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Xu G.-Z.,Hubei Key Laboratory of Central Nervous System Tumor and Intervention | Zhang Y.,Wuhan General Hospital of Guangzhou Command | Yu J.,Wuhan General Hospital of Guangzhou Command | Diao B.,Hubei Key Laboratory of Central Nervous System Tumor and Intervention
International Journal of Clinical and Experimental Medicine | Year: 2015

Objective: We investigated the correlation between vascular endothelial growth factor 2 (VEGFR2) polymorphism and glioma risk among Chinese population. Method: Case-control study design was adopted, and blood samples and clinical data of 250 glioma cases and 260 control subjects were collected. Epidemiological questionnaire survey was performed, and DNA extraction, concentration normalization and packaging were carried out using Qiagen Blood Kit. TaqMan method was performed for VEGFR2 rs2071559 genotyping. Results: C allele of VEGFR2 rs2071559 genotype was the susceptibility allele contributing to the risk of glioma (OR=1.813, 95% CI: 1.393-2.359, P=0.014). CC genotypes of VEGFR2 rs2071559 were associated with increased risk of glioma (OR=2.068, 95% CI: 1.164-3.674, P=0.014; Adjusted OR=1.883, 95% CI: 1.430~3.013, P=0.018). Conclusion: CC genotypes of VEGFR2 rs2071559 were associated with glioma risk among Chinese population. However, the role of VEGFR2 rs2071559 polymorphism in glioma susceptibility remains to be further clarified. © 2015, E-Century Publishing Corporation. All rights reserved. Source


Xu G.,Wuhan General Hospital of Guangzhou Command | Xu G.,Hubei Key Laboratory of Central Nervous System Tumor and Intervention | Zhang Y.,Wuhan General Hospital of Guangzhou Command | Yang Q.,Wuhan General Hospital of Guangzhou Command | And 2 more authors.
Oncology Letters | Year: 2016

Glioma is a common malignacy of the brain that affects elderly patients in particular. Despite treatment, however, the survival rate is 12 months. The aim of the present study was to examine the therapeutic effect of neural progenitor cells (NPCs) on a glioma murine model, and to determine the possible mechanism of action. A glioma murine model was constructed and the tumor volume and tumor growth rate were measured. The therapeutic effect of cell injection on the glioma mouse model mice was confirmed. The quantitative polymerase chain reaction method was used to detect the expression of proto‑oncogene and tumor suppressor gene. Intracranial injection of NPCs was performed to determine cell apoptosis. Preliminary results showed the mechanism of cell therapy effect at the transcription and cellular level. Compared with the model group, the tumor volume of the mice of the cell therapy group was significantly reduced from the 6th to 8th week, and the tumor growth rate was downregulated. The mechanism of action identified that NPCs regulate gene expression in tumor tissues, increase the expression of tumor suppressor gene, downregulate the gene expression of tumor cells, and reverse the proto‑oncogene and imbalance of gene expression in gliomas. In conclusion, the new type of cell injection method can regulate the proto‑oncogene of tumor tissue and tumor suppressor gene, improve the function phenotype of the cell, and effectively improve the clinical symptoms of mice with gliomas. © Spandidos Publications 2016. Source

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