Hubei Key Laboratory of Natural Drug Chemistry and Evaluation HUST

Wuhan, China

Hubei Key Laboratory of Natural Drug Chemistry and Evaluation HUST

Wuhan, China
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Xiong Z.,Huazhong University of Science and Technology | Jiang B.,Huazhong University of Science and Technology | Wu P.-F.,Huazhong University of Science and Technology | Tian J.,Huazhong University of Science and Technology | And 14 more authors.
Biological and Pharmaceutical Bulletin | Year: 2011

Depression and related mood disorders are among the world's greatest public health problems. Previous studies have demonstrated that baicalein (Bai), one plant-derived active flavonoid, exhibits neuroprotection against ischemic brain injury and stimulates the levels of phosphorylation of extracellular signal-regulated kinase (pERK) and brain-derived neurotrophic factor (BDNF) expression in vivo. In this study, the antidepressantlike effects of baicalein was investigated using acute and chronic animal models of depression. The results showed that acute application of Bai at doses of 1, 2 and 4 mg/kg by intraperitoneal injection (i.p.) significantly reduced the immobility time in the forced swimming test (FST) and tail suspending test (TST) of mice. In addition, the chronic application of Bai by i.p. for 21 d also reduced the immobility time and improved locomotor activity in chronic unpredictable mild stress (CMS) model rats. Furthermore, it was shown that Bai reversed the reduction of extracellular ERKs phosphorylation and the level of BDNF expression in the hippocampus of CMS model rats. These results suggest that Bai produce an antidepressant-like effect and this effect is at least partly mediated by hippocampal ERK-mediated neurotrophic action. © 2011 Pharmaceutical Society of Japan.


Wu P.-F.,Huazhong University of Science and Technology | Zhang Z.,Huazhong University of Science and Technology | Wang F.,Huazhong University of Science and Technology | Wang F.,Key Laboratory of Neurological Diseases HUST | And 4 more authors.
Acta Pharmacologica Sinica | Year: 2010

More and more attention in the field of drug discovery has been focused on the neuroprotection of natural compounds from traditional medicinal herbs. Cerebral ischemia is a complex pathological process involving a series of mechanisms, and a framework for the development of neuroprotectants from traditional herb medicine is a promising treatment for cerebral ischemia. Natural compounds with the effects of anti-oxidation, anti-inflammation, calcium antagonization, anti-apoptosis, and neurofunctional regulation exhibit preventive or therapeutic effects on experimental ischemic brain injury. According to the pharmacological mechanisms underlying neuroprotection, we evaluated natural products from traditional medicinal herbs that exhibit protective effects on ischemic brain injury and characterized the promising targets. © 2010 CPS and SIMM All rights reserved.


Wang T.,Huazhong University of Science and Technology | Wang T.,China Three Gorges University | Yang Y.-J.,Huazhong University of Science and Technology | Wu P.-F.,Huazhong University of Science and Technology | And 19 more authors.
European Journal of Pharmacology | Year: 2011

Plant or food derived polyphenols have received a great deal of attention due to their biological properties including anti-oxidative effects, neuroprotection and memory enhancement. Here, we investigated the roles of 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside (TSG), an active component of the rhizome extracted from Polygonum multiflorum, in the regulation of hippocampal synaptic plasticity in normal mice as well as the underlying mechanisms. It was shown that TSG promoted the differentiation of PC12 cells and increased the intracellular calcium level in hippocampal neurons. TSG facilitated high-frequency stimulation (HFS)-induced hippocampal long-term potentiation (LTP) in a bell-shaped manner. The facilitation of LTP induction by TSG required calcium/calmodulin-dependent protein kinase II (CaMKII) and extracellular signal-regulated kinase (ERK) activation. Taken together, our data demonstrate that TSG promotes LTP induction and this effect may contribute to the enhancement of learning and memory seen in animal models. © 2010 Elsevier B.V. All rights reserved.

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