltrability of surface soil (0-5 cm depth) covered with forestland and grassland, which were under two antecedent soil water contents of 12% and 40%, respectively. In addition, the changes of soil infiltration process over time were estimated with different infiltration models. The results indicated that the initial soil infiltration rate of forestland and grassland tended to decrease with increasing initial soil water content. And an increase in initial soil water content results in an increase in steady infiltration rate and cumulative infiltration rate. Whether forestland or grassland, soil infiltration process with higher initial soil water content reaches the steady infiltration stage earlier than that with lower initial soil water content. For forestland with initial soil gravimetric water content rate of 12%, the initial soil infiltration rate was 8.95 mm/min, which was four times to the initial infiltration rate for forestland soil with gravimetric water content rate of 40%. However, its steady infiltration rate 0.24 mm/min was only one eighth of the forestland with initial soil gravimetric water content rate of 40%, and the cumulative infiltration in an hour was only two thirds of that. This phenomena may attribute to the faster wetting rate of drier soil in infiltration process, which cause stronger slaking forces of the soil and severe aggregates breakdown, enhance surface sealing or promote the destruction of soil structure, and then significantly decrease the soil infiltrability. For grassland surface soil with ample organic matter, soil infiltrability and infiltration process suggested lower sensitivity to initial soil water content. Initial infiltration rate, steady infiltration rate, and one hour cumulative infiltration of grassland with 12% soil water content were 2.21 mm/ min, 0.62 mm/min, 59.16 mm, respectively. And these parameters of grassland with 41% soil water content were 2.07 mm/min, 1.7 mm/min, 110.27 mm, which suggested less significant difference than that of forestland. Whether covered with forestland or grassland, soil instant infiltration rate decreased rapidly at the beginning of the infiltration process, and then decreased approximately linearly with time until approached to constant, especially under the condition of the initial soil water content to be 12%. The least square method was used to simulate the infiltration rate changes with time, and the results indicated that soil infiltration process of forestland and grassland were all fitted better by Horton and Kostiakov infiltration models than by Philip infiltration model. Besides, Horton infiltration model was the best model to describe soil infiltration process, which made it suitable to describe the soil infiltration process of forestland and grassland in the Three Gorges Reservoir area.


Meng L.,Nagoya University | Meng L.,Hubei University | Kamada Y.,Nagoya University | Muto K.,Nagoya University | And 2 more authors.
Angewandte Chemie - International Edition | Year: 2013

Rather u(Ni)que: Two new C-H alkenylation reactions, that is C-H/CO alkenylation and decarbonylative C-H alkenylation, of azoles are uniquely catalyzed by Ni/dcype. These azole alkenylation reactions are successfully applied to the convergent formal synthesis of siphonazoleB. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Cheng H.,Hubei University
Proceedings - 3rd International Conference on Information Management, Innovation Management and Industrial Engineering, ICIII 2010 | Year: 2010

Personal Space of Information (PSI) is the whole information collection about or of the person which can be the important resource to mine personal competence, personal task and corresponding required knowledge which can be converted to the evidence of individual competence and update the competence model. This paper analysises the character of PSI and introduces the method of competence modeling automaticlly based on PSI. The method includes four main steps which are: set up the description frame of competence model or competence ontology, decide the system architecture of personal competence modeling, extract expertise information from PSI for buliding competence model, aggregate the personal competence and assess competence weight. Finally, the advantages and limitations are analyzed. © 2010 IEEE.


Aschauer U.,Princeton University | He Y.,Tulane University | He Y.,Hubei University | Cheng H.,Princeton University | And 3 more authors.
Journal of Physical Chemistry C | Year: 2010

The adsorption of water on a reduced TiO2 anatase (101) surface is investigated with scanning tunneling microscopy and density functional theory calculations. The presence of subsurface defects, which are prevalent on reduced anatase (101), leads to a higher desorption temperature of adsorbed water, indicating an enhanced binding due to the defects. Theoretical calculations of water adsorption on anatase (101) surfaces containing subsurface oxygen vacancies or titanium interstitials show a strong selectivity for water binding to sites in the vicinity of the subsurface defects. Moreover, the water adsorption energy at these sites is considerably higher than that on the stoichiometric surface, thus giving an explanation for the experimental observations. The calculations also predict facile water dissociation at these sites, confirming the important role of defects in the surface chemistry of TiO2. © 2010 American Chemical Society.


Liu H.,Hubei University
Information Technology and Computer Application Engineering - Proceedings of the 2013 International Conference on Information Technology and Computer Application Engineering, ITCAE 2013 | Year: 2014

The concept of cloud computing trends will certainly become a part of the triple play, cloud computing and media content resources management and use of the future, can be calculated by the cloud of the contents of the resource management system transformation, building regional video content resources that cloud video which to build a cloud digital video communications platform. © 2014 Taylor & Francis Group, London.


Objective: To develop a real-time fluorescent quantitative PCR (FQ-PCR) combined with Sanger sequencing method for determination of epidermal growth factor receptor (EGFR), KRAS. and BRAF gene mutations in colorectal cancer. Methods: Primers and TaqMan probes were designed based on common mutations of EGFR, KRAS and BRAF gene in colorectal cancer for FQ-PCR amplification using the tumor tissue DNAs of 86 patients with colorectal cancer as templates. The PCR products were digested with SAP and EXO I and purified by ethanol/sodium acetate method, then sequenced. The sequencing result was analyzed by Bioedit software. The mutations of EGFR, KRAS and BRAF genes were tested, and the results were compared with that of test for KRAS12/13 codon mutation by FQ-PCR. Results: A method for determination of EGFR, KRAS and BRAF gene mutations in colorectal cancer by FQ-PCR combined with Sanger sequencing was successfully developed. The PCR amplification curves of various genes were in standard "S" shape, and the sequencing peaks were clear and stable. The probability of EGFR gene mutation in 86 colorectal cancer specimens was 2.3% (2/86), both of which were found in exon 21, and expressed as L858R and L861Q respectively. However, the probability of KRAS gene mutation was 33.7% (29/86), of which 79.3% (23/29) in codon 12 (G12D and G12V), 10.3% (3/29) in codon 13 (G13D), and 3.4% in both codons 12 and 13. No mutations in codon 61 were observed, while those in codon 146 were observed in 2 of 29 specimens (6.9%), both of which were expressed as A146V. No mutations of BRAF gene were found. The probability of KRAS12/13 mutation determined by FQ-PCR was insignificantly higher than that by FQ-PCR combined with Sanger sequencing (P > 0.05), with a total coincidence rate of 97.7% (84/86). Conclusion: Real-time FQ-PCR combined with Sanger sequencing may be used for rapid determination of ECFR, KRAS and BRAF gene mutations in colorectal cancer, which was stable and reliable.


Mao Z.,Hubei University of Medicine | Hu L.,Huazhong University of Science and Technology | Dong X.,Xian Modern Chemistry Research Institute | Zhong C.,Hubei University | And 2 more authors.
Analytical Chemistry | Year: 2014

Zn2+ plays vital roles in regulating physiological and pathological processes. A number of diseases are associated with the disruption of intracellular free Zn2+ homeostasis, and the relationship is still uncovered. Thus, it is important to monitor intracellular free Zn2+ ions in real time, which is still challenging due to the low content of intracellular free Zn2+. In this work, we report on the design and synthesis of a new two-photon (2P) fluorescent probe, QZn, based on quinoline derivative for intracellular free Zn2+. Theoretical calculations were carried out to rationalize the design. The probe displayed a moderate 2P action cross section value of 51 GM at 820 nm and up to 10-fold fluorescence enhancement upon Zn2+ binding. The detection limit of Zn2+ was 15.1 pM, which presented a pronounced sensitivity toward Zn2+ and indicated that QZn would be competent for detecting the low-content intracellular Zn2+. By using two-photon microscopy, QZn was capable of monitoring the fluctuation of intracellular free zinc ions in real time. © 2014 American Chemical Society.


Tang D.,Hubei University
Advance Journal of Food Science and Technology | Year: 2015

The study is explaining briefly about the supplement for the physical fatigue during the process of the movement, putting forward the effective recovery means for the fatigue caused by physical fitness through the principle of physical fitness, so that the exercise fatigue can be quickly recovered and people can have scientific physical exercise and fitness. Table tennis game is a non-cyclical sports item, with the characteristics of high intensity motion, high density, long time, fierce confrontation, etc. Generally speaking, Modern Ping-pang games ask players to have higher overall quality with the special speed, overall strength, stamina, bounce force, etc. © Maxwell Scientific Organization, 2015.


Ai F.,Hubei University
Proceedings of 4th International Workshop on Advanced Computational Intelligence, IWACI 2011 | Year: 2011

The number of neurons in hidden layers of Feedforward Neural Networks is very relative to their learning ability and generalization ability. The Iterative Pruning(IP) algorithm spends much time computing adjusting factors of the remaining weights. So the Improved Iterative Pruning(IIP) algorithm is put forward, which adopts dividing blocks strategy and uses the Generalized Inverse Matrix(GIM) algorithm to replace the Conjugate Gradient Precondition Normal Equation(CGPCNE) algorithm for updating the remaining weights. The IIP algorithm is applied in the hidden layers of Feedforward Neural Networks to simplify their structures in a great extent and preserve a good level of accuracy and generalization ability without retraining after pruning. The simulation results demonstrate the effectiveness and the feasibility of the algorithm. © 2011 IEEE.


Jiang L.,Hubei University
Pattern Recognition Letters | Year: 2011

Many approaches attempt to improve naive Bayes and have been broadly divided into five main categories: (1) structure extension; (2) attribute weighting; (3) attribute selection; (4) instance weighting; (5) instance selection, also called local learning. In this paper, we work on the approach of structure extension and single out a random Bayes model by augmenting the structure of naive Bayes. We called it random one-dependence estimators, simply RODE. In RODE, each attribute has at most one parent from other attributes and this parent is randomly selected from log2m (where m is the number of attributes) attributes with the maximal conditional mutual information. Our work conducts the randomness into Bayesian network classifiers. The experimental results on a large number of UCI data sets validate its effectiveness in terms of classification, class probability estimation, and ranking. © 2010 Elsevier B.V. All rights reserved.


Ding Q.,CAS Institut Pasteur of Shanghai | Cao X.,CAS Institut Pasteur of Shanghai | Lu J.,CAS Institut Pasteur of Shanghai | Huang B.,CAS Institut Pasteur of Shanghai | And 5 more authors.
Journal of Hepatology | Year: 2013

Background & Aims Hepatitis C virus (HCV) is a major human viral pathogen that causes chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. In most cases, acute HCV infection becomes persistent, at least in part due to viral evasion of host innate immune response. Although HCV genomic RNA contains pathogen-associated molecular pattern (PAMP) that is able to induce host interferon responses, HCV can shut down the responses by using the viral NS3/4A protease to cleave MAVS/VISA and TRIF, two key adaptor molecules essential for the interferon signaling activation. The aim of this study was to explore a novel NS3/4A-independent mechanism HCV utilizes to evade host innate immune responses. Methods We used the interferon promoter-reporter system to screen HCV encoded proteins for their activities to suppress the interferon signaling and to determine the molecular targets of viral proteins. Co-immunoprecipitation, confocal microscopy, and siRNA-based gene silencing were used to investigate the molecular mechanism. Results We found that, in addition to NS3/4A, NS4B can suppress double-stranded RNA or RNA virus induced interferon activation. NS4B interacts with STING/MITA, an important molecule that mediates the HCV PAMP induced interferon signaling. Mechanistic studies indicated that NS4B disrupts the interactions between STING/MITA and TBK1. Conclusions In conclusion, we reported an additional mechanism for HCV evasion of host interferon responses in which viral NS4B protein targets STING/MITA to suppress the interferon signaling. Our results present important evidence for the control of interferon response by HCV, and shed more light on the molecular mechanisms underlying the persistence of HCV infection. © 2013 European Association for the Study of the Liver. Published.


Cao P.,Hubei University
Industrial, Mechanical and Manufacturing Science - Proceedings of the 2014 International Conference on Industrial, Mechanical and Manufacturing Science, ICIMMS 2014 | Year: 2015

This work advanced thinking on improving Physical Education and Training methods of China’s universities in the new period. On the basis of problem analysis, it put forward thinking on Physical Education and Training methods in the new era, especially for problems in reality. Then some thinking and suggestions on its development were made on this basis. Physical Education and Training methods in the new era should pay attention to absorbing theoretical knowledge of various related disciplines without losing their own characteristics. The innovation in this work used Subject Penetration Theory to analyze and clarify Physical Education and Training methods in the new era. © 2015 Taylor & Francis Group, London.


Ding Y.,Michigan State University | Zhang W.,Hubei University | Gu C.,Michigan State University | Xagoraraki I.,Michigan State University | Li H.,Michigan State University
Journal of Chromatography A | Year: 2011

An analytical method was developed to quantitatively determine pharmaceuticals in biosolid (treated sewage sludge) from wastewater treatment plants (WWTPs). The collected biosolid samples were initially freeze dried, and grounded to obtain relatively homogenized powders. Pharmaceuticals were extracted using accelerated solvent extraction (ASE) under the optimized conditions. The optimal operation parameters, including extraction solvent, temperature, pressure, extraction time and cycles, were identified to be acetonitrile/water mixture (v/v 7:3) as extraction solvent with 3 extraction cycles (15. min for each cycle) at 100 °C and 100. bars. The extracts were cleaned up using solid-phase extraction followed by determination by liquid chromatography coupled with tandem mass spectrometry. For the 15 target pharmaceuticals commonly found in the environment, the overall method recoveries ranged from 49% to 68% for tetracyclines, 64% to 95% for sulfonamides, and 77% to 88% for other pharmaceuticals (i.e. acetaminophen, caffeine, carbamazepine, erythromycin, lincomycin and tylosin). The developed method was successfully validated and applied to the biosolid samples collected from WWTPs located in six cities in Michigan. Among the 15 target pharmaceuticals, 14 pharmaceuticals were detected in the collected biosolid samples. The average concentrations ranged from 2.6 μg/kg for lincomycin to 743.6 μg/kg for oxytetracycline. These results indicated that pharmaceuticals could survive wastewater treatment processes, and accumulate in sewage sludge and biosolids. Subsequent land application of the contaminated biosolids could lead to the dissemination of pharmaceuticals in soil and water environment, which poses potential threats to at-risk populations in the receiving ecosystems. © 2010 Elsevier B.V.


Lili L.,Central China Normal University | Xu H.,Central China Normal University | Song D.,Central China Normal University | Cui Y.,Central China Normal University | And 2 more authors.
Journal of Chromatography A | Year: 2010

A new dispersive liquid-liquid microextraction based on solidification of floating organic droplet method (DLLME-SFO) was developed for the determination of volatile aldehyde biomarkers (hexanal and heptanal) in human blood samples. In the derivatization and extraction procedure, 2,4-dinitrophenylhydrazine (DNPH) as derivatization reagent and formic acid as catalyzer were injected into the sample solution for derivatization with aldehydes, then the formed hydrazones was rapidly extracted by dispersive liquid-liquid microextraction with 1-dodecanol as extraction solvent. After centrifugation, the floated droplet was solidified in an ice bath and was easily removed for analysis. The effects of various experimental parameters on derivatization and extraction conditions were studied, such as the kind and volume of extraction solvent and dispersive solvent, the amount of derivatization reagent, derivatization temperature and time, extraction time and salt effect. The limit of detections (LODs) for hexanal and heptanal were 7.90 and 2.34nmolL-1, respectively. Good reproducibility and recovery of the method were also obtained. The proposed method is an alternative approach to the quantification of volatile aldehyde biomarkers in complex biological samples, being more rapid and simpler and providing higher sensitivity compared with the traditional dispersive liquid-liquid microextraction (DLLME) methods. © 2010 Elsevier B.V.


Zhou B.,Hubei University
International Journal of Modern Physics B | Year: 2011

In this paper, we investigate the role of DzyaloshinskiMoriya (DM) interaction in the pairwise entanglement in the three- and four-qubit XX models with magnetic field. In the four-qubit model, the pairwise entanglements of two nearest-neighbor qubits and two next-neighbor qubits are investigated, respectively. The dependences of the critical temperature at which the pairwise thermal entanglement disappears on DM interaction and magnetic fields are studied in details. At zero temperature, the entanglement can undergo sudden changes with adjustment of the parameters, and the general results of the concurrence are obtained in all cases. © 2011 World Scientific Publishing Company.


Ma Z.J.,Hubei University
Applied Mechanics and Materials | Year: 2014

CorelDraw software is the contemporary design of the main software industry. Tthe paper studies how to use CorelDraw software in the production of electronic plans to open up new areas of CorelDraw software, and train plan designers to draw electronic tracing the ability of sperm. As a result of advertising design and layout software, CorelDraw applied to the design of e-plan that has very little development. In this case,the article respectively analysis on diagrams, maps, architectural plans of the system and research CorelDraw software process in the electronic plan in the application. © (2014) Trans Tech Publications, Switzerland.


Eaton D.A.R.,University of Chicago | Fenster C.B.,University of Maryland University College | Hereford J.,University of Maryland University College | Huang S.-Q.,Hubei University | Ree R.H.,Field Museum of Natural History
Ecology | Year: 2012

A pervasive hypothesis at the interface of ecology and evolution is that biotic interactions contribute to regional biodiversity by accelerating adaptation and speciation. We investigated this question in the context of closely related, bumble bee-pollinated plants (Pedicularis spp.) in the Hengduan Mountains of south-central China, where they exhibit spectacular levels of richness, endemism, and floral diversity. Because these species co-occur frequently, flower synchronously, and share pollinators during the brief reproductive season, we predict that pollinator-mediated interactions may influence their community assembly and evolutionary diversification. If disparity in floral traits reduces competitive interactions between species, as would happen if floral isolation mitigates reproductive interference caused by heterospecific pollen flow, then species with dissimilar flowers should co-occur more often, yielding greater floral diversity at local scales than expected by chance. Moreover, if such interactions have repeatedly driven character displacement, then floral traits should exhibit homoplasy, the phylogenetic signature of labile evolution. We present evidence supporting these predictions, and find that local species richness is best explained by a model including both floral diversity and phylogenetic distance. Our results suggest that a dynamic mosaic of pollinator-mediated interactions among Pedicularis in the Hengduan region promotes ecological sorting through recurrent selection against reproductive interference, causing rapid species turnover at local scales, and accelerating the rate of floral divergence among species. Together these processes may have contributed to the remarkable accumulation of florally diverse species of Pedicularis endemic to the Hengduan Mountains biodiversity hotspot. © 2012 by the Ecological Society of America.


Hu G.,Wenzhou University | Hu G.,University of Northern British Columbia | Li J.,Wenzhou University | Li J.,University of Northern British Columbia | Hou H.,Hubei University
Journal of Hazardous Materials | Year: 2015

A combination of solvent extraction and freeze thaw was examined for recovering oil from the high-moisture petroleum refinery wastewater treatment pond sludge. Five solvents including cyclohexane (CHX), dichloromethane (DCM), methyl ethyl ketone (MEK), ethyl acetate (EA), and 2-propanol (2-Pro) were examined. It was found that these solvents except 2-Pro showed a promising oil recovery rate of about 40%, but the recycling of DCM solvent after oil extraction was quite low. Three solvents (CHX, MEK and EA) were then selected for examining the effect of freeze/thaw treatment on improving the quality of recovered oil. This treatment increased the total petroleum hydrocarbon (TPH) content in recovered oil from about 40% to 60% for both MEK and EA extractions, but little effect was observed for CHX extraction. Although the solid residue after oil recovery had a significantly decreased TPH content, a high concentration of heavy metals was observed, indicating that this residue may require proper management. In general, the combination of solvent extraction with freeze/thaw is effective for high-moisture oily hazardous waste treatment. © 2014 Elsevier B.V.


Xiong M.,Hubei University
Wei sheng wu xue bao = Acta microbiologica Sinica | Year: 2011

Prokaryotes synthesize phosphotidylcholine by using phospholipid N-methylation or phosphatidylcholine synthase pathway or both. To confirm which pathway the soil bacterium Pseudomonas sp. 593 utilizes, we tested its phosphotidylcholine synthesis, cloned the pcs gene encoding phosphatidylcholine synthase, examined Pcs activity, and constructed a pcs mutant. To clone the pcs gene from Pseudomonas sp. 593 genomic DNA, we firstly aligned amino acid sequences of phosphatidylcholine synthases in different pseudomonas strains reported in databases. Then we designed degenerate primers based on two amino acid segments conserved in sequences of phosphatidylcholine synthases. A partial fragment of the pcs gene was finally amplified from Pseudomonas sp. 593 genomic DNA. The amplified partial fragment was labeled with digoxigenin-dUTP (DIG) as a probe, sub-cloning library of Pseudomonas sp. 593 genomic DNA was prepared and then screened using DIG-labelled probe via in situ colony hybridization. DNA homologous recombination in vivo was preformed to delete pcs gene of Pseudomonas sp. 593. Thin-layer chromatography (TLC) assay was used to analyze total phospholipids, detect phosphotidylcholine content and determine pcs gene activity. TLC analysis revealed that Pseudomonas sp. 593 growing in the M9 or LB medium with choline was able to synthesize phosphotidylcholine, but wasn't without addition of choline. A 894 bp DNA fragment coded a protein with phosphatidylcholine synthase activity was cloned from Pseudomonas sp. 593. The pcs mutant obtained from in vivo mutagenesis was unable to form phosphotidylcholine, no matter choline was presented in the medium or not. Phosphatidylcholine synthase pathway is a sole way for phosphotidylcholine synthesis in soil bacterium Pseudomonas sp. 593 or other Pseudomonas strains.


Yang B.,Wuhan General Hospital of Guangzhou Command PLA | Gao J.,Wuhan General Hospital of Guangzhou Command PLA | Rao Z.,Wuhan General Hospital of Guangzhou Command PLA | Shen Q.,Hubei University
Scandinavian Journal of Clinical and Laboratory Investigation | Year: 2012

The purpose of this study was to evaluate the association of matrix metalloproteinase-13 (MMP-13) expression with clinicopathological features and prognosis in colorectal cancer (CRC) patients. CRC tissues and distal normal mucosa tissues of 158 CRC patients were detected by immunohistochemistry. The correlations between MMP-13 expression, the patients' clinicopathological features, and overall survival rate were analyzed. It was found that positive expression rate of MMP-13 in distal normal mucosa tissues was significantly lower than that in CRC tissues (36.7% vs 60.8%, p < 0.001). Poor histological differentiation, advanced clinical stage and lymph node metastasis were significantly correlated with the MMP-13 expression in CRC. The overall survival rate of the MMP-13-negative group was significantly higher than the positive group (Log-rank test12.452, p <0.001). Collectively, we found that MMP-13 was correlated with progression and metastasis of CRC and could be used as a prognostic marker in CRC. © 2012 Informa Healthcare.


Wu H.,Hubei University | Wexler D.,University of Wollongong | Liu H.,University of Wollongong
Materials Chemistry and Physics | Year: 2012

20 wt.% PtNi/C catalysts were prepared using a chemical reduction method, with Vulcan XC-72 conducting furnace black and graphene as the carbon support, respectively, and compared to commercial BASF 20 wt.% Pt/C (using Vulcan XC-72 carbon as support). The materials were characterized by X-ray diffraction, and transmission electron microscopy (TEM). The electrochemical performance of the PtNi/C catalysts was evaluated by cyclic voltammetry, and by steady-state measurements. Electrochemical measurements indicate that the PtNi nanocatalysts exhibited improved activity in the oxygen reduction reaction (ORR) on graphene compared with those on Vulcan XC-72 carbon, and graphene could potentially provide much higher durability than XC-72. This suggests that graphene is a more effective catalyst support than Vulcan XC-72 carbon. © 2012 Elsevier B.V. All rights reserved.


Huang R.,Wuhan University | Shen Y.,Wuhan University | Zhao L.,Hubei University | Yan M.,Wuhan University
Advanced Powder Technology | Year: 2012

Tungsten trioxide (WO 3) powders were prepared via a simple hydrothermal method. The morphology, structure and photochromic activity of the synthesized WO 3 powders were studied by X-ray diffraction, scanning electron microscopy and UV-vis spectrophotometer combined with color difference meter. The results showed the synthesized WO 3 powders with hexagonal phase got much better photochromic properties than the WO 3 powders with cubic phase, the ones not appear until about 160°C. Besides, the WO 3 powder synthesized at 120°C exhibited the best photochromic properties of the samples prepared below 160°C, the particles of which formed a shape of clusters of cactus with uniform size and good dispersion. © 2011 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.


Wan X.,Hubei University
Proceedings of 2011 IEEE CIE International Conference on Radar, RADAR 2011 | Year: 2011

Digital Radio Mondiale (DRM)-based HF passive bistatic radar has massive potential for surveillance purposes. Progress about DRM based passive bistatic radar is described. Several key problems need to be overcome for the base-band signal processing, including the vice-peaks suppression of DRM signal ambiguity function, the rejection of direct-path and multipath clutter in the surveillance channel and the extraction of the reference signal in the reference channel. Relative solutions of these problems will be presented. In addition, some results based on simulation data are shown in this paper. © 2011 IEEE.


Jin L.,Wuhan University of Technology | Wu Y.,Hubei University
Journal of Molecular Recognition | Year: 2011

δ-Dendrotoxin, isolated from mamba snake venom, has 57 residues cross-linked by three disulfide bridges. The protein shares a pharmacological activity with other animal toxins, the potent blockade of potassium channels, but is structurally unrelated to toxins of different species. We employed alanine-scanning mutagenesis to explore the molecular mechanism of δ-dendrotoxin binding to potassium channels, using protein-protein docking and molecular dynamic simulations. In our reasonable model of the δ-dendrotoxin-ShaKv1.1 complex, δ-dendrotoxin interacted mainly with the N-terminal region and the turn of two antiparallel β-sheets of the channel. This binding mode could well explain the functional roles of critical residues in δ-dendrotoxin and the ShaKv1.1 channel. Structural analysis indicated that the critical Lys6 residue of δ-dendrotoxin plugged its side chain into a channel selectivity filter. Another two critical δ-dendrotoxin residues, Lys3 and Arg10, were found to contact channel residues through strong polar and nonpolar interactions, especially salt-bridge interactions. As for the ShaKv1.1 channel, the channel turrets were found in the "half-open state," and two of four Glu423 in the turrets of the channel B and D chains could interact, respectively, with Lys3 and Lys26 of δ-dendrotoxin through electrostatic interactions. The essential Asp431 channel residue was found to associate electrostatically with Arg10 of δ-dendrotoxin, and a critical Tyr449 channel residue was just under the channel-interacting surface of δ-dendrotoxin. Together, these novel data may accelerate the structure-function research of toxins in the dendrotoxin family and be of significant value in revealing the diverse interactions between animal toxins and potassium channels. Copyright © 2010 John Wiley & Sons, Ltd.


Jihong Z.,Hubei University
Proceedings - 7th International Conference on Intelligent Computation Technology and Automation, ICICTA 2014 | Year: 2015

In the Internet era, online media and ordinary consumers can release a variety of information about food safety on the Internet. Therefore, it can effectively eliminate asymmetric information and reduce food safety risks to collect food safety information from the Internet for statistical analysis and management. On such basis, this paper has proposed a framework of food safety alert system and also put forward a new model for food safety management in China based on statistical analysis of food quality information on the Internet. © 2014 IEEE.


Wu D.,Sichuan University of Arts and Science | Huang X.,Sichuan University of Arts and Science | Deng X.,Sichuan University of Arts and Science | Wang K.,Sichuan University of Arts and Science | Liu Q.,Hubei University
Analytical Methods | Year: 2013

A friendly environmental and low-cost preparation of water-soluble photoluminescent carbon nanodots (C-Dots) utilizing the rhizome of the plant Giant Knotweed Rhizome, a traditional Chinese medicine, as a carbon source via hydrothermal method is developed for the first time. The as-prepared photoluminescent C-Dots show favorable blue color photoluminescence at the peak wavelength of 430 nm with a quantum yield of approximately 11.5%. It has been successfully applied as a novel probe for the detection of Hg2+. This novel probe exhibits excellent sensitivity and selectivity toward Hg 2+ in the broad linear range from 50 nM to 100.0 μM with a limit of detection as low as 8.2 nM. The practical use of this system was tested in river water by adding 10.0 μM and 50.0 μM Hg2+. The recoveries ranged from 101.0% to 104.0% and from 99.2% to 101.2%, respectively. These stable and economical photoluminescent C-Dots show promise as a powerful tool for environmental analysis. This journal is © The Royal Society of Chemistry.


Nowadays, data combination/fusion is a common practice to integrate multiple data sources into a spatially and/or temporally regular data set for facilitating analysis and interpretation. Given the advancement in active remote sensing for monitoring our changing environment (no matter ocean, land or ice), the data acquisition from various spaceborne platforms with different spatio-temporal resolutions is enormous; calling for a need of multisatellite data combination. Instead of equally or spatially weighted solution, this article illustrates a spatio-temporal combination approach that weights data both in space and in time simultaneously for ocean tide modelling using multisatellite altimetry data sets under different spatial and temporal resolutions. The tide models generated from this approach show substantial improvement near coastal regions when compared to other contemporary ocean tide models by using independent pelagic and coastal tide gauges serving as ground truth. The discrepancy of the best model is ~23%, three times larger than that of the deep ocean. Further improvement lies in more and better spatio-temporal observations in the near future. We anticipate this approach can be applied to other spatio-temporal data in a similar settings for spatio-temporal dependent unknown parameters, including geodetic, geophysical, oceanographic data and imagery under different spatial and temporal resolutions. © 2015 Taylor & Francis.


Bo Liao W.,China West Normal University | Bo Liao W.,Hubei University | Lu X.,China West Normal University
Zoologischer Anzeiger | Year: 2010

Age, body size, and growth patterns in the subtropical anuran Hyla annectans chuanxiensis from high (Dengchigou Protection Station) and low (Lingguan Town) elevations in Baoxing County of Sichuan province (China) were described using skeletochronology. Females were significantly older than males at the low-elevation site, but there was no significant difference between the sexes at the high-elevation site. Age at sexual maturity of both males and females was 2 years at the high-elevation site, whereas males matured at 1 year and females at 2 years at the low-elevation site. Males and females from the low-elevation population reached a maximum age of 3 and 4 years, respectively, whereas males and females from the high-elevation population reached a maximum age of 4 and 5 years, respectively. At both sites, females were significantly larger than males. Females and males from the high-elevation population were larger than individuals from the low-elevation population. When the effect of age was controlled, the differences in body size of the two populations were significant only for females. Von Bertalanffy growth curves indicated that the growth rates in males was greater than in females in both populations. They also showed that the growth of both sexes slowed at an earlier age in the low-elevation population than in the high-elevation population. The findings suggest that age is a major factor underlying body size patterns for both sexes, but that the elevation of the locality affects the body size of females. © 2009 Elsevier GmbH.


Yao A.,CAS Institute of Genetics and Developmental Biology | Jin S.,CAS Institute of Genetics and Developmental Biology | Jin S.,Hubei University | Li X.,CAS Institute of Genetics and Developmental Biology | And 4 more authors.
Human Molecular Genetics | Year: 2011

Fragile X syndrome, the most common form of inherited mental retardation, is caused by the absence of the fragile X mental retardation protein FMRP. The RNA-binding FMRP represses translation of the microtubule (MT)-associated protein 1B (MAP1B) during synaptogenesis in the brain of the neonatal mouse. However, the effect of FMRP on MTs remains unclear. Mounting evidence shows that the structure and the function of FMRP are well conserved across species from Drosophila to human. From a genetic screen, we identified spastin as a dominant suppressor of rough eye caused by dfmr1 over-expression. spastin encodes an MTsevering protein, and its mutations cause neurodegenerative hereditary spastic paraplegia. Epistatic and biochemical analyses revealed that dfmr1 acts upstream of or in parallel with spastin in multiple processes, including synapse development, locomotive behaviour and MT network formation. Immunostaining showed that both loss- and gain-of-function mutations of dfmr1 result in an apparently altered MT network. Western analysis revealed that the levels of a-tubulin and acetylated MTs remained normal in dfmr1 mutants, but increased significantly when dfmr1 was over-expressed. To examine the consequence of the aberrant MTs in dfmr1 mutants, we analysed the MT-dependent mitochondrial transport and found that the number of mitochondria and the flux of mitochondrial transport are negatively regulated by dfmr1. These results demonstrate that dFMRP plays a crucial role in controlling MT formation and mitochondrial transport. Thus, defective MTs and abnormal mitochondrial transport might account for, at least partially, the pathogenesis of fragile X mental retardation. © The Author 2010. Published by Oxford University Press. All rights reserved.


Chen Y.,Hubei University | Yang K.,Huazhong University of Science and Technology
Optik | Year: 2013

In order to enhance the visual quality of underwater images, applications such as enhancement and restoration can be applied, but the resolution is still limited. Super-resolution reconstruction is a widely used technique for improving resolution beyond the limit of imaging system. With knowledge of the point spread function and techniques of regularization, the performance of reconstruction can be further enhanced. The presented effort proposed a robust image super-resolution reconstruction method under maximum a posteriori framework with regularization by the point spread function for underwater imaging detection. Objective image quality metrics are used to quantify the effectiveness of the reconstruction. Experimental results showed that the proposed method can effectively improve the resolution and quality of underwater imaging detection. © 2013 Elsevier GmbH.


Zhang Z.-J.,Hubei University
Annals of Clinical Biochemistry | Year: 2013

Background: Oxidative stress may play an aetiological role in the development and progression of cardiovascular disease (CVD). However, evidence on its biochemical markers has been controversial. This article aimed to assess the role of F2-isoprostanes, a marker for measuring in vivo lipid oxidation, as a biomarker for CVD, including coronary artery disease, stroke and peripheral artery disease. Methods: A literature search was performed using PubMed and EMBASE (from 1966 to February 2012). Studies that investigated the association between F2-isoprostanes and CVD were eligible. Results: Of the 22 eligible studies retrieved, 20 studies showed a significant association between F2-isoprostanes and CVD. However, to date, there have been only four population-based studies, with one study reporting null association. Although data from prospective studies are ideal to examine a role of such biomarkers in predicting future CVD events, only two studies were prospective. In addition, differences in population characteristics, sample handling/storage and assays, coupled with a lack of confounding adjustment, may all contribute to the enormous variation in previous studies. Conclusions: High levels of F2-isoprostanes in urine or blood may be a non-specific indicator of CVD. However, further population-based studies are needed. In addition, multivariable analyses are required for future studies to control confounding and improve classification accuracy.


Tian N.,Texas State University | Gaines Wilson J.,University of Texas at Brownsville | Benjamin Zhan F.,Texas State University | Benjamin Zhan F.,Hubei University
Health and Place | Year: 2010

Although breast cancer is the second leading cause of cancer deaths among women in the Unites States, to date there have been no nationwide studies systematically analyzing geographic variation and clustering. An assessment of spatial-temporal clusters of cancer mortality by age and race at the county level in the lower 48 United States indicated a primary cluster in the Northeast US for both younger (RR=1.349; all RR are p≤0.001) and older (RR=1.283) women in the all-race category. Similar cluster patterns in the North were detected for younger (RR=1.390) and older (RR=1.292) white women. The cluster for both younger (RR=1.337) and older (RR=1.251) black women was found in the Midwest. The clusters for all other racial groups combined were in the West for both younger (RR=1.682) and older (RR=1.542) groups. Regression model results suggest that lower socioeconomic status (SES) was more protective than higher status at every quartile step (Medium-high SES, OR=0.374; Medium-low, OR=0.137; Low, OR=0.061). This study may provide insight to aid in identifying geographic areas and subpopulations at increased risk for breast cancer. © 2009 Elsevier Ltd. All rights reserved.


Cao Y.,Pacific Northwest National Laboratory | Cao Y.,Hubei University | Xiao L.,Pacific Northwest National Laboratory | Xiao L.,Central China Normal University | And 8 more authors.
Nano Letters | Year: 2012

Hollow carbon nanowires (HCNWs) were prepared through pyrolyzation of a hollow polyaniline nanowire precursor. The HCNWs used as anode material for Na-ion batteries deliver a high reversible capacity of 251 mAh g -1 and 82.2% capacity retention over 400 charge-discharge cycles between 1.2 and 0.01 V (vs Na +/Na) at a constant current of 50 mA g -1 (0.2 C). Excellent cycling stability is also observed at an even higher charge-discharge rate. A high reversible capacity of 149 mAh g -1 also can be obtained at a current rate of 500 mA g -1 (2C). The good Na-ion insertion property is attributed to the short diffusion distance in the HCNWs and the large interlayer distance (0.37 nm) between the graphitic sheets, which agrees with the interlayered distance predicted by theoretical calculations to enable Na-ion insertion in carbon materials. © 2012 American Chemical Society.


Xu J.,CAS Institute of Genetics and Developmental Biology | Wang W.,Qinghai Normal University | Yin H.,Qinghai Normal University | Liu X.,CAS Institute of Genetics and Developmental Biology | And 2 more authors.
Plant and Soil | Year: 2010

The effects of nitric oxide (NO) on cadmium toxicity in Medicago truncatula seedlings were studied by investigating root growth and uptake of antioxidants, IAA and ions. Exposure to cadmium reduced root growth and NO accumulation, and increased the production of reactive oxygen species (ROS) in roots. Supplementation with NO improved root growth and reduced ROS accumulation in roots. The NO-scavenger cPTIO, the nitrate reductase (NR) inhibitor tungstate, and the NO synthase (NOS) inhibitor L-NAME all inhibited the accumulation of NO in roots and reversed the effects of NO in promoting the root growth and accumulation of proline and glutathione. Application of NO reduced auxin degradation by inhibiting the activity of IAA oxidase. Exogenous NO also enhanced the uptake of K + and Ca 2+. These results suggest that NO improves cadmium tolerance in plants by reducing oxidative damage, maintaining the auxin equilibrium and enhancing ion absorption. © Springer Science + Business Media B.V. 2009.


Yu H.-L.,Hubei University of Medicine | Zhao Z.-K.,Hubei University | Zhu F.,Hubei University of Medicine
International Journal of Molecular Medicine | Year: 2013

Human endogenous retrovirus (HERV) and solitary long terminal repeats (LTRs) constitute 8% of the human genome. Although most HERV genes are partially deleted and not intact, HERV LTRs comprise features including promoters, enhancers, selective splicer sites and polyadenylation sites in order to regulate the expression of neighboring genes. Owing to the genetic instability of LTRs, their wide distributions along human chromosomes are not only non-random, but are also correlated with gene density. Considerable evidence indicates that HERV LTRs regulate the expression of their adjacent viral and cellular genes in placental development and tumorigenesis. However, the regulatory mechanism of HERV LTRs on the expression of its neighboring cancer-associated genes in human cancers remains to be elucidated. Insertional mutagenesis, recombination and polymorphism are three principal factors of LTR that contribute to its genetic instability. Moreover, genetic instability, hypomethylation, transactivation and the antisense transcript of LTRs enhance the activity of LTRs and regulate the expression of their adjacent genes in human cancers. Therefore, in the present review, we examined the mechanism of HERV LTRs in tumorigenesis in combination with the structure and function of LTRs.


Xu W.H.,Hubei University
Advanced Materials Research | Year: 2014

By the application of literature consultation methods, inductive and deductive methods and behavioral economics, this thesis concerns itself with the study of risk and risk transfer during major sports events, and the analysis of risk transfer regarding facility construction, logistics, tourism and so on. The purpose of this thesis is that the smooth process of major sports events should be guaranteed by effective management of sports events risks. Based on the analysis of internal and external causes of risks emerged in major sports events, this thesis puts forward a concrete solution to the risk transfer - sports commercial insurance, which enables sports event organizers to reduce risks based on the knowledge of the causes of them. © (2014) Trans Tech Publications, Switzerland.


Mo J.-Y.,Hubei University | Xu X.,CAS Institute of Vertebrate Paleontology and Paleoanthropology | Evans S.E.,University College London
Proceedings of the Royal Society B: Biological Sciences | Year: 2010

Until recently, it was considered axiomatic that the skull of lizards and snakes arose from that of a diapsid ancestor by loss of the lower temporal bar. The presence of the bar in the living New Zealand Tuatara, Sphenodon, was thus considered primitive, corroborating its status as a 'living fossil'. A combination of new fossils and rigorous phylogeny has demonstrated unequivocally that the absence of the bar is the primitive lepidosaurian condition, prompting questions as to its function. Here we describe new material of Tianyusaurus, a remarkable lizard from the Late Cretaceous of China that is paradoxical in having a complete lower temporal bar and a fixed quadrate. New material from Jiangxi Province is more complete and less distorted than the original holotype. Tianyusaurus is shown to be a member of the Boreoteiioidea, a successful clade of large herbivorous lizards that were dispersed through eastern Asia, Europe and North America in the Late Cretaceous, but disappeared in the end-Cretaceous extinction. A unique combination of characters suggests that Tianyusaurus took food items requiring a large gape. © 2009 The Royal Society.


Zhang J.,University of Wisconsin - Milwaukee | Zhao Y.,Hubei University
Information Processing and Management | Year: 2013

The authors of this paper investigate terms of consumers' diabetes based on a log from the Yahoo!Answers social question and answers (Q&A) forum, ascertain characteristics and relationships among terms related to diabetes from the consumers' perspective, and reveal users' diabetes information seeking patterns. In this study, the log analysis method, data coding method, and visualization multiple-dimensional scaling analysis method were used for analysis. The visual analyses were conducted at two levels: terms analysis within a category and category analysis among the categories in the schema. The findings show that the average number of words per question was 128.63, the average number of sentences per question was 8.23, the average number of words per response was 254.83, and the average number of sentences per response was 16.01. There were 12 categories (Cause & Pathophysiology, Sign & Symptom, Diagnosis & Test, Organ & Body Part, Complication & Related Disease, Medication, Treatment, Education & Info Resource, Affect, Social & Culture, Lifestyle, and Nutrient) in the diabetes related schema which emerged from the data coding analysis. The analyses at the two levels show that terms and categories were clustered and patterns were revealed. Future research directions are also included. © 2013 Elsevier Ltd. All rights reserved.


Ali J.R.,University of Hong Kong | Cheung H.M.C.,University of Hong Kong | Aitchison J.C.,University of Sydney | Sun Y.,Hubei University | Sun Y.,University of Leeds
Geophysical Journal International | Year: 2013

A palaeomagnetic investigation was carried out on a series of rift basalts (Woniusi Formation) that accumulated on the Baoshan block (SW China) in the Early Permian, the aim being to provide quantitative palaeogeographical information on the eastern Cimmerian terrane as it detached from eastern Gondwana. Reliable data were obtained from four locations/28 individual cooling units, and when combined with the findings of an earlier study (three locations/19 sites) indicate that breakup occurred at 41.9°S (with errors, 34.2-51.2°S). Using this information, we fit Baoshan against Gondwana within a narrow longitudinal belt close to where northeast Greater India and northwest Australia were once in close proximity. Furthermore, we suggest that Sibumasu (Simao-Burma-Malyasia-Sumatra; the largest of the eastern Cimmerian blocks) lay directly to the east, offshore of Australia; Qiangtang and Lhasa almost certainly sat to the west (off northern Greater India-SE Arabia), but we are uncertain as to their exact configuration. Our findings are compared with several rather different models that have been published in recent years. The new palaeomagnetic constraint highlights the flexibility authors currently have in reconstructing the region, principally because of the overall lack of similar high-quality data from the various blocks. We explain how new data could resolve these ambiguities, thereby offering more robust explanations for eastern Gondwana's late Palaeozoic development. © The Authors 2013. Published by Oxford University Press on behalf of The Royal Astronomical Society.


Hu S.,Hubei University | Wang L.,State University of New York at Buffalo
International Journal of Remote Sensing | Year: 2013

Urban land-use information plays a key role in a wide variety of planning and environmental management processes. The purpose of this study was to develop an automatic method for classifying detailed urban land-use classes with remote-sensing data. Seven land-use parcel attributes, derived from relevant remote-sensing data, were incorporated for classifying four land-use classes, namely office, industrial, civic, and transportation, which were reported as the most difficult ones to classify from previous studies. An experiment was carried out in a study site in Austin, Texas. An overall accuracy of 61.68% and a kappa coefficient of 0.54 were achieved with a decision tree method. Building area and building height turned out to be the most influential factors among all the adopted variables. In addition, the variable of floor area ratio played the second dominant role among the seven variables, demonstrating that synthesized horizontal and vertical properties of buildings and their relevant spatial characteristics are important in differentiating the four classes. © 2013 Copyright Taylor and Francis Group, LLC.


Cai H.B.,Hubei University
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society | Year: 2010

This study was performed to determine whether the incidence of cervical cancer in women aged 35 or younger has changed for the past 30 years and to examine the clinical characteristics of the cases. The clinical and pathological data of 6257 patients with cervical cancer treated between January 1975 and December 2009 were retrospectively analyzed. The prevalence of young (≤ 35 years old) patients steadily increased from 2.8% to 15.7% for the past 30 years. The ratio of adenocarcinoma also rose from 1975-1979 to 2005-2009. In an analysis by age group, in group A, adenocarcinoma was found in 17% (≤ 35 years old); in group B, 7.1% (> 35 years old) [χ2 = 78.92, P < 0.0001]. The clinical presentation presented showed that 36.4% of patients presented mainly postcoital bleeding in group A, whereas the symptom of irregular genital bleeding predominated in group B (P < 0.0001). The patients detected by routine cytological screening in group A (8.7%) were more than the patients in group B (3%). The prevalence of cervical cancer in young women has been increasing steadily in Hubei, China. It is necessary for all sexually active women and women aged 35 years or even younger to undergo cervical cancer screening.


Chen H.,Hubei University | Chen H.,Georgia Regents University | Wu X.,Hubei Maternity and Child Care Hospital | Pan Z.K.,University of Toledo | Huang S.,Georgia Regents University
Cancer Research | Year: 2010

Ovarian cancer is mainly confined in peritoneal cavity and its metastasis is often associated with the formation of malignant ascites. As lysophosphatidic acid (LPA) is present at high levels in ascites of ovarian cancer patients and potently stimulates cell migration, we reason that LPA-stimulated cell migration may play an important role in ovarian cancer metastasis. Here, we show that only ovarian cancer cell lines with LPA migratory response undergo peritoneal metastatic colonization. LPA-stimulated cell migration is required for metastatic colonization because knockdown of LPA receptor subtype 1 (LPAR1) abolishes this event. However, the difference in metastatic potentials is not caused by the absence of LPAR1 because both metastatic and nonmetastatic lines express similar levels of LPAR1. Instead, we find that LPA can activate Rac only in metastatic cells and that metastatic colonization of ovarian cancer cells necessitates Rac activity. These results thus suggest that LPA-induced Rac activation is a prerequisite for ovarian cancer metastasis. In metastatic cells, Rac activation is facilitated by SOS1/EPS8/ABI1 tri-complex and the integrity of this tri-complex is essential for LPAstimulated cell migration and metastatic colonization. We show that at least 1 member of SOS1/EPS8/ABI1 tricomplex is absent in nonmetastatic ovarian cancer cells and reexpressing the missing one conferred them with metastatic capability. Importantly, coexpression of SOS1, EPS8, and ABI1, but not of any individual member of SOS1/EPS8/ABI1 tri-complex, correlates with advanced stages and shorter survival of ovarian cancer patients. Our study implicates that the integrity of SOS1/EPS8/ABI1 tri-complex is a determinant of ovarian cancer metastasis. ©2010 AACR.


Wang X.,Hubei University
Jinshu Rechuli/Heat Treatment of Metals | Year: 2016

Isothermal compression tests were conducted under the temperature ranges of 850-1150℃ and the strain rates of 0.01-10 s-1 by Gleeble-3800 thermal simulated test machine. By the introduction of Zener-Hollomon parameter, the thermal plastic constitutive analysis of flow stress was carried out by using the hyperbolic sine function. The processing maps for the alloy under different strain were established based on the dynamic materials model. The results show that the flow instability for Ti-10V-2Fe-3Al alloy mainly occurs in the high strain rate, and the hot deformation areas of safety are located in the temperature range of 1100-1150℃ and the strain rates of 0.01-0.07 s-1. © 2016, Editorial Office of "Jinshu Rechuli". All right reserved.


Gu Y.,Wuhan University | Gu Y.,Hubei University | Zhao Z.,Chinese Academy of Sciences | Pearsall D.M.,University of Missouri
Quaternary International | Year: 2013

Systematical descriptions of phytoliths from rice species in East Asia are scarce. In order to investigate the relationship among diversity of phytolith morphology, taxonomy and genome, comparative research on phytolith morphology of the wild and domesticated rice species is first performed on the basis of statistics and cluster analysis. All morphological parameters were measured at 500× magnification using a Zeiss light microscope. 3-D plots and cluster analysis are performed by SPSS 10.0 software. The leaves and inflorescences of domesticated and wild rice contain a great diversity of phytolith types including long cells, short cells, bulliform cells, hair cells, irregular epidermal cells, mesophyll and vascular tissues. Comparative research on phytolith morphology demonstrates that most overlap occurs among long cells, short cells, bulliform cells, hair cells and vascular tissues at the species level. Rondels, crosses, long cells, hair cells, parallepipedal bulliform cells, tracheid and vascular tissue exhibit no taxonomical value. Complex saddles and irregular epidermal phytoliths might be diagnostic to the rice species that had not been described before. Further comparative research on the morphological features of three phytolith types from the wild and domesticated rice species has confirmed that double-peaked glume cells measurements can separate domesticated Oryza species from wild ones successfully. Hierarchical cluster analysis on all morphological parameters of bilobates, cuneiform bulliform cells and double-peaked glume cells strongly demonstrates that phytolith assemblage appears to be under genetic control and therefore reflect taxonomical significance. The results are significant for plant physiology, rice cultivation and environmental archaeology. © 2012 Elsevier Ltd and INQUA.


Wang Y.,Hubei University | Wang Y.,Emory University | Tandan S.,University of Texas Southwestern Medical Center | Hill J.A.,University of Texas Southwestern Medical Center
Trends in Cardiovascular Medicine | Year: 2014

Calcineurin, a serine-threonine-specific, Ca2+-calmodulin-activated protein phosphatase, conserved from yeast to humans, plays a key role in regulating cardiac development, hypertrophy, and pathological remodeling. Recent studies demonstrate that calcineurin regulates cardiomyocyte ion channels and receptors in a manner which often entails direct interaction with these target proteins. Here, we review the current state of knowledge of calcineurin-mediated regulation of ion channels in the myocardium with emphasis on the transient outward potassium current (Ito) and L-type calcium current (ICa,L). We go on to discuss unanswered questions that surround these observations and provide perspective on future directions in this exciting field. © 2013.


Ma D.-Z.,Hubei University | Wu J.-P.,Bohai University | Zhang J.,Bohai University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2014

By the Poincare sections, the dynamical behaviors of the ring string in the anti-de Sitter-Gauss-Bonnet black hole are studied. A threshold value of the Gauss-Bonnet parameter λ is found by the numerical method, below which the behavior of this dynamical system is nonchaotic and above which the behavior becomes gradually chaotic. The chaotic behavior becomes stronger with the increases of the Gauss-Bonnet parameter. It is different from the case in the anti-de Sitter-Schwarzschild black hole, which is weakly chaotic. Furthermore, we confirm our findings by the fast Lyapunov indicator. © 2014 American Physical Society.


Hagihara M.,Osaka University | He H.,Osaka University | He H.,Hubei University | Kimura M.,Osaka University | Nakatani K.,Osaka University
Bioorganic and Medicinal Chemistry Letters | Year: 2012

Unusual expansion of trinucleotide repeats has been identified as a common mechanism of hereditary neurodegenerative diseases. Although the actual mechanism of repeat expansion remains uncertain, trinucleotide repeat instability may be related to the increased stability of an alternative DNA hairpin structure formed in the repeat sequences. Here we report that a synthetic ligand naphthyridine carbamate dimer (NCD) selectively bound to and stabilized an intra-stranded hairpin structure in CGG repeat sequences. The NCD-CGG hairpin complex was a stable structure that efficiently interfered with DNA replication by Taq DNA polymerase. Considering the sequence preference of NCD, the use of NCD would be valuable to investigate the genetic instabilities of CGG/CCG repeat sequences in human genomes. © 2012 Elsevier Ltd. All rights reserved.


This study investigated the expression and biological role of TLR4 in human colon cancer cells' growth and survival, and its potential as a target for colon cancer therapy. Reverse transcription polymerase chain reaction (RT-PCR) and flow cytometry (FCM) were used to detect the expression level of TLR4. MTT analysis was performed to evaluate cell proliferation and enzyme-linked immunosorbent assay (ELISA) to test the production of IL-8, VEGF, and TGF-β. MAPKs and NF-κB were analyzed by Western blotting. Apoptosis was analyzed by flow cytometry with Annexin V and propidium iodide staining. The results showed that the human colon cancer cells HT-29, SW480, and Lovo all expressed TLR4 at both mRNA and protein levels, and TLR4 ligand LPS could not affect the expression of TLR4 and the proliferation of colon cancer cells. LPS increased phosphorylation of ERK1/2 and p38 and activated NF-κB. LPS promoted cytokine production, such as IL-8, VEGF, and TGF-β. In addition, LPS induced resistance of human colon cancer cells to TRAIL-induced apoptosis and NF-κB activation was necessary for apoptosis resistance. The study identified the expression level of TLR4 in human colon cancer cells and TLR4 was functionally active. TLR4 may play important roles in promoting immune escape of human colon cancer cells by inducing immunosuppressive factors and apoptosis resistance. Copyright © 2012 Cognizant Comm. Corp. All rights reserved.


Jianming L.,State Grid Corporation of China | Bingzhen Z.,Hubei University
CCIS2011 - Proceedings: 2011 IEEE International Conference on Cloud Computing and Intelligence Systems | Year: 2011

Energy and information are two important parts of utility services. Smart grid applies the information and communications technology in the energy industry which will bring new methods and techniques for the application of the renewable energy, smart home and other smart services. By using Optical Fiber Composite Low-voltage Cable (OPLC), Power Fiber to the Home (PFTTH) realizes the transmission of energy and information over the same cable which will bring about the multipurpose use of resources. Therefore, PFTTH is the top choice for constructing the smart grid utilization network integrating energy industry and information industry which will not only meet the requirements of electric power supply of smart grid, but also meet the diversity requirements of the users including service providers and residential customers, such as leasing the optical fiber resources to the telecom operator and serving the 'triple play' to the residential customers. The PFTTH constructs a multi-utility services platform and the scope of the smart power consumption will be extended that both energy and information services can be provided simultaneously based on this platform. This paper describes the PFTTH's key technologies and its applications in the construction of smart grid, and then introduces the capability and the application scenario of the constructed platform. Finally, further open issues of the future development of PFTTH and the constructed platform are presented. © 2011 IEEE.


Chen Y.,Zhejiang University | Wang Y.,Hubei University | Zhuang Y.,Zhejiang University | Zhou F.,Zhejiang University | Huang L.,Zhejiang University
PLoS ONE | Year: 2012

Background: Mifepristone (RU486), a potent antagonist of progesterone and glucocorticoids, is involved in immune regulation. Our previous studies demonstrated that mifepristone directly augments the cytotoxicity of human uterine natural killer (uNK) cells. However, the mechanism responsible for this increase in cytotoxicity is not known. Here, we explored whether the increased cytotoxicity in uNK cells produced by mifepristone is due to either anti-progesterone or anti-glucocorticoid activity, and also investigated relevant changes in the mitogen-activated protein kinase (MAPK) pathway. Methodology/Principal Findings: Uterine NK cells were isolated from decidual samples and incubated with different concentrations of progesterone, cortisol, or mifepristone. The cytotoxicity and perforin expression of uNK cells were detected by mitochondrial lactate dehydrogenase-based MTS staining and flow cytometry assays, respectively. Phosphorylation of components of the MAPK signaling pathway was detected by Western blot. Cortisol attenuated uNK cell-mediated cytotoxicity in a concentration-dependent manner whereas progesterone had no effect. Mifepristone alone increased the cytotoxicity and perforin expression of uNK cells; these effects were blocked by cortisol. Furthermore, mifepristone increased the phosphorylation of ERK1/2 in a cortisol-reversible manner. Specific ERK1/2 inhibitor PD98059 or U0126 blocked cortisol- and mifepristone-induced responses in uNK cells. Conclusions/Significance: These results suggest that mifepristone acts as a glucocorticoid antagonist to augment uNK cell-mediated cytotoxicity via ERK activation, which may be caused by increased perforin expression. These observations may reveal an important mechanism by which mifepristone upregulates the cytotoxicity of uNK cells. © 2012 Chen et al.


Hu D.H.,Hubei University
Advanced Materials Research | Year: 2011

Two-thirds of fuel consumption is from coal, coal mine safety accident causes huge loss of property and threatens the life safety of workers. However, 80% of the accidents are caused by poor management. It is greatly necessary to study coal mine safety management control. The construction of forewarning management control system has great benefits on reducing accident. As it transforms the management model of the coal mine from afterwards controls to beforehand control. Forewarning management control system that composed by subsystem, data storage layer and show layer have the functions of. This paper will focus on management control with building forewarning management control system identifying, monitoring and diagnosing and evaluating dangerous factors to change it within security state. © 2011 Trans Tech Publications.


Zhang W.,Michigan State University | Zhang W.,Hubei University | Ding Y.,Michigan State University | Boyd S.A.,Michigan State University | And 2 more authors.
Chemosphere | Year: 2010

Carbamazepine is a prescription anticonvulsant and mood stabilizing pharmaceutical administered to humans. Carbamazepine is persistent in the environment and frequently detected in water systems. In this study, sorption and desorption of carbamazepine from water was measured for smectite clays with the surface negative charges compensated with K+, Ca2+, NH4+, tetramethylammonium (TMA), trimethylphenylammonium (TMPA) and hexadecyltrimethylammonium (HDTMA) cations. The magnitude of sorption followed the order: TMPA-smectite≥HDTMA-smectite>NH4-smectite>K-smectite>Ca-smectite≥TMA-smectite. The greatest sorption of carbamazepine by TMPA-smectite is attributed to the interaction of conjugate aromatic moiety in carbamazepine with the phenyl ring in TMPA through π-π interaction. Partitioning process is the primary mechanism for carbamazepine uptake by HDTMA-smectite. For NH4-smectite the urea moiety in carbamazepine interacts with exchanged cation NH4+ by H-bonding hence demonstrating relatively higher adsorption. Sorption by K-, Ca- and TMA-smectites from water occurs on aluminosilicate mineral surfaces. These results implicate that carbamazepine sorption by soils occurs primarily in soil organic matter, and soil mineral fractions play a secondary role. Desorption of carbamazepine from the sorbents manifested an apparent hysteresis. Increasing irreversibility of desorption vs. sorption was observed for K-, Ca-, TMA-, TMPA- and HDTMA-clays as aqueous carbamazepine concentrations increased. Desorption hysteresis of carbamazepine from K-, Ca-, NH4-smectites was greater than that from TMPA- and HDTMA-clays, suggesting that the sequestrated carbamazepine molecules in smectite interlayers are more resistant to desorption compared to those sorbed by organic phases in smectite clays. © 2010 Elsevier Ltd.


Wu H.,Hubei University | Wexler D.,University of Wollongong | Liu H.,University of Wollongong
International Journal of Hydrogen Energy | Year: 2012

The effects of different amounts palladium loading on the hydrogen sorption characteristics of double-walled carbon nanotubes (DWCNTs) have been investigated. The physical properties of the pristine DWCNTs and Pd/DWCNTs were systematically characterized by X-ray diffraction, transmission electron microscopy, and Brunauer-Emmett-Teller surface area measurements. Pd nanoparticles were loaded on DWCNT surfaces for the dissociation of H 2 into atomic hydrogen, which spills over to the defect sites on the DWCNTs. When we use different Pd content, the particle size and dispersion will be different, which affects the hydrogen storage capacity of the DWCNTs. In this work, the hydrogen storage capacities were measured at ambient temperature and found to be 1.7, 1.85, 3.0, and 2.0 wt% for pristine DWCNTS, 1.0 wt%Pd/DWCNTs, 2.0 wt%Pd/DWCNTs, and 3.0 wt%Pd/DWCNTs, respectively. We found that the hydrogen storage capacity can be enhanced by loading with Pd nanoparticles and selecting a suitable content. Furthermore, the sorption can be attributed to the chemical reaction between the atomic hydrogen and the dangling bonds of the DWCNTs. © 2011, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights.


Tian L.,Wuhan University | Tian L.,Hubei University | Ye L.,Wuhan University | Deng K.,South-Central University for Nationalities | Zan L.,Wuhan University
Journal of Solid State Chemistry | Year: 2011

MWCNT/TiO2 hybrid nanostructures were prepared via solvothermal synthesis and solgel method with benzyl alcohol as a surfactant. As-prepared hybrid materials were characterized by X-ray diffraction, transmission electron microscopy, UVvis diffuse reflectance spectra and X-ray photoelectron spectroscopy. The results showed that MWCNTs were uniformly decorated with anatase nanocrystals in solvothermal condition, but MWCNTs were embedded in a majority of TiO2 nanoparticles by solgel method. When the weight ratio of MWCNTs to TiO2 was 20%, MWCNT/TiO2 hybrid nanostructures prepared by solvothermal synthesis exhibited higher visible-light-driven photocatalytic activity than that prepared by solgel method. Post-annealing of MWCNT/TiO2 nanostructures at 400 °C resulted in the formation of the carbonaceous TiC bonds on the interface between TiO2 and MWCNTs, which enhanced the photoabsorbance of the hybrid materials in the visible light region and improved the visible-light degradation efficiency of methylene blue. © 2011 Elsevier Inc. All rights reserved.


Jia Z.,Hubei University
Energy Education Science and Technology Part A: Energy Science and Research | Year: 2012

In this paper, single-crystalline Ni(SO 4) 0.3(OH) 1.4nanocrystals could be synthesized on a large scale by a facile hydrothermal treatment without using templates or organic additives. Ammonia concentration played an important role for the composition, phase structure and shape control of the the Ni(SO 4) 0.3(OH) 1.4nanobelts. Electrochemical measurement revealed that the as-prepared Ni(SO 4) 0.3(OH) 1.4nanobelts exhibited high specific capacity close to the theoretical capacity performance of β-Ni(OH) 2. On the other hand, the single-crystalline porous nickel oxide nanobeltsnanobelts can be obtained through calcination of the Ni(SO 4) 0.3(OH) 1.4. nanobelts. © Sila Science.


Peng F.,China University of Technology | Wen S.,Hubei University
Nonlinearity | Year: 2014

According to the size of sets in the sense of doubling measures, subsets of the Euclidean space Rn can be divided into six classes: very fat VF, fairly fat FF, minimally fat MF, very thin VT, fairly thin FT and minimally thin MT. Let S be a Sierpiński carpet and let C be anyone of the above classes of sets in the plane. We obtain a sufficient and necessary condition for S∈C in terms of the defining data of S. © 2014 IOP Publishing Ltd & London Mathematical Society.


Jia Z.,Hubei University | Zhang Y.,Petrochina
Energy Education Science and Technology Part A: Energy Science and Research | Year: 2012

This study has developed several multivariate regression models to forecast pulverized coal ignition temperature based on plenty of pulverized coal ignition experiments by using coal property parameters from proximate analysis and calorific value. Comparing the models a satisfied model with high accuracy has been achieved. It has been found that multivariate regression method is useful and accurate for establishing ignition temperature calculation formula. The optimum model can be used to predict pulverized coal ignition temperature and determine coal ignition characteristics. © Sila Science.


Wang H.,University of Wollongong | Zhang C.,University of Wollongong | Chen Z.,University of Wollongong | Liu H.K.,University of Wollongong | And 2 more authors.
Carbon | Year: 2015

A novel type of one-dimensional ordered mesoporous carbon fiber has been prepared via the electrospinning technique by using resol as the carbon source and triblock copolymer Pluronic F127 as the template. Sulfur is then encapsulated in this ordered mesoporous carbon fibers by a simple thermal treatment. The interwoven fibrous nanostructure has favorably mechanical stability and can provide an effective conductive network for sulfur and polysulfides during cycling. The ordered mesopores can also restrain the diffusion of long-chain polysulfides. The resulting ordered mesoporous carbon fiber sulfur (OMCF-S) composite with 63% S exhibits high reversible capacity, good capacity retention and enhanced rate capacity when used as cathode in rechargeable lithium-sulfur batteries. The resulting OMCF-S electrode maintains a stable discharge capacity of 690 mAh/g at 0.3 C, even after 300 cycles. © 2014 Elsevier Ltd. All rights reserved.


Huang C.,Hubei University | Wang S.,University of Western Australia
Operations Research Letters | Year: 2010

We propose a novel power penalty approach to a Nonlinear Complementarity Problem (NCP) in which the NCP is approximated by a nonlinear equation containing a power penalty term. We show that the solution to the penalty equation converges to that of the NCP at an exponential rate when the function involved is continuous and ξ-monotone. A higher convergence rate is also obtained when the function becomes Lipschitz continuous. Numerical results are presented to confirm the theoretical findings. © 2009 Elsevier B.V. All rights reserved.


Wang C.,City University of Hong Kong | Ren K.,State University of New York at Buffalo | Wang J.,Illinois Institute of Technology | Wang Q.,Hubei University
IEEE Transactions on Parallel and Distributed Systems | Year: 2013

Cloud computing economically enables customers with limited computational resources to outsource large-scale computations to the cloud. However, how to protect customers' confidential data involved in the computations then becomes a major security concern. In this paper, we present a secure outsourcing mechanism for solving large-scale systems of linear equations (LE) in cloud. Because applying traditional approaches like Gaussian elimination or LU decomposition (aka. direct method) to such large-scale LEs would be prohibitively expensive, we build the secure LE outsourcing mechanism via a completely different approach—iterative method, which is much easier to implement in practice and only demands relatively simpler matrix-vector operations. Specifically, our mechanism enables a customer to securely harness the cloud for iteratively finding successive approximations to the LE solution, while keeping both the sensitive input and output of the computation private. For robust cheating detection, we further explore the algebraic property of matrix-vector operations and propose an efficient result verification mechanism, which allows the customer to verify all answers received from previous iterative approximations in one batch with high probability. Thorough security analysis and prototype experiments on Amazon EC2 demonstrate the validity and practicality of our proposed design. © 1990-2012 IEEE.


Ahmed Djae K.,Wuhan University | Li Z.,Hubei University | Li Z.-B.,Wuhan University
International Journal of Oral and Maxillofacial Surgery | Year: 2011

This study evaluated the advantages and complications associated with immediate reconstruction of maxillary defects after maxillectomy and the relationship between defect tissues classification and postoperative results after using the temporalis muscle flap. In this retrospective study, the records of 39 patients who underwent immediate reconstruction surgery using temparolis myofascial flap following maxillectomy from April 1989 to February 2009 were reviewed. Demographic data, features of the disease, follow-up, outcome and complications were analysed. Patients were classified into three groups, to ascertain the influence between defect classification and functional results, aesthetic outcomes and complications in each group. Of the 39 cases, all tissue flaps survived. 5 patients underwent postoperative radiotherapy, which did not seem to influence the outcome of the reconstructive procedure. There was one case of oroantral fistula, which could easily be obturated with the prosthesis. One patient developed haematoma in the donor site 5 days after surgery. Postoperative speech was good, facial appearance was normal and ocular function remained unchanged. Postoperative aesthetic and functional results were satisfying. The temporalis muscle flap can be considered as a first-line reconstructive option for maxillary defects. Acceptable functional and aesthetic outcomes can be expected in high rates. © 2011 International Association of Oral and Maxillofacial Surgeons.


Wu S.,Hubei University
Zhongguo zhen jiu = Chinese acupuncture & moxibustion | Year: 2012

To discuss the mechanisms of electroacupuncture at "Neiguan" (PC 6) on p38 MAPK signaling pathway in rats with cardiac hypertrophy. Forty SD rats were randomly divided into four groups: a normal group, a model group, a model plus p38 MAPK inhibitor group, a model plus electroacupuncture group, ten rats in each group. The model rats were established by subcutaneous injection 3 mg/(kg x d) of Isoprenaline Hydrochloride; model plus p38 MAPK inhibitor group were injected 0.3 mg/(kg x d) of specific inhibitor SB 203580; model plus electroacupuncture group was treated by electroacupuncture at "Neiguan"(PC 6) with continuous-wave, 2 Hz and 1 mA for 20 minutes, once a day for 14 days. There was no treatment in other two groups. The contents of TNF-alpha and IL-1beta in heart tissue were detected by radioimmunoassay and the p38 MAPK, p-p38 MAPK by western blot. Compared with normal group, the contents of TNF-alpha, IL-1beta, p38 MAPK, p-p38 MAPK were significantly increased in model group (all P < 0.01). The contents of TNFalpha, IL-1beta, p38 MAPK, p-p38 MAPK were significantly decreased in model plus p38 MAPK inhibitor group and model plus electroacupuncture group, compared with model group, all P < 0.05; compared with normal group, P < 0.05, P < 0.01; but no significant difference between model plus p38 MAPK inhibitor group and model plus electroacupuncture group (P > 0.05). Electroacupuncture at "Neiguan" (PC 6) can prevent the phosphorylation of p38 MAPK of myocardial hypertrophy, and the mechanism maybe adjust p38 MAPK signaling pathway by inhibiting the expression of TNF-alpha and IL-1beta.


Zhang H.X.,Hubei University
Zhongguo zhen jiu = Chinese acupuncture & moxibustion | Year: 2012

To explore the mechanism of electroacupuncture(EA) at "Fenglong" (ST 40) in hyperlipidemia (HLP) rats. Forty health SD rats were randomly divided into a normal control group (group A), a high fat forage feed group (group B) and a high fat forage feed treatment group (group C), a high fat forage + normal forage feed group (group D) and a high fat forage + normal forage feed treatment group (group E), eight rats in each group. EA was applied at "Fenglong" (ST 40) for the rats in group C and group E, once daily. After treatment of 30 days, blood lipid levels of rats, including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) in plasma were tested. Real time polymerase chain reaction (RT-PCR) and Western Blotting were applied to detect the gene expression changes of the contents of ATP-binding cassette transporter A1 (ABCA1), peroxisome proliferator-activated receptor alpha (PPARalpha), liver X receptor alpha (LXR-alpha) and retinoid X receptor alpha (RXR-alpha) in liver tissue of rats. Compared with group A, the contents of TC, LDL-C were significantly elevated in group B and group D (all P < 0.01); compared with group B, above indices were significantly decreased in group D (all P < 0.01). After the treatment of EA at "Fenglong"(ST 40), the contents of TC, LDL-C were significantly decreased (all P < 0.01), and the contents of TG, HDL-C did not change obviously (all P > 0.05). Compared with group A, the mRNA and protein contents of ABCA1, PPARalpha, LXR-alpha and RXR-alpha were decreased obviously in group B and group D (all P < 0.01). But compared with group B, the above indices were decreased in the group D. There were signficantly increasing in the protein content of ABCA1, PPARalpha, RXR-alpha and LXR-alpha mRNA after the treatment of EA (all P < 0.05). EA at "Fenglong" (ST 40) has some therapeutic effect on decrease the content of TC, LDL-C in rats of hyperlipemia and improve the gene expression of ABCA1, PPARalpha, LXR-alpha and RXR-alpha mRNA so as to promote reverse cholesterol transport.


Wu B.,Hubei University
Wei sheng wu xue bao = Acta microbiologica Sinica | Year: 2010

We investigated differences in morphology, physiology, periplasmic proteins and phagocytosis by macrophage among E. coli strains AD93 (PE- PC-), AD93/ptac67 (PE- PC+), Top10/ptac66(PE+ PC+) and the wild types in order to understand if phosphatidylcholine (PC) can substitute phosphatidylethanolamine (PE) in vivo. Bacterial cells were observed under microscope after staining with Gram-staining kit or by electron microscope. Bacterial growth under different conditions was monitored by measuring the absorbance at the wavelength of 600 nm. Periplasmic proteins were analyzed using SDS-PAGE and 2-D electrophoresis. Bacterial adherence and phagocytosis by macrophage were also examined by using murine RAW264.7 macrophage. 100% bacterial cells in AD93/pDD72 were bar-shaped but 25% AD93/ptac67 cells came out as long filaments. Different from AD93/ pDD72, AD93/ptac67 and AD93 required Mg2+ or Ca2+ for growth. Moreover, AD93/ptac67 displayed a different pattern of periplasmic proteins on a 2-D gel and a low relatively phagocytic efficiency in the phagocytosis test when compared to AD93/pDD72 and AD93. Both Top10/ptac66 and the wild-type Top10/ptac85 cells were bar-shaped under microscope, but the former showed noticeably difference in the outer-layer structure of cell wall, and its stress resistance and periplasmic protein composition were also different from those of the latter. Substitution of phosphatidylethanolamine with phosphatidylcholine in E. coli cells is unable to restore the phonotype of PE- mutant to the wild type. Biological functions of PE and PC are different, and phosphatidylcholine cannot substitute phosphatidylethanolamine in vivo.


Harada Y.,Hubei University | Goossens S.,University of Maryland Baltimore County | Matsumoto K.,Japan National Astronomical Observatory | Yan J.,Hubei Engineering University | And 3 more authors.
Nature Geoscience | Year: 2014

Tidal heating of a solid planetary body occurs by viscous dissipation, depending on its internal structure and thermal and orbital states. Calculations of the response of the Moon to tidal forces have considered lunar interior structure, but have not reproduced the geodetically observed dependence of dissipation on the lunar tidal period. The attenuation of seismic waves in the deep lunar interior is expected to be consistent with a low-viscosity layer at the core-mantle boundary, which may explain the observed frequency dependence. Here we numerically simulate the viscoelastic tidal response of a Moon that contains a low-viscosity layer at the core-mantle boundary and compare with geodetic observations. In our simulations, a layer with a viscosity of about 2 × 1016 Pa s leads to frequency-dependent tidal dissipation that matches tidal dissipation measurements at both monthly and annual periods. Compared with the lunar asthenosphere, the calculated viscosity is extremely low, and suggests partial melting at the lunar core-mantle boundary. We also find that tidal dissipation is not evenly distributed in the lunar interior, but localized within the low-viscosity layer, which implies that this layer may act as a thermal blanket on the lunar core and influence the Moon's thermal evolution. © 2014 Macmillan Publishers Limited.


Zhu L.,Southwest University | Yang H.B.,Nanyang Technological University | Zhong C.,Hubei University | Li C.M.,Southwest University
Dyes and Pigments | Year: 2014

Two new sensitizers based on triphenylamine-dicyanovinylene have been synthesized and used for p-type dye-sensitized solar cells. The best performance amongst solar cells was achieved by the dye with a ter-thiophene bridge ligand between carboxylic acid group and the triphenylamine part (with power conversion efficiency of 0.19%, short circuit current of 4.01 mA cm-2, open circuit voltage at 144 mV, and fill factor of 0.33). Results indicate that the ter-thiophene groups in the dyes strongly affects both charge recombination and hole injection in the photoelectrode. In addition, the hexyl chains on the bridged thiophene rings also help to avoid dye aggregation on the nickel oxide film and block I- in electrolyte from approaching the surface of nickel oxide, which leads to a reduction in the charge recombination between nickel oxide semiconductor and electrolyte. This study suggested that modification of the bridge moiety between triphenylamine and the carboxylic group by increasing thiophene units is a promising way for preventing charge recombination and increasing the power conversion efficiency. © 2014 Elsevier Ltd. All rights reserved.


Dong Y.,CAS Lanzhou Institute of Chemical Physics | Dong Y.,University of Chinese Academy of Sciences | Li J.,CAS Lanzhou Institute of Chemical Physics | Shi L.,CAS Lanzhou Institute of Chemical Physics | And 4 more authors.
Chemical Communications | Year: 2014

Hydrophilic graphene oxide (GO) nanosheets can be easily coated onto stainless steel meshes. Compared to neat meshes, GO coated meshes become more hydrophilic in air and superoleophobic under water. Taking advantage of this completely opposite wettability, GO coated meshes were used for gravity-driven oil-water separation. © the Partner Organisations 2014.


Zhang J.,Hubei University
Applied Mechanics and Materials | Year: 2014

The economic phenomenon of high urban housing prices in our country reflects asymmetry of rights and interests among government, real estate developers and buyers in essence, and behind this economic phenomenon imbedded financial crisis as well as political and social crisis. Regarding academic thought on the causes of high housing prices in the real estate market such as the theories of supply and demand, cost, the system, and power imbalance between interest groups, this thesis proceeds institutional analysis, from the perspective of institutional economics, discusses the institutional causes of the persistent existence of four factors theories in the angle of vacancy of civil rights in the supply process of institution and rules, and puts forward policy suggestions of increasing effective supplies of institution in the system level. © (2014) Trans Tech Publications, Switzerland.


Wang Z.,University of British Columbia | Wang Z.,Hubei University | Shen Y.,University of British Columbia | Haapasalo M.,University of British Columbia
Journal of Endodontics | Year: 2013

Introduction: This study examined the effect of the smear layer on the antibacterial effect of different disinfecting solutions in infected dentinal tubules. Methods: Cells of Enterococcus faecalis were forced into dentinal tubules according to a previously established protocol. After a 3-week incubation period of infected dentin blocks, a uniform smear layer was produced. Forty infected dentin specimens were prepared and subjected to 3 and 10 minutes of exposure to disinfecting solutions including sterile water, 2% and 6% sodium hypochlorite (NaOCl), 2% chlorhexidine (CHX), 17% EDTA, and QMiX (Dentsply Tulsa Dental, Tulsa, OK). The following combinations were also included: 2% NaOCl + 2% CHX, 2% NaOCl + QMiX, 6% NaOCl + QMiX, and 6% NaOCl + 17% EDTA + 2% CHX. Four other dentin specimens similarly infected but with no smear layer were subjected to 3 minutes of exposure to 2% CHX and 6% NaOCl for comparison. Confocal laser scanning microscopy and viability staining were used to analyze the proportions of dead and live bacteria inside the dentin. Results: In the presence of a smear layer, 10 minutes of exposure to QMiX, 2% NaOCl + QMiX, 6% NaOCl + QMiX, and 6% NaOCl + 17% EDTA + 2% CHX resulted in significantly more dead bacteria than 3 minutes of exposure to these same disinfecting solutions (P <.05). No statistically significant difference between 3 and 10 minutes was found in other groups (P >.05); 6% NaOCl + QMiX and 6% NaOCl + 17% EDTA + 2% CHX showed the strongest antibacterial effect. In the absence of a smear layer, 2% CHX and 6% NaOCl killed significantly more bacteria than they did in the presence of a smear layer (P <.05). Conclusions: The smear layer reduces the effectiveness of disinfecting agents against E. faecalis in infected dentin. Solutions containing 6% NaOCl and/or QMiX showed the highest antibacterial activity. © 2013 American Association of Endodontists.


Wu F.,Georgia Institute of Technology | Wu F.,Hubei University | Feng Y.,Georgia Institute of Technology | Jones C.W.,Georgia Institute of Technology
ACS Catalysis | Year: 2014

A mesoporous silica (SBA-15)-supported bipyridine iridium complex is prepared by grafting of bipyridine onto the silica support, followed by complexation of an iridium(I) precursor in the presence of HBpin and cyclooctene. Structural analyses by X-ray powder diffraction, nitrogen physisorption, FT-IR, and solid-state NMR spectroscopy demonstrate that the 3-dimensional, hexagonal pore structure of SBA-15 is maintained after the immobilization. In particular, as a heterogeneous catalyst, this silica-supported iridium complex shows moderate to good catalytic activity in the aromatic C-H borylation of a variety of substrates. More importantly, the heterogeneous catalyst is recovered easily and reused repeatedly by simple washing without chemical treatment and exhibits good recycling performance with a modest decrease in the catalytic rate, showing good potential for increasing the overall turnover number of this synthetically useful catalyst. © 2014 American Chemical Society.


Xia X.H.,University of Bolton | Xia X.H.,Hubei University | Lu L.,University of Bolton | Walton A.S.,University of Leeds | And 5 more authors.
Acta Materialia | Year: 2012

It is highly desirable to induce significant red-shift in the optical absorption edges of TiO 2 phases so that this class of low-cost and environmentally friendly materials can be used as effective optical absorbing materials in novel photovoltaic cells with long-term sustainability or smart photo-catalysts beyond the ultraviolet range. This work focuses on studying the mechanisms of Mn-induced red-shift by combining theoretical modeling with advanced structural and spectroscopic characterization of doped thin films, aiming to provide fundamental guidance for effective doping through enhanced understanding of doping chemistry resulting from the interplay between doping atoms and defects. It is shown that Mn atoms doped into the Ti lattice sites are associated with oxidation valency higher than +3, resulting in maximized effectiveness in modifying the band structure to achieve remarkable optical red-shifting. The presence of oxygen vacancies reduces the Mn valency and its red-shifting effect, but their detrimental effect in bringing about localized defect levels is reduced owing to their association with Mn atoms, making Mn doping highly promising in activating various visible light functionalities of TiO 2. © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.


Wu K.,Vanderbilt University | Wu K.,Hubei University | Cappel D.,Vanderbilt University | Martinez M.,Vanderbilt University | Stafford J.M.,Vanderbilt University
Endocrinology | Year: 2010

For patients with diabetes, insulin resistance and hyperglycemia both contribute to increased serum triglyceride in the form of very low-density lipoprotein (VLDL). Our objective was to define the insulin conditions in which hyperglycemia promotes increased serum VLDL in vivo. We performed hyperglycemic-hyperinsulinemic clamp studies and hyperglycemic-hypoinsulinemic clamp studies in rats, with metabolic tracers for glucose flux and de novo fatty acid synthesis. When blood glucose was clamped at hyperglycemia (17 mM) for 2 h under hyperinsulinemic conditions (4 mU/kg · min), serum VLDL levels were not increased compared with baseline. We speculated that hyperinsulinemia minimized glucose-mediated VLDL changes and performed hyperglycemic- hypoinsulinemic clamp studies in which insulin was clamped near fasting levels with somatostatin (17 mM blood glucose, 0.25 mU/kg · min insulin). Under low-insulin conditions, serum VLDL levels were increased 4.7-fold after hyperglycemia, and forkhead box O1 (FoxO1) was not excluded from the nucleus of liver cells. We tested the extent that impaired inactivation of FoxO1 by insulin was sufficient for glucose to promote increased serum VLDL. We found that, when the ability of insulin to inactivate FoxO1 is blocked after adenoviral delivery of constitutively active FoxO1, glucose increased serum VLDL triglyceride when given both by ip glucose tolerance testing (3.5-fold increase) and by a hyperglycemic clamp (4.6-fold). Under both experimental conditions in which insulin signaling to FoxO1 was impaired, we found increased activation of carbohydrate response element binding protein. These data suggest that glucose more potently promotes increased serum VLDL when insulin action is impaired, with either low insulin levels or disrupted downstream signaling to the transcription factor FoxO1. Copyright © 2010 by The Endocrine Society.


Yi M.,National University of Singapore | Yi M.,Hubei University | Hong N.,National University of Singapore | Hong Y.,National University of Singapore | Hong Y.,Chinese Academy of Sciences
Nature Protocols | Year: 2010

Embryonic stem (ES) cells are pluripotent cells capable of differentiation into various cell types. Haploid ES cells elegantly combine the advantages of haploidy and pluripotency and offer a unique in vitro system for genetic analyses of molecular, cellular and developmental events in various cell lineages. Our recent success in generating haploid ES cell lines from gynogenetic embryos of the medaka fish suggests that haploidy can support ES cell derivation and maintenance in a vertebrate. In this study, we present a step-by-step protocol for derivation and characterization of medaka haploid ES cells. We have used this procedure to produce three haploid ES cell lines from five primary cultures. It takes about 15 weeks to generate stable cultures, 5g-8 weeks to obtain pure haploid cells and 5-6 weeks to characterize ES cells in vitro and in vivo. © 2010 Nature America, Inc. All rights reserved.


Guo Q.,Hubei University
Applied Geochemistry | Year: 2012

As an important part of the Mediterranean-Himalayas geothermal belt, southern Tibet and western Yunnan are the regions of China where high-temperature hydrothermal systems are intensively distributed, of which Rehai, Yangbajing and Yangyi have been investigated systematically during the past several decades. Although much work has been undertaken at Rehai, Yangbajing and Yangyi to study the regional geology, hydrogeology, geothermal geology and geophysics, the emphasis of this review is on hydrogeochemical studies carried out in these geothermal fields. Understanding the geochemistry of geothermal fluids and their environmental impact is critical for sustainable exploitation of high-temperature hydrothermal resources in China. For comparison, the hydrogeochemistry of several similar high-temperature hydrothermal systems in other parts of the world are also included in this review. It has been confirmed by studies on Cl - and stable isotope geochemistry that magma degassing makes an important contribution to the geothermal fluids from Rehai, Yangbajing and Yangyi, though meteoric water is still the major source of recharge for these hydrothermal systems. However, the mechanisms of magma heat sources appear to be quite different in the three systems, as recorded by the 3He/ 4He ratios of escaping geothermal gases. A mantle-derived magma intrusion to shallow crust is present below Rehai, although the intruding magma has been heavily hybridized by crustal material. By contrast, the heat sources below Yangbajing and Yangyi are inferred to be remelted continental crust. Besides original sources, the geochemistry of characteristic constituents in the geothermal fluids have also been affected by temperature-dependent fluid-rock interactions, boiling and redox condition changes occurring in the upper part of hydrothermal systems, and mixing with cold near-surface waters. The geothermal fluids from Rehai, Yangbajing and Yangyi contain very high concentrations of some toxic elements. Since local drinking water sources may be mixed with geothermal water, and irrigation with water containing geothermally-derived harmful elements, possibly leading to accumulation in crops consumed by human beings, the natural geothermal spring discharge or anthropogenic geothermal wastewater drainage of these fields poses a threat to the environment and human health. Future research work should focus on estimation of stable O and H isotope compositions of magmatic water related to high-temperature hydrothermal systems in China, which is of significance for the quantitative source study of geothermal fluid recharged by degassed magmatic waters. Attention should also be paid to some constituent species in geothermal fluid of strong environmental significance, such as thioarsenate that is crucial for the fate of As discharged from geothermal springs, especially sulfidic hot springs. © 2012 Elsevier Ltd.