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Zhang Z.-F.,Beijing University of Chinese Medicine | Xu F.-Q.,Chinese Academy of Sciences | Liu H.-X.,Beijing Hospital of Traditional Chinese Medicine | Wang F.-R.,Liaoning University of Traditional Chinese Medicine | And 4 more authors.
Chinese Journal of Integrative Medicine | Year: 2015

Objective: To confirm the efficacy and safety of Wufuxinnaoqing Soft Capsule (五福心脑清胶囊, WSC) in the treatment of chronic stable angina (blood stasis syndrome). Methods: A multicenter, randomized, double-blind, placebo-controlled trial with superiority test was designed. A total of 240 patients with chronic stable angina (blood stasis syndrome) from multiple centers were randomly and equally assigned to the treatment group and the control group. Based on standard treatment of Western medicine, the treatment group was given WSC, while the control group was given WSC mimetic, both for 12 weeks. Observed indicators included the efficacy in angina, the efficacy in Chinese medicine syndrome, the withdrawal or reduce rate of nitroglycerin and routine safety indices. Results: After 12-week treatment, the significant effective rate and total effective rate of the treatment group were significantly better than those of the control group (23.5% vs. 9.2%, 64.7% vs. 30.8%), respectively, with statistically significant difference (P<0.01). After 12-week treatment, the decreased points and the decreased rate of angina symptom score in the treatment group were better than in the control group (5.1±4.2 points vs. 2.8±3.5 points, 44.9%±37.2% vs. 25.4%±30.7%) respectively, with significant difference (P<0.01). After 12-week treatment, the significant effective rate and total effective rate of the treatment group were better than the control group (respectively, 30.3% vs. 15.0%, 67.2% vs. 45.0%,P<0.01). After 8- or 12-week treatment, the decreased points and the decreased rate of Chinese medicine syndrome score in the treatment group were better than the control group (P<0.05 orP<0.01). After 12-week treatment, nitroglycerin withdrawal rate and the withdrawal or reduce rate in treatment group were better than the control group (P<0.01). On safety evaluation, the incidence of adverse events (7.563% vs. 7.500%) and the incidence of cardiovascular events (0.840% vs. 0.000%) in the treatment group were similar with the control group, and the difference was not statistically significant (P>0.05). Conclusion: In treatment of chronic stable angina (blood stasis syndrome), WSC can reduce angina attacks and consumption of nitroglycerin, decrease angina severity degree, effectively relieve the blood stasis syndromes, such as chest pain, chest tightness, palpitations, dark purple tongue and other symptoms. Besides, adverse events and cardiovascular adverse events in the treatment group and the control group showed no difference. All shows that the drug is safe and effective. [This study was registered in Chinese Clinical Trial Registry (ChiCTR), with registration number: ChiCTR-TRC-14005158.] © 2015, Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg. Source


Xu X.-Q.,Huazhong University of Science and Technology | Wu H.,Huazhong University of Science and Technology | Li G.-H.,Huazhong University of Science and Technology | Li F.,Hubei Provincial Hospital of Traditional Chinese Medicine
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2010

BACKGROUND: Lumbar degenerative disease has been commonly treated with nucleus pulposus extirpation or nucleus pulposus extirpation combined with internal fixation; however, with the development of non-rigidity fixation, interspinous dynamic stabilization and intervertebral disk displacement attract more and more attention. OBJECTIVE: To evaluate the therapeutic effect of Wallis interspinous dynamic stabilization on lumbar degenerative disease compared with lumbar spinal canal decompression. METHODS: A total of 40 patients with lumbar degenerative disease were selected from Department of Orthopedic Surgery, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology between December 2007 and December 2008. Twenty patients were treated with nucleus pulposus extirpation alone, considering as control group; while, other 20 patients were treated with nucleus pulposus extirpation combined with Wallis interspinous dynamic stabilization, considering as experimental group. JOA score and VAS score were made at 1 week and 1 year postoperatively for all the patients. RESULTS AND CONCLUSION: There was no significant difference in JOA score and VAS score between two groups at 1 week postoperatively (P > 0.05); but there was significant difference in both scores at 1 year postoperatively (P < 0.05). The results demonstrated that both methods achieved well therapeutic effects, which depended on effective decompression. The therapeutic effect of the first group was better than the second group, depending on the favourable biologic effect of the implantation of Wallis interspinous dynamic stabilization, which could effectively relieve the residual low back pain. Source


Ba Y.-M.,Hubei Provincial Hospital of Traditional Chinese Medicine | Cao Q.-S.,Hubei University
Journal of Shanghai Jiaotong University (Medical Science) | Year: 2014

Objective: To compare the renal pathological changes and functional impairments of rats of the calcium oxalate calculus model established by the ethylene glycol (EG) method and ammonium oxalate (AmOx) method and to explore the selection and application of two calcium oxalate calculus models. Methods: A total of 36 SPF level healthy male Wistar rats were randomly divided into the control group, EG group, and AmOx group (n=12). Each rat of the EG group was intragastrically administered 2% ammonium chloride(AC) of 2 mL per day and was administered 1% EG for free drink. Rats of the AmOx group were fed by forage with 5% AmOx. After models were established, levels of serum urea nitrogen, creatinine, calcium, phosphorus, magnesium, 24 h urinary oxalate were detected. The paraffin kidney sections were observed under the microscope for calcium oxalate deposit and pathological changes. Results: The levels of urinary oxalate, calcium, and phosphorus of the EG group and AmOx group were significantly higher than those of the control group (P<0.05, P<0.01). Effects of both calcium oxalate calculus models established by two methods were remarkable and stable, whereas renal pathological changes and functional impairments of rats were significantly different (P<0.05). Conclusion: Compared to the model established by EG method, the model established by AmOx method can cause severer renal pathological changes and functional impairment of rats and is more suitable for studying renal functional impairment due to nephrolithiasis. ©, 2014, Editorial Department of Journal of Shanghai Second Medical University. All right reserved. Source


Li F.,Hubei Provincial Hospital of Traditional Chinese Medicine | Wu H.,Tongji Hospital of Wuhan
Chinese Journal of Tissue Engineering Research | Year: 2013

Background: The finite element model has been developed from two-dimensional model to three-dimensional model, from linear model to nonlinear model. As the advantage of this method in the analysis of mechanical characteristics of the irregular objects, the finite element model has been widely used in the research of orthopedic biomechanics, especially in the research of hip joint. Objective: To analyze the stress state of human femur with finite element analysis method and to investigate a method that can rapidly construct femoral finite element model and precisely analyze the biomechanics. Methods: Normal male femur was used as specimen for CT scan to obtain cross-sectional images of femur in each slice. Three-dimensional reconstruction was performed with DICOM data and MIMICS software, then the femoral three-dimensional finite element model was established with the finite element analysis ABQUS 6.8 software, and the stress distribution of the model was analyzed under loading condition. Results and conclusion: Based on DICOM data, three-dimensional finite element model of femur was constructed more quickly and precisely. The models were divided into 38 636 nodes and 201 422 units. The model included the parts of cortical and cancellous bone. The biomechanical test results were accorded with the previous results, so the model could objectively reflect the real femur shape and biomechanical behavior with high precision. The Mimics software provided a simpler and effective method for the construction of femur model and improved the efficiency of modeling, and the three-dimensional finite element model based on DICOM data was accurate in shape and can be used for the normal research on biomechanical behavior of femur. The stress distribution analyzed with ABQUS 6.8 software is consistent with the clinical observation. Source


Tan Z.H.,Hubei Provincial Hospital of Traditional Chinese Medicine
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban | Year: 2013

To observe early intervention effects of Modified Shuyu Pill (MSP) on vascular cognitive impairment no dementia (VCIND). Totally 100 patients VCIND were randomly assigned to the treatment group (43 cases) and the control group (33 cases). On the basis of the treatment targeting risk factors of blood vessels, patients in the treatment group were treated by MSP, while those in the control group were treated by donepezil hydrochloride. The therapeutic course was 16 weeks. The neuropsychological scales [mini-mental state examination (MMSE) and Montreal cognitive assessment (MOCA) score] and Chinese medicine dementia syndromes scales were observed before and after treatment. The MMSE and MOCA score of the two groups increased when compared with the same group before treatment (P < 0.01). But there was no statistical difference in MMSE or MOCA score after treatment between the two groups (P > 0.05). The Chinese medicine dementia syndromes scales significantly decreased in the treatment group when compared with before treatment (P < 0.01). But there was no statistical difference in Chinese medicine dementia syndromes scales in the control group between before and after treatment (P > 0.05). There was statistical difference in Chinese medicine dementia syndromes scales after treatment between the two groups (P < 0.01). MSP could effectively intervene the progress of VCIND. Source

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