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Wuhan, China

The Huazhong University of Science and Technology is a public, coeducational research university located in Wuhan, Hubei province, China. As a national key university, HUST is directly affiliated to the Ministry of Education of China. HUST has been referred toas the flagship of China's higher education system after the Chinese Civil War. HUST manages Wuhan National Laboratories for Opto-electronics at Wuchang, which is one of the five national laboratories in China. Wikipedia.

Lei L.,Huazhong University of Science and Technology
Scientometrics | Year: 2016

Guo X.,Huazhong University of Science and Technology | Guo X.,Julich Research Center
Physical Chemistry Chemical Physics | Year: 2014

As a classic dielectric material, BaTiO3 is one of the most important materials used in electronic applications. In this work, highly dense BaTiO3 ceramics with an average grain size of 35 nm were prepared, and dielectric and electrical properties were investigated. Microcrystalline BaTiO3 is an insulator at low temperatures; however, nanocrystalline BaTiO3 shows considerable semiconductivity with an activation energy of only 0.27 eV at temperatures ≤200 °C. At room temperature, the conductivity of nanocrystalline BaTiO3 is about fourteen orders of magnitude higher than that of the microcrystalline counterpart. Only by decreasing the grain size, one can transform BaTiO3 from an insulator to a semiconductor. © the Owner Societies 2014. Source

Zuo F.,Huazhong University of Science and Technology
EPJ Web of Conferences | Year: 2014

Confinement in SU(N) gauge theory is due to the linear potential between colored objects. At short distances, the linear contribution could be considered as the quadratic correction to the leading Coulomb term. Recent lattice data show that such quadratic corrections also appear in the deconfined phase, in both the thermal quantities and the Polyakov loop. These contributions are studied systematically employing the gauge/string duality. "Confinement" in ${\cal N}$ = 4 SU(N) Super Yang-Mills (SYM) theory could be achieved kinematically when the theory is defined on a compact space manifold. In the large-N limit, deconfinement of ${\cal N}$ = 4 SYM on ${{\Bbb S} 3}$ at strong coupling is dual to the Hawking-Page phase transition in the global Anti-de Sitter spacetime. Meantime, all the thermal quantities and the Polyakov loop achieve significant quadratic contributions. Similar results can also be obtained at weak coupling. However, when confinement is induced dynamically through the local dilaton field in the gravity-dilaton system, these contributions can not be generated consistently. This is in accordance with the fact that there is no dimension-2 gauge-invariant operator in the boundary gauge theory. Based on these results, we suspect that quadratic corrections, and also confinement, should be due to global or non-local effects in the bulk spacetime. © Owned by the authors, published by EDP Sciences, 2014. Source

Min H.,Huazhong University of Science and Technology
Journal of Convergence Information Technology | Year: 2012

The design of The High-Tech Enterprise Value Evaluating Measure System Grounded on Value Based Management embodies the financing Aim of the Enterprise Value Maximum. In the design, the effect of the existing profitability, the potential profitability and the opportunity value of the future industry development to high-tech enterprise value must be comprehensive considered. And financial value drivers and non-financial value drivers as a starting point to design and select indicators, in the assessing system, there are financial indicators and non-financial indicators; both quantitative indicators and qualitative indicators. Therefore, using the evaluation measure system in combination with ANP model to set up enterprise evaluation model must be more integrated, if we use it to assess enterprise value, the result must be more scientific, objective and reliable. Source

Wang J.,University of Southern California | Wang J.,Huazhong University of Science and Technology | Yang J.-Y.,University of Southern California | Fazal I.M.,University of Southern California | And 8 more authors.
Nature Photonics | Year: 2012

The recognition in the 1990s that light beams with a helical phase front have orbital angular momentum has benefited applications ranging from optical manipulation to quantum information processing. Recently, attention has been directed towards the opportunities for harnessing such beams in communications. Here, we demonstrate that four light beams with different values of orbital angular momentum and encoded with 42.8 × 4 Gbit s-1 quadrature amplitude modulation (16-QAM) signals can be multiplexed and demultiplexed, allowing a 1.37 Tbit s-1 aggregated rate and 25.6 bit s-1 Hz-1 spectral efficiency when combined with polarization multiplexing. Moreover, we show scalability in the spatial domain using two groups of concentric rings of eight polarization-multiplexed 20 × 4 Gbit s-1 16-QAM-carrying orbital angular momentum beams, achieving a capacity of 2.56 Tbit s-1 and spectral efficiency of 95.7 bit s -1 Hz-1. We also report data exchange between orbital angular momentum beams encoded with 100 Gbit s-1 differential quadrature phase-shift keying signals. These demonstrations suggest that orbital angular momentum could be a useful degree of freedom for increasing the capacity of free-space communications. © 2012 Macmillan Publishers Limited. All rights reserved. Source

Zhao Y.,CAS Nanjing Institute of Geography and Limnology | Xie L.,CAS Nanjing Institute of Geography and Limnology | Yan Y.,Huazhong University of Science and Technology
Chemosphere | Year: 2015

Previous studies have shown that microcystins (MCs) are able to exert negative effects on the reproductive system of fish. However, few data are actually available on the effects of MC-LR on the reproductive system of female fish. In the present study, female zebrafish were exposed to 2, 10, and 50μgL-1 of MC-LR for 21 d, and its effects on oogenesis, sex hormones, transcription of genes on the hypothalamic-pituitary-gonad (HPG) axis, and reproduction were investigated for the first time. It was observed that egg production significantly declined at ≥10μgL-1 MC-LR. MC-LR exposure to zebrafish increased the concentrations of 17β-estradiol (E2) and vitellogenin (VTG) at 10μgL-1 level, whereas concentrations of E2, VTG and testosterone declined at 50μgL-1 MC-LR. The transcriptions of steroidogenic pathway gene (cyp19a, cyp19b, 17βhsd, cyp17 and hmgra) changed as well after the exposure and corresponded well with the alterations of hormone levels. A number of intra- and extra-ovarian factors, such as gnrh3, gnrhr1, fshβ, fshr, lhr, bmp15, mrpβ, ptgs2 and vtg1 which regulate oogenesis, were significantly changed with a different dose-related effect. Moreover, MC-LR exposure to female zebrafish resulted in decreased fertilization and hatching rates, and may suggest the possibility of trans-generational effects of MC-LR exposure. The results demonstrate that MC-LR could modulate endocrine function and oogenesis, eventually leading to disruption of reproductive performance in female zebrafish. These data suggest there is a risk for aquatic population living in MC polluted areas. © 2014 Elsevier Ltd. Source

Yang Q.,Huazhong University of Science and Technology | Yang Q.,Peking University | Chen G.Q.,Peking University
Energy Policy | Year: 2012

Nonrenewable energy cost is accounted for the believed renewable biofuel of corn-ethanol in China. By a process-based energy analysis, nonrenewable energy cost in the corn-ethanol production process incorporating agricultural crop production, industrial conversion and wastewater treatment is conservatively estimated as 1.70 times that of the ethanol energy produced, corresponding to a negative energy return in contrast to the positive ones previously reported. Nonrenewable energy cost associated with wastewater treatment usually ignored in previous researches is shown important in the energy balance. Denoting the heavy nonrenewability of the produced corn-ethanol, the calculated nonrenewable energy cost would rise to 3.64 folds when part of the nonrenewable energy cost associated with water consumption, transportation and environmental remediation is included. Due to the coal dominated nonrenewable energy structure in China, corn-ethanol processes in China are mostly a conversion of coal to ethanol. Validations and discussions are also presented to reveal policy implications against corn based ethanol as an alternative energy in long term energy security planning. © 2011 Elsevier Ltd. Source

Huang K.,Huazhong University of Science and Technology
Journal of Exposure Science and Environmental Epidemiology | Year: 2016

Early studies have investigated the effect of prenatal cadmium (Cd) exposure on birth outcomes, such as preterm birth and low birth weight, although the results of these studies are inconsistent. The aim of the present study was to investigate the association between prenatal exposure to Cd and the risk of preterm low birth weight (PLBW). A total of 408 mother–infant pairs (102 PLBW cases and 306 pair matched controls) were selected from the participants enrolled in the Healthy Baby Cohort (HBC) study between 2012 and 2014 in Hubei province, China. Concentrations of Cd in maternal urine collected before delivery were measured by inductively coupled plasma mass spectrometry and adjusted by creatinine. A significant association was observed between higher maternal urinary Cd levels and risk of PLBW (adjusted odds ratio (OR)=1.75 for the medium tertile, 95% confidence interval (CI): 0.88, 3.47; adjusted OR=2.51 for the highest tertile, 95% CI: 1.24, 5.07; P trend=0.03). The association was more pronounced among female infants than male infants. Our study suggested that prenatal exposure to Cd at the current level encountered in China may potentially increase the risk of delivering PLBW infants, particularly for female infants.Journal of Exposure Science and Environmental Epidemiology advance online publication, 20 July 2016; doi:10.1038/jes.2016.41. © 2016 Nature America, Inc. Source

Zhao L.,CAS Institute of Physics | Zhao J.,CAS Institute of Process Engineering | Hu Y.-S.,CAS Institute of Physics | Li H.,CAS Institute of Physics | And 4 more authors.
Advanced Energy Materials | Year: 2012

In this contribution, a cheap organic material, disodium terephthalate, Na 2C 8H 4O 4, has been firstly evaluated as a novel anode for room-temperature Na-ion batteries. The material exhibits a high reversible capacity of 250 mAh/g with excellent cycleability. The average Na storage voltage is approximately 0.43 V vs. Na +/Na. A thin layer of Al 2O 3 coating on the electrode surface derived from the atomic layer deposition technique is effective in further enhancing Na storage performance. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

Zhang M.,Huazhong University of Science and Technology
Cornea | Year: 2015

PURPOSE:: This study explored a new method for removing thermosensitive acrylic punctal plugs from lacrimal puncta. METHODS:: A total of 14 dry eye patients (14 eyes), who required the removal of thermosensitive acrylic punctal plugs from the lacrimal puncta because of serious complications, were recruited. Among the 14 patients, lacrimal punctal granuloma formation occurred in 3 patients, tearing occurred in 6 patients, canaliculitis occurred in 3 patients, and chronic inflammation of the ocular surface occurred in 2 patients. The plugs were removed using a new method. Briefly, after local anesthesia was administered, a small lid clamp was used to flip the eyelid outward. After the application of the lid clamp, the plug could be removed without the use of any additional tools if the lacrimal punctum was large enough. If the lacrimal punctum was not large enough, microforceps were used to expand the lacrimal punctum before the application of the lid clamp. If the plug still could not be removed after the expansion of the lacrimal punctum, we moved the small lid clamp from the distal side of the lacrimal ductule to the lacrimal punctum. RESULTS:: Using this method, the plug was successfully removed in all of the patients. CONCLUSIONS:: This is a simple and effective method for removing thermosensitive acrylic punctal plugs from lacrimal puncta. CLINICAL TRIAL REGISTRATION—URL:: http://www.clinicaltrials.gov. Unique identifier: ChiCTR-IPR-14005476. © 2015 Wolters Kluwer Health, Inc. All rights reserved. Source

Rong Y.,Huazhong University of Science and Technology
American journal of epidemiology | Year: 2012

The hemochromatosis gene (HFE) has been involved in the etiology of type 2 diabetes mellitus and investigated in numerous epidemiologic studies. The current meta-analysis was conducted to evaluate the gene-disease association in relevant studies. Electronic literature search was performed on June 18, 2011, from databases of PubMed/MEDLINE, EMBASE, and HuGE Navigator. Articles were inspected by 2 authors independently, and data were extracted by identical extraction form. A total of 5,528 type 2 diabetes cases and 6,920 controls in relation to HFE polymorphisms (a cysteine to tyrosine substitution at amino acid position 282 (C282Y) and a histidine to aspartate substitution at amino acid position 63 (H63D)) were included in the meta-analysis (1997-2011). A fixed- or random-effect model was used to calculate the pooled odds ratios based on the results from the heterogeneity tests. An increased odds ratio for type 2 diabetes mellitus was observed in persons carrying a D allele at the H63D polymorphism compared with those with an H allele (odds ratio (OR) = 1.21, 95% confidence interval (CI): 1.03, 1.41; P = 0.02). Moreover, carriers of a D allele had a modestly increased risk compared with persons with the wild genotype (OR = 1.12, 95% CI: 1.00, 1.25; P = 0.04). The C282Y variant was not significantly associated with diabetes risk. In summary, persons with a D allele may have a moderately increased risk of type 2 diabetes mellitus. Source

Yang M.,Huazhong University of Science and Technology | Kloeden P.E.,Goethe University Frankfurt
Nonlinear Analysis: Real World Applications | Year: 2011

The existence of a random attractor is established for a class of stochastic semi-linear degenerate parabolic equations with the leading term of the form div(σ(x)∇u) and additive spatially distributed temporal noise. The nonlinearity is dissipative for large values of the state without restriction on the growth order of the polynomial, while the spatial domain is either bounded or unbounded. © 2011 Elsevier Ltd. All rights reserved. Source

Wang L.,Huazhong University of Science and Technology | Dai H.L.,Hubei Key Laboratory for Engineering Structural Analysis and Safety Assessment
Archive of Applied Mechanics | Year: 2012

In this paper, the vibration and stability properties of fluid-conveying pipes with two symmetric elbows fitted at downstream end are investigated. The fluid, after entering from the upstream end, is pushed downwards and eventually exits from the downstream end fitted with two symmetric elbows. The equation of motion is solved by means of Galerkin's method with a four-mode approximation. Calculations are conducted for cantilevered and also for pinned-pinned slender pipes. It is found that the stability of the pipe system can be greatly enhanced with such downstream elbows. The vibration frequency of the fluid-conveying pipes can be comfortably controlled due to the downstream elbows with a selection of angle of inclination. The proposed geometry configuration of fluid-conveying pipes may be useful for the design and improvement of engineering pipeline systems and fluidic devices. © 2011 Springer-Verlag. Source

Wang N.,Osaka University | Wang N.,Huazhong University of Science and Technology | Tachikawa T.,Osaka University | Majima T.,Osaka University
Chemical Science | Year: 2011

Electronic communication between the building blocks of nanocomposites is an important property that affects their functionality with regard to many optoelectronic and catalytic applications. Herein, we report a single-molecule, single-particle approach for elucidating the inherent photocatalytic activity of individual Au nanoparticle-loaded TiO2 particles using a novel redox-responsive fluorescent dye. A single-particle kinetic analysis of the fluorescence bursts emitted from the products revealed that the photocatalytic activity leading to reduction of the probe molecules is controlled by not only the substrate concentration and excitation intensity but also the Au particle size, and that these factors are intricately interrelated. Furthermore, we discovered that the stochastic photocatalytic events around the millisecond-to-second time scale showed considerable temporal and spatial heterogeneity during photoirradiation, and that they actually originate from the charging/discharging of Au nanoparticles on TiO2. Our findings represent a significant contribution to the scientific understanding of the interfacial electron transfer dynamics in composite systems, and more fundamentally, in heterogeneous (photo)chemical processes. © The Royal Society of Chemistry 2011. Source

Jin G.Q.,Coventry University | Li W.D.,Coventry University | Gao L.,Huazhong University of Science and Technology
Robotics and Computer-Integrated Manufacturing | Year: 2013

This paper presents an adaptive approach to improve the process planning of Rapid Prototyping/Manufacturing (RP/M) for complex product models such as biomedical models. Non-Uniform Rational B-Spline (NURBS)-based curves were introduced to represent the boundary contours of the sliced layers in RP/M to maintain the geometrical accuracy of the original models. A mixed tool-path generation algorithm was then developed to generate contour tool-paths along the boundary and offset curves of each sliced layer to preserve geometrical accuracy, and zigzag tool-paths for the internal area of the layer to simplify computing processes and speed up fabrication. In addition, based on the developed build time and geometrical accuracy analysis models, adaptive algorithms were designed to generate an adaptive speed of the RP/M nozzle/print head for the contour tool-paths to address the geometrical characteristics of each layer, and to identify the best slope degree of the zigzag tool-paths towards achieving the minimum build time. Five case studies of complex biomedical models were used to verify and demonstrate the improved performance of the approach in terms of processing effectiveness and geometrical accuracy. © 2012 Elsevier Ltd. Source

Ouyang M.,Rice University | Ouyang M.,Huazhong University of Science and Technology | Duenas-Osorio L.,Rice University | Min X.,Rice University
Structural Safety | Year: 2012

This paper proposes a new multi-stage framework to analyze infrastructure resilience. For each stage, a series of resilience-based improvement strategies are highlighted and appropriate correlates of resilience identified, to then be combined for establishing an expected annual resilience metric adequate for both single hazards and concurrent multiple hazard types. Taking the power transmission grid in Harris County, Texas, USA, as a case study, this paper compares an original power grid model with several hypothetical resilience-improved models to quantify their effectiveness at different stages of their response evolution to random hazards and hurricane hazards. Results show that the expected annual resilience is mainly compromised by random hazards due to their higher frequency of occurrence relative to hurricane hazards. In addition, under limited resources, recovery sequences play a crucial role in resilience improvement, while under sufficient availability of resources, deploying redundancy, hardening critical components and ensuring rapid recovery are all effective responses regardless of their ordering. The expected annual resilience of the power grid with all three stage improvements increases 0.034% compared to the original grid. Although the improvement is small in absolute magnitude due to the high reliability of real power grids, it can still save millions of dollars per year as assessed by energy experts. This framework can provide insights to design, maintain, and retrofit resilient infrastructure systems in practice. © 2011 Elsevier Ltd. Source

Wang L.,Huazhong University of Science and Technology | Wang L.,Hubei Key Laboratory for Engineering Structural Analysis and Safety Assessment
Acta Mechanica Solida Sinica | Year: 2012

In the past decades, it has been reported that divergence is the expected form of instability for fluid-conveying pipes with both ends supported. In this paper, the form of instability of supported pipes conveying fluid subjected to distributed follower forces is investigated. Based on the Pflüger column model, the equation of motion for supported pipes subjected concurrently to internal fluid flow and distributed follower forces is established. The analytical model, after Galerkin discretization to two degrees of freedom, is evaluated by analyzing the corresponding eigenvalue problem. The complex frequencies versus fluid velocity are obtained for various system parameters. The results show that either buckling or flutter instabilities could occur in supported fluid-conveying pipes under the action of distributed follower forces, depending on the parameter values of distributed follower forces. © 2012 The Chinese Society of Theoretical and Applied Mechanics. Source

Candelaria S.L.,University of Washington | Chen R.,Intel Corporation | Chen R.,Huazhong University of Science and Technology | Jeong Y.-H.,Pohang University of Science and Technology | Cao G.,University of Washington
Energy and Environmental Science | Year: 2012

Highly porous carbon cryogels with tunable pore structure and chemical composition were synthesized through controlled hydrolysis and polycondensation reactions using different chemicals as precursors and either NaOH or hexamine (C 6N 12N 4) as catalysts. Gelation was followed with freeze drying to preserve the highly porous structure during solvent removal and controlled pyrolysis of the organic hydrogels and subsequent optional activation was performed. In addition, two different approaches were taken to modify the surface chemistry of porous carbon to introduce nitrogen or nitrogen-boron, leading to different porous structures and surface chemistry, as well as electrochemical properties. These carbon cryogels have been characterized and studied for energy storage applications. Specifically, they have been investigated as electrodes for electric double layer supercapacitors, high energy and high power density lithium-ion batteries with vanadium pentoxide deposited inside the pores, porous media for natural gas (methane) storage at reduced pressure, and scaffolds for hydride nanocomposites for greatly improved hydrogen storage. The relationship between processing conditions, chemical composition, pore structure, and energy storage properties are discussed. © The Royal Society of Chemistry 2012. Source

Lei W.-H.,University of Nevada, Las Vegas | Lei W.-H.,Huazhong University of Science and Technology | Zhang B.,University of Nevada, Las Vegas
Astrophysical Journal Letters | Year: 2011

Recently, a hard X-ray transient event, SwJ1644+57, was discovered by the Swift satellite. It likely marks the onset of a relativistic jet from a supermassive black hole (BH), possibly triggered by a tidal disruption event (TDE). Another candidate in the same category, SwJ2058+05, was also reported. The low event rate suggests that only a small fraction of TDEs launch relativistic jets. A common speculation is that these rare events are related to rapidly spinning BHs. We attribute jet launching to the Blandford-Znajek mechanism and use the available data to constrain the BH spin parameter for the two events. It is found that the two BHs indeed carry a moderate to high spin, suggesting that BH spin is likely the crucial factor behind the SwJ1644+57-like events. © 2011. The American Astronomical Society. All rights reserved. Source

Chen S.,Huazhong University of Science and Technology | Chen S.,National Technology Center
International Journal of Hydrogen Energy | Year: 2010

In this paper, entropy generation in counter-flow premixed hydrogen-air combustion confined by planar opposing jets is investigated for the first time. The effects of the equivalence ratio and the inlet Reynolds number (corresponding to the global stretch rate) on entropy generation are studied by numerical evaluating the entropy generation equation. The lattice Boltzmann model proposed in our previous work, instead of traditional numerical methods, is used to solve the governing equations for combustion process. Through the present study, three interesting features of this kind of combustion, which are quite different from that reported in previous literature on entropy generation analysis for reactive flows, are revealed. Moreover, it is observed that the whole investigated domain can be divided into two parts according to the predominant irreversibilities. The total entropy generation number can be approximated as a linear increasing function of the equivalence ratio and the inlet Reynolds number for all the cases under the present study. © 2009 Professor T. Nejat Veziroglu. Source

Zhang X.,Huazhong University of Science and Technology
Journal of Statistical Physics | Year: 2010

Global-in-time existence of weak solutions to the Cauchy problem of the three dimensional Vlasov-Poisson-BGK system is shown for initial data belonging to the space Lp(ℝ3×ℝ3) with p >9 and having finite second order velocity moments. This result solves partially the well-posed problem for the Vlasov-Poisson-BGK system proposed by B. Perthame: "Higher moments for kinetic equations: the Vlasov-Poisson and Fokker-Planck cases," Math. Meth. Appl. Sci. 13:441-452, 1990. © 2010 Springer Science+Business Media, LLC. Source

Cheng Z.,Huazhong University of Science and Technology
Physica A: Statistical Mechanics and its Applications | Year: 2010

We investigate a squeezed thermal spin state of nonlinear spin waves in Heisenberg ferromagnets. In this state, the magnon system possesses a new kind of quasiparticle, the dressed magnon, whose mass is a monotonically decreasing function of temperature. The noise of one spin component in the squeezed thermal spin state can be below the noise level in the vacuum state. The magnon system undergoes a first-order phase transition from the normal state to the squeezed thermal spin state. The critical temperature is much lower than the Curie temperature. A possible detection scheme based on a polarized neutron-scattering technique is suggested. © 2010 Elsevier B.V. All rights reserved. Source

Chen T.,Zhejiang GongShang University | Xiao R.,Huazhong University of Science and Technology
The Scientific World Journal | Year: 2014

Artificial bee colony (ABC) algorithm, inspired by the intelligent foraging behavior of honey bees, was proposed by Karaboga. It has been shown to be superior to some conventional intelligent algorithms such as genetic algorithm (GA), artificial colony optimization (ACO), and particle swarm optimization (PSO). However, the ABC still has some limitations. For example, ABC can easily get trapped in the local optimum when handing in functions that have a narrow curving valley, a high eccentric ellipse, or complex multimodal functions. As a result, we proposed an enhanced ABC algorithm called EABC by introducing self-adaptive searching strategy and artificial immune network operators to improve the exploitation and exploration. The simulation results tested on a suite of unimodal or multimodal benchmark functions illustrate that the EABC algorithm outperforms ACO, PSO, and the basic ABC in most of the experiments. © 2014 Tinggui Chen and Renbin Xiao. Source

Liu F.,Nanjing University of Aeronautics and Astronautics | Yan J.,Bel Power Company | Ruan X.,Huazhong University of Science and Technology
IEEE Transactions on Industrial Electronics | Year: 2010

This paper proposes a zero-voltage and zero-current-switching (ZVZCS) PWM combined three-level (TL) dc/dc converter, which is a combination of a ZVZCS PWM TL converter with a ZVZCS PWM full-bridge converter. The proposed converter has the following advantages: all power switches suffer only half of the input voltage; the voltage across the output filter is very close to the output voltage, which can reduce the output filter inductance significantly; and the voltage stress of the rectifier diodes is reduced too, so that the converter is very suitable for high input voltage and wide input voltage range applications. The converter also can achieve zero-voltage-switching for the leading switches and ZCS for the lagging switches in a wide load range to achieve higher efficiency. The design considerations and procedures are presented in this paper. The operation principle and characteristics of the proposed converter are analyzed and verified on a 400800-V input and 54-V/20-A output prototype. © 2006 IEEE. Source

He Y.,Huazhong University of Science and Technology | Keung Lai K.,City University of Hong Kong | Sun H.,City University of Hong Kong | Chen Y.,Hubei University of Economics
International Journal of Production Economics | Year: 2014

The impact of supply chain integration on new product development has been very well studied in literature. However, little literature examines the relationship between supplier integration and customer integration when they influence new product performance. This study aims to explore the complicated relationships among supplier integration, customer integration and new product performance via the mediating roles of manufacturing flexibility and service capability under the trust theory. The research is based on the data from International Manufacturing Strategy Survey (IMSS). It is found that both supplier integration and customer integration had positive direct effects on new product performance. It is also found that supplier integration has a positive impact on customer integration through the mediating role of manufacturing flexibility. The study contributes to supply chain integration by exploring the complicated relationship between supplier integration and customer integration based on the trust theory. It bears implications for both practice and future research. © 2013 Elsevier B.V. Source

Zhu S.,China University of Mining and Technology | Shen Y.,Huazhong University of Science and Technology
Neural Networks | Year: 2013

This paper analyzes the robustness of global exponential stability of stochastic recurrent neural networks (SRNNs) subject to parameter uncertainty in connection weight matrices. Given a globally exponentially stable stochastic recurrent neural network, the problem to be addressed here is how much parameter uncertainty in the connection weight matrices that the neural network can remain to be globally exponentially stable. We characterize the upper bounds of the parameter uncertainty for the recurrent neural network to sustain global exponential stability. A numerical example is provided to illustrate the theoretical result. © 2012 Elsevier Ltd. Source

Zhou S.,Nanchang Hangkong University | Zeng X.,Huazhong University of Science and Technology
Journal of Alloys and Compounds | Year: 2010

WC-reinforced Fe matrix composite coatings were prepared by laser induction hybrid rapid cladding (LIHRC). X-ray diffraction (XRD) was used to identify the phases and the growth characteristics of the precipitated carbides were observed by environmental scanning electron microscope (ESEM). The results show that WC particles are almost dissolved completely and interact with Fe-based alloy liquid in the molten pool to precipitate M6C carbides with different shapes during LIHRC. With increasing the weight percent of WC particles, the transition from the fine M6C carbides, which are precipitated in an intergranular network of the coarse α-Fe, to the coarse herringbone M6C eutectics and the primary faceted dendritic M 6C occur and the partially dissolved WC particles with an alloyed reaction layer can be occasionally found in the composite coating. Moreover, the eutectic M6C carbides in herringbone shape grow in terms of the intergrowth mode of layer and slice, while the primary faceted dendritic M 6C in equiaxial branched shape are only precipitated in the crossed region of the coarse eutectic carbides and grow in terms of dissolution and propagation. © 2010 Elsevier B.V.All rights reserved. Source

Zhu S.,Huazhong University of Science and Technology
Nonlinearity | Year: 2010

Let μ be a self-conformal measure on Rd associated with a family of contractive conformal mappings {fi}N i=1 and a probability vector (pi)N i=1. When {fi}N i=1 satisfies the strong separation condition, we determine the quantization dimension D(μ) with respect to the geometric mean error and show that D(μ) coincides with the Hausdorff dimension of μ. Various expressions for the Hausdorff dimension dim H μ of μ are established in terms of cylinder sets for the proof of the main result. © 2010 IOP Publishing Ltd & London Mathematical Society. Source

Liu X.,Wuhan University of Science and Technology | Liu X.,Huazhong University of Science and Technology | Tang J.,Michigan Technological University
IEEE Systems Journal | Year: 2014

Masses are the primary indications of breast cancer in mammograms, and it is important to classify them as benign or malignant. Benign and malignant masses differ in geometry and texture characteristics. However, not every geometry and texture feature that is extracted contributes to the improvement of classification accuracy; thus, to select the best features from a set is important. In this paper, we examine the feature selection methods for mass classification. We integrate a support vector machine (SVM)-based recursive feature elimination (SVM-RFE) procedure with a normalized mutual information feature selection (NMIFS) to avoid their singular disadvantages (the redundancy in the selected features of the SVM-RFE and the unoptimized classifier for the NMIFS) while retaining their advantages, and we propose a new feature selection method, which is called the SVM-RFE with an NMIFS filter (SRN). In addition to feature selection, we also study the initialization of mass segmentation. Different initialization methods are investigated, and we propose a fuzzy c-means (FCM) clustering, with spatial constraints as the initialization step. In the experiments, 826 regions of interest (ROIs) from the Digital Database for Screening Mammography were used. All 826 were used in the classification experiments, and 413 ROIs were used in the feature selection experiments. Different feature selection methods, including F-score, Relief, SVM-RFE, SVM-RFE with a minimum redundancy-maximum relevance (mRMR) filter [SVM-RFE (mRMR)], and SRN, were used to select features and to compare mass classification results using the selected features. In the classification experiments, the linear discriminant analysis and the SVM classifiers were investigated. The accuracy that is obtained with the SVM classifier using the selected features obtained by the F-score, Relief, SVM-RFE, SVM-RFE (mRMR), and SRN methods are 88 %, 88 %, 90 %, 91 %, and 93 %, respectively, with a tenfold cross-validation procedure, and 91 %, 89 %, 92 %, 92 %, and 94 %, respectively, with a leave-one-out (LOO) scheme. We also compared the performance of the different feature selection methods using the receiver operating characteristic analysis and the areas under the curve (AUCs). The AUCs for the F-score, Relief, SVM-RFE, SVM-RFE (mRMR), and SRN methods are 0.9014, 0.8916, 0.9121, 0.9236, and 0.9439, respectively, with a tenfold cross-validation procedure, and are 0.9312, 0.9178, 0.9324, 0.9413, and 0.9615, respectively, with a LOO scheme. Both the accuracy and AUC values show that the proposed SRN feature selection method has the best performance. In addition to the accuracy and the AUC, we also measured the significance between the two best feature selection methods, i.e., the SVM-RFE (mRMR) and the proposed SRN method. Experimental results show that the proposed SRN method is significantly more accurate than the SVM-RFE (mRMR) (p = 0.011). © 2014 IEEE. Source

Lin S.,Huazhong University of Science and Technology
Nan fang yi ke da xue xue bao = Journal of Southern Medical University | Year: 2013

Ouyang M.,Huazhong University of Science and Technology | Duenas-Osorio L.,Rice University
Structural Safety | Year: 2014

Electric power systems are critical to economic prosperity, national security, public health and safety. However, in hurricane-prone areas, a severe storm may simultaneously cause extensive component failures in a power system and lead to cascading failures within it and across other power-dependent utility systems. Hence, the hurricane resilience of power systems is crucial to ensure their rapid recovery and support the needs of the population in disaster areas. This paper introduces a probabilistic modeling approach for quantifying the hurricane resilience of contemporary electric power systems. This approach includes a hurricane hazard model, component fragility models, a power system performance model, and a system restoration model. These coupled four models enable quantifying hurricane resilience and estimating economic losses. Taking as an example the power system in Harris County, Texas, USA, along with real outage and restoration data after Hurricane Ike in 2008, the proposed resilience assessment model is calibrated and verified. In addition, several dimensions of resilience as well as the effectiveness of alternative strategies for resilience improvement are simulated and analyzed. Results show that among technical, organizational and social dimensions of resilience, the organizational resilience is the highest with a value of 99.964% (3.445 in a proposed logarithmic scale) while the social resilience is the lowest with a value of 99.760% (2.620 in the logarithmic scale). Although these values seem high in absolute terms due to the reliability of engineered systems, the consequences of departing from ideal resilience are still high as economic losses can add up to \$83 million per year. © 2014 Elsevier Ltd. Source

Lei M.,Huazhong University of Science and Technology
Journal of the American Ceramic Society | Year: 2015

A theoretical study was carried out to analyze the impact of composite effect on dielectric constant and tunability in the ferroelectric-dielectric system. Models of Ba0.5Sr0.5TiO3-Mg2TiO4, Ba0.45Sr0.55TiO3-MgO and Ba0.5Sr0.5TiO3-MgO-Mg2SiO4 system were constructed. The corresponding dielectric constant, tunability, and electric field distribution were obtained from the finite element analysis and the connections between these parameters were analyzed. The effects of the relative relationship between the dielectric constant of ferroelectric and dielectric on the whole dielectric properties were also analyzed by constructing a series of models with different dielectrics. © 2015 The American Ceramic Society. Source

Lu H.-J.,University of Nevada, Las Vegas | Zhang B.,University of Nevada, Las Vegas | Lei W.-H.,Huazhong University of Science and Technology | Li Y.,University of Nevada, Las Vegas | And 2 more authors.
Astrophysical Journal | Year: 2015

One favored progenitor model for short duration gamma-ray bursts (GRBs) is the coalescence of two neutron stars (NS-NS). One possible outcome of such a merger would be a rapidly spinning, strongly magnetized neutron star (known as a millisecond magnetar). These magnetars may be "supra-massive," implying that they would collapse to black holes after losing centrifugal support due to magnetic dipole spin down. By systematically analyzing the Burst Alert Telescope (BAT)-XRT light curves of all short GRBs detected by Swift, we test how consistent the data are with this central engine model of short GRBs. We find that the so-called "extended emission" feature observed with BAT in some short GRBs is fundamentally the same component as the "internal X-ray plateau" observed in many short GRBs, which is defined as a plateau in the light curve followed by a very rapid decay. Based on how likely a short GRB is to host a magnetar, we characterize the entire Swift short GRB sample into three categories: the "internal plateau" sample, the "external plateau" sample, and the "no plateau" sample. Based on the dipole spin-down model, we derive the physical parameters of the putative magnetars and check whether these parameters are consistent with expectations from the magnetar central engine model. The derived magnetar surface magnetic field and the initial spin period P0 fall into a reasonable range. No GRBs in the internal plateau sample have a total energy exceeding the maximum energy budget of a millisecond magnetar. Assuming that the beginning of the rapid fall phase at the end of the internal plateau is the collapse time of a supra-massive magnetar to a black hole, and applying the measured mass distribution of NS-NS systems in our Galaxy, we constrain the neutron star equation of state (EOS). The data suggest that the NS EOS is close to the GM1 model, which has a maximum non-rotating NS mass of . © 2015. The American Astronomical Society. All rights reserved. Source

Ma R.,Huazhong University of Science and Technology
Nature communications | Year: 2013

Gluconeogenesis is a fundamental feature of hepatocytes. Whether this gluconeogenic activity is also present in malignant hepatocytes remains unexplored. A better understanding of this biological process may lead to novel therapeutic strategies. Here we show that gluconeogenesis is not present in mouse or human malignant hepatocytes. We find that two critical enzymes 11β-HSD1 and 11β-HSD2 that regulate glucocorticoid activities are expressed inversely in malignant hepatocytes, resulting in the inactivation of endogenous glucocorticoids and the loss of gluconeogenesis. In patients' hepatocarcinoma, the expression of 11β-HSD1 and 11β-HSD2 is closely linked to prognosis and survival. Dexamethasone, an active form of synthesized glucocorticoids, is capable of restoring gluconeogenesis in malignant cells by bypassing the abnormal regulation of 11β-HSD enzymes, leading to therapeutic efficacy against hepatocarcinoma. These findings clarify the molecular basis of malignant hepatocyte loss of gluconeogenesis and suggest new therapeutic strategies. Source

Liu S.,Wuhan University | Wang L.,Huazhong University of Science and Technology
International Journal of Project Management | Year: 2014

Successfully managing the risks of information technology projects continues to be a central problem for organizations regardless of whether the project is outsourced or not. While a plethora of studies has examined the effects of risks on performance, majority fail to distinguish the sourcing characteristics of the projects investigated. Furthermore, little is known about the joint effects of strategic importance and the risk on system performance across internal and outsourced projects. Based on data collected from 77 internal projects and 51 outsourced projects, we find that social subsystem and project management risks are negatively associated with system performance in both internal and outsourced projects. However, technical subsystem risk negatively affects performance only in internal projects. While social subsystem risk exerts greater influence on system performance in outsourced projects than in internal projects, the technical subsystem risk has greater effect on performance in internal than that in outsourced projects. Moreover, the effect of project management risk is not different in both types of projects. In addition, strategic importance moderates the relationship between risks and performance. The negative impact of risks on performance is greater in projects that are more strategic. Strategies are proposed to reduce the complexity and potential conflicts inherent to strategic projects because these characteristics may amplify a risk's impact. © 2014. Source

Zhu G.-R.,Wuhan University of Technology | Tan S.-C.,University of Hong Kong | Chen Y.,Huazhong University of Science and Technology | Tse C.K.,Hong Kong Polytechnic University
IEEE Transactions on Power Electronics | Year: 2013

Fuel-cell power systems comprising single-phase dc/ac inverters draw low-frequency ac ripple currents at twice the output frequency from the fuel cell. Such a 100/120Hz ripple current may create instability in the fuel-cell system, lower its efficiency, and shorten the lifetime of a fuel cell stack. This paper presents a waveform control method that can mitigate such a low-frequency ripple current being drawn from the fuel cell while the fuel-cell system delivers ac power to the load through a differential inverter. This is possible because with the proposed solution, the pulsation component (cause of ac ripple current) of the output ac power will be supplied mainly by the two output capacitors of the differential inverter while the average dc output power is supplied by the fuel cell. Theoretical analysis, simulation, and experimental results are provided to explain the operation and showcase the performance of the approach. Results validate that the proposed solution can achieve significant mitigation of the current ripple as well as high-quality output voltage without extra hardware. Application of the solution is targeted at systems where current ripple mitigation is required, such as for the purpose of eliminating electrolytic capacitor in photovoltaic and LED systems. © 1986-2012 IEEE. Source

Huang W.-Z.,Wuhan Institute of Technology | Huang Y.,Huazhong University of Science and Technology
International Journal of Bifurcation and Chaos | Year: 2011

Chaos, bifurcation and robustness of a new class of Hopfield neural networks are investigated. Numerical simulations show that the simple Hopfield neural networks can display chaotic attractors and limit cycles for different parameters. The Lyapunov exponents are calculated, the bifurcation plot and several important phase portraits are presented as well. By virtue of horseshoes theory in dynamical systems, rigorous computer-assisted verifications for chaotic behavior of the system with certain parameters are given, and here also presents a discussion on the robustness of the original system. Besides this, quantitative descriptions of the complexity of these systems are also given, and a robustness analysis of the system is presented too. © 2011 World Scientific Publishing Company. Source

Zhang C.,Huazhong University of Science and Technology
European review for medical and pharmacological sciences | Year: 2012

Ankylosing spondylitis (AS) is a chronic inflammatory arthritis involving primarily the sacroiliac joints and the axial skeleton that can lead to bone resorption and bone formation, ultimately resulting in ankylosis. However, our understanding of the genetic mechanisms of AS are far from being clear. In this study, we identified the differentially expressed genes (DEGs) in AS samples compared with healthy control, and mapped these DEGs to the protein-protein interaction network. We applied a statistical approach of MCODE to cluster proteins in the network. Six functional modules were identified in our network. Functional studies of these 6 modules suggest that the DEGs may play roles in both the inflammatory environment and bone and cartilage effects. We anticipate the results from this study will provide the groundwork for the understanding of AS pathogenesis. Source

Gu L.,Harbin Institute of Technology | Wang J.,Huazhong University of Science and Technology | Wang J.,Harbin Institute of Technology | Zou Z.,Harbin Institute of Technology | Han X.,Harbin Institute of Technology
Journal of Hazardous Materials | Year: 2014

Anatase TiO2 nanosheets with dominant {001} facets were hybridized with graphitic carbon nitride (g-C3N4) using a facile solvent evaporation method. On top of the superior photocatalytic performance of highly reactive {001} facets, the hybridization with g-C3N4 is confirmed to further improve the reactivity through degrading a series of organic molecules under both UV- and visible-light irradiation. It is proposed that an effective charge separation between g-C3N4 and TiO2 exists in the photocatalytic process, i.e., the transferring of photogenerated holes from the valence band (VB) of TiO2 to the highest occupied molecular orbital (HOMO) of g-C3N4, and the injecting of electrons from the lowest unoccupied molecular orbital (LUMO) of g-C3N4 to the conduction band (CB) of TiO2. Due to this synergistic effect, the enhancement of UV- and visible-light photoactivity over the hybrid is achieved. Furthermore, it has been revealed that holes were the main factor for the improved photoactivity under UV-light, while the OH radicals gained the predominance for degrading organic molecules under visible-light. Overall, this work would be significant for fabricating efficient UV-/visible-photocatalysts and providing deeper insight into the enhanced mechanisms of π-conjugated molecules hybridized semiconductors. © 2014 Elsevier B.V. Source

Pan Q.-K.,Liaocheng University | Wang L.,Tsinghua National Laboratory for Information Sciences and Technology | Gao L.,Huazhong University of Science and Technology | Li W.D.,Coventry University
Information Sciences | Year: 2011

In this paper, an effective hybrid discrete differential evolution (HDDE) algorithm is proposed to minimize the maximum completion time (makespan) for a flow shop scheduling problem with intermediate buffers located between two consecutive machines. Different from traditional differential evolution algorithms, the proposed HDDE algorithm adopted job permutation to represent individuals and applies job-permutation-based mutation and crossover operations to generate new candidate solutions. Moreover, a one-to-one selection scheme with probabilistic jumping is used to determine whether the candidates will become members of the target population in next generation. In addition, an efficient local search algorithm based on both insert and swap neighborhood structures is presented and embedded in the HDDE algorithm to enhance the algorithm's local searching ability. Computational simulations and comparisons based on the well-known benchmark instances are provided. It shows that the proposed HDDE algorithm is not only capable to generate better results than the existing hybrid genetic algorithm and hybrid particle swarm optimization algorithm, but outperforms two recently proposed discrete differential evolution (DDE) algorithms as well. Especially, the HDDE algorithm is able to achieve excellent results for large-scale problems with up to 500 jobs and 20 machines. © 2010 Elsevier Inc. All rights reserved. Source

Liu H.,Huazhong University of Science and Technology
Journal of Geotechnical and Geoenvironmental Engineering | Year: 2016

A nonlinear elastic method to analyze the reinforcement loads at the potential failure surface of a reinforced soil composite without facing restriction is developed in this study. The method makes use of the compatible deformations of soil and reinforcement at the potential failure surface and employs the hyperbolic stress-strain relationship to determine the tangential modulus of soil. Nonconstant Poisson-s ratio, nonlinear reinforcement load-strain behavior, and nonuniform reinforcement spacing can be taken into account. Effect of soil compaction is conveniently modeled by an equivalent compaction pressure and a pressure-dependent unloading-reloading Young-s modulus. The method can be implemented by a simple computer code. Four numerical model walls and four large-scale tests of reinforced soil composites were employed to validate the proposed method. It was shown that the method can be used to analyze the reinforcement loads of reinforced soil composites under working stress conditions. The method excludes the necessity to carry out sophisticated numerical analyses to determine the reinforcement loads. © 2016 American Society of Civil Engineers. Source

Liu T.,Huazhong University of Science and Technology
Bioresource technology | Year: 2013

A novel oriented immobilized lipase was derived from Yarrowia lipolytica lipase LIP2 covalently immobilized on functionalized Fe3O4 magnetic nanoparticles (MNPs) in reverse micelles system (RMS). The activity recovery reached 382% compared with 29% in aqueous phase, and further ran up to 1425% under optimum conditions. (3-Aminopropyl) triethoxysilane (APTES) coated Fe3O4 nanoparticles were characterized by Fourier transform infrared (FT-IR) and X-ray diffraction (XRD). A significant alteration in the secondary structure of the lipase in RMS with a 15.5% increase of α-helix content and a 12.5% decrease of β-sheet content was detected by circular dichroism (CD). The immobilized lipase was employed to enrich polyunsaturated fatty acids in fish oil, a 90% increase of DHA content was obtained after 12h, and after 20 cycles of successive usage, it still remained over 80% of relative hydrolysis degree, which shows a good recyclability. Copyright © 2013 Elsevier Ltd. All rights reserved. Source

Su H.,Huazhong University of Science and Technology | Chen M.Z.Q.,University of Hong Kong | Wang X.,Shanghai JiaoTong University | Lam J.,University of Hong Kong
IEEE Transactions on Industrial Electronics | Year: 2014

This paper studies the observer-based leader-following consensus of a linear multiagent system on switching networks, in which the input of each agent is subject to saturation. Based on a low-gain output feedback method, distributed consensus protocols are developed. Under the assumptions that the networks are connected or jointly connected and that each agent is asymptotically null controllable with bounded controls and detectable, semiglobal observer-based leader-following consensus of the multiagent system can be reached on switching networks. A numerical example is presented to illustrate the theoretical results. © 1982-2012 IEEE. Source

Wei T.,University of South Carolina | Singh P.,University of Texas at Austin | Gong Y.,University of South Carolina | Goodenough J.B.,University of Texas at Austin | And 2 more authors.
Energy and Environmental Science | Year: 2014

We here report that a newly discovered superior oxide-ion conductor Sr 3-3xNa3xSi3O9-1.5x (x = 0.45) (SNS) demonstrates full potential to be a practical solid electrolyte for intermediate temperature-solid oxide fuel cells (IT-SOFCs). It exhibits the highest oxide-ion conductivity with the lowest activation energy among all the chemically stable solid oxide-ion conductors reported. The ionic conductivity is stable over a broad range of partial pressures of oxygen (10-30 to 1 atm) for an extended period of time. A SOFC based on a 294 μm thick SNS-electrolyte produces peak power densities of 431 and 213 mW cm-2 at 600 and 500 °C, respectively. Considering its competitive costs in materials and manufacturing and rare-earth free composition, SNS has great potential to become a new class of technologically and strategically important electrolytes for commercial IT-SOFCs. This journal is © 2014 the Partner Organisations. Source

Zhang X.,Huazhong University of Science and Technology | Zhang X.,Hubei Key Laboratory of Engineering Structural Analysis and Safety Assessment | Zhang H.,Wuhan Textile University
International Journal of Impact Engineering | Year: 2014

Multi-cell columns are highly efficient energy absorbing components under axial compression. However, the experimental investigations and theoretical analyses for the deformation modes and mechanisms of them are quite few. In this paper, the axial crushing of circular multi-cell columns are studied experimentally, numerically and theoretically. Circular multi-cell columns with different sections are axially compressed quasi-statically and numerical analyses are carried out by nonlinear finite element code LS-DYNA to simulate the experiments. The deformation modes of the multi-cell columns are described and the energy absorption properties of them are compared with those of simple circular tube. Theoretical models based on the constituent element method are then proposed to predict the crush resistance of circular multi-cell specimens. The theoretical predictions are found to be in a good agreement with the experimental and numerical results. © 2013 Elsevier Ltd. All rights reserved. Source

Tan J.G.,Huazhong University of Science and Technology
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] | Year: 2012

This study aimed to explore and evaluate the effects of combination intervention model conducted by Center for Disease Control and Prevention and activity place to men who have sex with men (MSM). To implement one-year combination intervention in 4 MSM venues during May, 2009 and April, 2010. Meanwhile, 3 similar MSM venues were chosen as control. MSM places introduced CDC to consumption crowds. Experts and volunteers sent by CDC undertook health education programme on site and condom, lubricant, pamphlet, consultation, test were provided at the same time. The intervention measures applied to control only included providing pamphlet, condom, lubricant by volunteers. Investigations were conducted among subjects of combination intervention group and control group before (111, 120 subjects) and after (105, 98 subjects) the intervention with questions related to knowledge and behavior of AIDS prevention. After one-year intervention, among MSM with combination intervention, the awareness rate of knowledge level about acquired immune deficiency syndrome (AIDS) increased from 73.0% (81/111) to 91.7% (110/120), proportion of condom-use with male at last anal intercourse increased from 73.0% (81/111) to 85.0% (102/120), ratio of never-use condom with male decreased from 10.8% (11/102) to 1.7% (2/112), percentage of acquiring AIDS-related service and intervention improved significantly, acquiring condom (lubricant) increased from 70.3% (78/111) to 85.0% (102/120), acquiring peer education increased from 10.8% (12/111) to 24.2% (29/120), the proportion of acquiring counseling and testing of HIV increased from 69.4% (77/111) to 90.8% (109/120) (all P values < 0.05). The above index show no statistic difference before and after the intervention (all P values > 0.05) in control MSM venues. Combination intervention model was an effective intervention model contributing to an increase in knowledge of AIDS prevention and decreasing high risk behavior in MSM population. Source

Tsai C.-W.,Chia Nan University of Pharmacy and Science | Lai C.-F.,National Chung Cheng University | Chiang M.-C.,National Sun Yat - sen University | Yang L.T.,Huazhong University of Science and Technology | Yang L.T.,St. Francis Xavier University
IEEE Communications Surveys and Tutorials | Year: 2014

It sounds like mission impossible to connect everything on the earth together via internet, but Internet of Things (IoT) will dramatically change our life in the foreseeable future, by making many «impossibles» possible. To many, the massive data generated or captured by IoT are considered having highly useful and valuable information. Data mining will no doubt play a critical role in making this kind of system smart enough to provide more convenient services and environments. This paper begins with a discussion of the IoT. Then, a brief review of the features of «data from IoT» and «data mining for IoT' is given». Finally, changes, potentials, open issues, and future trends of this field are addressed. © 2014 IEEE. Source

Shan B.,Huazhong University of Science and Technology | Shan B.,University of Texas at Dallas | Cho K.,University of Texas at Dallas
Chemical Physics Letters | Year: 2010

Nitrogen-doped (N-doped) single wall nanotubes (SWNTs) have recently been shown to have good catalytic reactivity towards oxygen reduction reaction (ORR). We used density functional theory calculations to explore reaction paths for facile oxygen dissociation on modified SWNTs, including nitrogen doping, Stone-Wales (SW) defects, and a combination of these two. It was found that oxygen dissociation is facilitated on carbon atoms neighboring a nitrogen dopant, with the dissociation barrier reduced from 2 eV to 0.68 eV. The activation barrier can be further reduced to 0.03 eV in the vicinity of a N-doped SW defect. The reduction in barrier height is explained through the local density of states analysis. © 2010 Elsevier B.V. All rights reserved. Source

Liu H.,Huazhong University of Science and Technology | Won M.-S.,Kunsan National University
Journal of Engineering Mechanics | Year: 2014

A straightforward analytical method is proposed to calculate the reinforcement loads of vertical-reinforced soil composites before the strength of soil is fully mobilized. The method assumes compatibility of soil and reinforcement deformations along the potential failure surface. It makes use of the nonlinear stress-strain relationship of soil in a plane-strain condition and Rowe's stress-dilatancy relationship. It has the advantage of taking into account the soil dilatancy before failure and can properly estimate the reinforcement load with small or medium soil deformation. The effect of soil compaction on the reinforcement load is taken into account through an elastic unloading/reloading approach. The method was first validated against the results of a calibrated numerical analysis. It was then used to predict the reinforcement loads of two large-scale tests. The proposed method has the potential to fully develop into an analytical method for reinforced soil retaining walls, provided that effects of facing restriction and compaction can be quantified.DOI:10.1061/(ASCE)EM.1943-7889.0000686. © 2014 American Society of Civil Engineers. Source

Tu L.,Huazhong University of Science and Technology | Huang C.-M.,National Cheng Kung University
IEEE Transactions on Vehicular Technology | Year: 2010

Collision warning is one of the most important functions of a vehicle safety system. The emergence and expansion of the applications of positioning techniques and dedicated short-range communication (DSRC) have promoted the collision warning system evolution from a simple ranging-sensor-based system to a cooperative system. Differing from prior work that relied heavily on the e-Map, high-accuracy differential Global Positioning System (DGPS), or advanced car features like the controller area network (CAN) bus, this paper proposes Forwards, i.e., a map-free intersection collision-warning system for all road patterns with lower requirement and lower cost accessories. Forwards employs a triple Kalman filter (tri-KF)-based estimator that integrates GPS and external inertial sensor measurement to provide calibrated motion state information (MSI) such as position, velocity, and acceleration of the vehicle. Each vehicle then adaptively broadcasts its own MSI via the DSRC-based protocol. Using the steady-state maneuvering model, short-term trajectories of local and neighboring vehicles are further predicted, based on their current MSI. Collision-detection algorithms are then designed based on the model of finding the minimum distance of vehicles' future trajectories, and hierarchical warnings are given upon different criteria. Simulation results show that our approach outperforms the referenced approach in successful warning ratio and requires far fewer accessories and external conditions than the other referenced approaches. © 2006 IEEE. Source

Shao S.,Huazhong University of Science and Technology | Li X.,China Three Gorges University
Journal of Neurosurgical Sciences | Year: 2013

Jia Q.,Huazhong University of Science and Technology
PloS one | Year: 2013

Diamond-Blackfan anemia (DBA) is a rare inherited bone marrow failure syndrome that is characterized by pure red-cell aplasia and associated physical deformities. It has been proven that defects of ribosomal proteins can lead to this disease and that RPS19 is the most frequently mutated gene in DBA patients. Previous studies suggest that p53-dependent genes and pathways play important roles in RPS19-deficient embryos. However, whether there are other vital factors linked to DBA has not been fully clarified. In this study, we compared the whole genome RNA-Seq data of zebrafish embryos injected with RPS19 morpholino (RPS19 MO), RPS19 and p53 morpholino simultaneously (RPS19+p53 MO) and control morpholino (control). We found that genes enriched in the functions of hematological systems, nervous system development and skeletal and muscular disorders had significant differential expression in RPS19 MO embryos compared with controls. Co-inhibition of p53 partially alleviates the abnormalities for RPS19-deficient embryos. However, the hematopoietic genes, which were down-regulated significantly in RPS19 MO embryos, were not completely recovered by the co-inhibition of p53. Furthermore, we identified the genome-wide p53-dependent and -independent genes and pathways. These results indicate that not only p53 family members but also other factors have important impacts on RPS19-deficient embryos. The detection of potential pathogenic genes and pathways provides us a new paradigm for future research on DBA, which is a systematic and complex hereditary disease. Source

Chang H.,Tohoku University | Chang H.,Huazhong University of Science and Technology | Wu H.,Tohoku University | Wu H.,Hong Kong University of Science and Technology
Energy and Environmental Science | Year: 2013

Graphene, a two-dimensional carbon sheet with one atom thickness and one of the thinnest materials in universe, has inspired huge interest in physics, materials science, chemistry and biology. However, pure graphene sheets are limited for many applications despite their excellent characteristics and scientists face challenges to induce more and controlled functionality. Therefore graphene nanocomposites or hybrids are attracting increasing efforts for real applications in energy and environmental areas by introducing controlled functional building blocks to graphene. In this Review, we first give a brief introduction of graphene's unique physical and chemical properties followed by various preparation and functionalization methods for graphene nanocomposites in the second section. We focus on recent energy-related progress of graphene nanocomposites in solar energy conversion (e.g., photovoltaic and photoelectrochemical devices, artificial photosynthesis) and electrochemical energy devices (e.g., lithium ion battery, supercapacitor, fuel cell) in the third section. We then review the advances in environmental applications of functionalized graphene nanocomposites for the detection and removal of heavy metal ions, organic pollutants, gas and bacteria in the fourth section. Finally a conclusion and perspective is given to discuss the remaining challenges for graphene nanocomposites in energy and environmental science. © 2013 The Royal Society of Chemistry. Source

Yao K.,Nanjing University of Aeronautics and Astronautics | Ruan X.,Huazhong University of Science and Technology | Mao X.,Nanjing University of Aeronautics and Astronautics | Ye Z.,Lite-On Technology
IEEE Transactions on Industrial Electronics | Year: 2011

A discontinuous-current-mode (DCM) boost power factor correction (PFC) converter features zero-current turn-on for the switch, no reverse recovery in diode, and constantfrequency operation. However, the input power factor (PF) is relatively low when the duty cycle is constant in a half line cycle. This paper derives the expressions of the input current and PF of the DCM boost PFC converter, and based on that, variable-duty-cycle control is proposed so as to improve the PF to nearly unity in the whole inputvoltage range. A method of fitting the duty cycle is further proposed for simplifying the circuit implementation. Other than a higher PF, the proposed variable-duty-cycle control achieves a lower outputvoltage ripple and a higher efficiency over constant-duty-cycle control. The experimental results from a 120-W universal input prototype are presented to verify the effectiveness of the proposed method. © 2010 IEEE. Source

Yin X.,Huazhong University of Science and Technology
Medical Care | Year: 2015

BACKGROUND:: This study was the first of its kind to evaluate and compare the quality of private and public community health centers (CHCs) in urban China. METHODS:: A total of 2501 CHCs in 35 cities were chosen in 2011 using a multistage sampling method, and data on human resources, medical equipment and drug inventory were collected. A subset of 422 CHCs was randomly selected and 100 prescriptions from each CHCs were reviewed to evaluate prescribing practice. In total, 12,386 patients who visited the selected 422 CHCs were interviewed to assess patient satisfaction and payments. RESULTS:: Controlling for population covered per CHC and geographic regions, private CHCs were higher than public CHCs in average building area (2310.96 vs. 2000.92 square meters), average number of medical equipment (6.42 vs. 6.14), average number of physicians and nurses per 10,000 population (4.86 vs. 3.81 and 3.38 vs. 2.62), and average number of medicines in stock (435.08 vs. 375.83), but lower in average percentage of medicines on the national essential medicines list (67.29% vs. 77.55%). Prescriptions from private CHCs had significantly higher number of drugs per prescription (2.38 vs. 2.24), higher percentage of prescriptions with injections (36.44% vs. 30.50%), and higher percentage of prescriptions with antibiotics (37.17% vs. 30.14%). Patient satisfaction was similar between the 2 groups, and patient payments per visit were lower in private CHCs after controlling for patients’ sociodemographic characteristics. CONCLUSIONS:: Private CHCs are better equipped and better staffed than public CHCs but are less compliant with national policy on essential medicines and have poorer prescribing quality in China, warranting more rigorous government supervision. © 2015 Wolters Kluwer Health, Inc. All rights reserved. Source

Rong Y.,Huazhong University of Science and Technology
PloS one | Year: 2013

MicroRNAs (miRNAs), a class of small non-coding RNAs, are thought to serve as crucial regulators of gene expression. Dysregulated expression of miRNAs has been described in various diseases and may contribute to related pathologic processes. Our aim was to examine circulating miRNA-146a levels in newly diagnosed type 2 diabetes mellitus (new-T2DM) patients from a Chinese Han population. Circulating miRNA-146a was extracted from plasma samples of 90 new-T2DM patients and 90 age- and sex-matched controls. Quantitative PCR assessment revealed that circulating miRNA-146a levels were significantly elevated in new-T2DM patients compared with controls. Participants in the highest tertile of circulating miRNA-146a levels showed a notably higher risk for new-T2DM (crude OR 4.333, 95% CI, 1.935 to 9.705, P = 0.001) than persons in the lowest tertile. Controlling for known risk factors and some biochemical indicators did not attenuate the aforementioned association. In addition, receiver operating characteristic (ROC) curves generated for miRNA-146a revealed an area under the curve (AUC) of 0.725 (95% CI, 0.651 to 0.799, P < 0.001). Moreover, higher circulating miRNA-146a levels were significantly associated with higher plasma heme oxygenase-1 (HO-1) concentrations (β coefficient = 0.131, P < 0.001) and lower HOMA-beta (β coefficient = -0.153, P = 0.015). We found that circulating miRNA-146a levels were significantly elevated in new-T2DM patients compared with healthy controls. Whether expression of circulating miRNA-146a holds predictive value for T2DM warrants further investigations. Source

Wang J.,Huazhong University of Science and Technology
Frontiers of Optoelectronics | Year: 2014

Plasmonics squeezes light into dimensions far beyond the diffraction limit by coupling the light with the surface collective oscillation of free electrons at the interface of a metal and a dielectric. Plasmonics, referred to as a promising candidate for high-speed and high-density integrated circuits, bridges microscale photonics and nanoscale electronics and offers similar speed of photonic devices and similar dimension of electronic devices. Various types of passive and active surface plasmon polariton (SPP) enabled devices with enhanced deep-subwavelength mode confinement have attracted increasing interest including waveguides, lasers and biosensors. Despite the trade-off between the unavoidable metal absorption loss and extreme light concentration, the ever-increasing research efforts have been devoted to seeking low-loss plasmon-assisted nanophotonic devices with deep-subwavelength mode confinement, which might find potential applications in high-density nanophotonic integration and efficient nonlinear signal processing. In addition, other plasmon-assisted nanophotonic devices might also promote grooming functionalities and applications benefiting from plasmonics.In this review article, we give a brief overview of our recent progress in plasmon-assisted nanophotonic devices and their wide applications, including long-range hybrid plasmonic slot (LRHPS) waveguide, ultra-compact plasmonic microresonator with efficient thermo-optic tuning, high quality (Q) factor and small mode volume, compact active hybrid plasmonic ring resonator for deep-subwavelength lasing applications, fabricated hybrid plasmonic waveguides for terabit-scale photonic interconnection, and metamaterials-based broadband and selective generation of orbital angular momentum (OAM) carrying vector beams. It is believed that plasmonics opens possible new ways to facilitate next chip-scale key devices and frontier technologies. © 2014, Higher Education Press and Springer-Verlag Berlin Heidelberg. Source

Wang X.,Shanghai JiaoTong University | Su H.,Huazhong University of Science and Technology
Annual Reviews in Control | Year: 2014

In practice, directly control every node in a dynamical networked system with a huge number of nodes might be impossible or unnecessary; therefore, pinning control is a desirable approach. This paper surveys advances in pinning control approaches to making a dynamical networked system have a desired behavior. For a network with fixed topology, we review the feasibility, stability and effectiveness of pinning control. We then focus on pinning-based consensus and flocking control of mobile multi-agent networked systems. One of the main challenges with consensus and flocking control is that the topology of the corresponding dynamical network is time-varying, which depends on the states of all the agents in the network. Looking forward to the next decade, we expect to have a much deeper understanding of the relationship between the effectiveness of pinning control and the structural properties of a complex network, which may result in better control of large scale networked systems. © 2014 Elsevier Ltd. All rights reserved. Source

He D.,Huazhong University of Science and Technology
Journal of molecular neuroscience : MN | Year: 2012

Volume-regulated anion channels (VRACs) are involved in regulating the proliferation and cell cycle progression of a number of cell types. However, little is known about its role on astrocyte proliferation, although numerous VRACs were reported to play important roles in astrocytic neurotransmitters release during swelling. In the present study, we demonstrated that VRAC inhibition by 4-(2-butyl-6,7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid (DCPIB) can attenuate astrocyte proliferation and DNA synthesis in vitro. Simultaneously, Western blots showed that VRAC inhibition led to a decrease in CDK 4 and cyclin D1 expression accompanied with an increase in p27 expression, which caused the proliferating astrocytes arrested at the G1/S checkpoint. Furthermore, we showed that DCPIB-induced astrocyte proliferation inhibition was modulated through the ERK signaling cascade. These observations demonstrated that VRACs play essential roles in the proliferation of astrocyte. Source

Kong D.,Huazhong University of Science and Technology
Food Policy | Year: 2012

Using the melamine contamination incident in China as an exogenous shock, this paper studies how the investors respond to corporate social responsibilities (CSRs) of listed firms in food industry. We find that investors' or consumers' concerns for CSR in the food industry could be significantly influenced by the mounting attention given to CSR-related events. This study offers important policy implications. First, the government, as well as supervisors, should release appropriate policies to improve various firms' activities on CSR, especially in the food industry. Second, firms, particularly those in the food industry, can obtain long-term benefits by strengthening their CSR-related activities. © 2012 Elsevier Ltd. Source

Li B.,Huazhong University of Science and Technology
Spine | Year: 2015

STUDY DESIGN.: Clinical research and animal experiment. OBJECTIVE.: To investigate whether lumbar disc degeneration is associated with Propionibacterium Acnes (P. acnes) infection. SUMMARY OF BACKGROUND DATA.: The hypothesis that herniated discs may be infected with P. acnes by way of bacteremia is remarkable. This may bring a tremendous change in treatment of lumbar disc herniation (LDH). However, this hypothesis is still controversial. Since P. acnes isolated may be related to contamination. METHODS.: Nucleus pulposus from 22 patients (30 discs) with LDH was collected during discectomy, following aerobic and anaerobic cultures for ten days.Twenty-four rabbits were divided into four groups. After L3-L6 being exposed, an incision was made into the three discs in group A and B. While in group C and D, two random segments were operated. Six weeks later, 0.05 ml of 5?×?10?CFU/?ml P. acnes was inoculated into operated discs in group A, sterile physiological saline in group B. In group C, 0.2 ml of 5?×?10?CFU/?ml P. acnes was injected through ear vein. Sterile saline was used in group D. Six weeks later, MRI was performed. Then, nucleus pulposus and paraspinal muscles were harvested for aerobic and anaerobic cultures. RESULTS.: Clinical Research: Anaerobic cultures were positive in 3 cases: 2 coagulase-negative staphylococci, 1 particles chain bacteria. No P. acnes were found. Staphylococcus epidermidis were isolated in one aerobic culture.Animal Experiment: P. acnes were found in 11 out of 18 (61%) discs in group A. There were no P. acnes found in the other three groups. CONCLUSIONS.: Degenerated discs were suitable for P. acnes growth. But this research did not find the evidence of the symptomatic degenerated lumbar discs were infected with P. acnes or that P. acnes could infect the degenerated lumbar discs by way of bacteremia.Level of Evidence: N/A Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. Source

Zhang J.,Huazhong University of Science and Technology | Gao J.,National Renewable Energy Laboratory | Miller E.M.,National Renewable Energy Laboratory | Luther J.M.,National Renewable Energy Laboratory | Beard M.C.,National Renewable Energy Laboratory
ACS Nano | Year: 2014

We developed a simple non-hot-injection synthetic route that achieves in situ halide-passivated PbS and PbSe quantum dots (QDs) and simplifies the fabrication of Pb-chalcogenide QD solar cells. The synthesis mechanism follows a temperature-dependent diffusion growth model leading to strategies that can achieve narrow size distributions for a range of sizes. We show that PbS QDs can be produced with a diameter as small as 2.2 nm, corresponding to a 1.7 eV band gap, while the resulting size distribution (6-7%) is comparable to that of hot-injection syntheses. The in situ chloride surface passivation is demonstrated by X-ray photoelectron spectroscopy and an improved photostability of both PbS and PbSe QDs when stored under air. Additionally, the photoluminescence quantum yield of the PbS QDs is ∼30% higher compared to the traditional synthesis. We show that PbS QD solar cells with 6.5% power conversion efficiency (PCE) can be constructed. Finally, we fabricated PbSe QD solar cells in air (rather than in inert atmosphere), achieving a PCE of 2.65% using relatively large QDs with a corresponding band gap of 0.89 eV. © 2013 American Chemical Society. Source

Feng G.,Huazhong University of Science and Technology | Jiang X.,Virginia Polytechnic Institute and State University | Qiao R.,Virginia Polytechnic Institute and State University | Kornyshev A.A.,Imperial College London
ACS Nano | Year: 2014

Complete removal of water from room-temperature ionic liquids is nearly impossible. For the electrochemical applications of ionic liquids, how water is distributed in the electrical double layers when the bulk liquids are not perfectly dry can potentially determine whether key advantages of ionic liquids, such as a wide electrochemical window, can be harnessed in practical systems. In this paper, we study the adsorption of water on electrode surfaces in contact with humid, imidazolium-based ionic liquids using molecular dynamics simulations. The results revealed that water molecules tend to accumulate within subnanometer distance from charged electrodes. At low amount of water in the bulk, the distributions of ions and of electrostatic potential in the double layer are affected weakly by the presence of water, but the spatial distribution of water molecules is strongly dependent on both. The preferential positions of water molecules in double layers are determined by the balance of several factors: the tendency to follow the positions of the maximal absolute value of the electrical field, the association with their ionic surroundings, and the propensity to settle at positions where more free space is available. The balance between these factors changes with charging the electrode, but the adsorption of water generally increases with voltage. The ion specificity of water electrosorption is manifested in the stronger presence of water near positive electrodes (where anions are the counterions) than near negative electrodes (where cations are counterions). These predictions await experimental verification. (Figure Presented). © 2014 American Chemical Society. Source

Silva A.C.A.,Federal University of Uberlaindia | Da Silva S.W.,University of Brasilia | Morais P.C.,University of Brasilia | Morais P.C.,Huazhong University of Science and Technology | Dantas N.O.,Federal University of Uberlaindia
ACS Nano | Year: 2014

In this study, we report on the synthesis of CdSe/CdS core-shell ultrasmall quantum dots (CS-USQDs) using an aqueous-based wet chemistry protocol. The proposed chemical route uses increasing concentration of 1-thioglycerol to grow the CdS shell on top of the as-precipitated CdSe core in a controllable way. We found that lower concentration of 1-thioglycerol (3 mmol) added into the reaction medium limits the growth of the CdSe core, and higher and increasing concentration (5-11 mmol) of 1-thioglycerol promotes the growth of CdS shell on top of the CdSe core in a very controllable way, with an increase from 0.50 to 1.25 nm in shell thickness. The growth of CS-USQDs of CdSe/CdS was confirmed by using different experimental techniques, such as optical absorption (OA) spectroscopy, fluorescence spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and Raman spectroscopy. Data collected from OA were used to obtain the average values of the CdSe core diameter, whereas Raman data were used to assess the average values of the CdSe core diameter and CdS shell thicknesses. © 2014 American Chemical Society. Source

Cao J.,Huazhong University of Science and Technology
American journal of clinical pathology | Year: 2014

To investigate the clinical significance of miR-335 expression in epithelial ovarian cancer (EOC). Expression of miR-335 in normal ovaries, EOC, and omental metastases was determined by quantitative realtime polymerase chain reaction. Overall survival (OS) and relapse-free survival (RFS) were examined using KaplanMeier curves and the Cox proportional hazards regression model. miR-335 expression level was reduced in malignant tissue samples, especially in omental metastases. Low miR-335 levels in EOC were associated with shorter OS (P < .001) and RFS (P = .002). In the multivariate analyses, low miR-335 levels emerged as an independent prognostic factor for poor OS (P = .005) and RFS (P = .016). miR-335 was downregulated in the recurrence group compared with the nonrecurrence group. The area under the receiver operating characteristic curve was 0.818 (95% confidence interval, 0.675-0.961). Our results indicate that miR-335 relates to the prognosis of patients with EOC and is a promising predictor of EOC recurrence. Source

He Y.,Huazhong University of Science and Technology | Lai K.K.,City University of Hong Kong
International Journal of Production Economics | Year: 2012

This study builds a conceptual model to describe the relationships among operational integration and strategic integration of supply chain, product-based and customer action-based service provided by industrial manufacturers, and firm performance. Using sample data from Chinese equipment manufacturers, this study finds that operational integration of supply chain has positive direct effect on product-based service, while strategic integration has positive direct effect on customer action-based service. Furthermore, product-based service is the basic transformation strategy for industrial manufacturing companies and it has not only positive direct effect but also indirect effect through customer action-based service on firm performance. © 2011 Elsevier B.V. All Rights Reserved. Source

Huang J.,Huazhong University of Science and Technology | Shi H.,Wuhan Textile University
IEEE Transactions on Power Electronics | Year: 2014

High common-mode voltage (CMV) of an output will be produced in the conventional sinusoidal pulse width modulation three-phase inverter. Although the carrier phase-shift method can be used to reduce the peaks of CMV, it has the best suppression effect only when the SPWM modulation index is no more than 2/3. This letter presents a new scheme of carrier peak position modulation to break the limitation of modulation index. In this scheme, the peak positions of the triangular carriers are delayed or advanced to avoid the zero state. Thus, the peaks of CMV will be reduced under any modulation index. The feasibility and validity of this scheme are verified through the experiments. © 1986-2012 IEEE. Source

Zhang L.,Huazhong University of Science and Technology
Sheng li xue bao : [Acta physiologica Sinica] | Year: 2011

Febrile seizure (FS) is common in childhood and can impair cognitive function. The potential to exhibit plasticity at many synapses appears to be modulated by prior synaptic activity. This intriguing higher-order form of plasticity has been termed metaplasticity. Plasticity and metaplasticity have been considered to be one of the most important neurological fundaments of learning and memory. In the present study, field potential recording was carried out to detect the effects of FS on plasticity and metaplasticity in the lateral perforant path of rat hippocampus. Brain slices from rat pups of FS model were prepared and superfused. The recording electrodes were placed within the outer molecular layer for recording of lateral perforant path field excitatory postsynaptic potentials (fEPSP). Stimulation of the lateral perforant path and the dentate hilar region was carried out by placing bipolar stimulating electrodes within the outer molecular layer and hilus, respectively. The results showed that long term potentiation (LTP) of control and FS rats didn't show significant difference after 100 Hz conditioning stimulation. Subjected to 10 Hz priming stimulation applied to lateral perforant path or dentate hilar region 40 min prior to 100 Hz conditioning, the LTP of control group was inhibited, while the LTP of FS rats remained constant. Normalized fEPSP slope 1 h after tetanization of control group was 1.10 ± 0.26 and 1.15 ± 0.14 after homosynaptic and antidromic priming stimulation respectively. On the contrast, FS group didn't show any depression of LTP after homosynaptic and antidromic priming stimulation, normalized fEPSP slope 1 h after tetanization being 1.35 ± 0.2 and 1.47 ± 0.19, respectively. These results suggest that FS would impair lateral perforant path metaplasticity without affecting LTP. These findings represent an intriguing phenomenon of FS-caused brain damage and imply the injury of excitatory status in different pathways. Source

Wu X.,University of Hong Kong | Liu S.,Huazhong University of Science and Technology | Li J.,University of Hong Kong | Lam E.Y.,University of Hong Kong
Optics Express | Year: 2014

In 22nm optical lithography and beyond, source mask optimization (SMO) becomes vital for the continuation of advanced ArF technology node development. The pixel-based method permits a large solution space, but involves a time-consuming optimization procedure because of the large number of pixel variables. In this paper, we introduce the Zernike polynomials as basis functions to represent the source patterns, and propose an improved SMO algorithm with this representation. The source patterns are decomposed into the weighted superposition of some well-chosen Zernike polynomial functions, and the number of variables decreases significantly. We compare the computation efficiency and optimization performance between the proposed method and the conventional pixel-based algorithm. Simulation results demonstrate that the former can obtain substantial speedup of source optimization while improving the pattern fidelity at the same time. © 2014 Optical Society of America. Source

Wang J.,Wuhan Institute of Technology | Zhang K.,Huazhong University of Science and Technology
Energy | Year: 2014

In this paper, we analyze differences in per capita carbon dioxide emissions from 1996 to 2010 in six sectors across 28 provinces in China and examine the σ-convergence, stochastic convergence and β-convergence of these emissions. We also investigate the factors that impact the convergence of per capita carbon dioxide emissions in each sector. The results show that per capita carbon dioxide emissions in all sectors converged across provinces from 1996 to 2010. Factors that impact the convergence of per capita carbon dioxide emissions in each sector vary: GDP (gross domestic product) per capita, industrialization process and population density impact convergence in the Industry sector, while GDP per capita and population density impact convergence in the Transportation, Storage, Postal, and Telecommunications Services sector. Aside from GDP per capita and population density, trade openness also impacts convergence in the Wholesale, Retail, Trade, and Catering Service sector. Population density is the only factor that impacts convergence in the Residential Consumption sector. © 2013 Elsevier Ltd. Source

Chen S.,Huazhong University of Science and Technology | Du R.,Nanjing Southeast University
Energy | Year: 2011

Turbulent double-diffusive natural convection is of fundamental interest and practical importance. In the present work we investigate systematically the effects of thermal Rayleigh number (Ra), ratio of buoyancy forces (N) and aspect ratio (A) on entropy generation of turbulent double-diffusive natural convection in a rectangle cavity. Several conclusions are obtained: (1) The total entropy generation number (Stotal) increases with Ra, and the relative total entropy generation rates are nearly insensitive to Ra when Ra ≤ 109; (2) Since N > 1, Stotal increases quickly and linearly with N and the relative total entropy generation rate due to diffusive irreversibility becomes the dominant irreversibility; and (3) Stotal increases nearly linearly with A. The relative total entropy generation rate due to diffusive and thermal irreversibilities both are monotonic decreasing functions against A while that due to viscous irreversibility is a monotonic increasing function with A. More important, through the present work we observe a new phenomenon named as " spatial self-copy" in such convectional flow. The " spatial self-copy" phenomenon implies that large-scale regular patterns may emerge through small-scale irregular and stochastic distributions. But it is still an open question required further investigation to reveal the physical meanings hidden behind it. © 2011 Elsevier Ltd. Source

Liao Y.,China Institute of Technology | Qi H.,Huazhong University of Science and Technology | Li W.,Huawei
IEEE Sensors Journal | Year: 2013

Wireless sensor networks (WSNs) are composed of a large number of inexpensive power-constrained wireless sensor nodes, which detect and monitor physical parameters around them through self-organization. Utilizing clustering algorithms to form a hierarchical network topology is a common method of implementing network management and data aggregation in WSNs. Assuming that the residual energy of nodes follows the random distribution, we propose a load-balanced clustering algorithm for WSNs on the basis of their distance and density distribution, making it essentially different from the previous clustering algorithms. Simulated tests indicate that the new algorithm can build more balanceable clustering structure and enhance the network life cycle. © 2001-2012 IEEE. Source

Zhou Y.,Huazhong University of Science and Technology | Zhou Y.,University of Electro - Communications | Tolstikhin O.I.,Moscow Institute of Physics and Technology | Morishita T.,University of Electro - Communications
Physical Review Letters | Year: 2016

We revisit the concept of near-forward rescattering strong-field photoelectron holography introduced by Y. Huismans et al. [Science 331, 61 (2011)]. The recently developed adiabatic theory is used to show how the phase of the scattering amplitude for near-forward rescattering of an ionized electron by the parent ion is encoded in and can be read out from the corresponding interference pattern in photoelectron momentum distributions (PEMDs) produced in the ionization of atoms and molecules by intense laser pulses. A procedure to extract the phase is proposed. Its application to PEMDs obtained by solving the time-dependent Schrödinger equation for a model atom yields results in good agreement with scattering calculations. This establishes a novel general approach to extracting structural information from strong-field observables capable of providing time-resolved imaging of ultrafast processes. © 2016 American Physical Society. Source

Lin W.,Huazhong University of Science and Technology
IEEE Transactions on Power Electronics | Year: 2016

This paper studies the control and dc fault isolation of a dc-dc autotransformer topology (DC AUTO). The operating principle and power flow analysis of a DC AUTO are studied. Internal dynamic study shows that dynamics of the common bus ac voltage is a purely algebraic equation. A control strategy of using VSC2 to control common ac bus voltage, and VSC1 (3) to control the transferred dc power is then proposed. System responses to dc fault are analyzed. Corresponding design methods that enable bidirectional dc fault isolating are then proposed and their impacts on component cost are analyzed. A family of possible DC AUTO topologies is also proposed. Extensive simulations on power step change, dc and ac faults confirmed the theoretical studies of a DC AUTO employing the modular multilevel converter topology. Taking a ±320-kV/±500-kV DC AUTO transferring 1000-MW dc power as an example, conventional dc-ac-dc technology requires 2000-MW total converter rating with power loss ratio of 1.8%, while the DC AUTO technology only requires 1020-MW total converter rating with power loss ratio of about 0.8%. The DC AUTO is able to achieve exactly the same functions as a dc-ac-dc with significantly reduced investment and operating cost under low- and medium-dc voltage stepping ratio. © 2016 IEEE. Source

Zhu X.-F.,Huazhong University of Science and Technology
Journal of Applied Physics | Year: 2012

The acoustic waves switch based on meta-fluid phononic crystals (MEFL PCs) is theoretically investigated. The MEFL PCs consist of fluid matrix and fluid-like inclusions with extremely anisotropic-density. The dispersion relations are calculated via the plane wave expansion method, which are in good agreement with the transmitted sound pressure level spectra obtained by the finite element method. The results show that the width of absolute band gap in MEFL PCs depends sensitively upon the orientation of the extremely anisotropic-density inclusions and reaches maximum at the rotating angle of 45 °, with the gap position nearly unchanged. Also, the inter-mode conversion inside anisotropic-density inclusions can be ignored due to large acoustic mismatch. The study gives a possibility to realize greater flexibility and stronger effects in tuning the acoustic band gaps, which is very significant in the enhanced control over sound waves and has potential applications in ultrasonic imaging and therapy. © 2012 American Institute of Physics. Source

Shao Z.,Wuhan University | Liu J.,Wuhan University | Cheng Q.,Huazhong University of Science and Technology
Applied Optics | Year: 2012

Aiming at the differences of physical characteristics between infrared sensors and visible ones, we introduce the focus measure operators into the curvelet domain in order to propose a novel image fusion method. First, the fast discrete curvelet transform is performed on the original images to obtain the coefficient subbands in different scales and various directions, and the focus measure values are calculated in each coefficient subband. Then, the local variance weighted strategy is employed to the lowfrequency coefficient subbands for the purpose of maintaining the low-frequency information of the infrared image and adding the low-frequency features of the visible image to the fused image; meanwhile, the fourth-order correlation coefficient match strategy is performed to the high-frequency coefficient subbands to select the suitable high-frequency information. Finally, the fused image can be obtained through the inverse curvelet transform. The practical experiments indicate that the presented method can integrate more useful information from the original images, and the fusion performance is proved to be much better than the traditional methods based on the wavelet, curvelet, and pyramids. © 2012 Optical Society of America. Source

Yang D.,Nanjing University of Aeronautics and Astronautics | Yang M.,Nanjing University of Aeronautics and Astronautics | Ruan X.,Nanjing University of Aeronautics and Astronautics | Ruan X.,Huazhong University of Science and Technology
IEEE Transactions on Power Electronics | Year: 2012

In hybrid power systems, the use of a multiple-input converter (MIC) instead of several single-input converters leads to a simpler circuit and lower cost. Energy management is always required for the MICs in order to ensure the highest utilization of renewable energy. The MIC-based hybrid power system is a typical multiple-input multiple-output coupling system, and it has multiple operating modes. As a result, the design of the controllers is very complicated. This paper proposes one-cycle control (OCC) for double-input buck converter (DIBC) to eliminate the interactions of the control loops and, thus, to simplify the design of the controllers. The mode transition circuit is further proposed to realize seamless mode transition, according to the available renewable energy and the output power. Small signal models of DIBC in different operating modes are derived. It can be seen that with OCC, the two control loops are independent of each other, and no current regulator is required. Moreover, the design conditions of the output voltage regulator in different operating modes are the same. As a result, the controller design is greatly simplified. An 800-W prototype has been built and tested in the lab and the experimental results validate the proposed OCC. © 2012 IEEE. Source

Xu W.,Huazhong University of Science and Technology | Xu W.,Nankai University | Zhao L.,Nankai University
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2014

The extended thermodynamics of static charged AdS black holes in conformal gravity is analyzed. The P-V criticality of these black holes has some unusual features. There exists a single critical point with critical temperature T c and critical pressure P c. At fixed T > T c (or at fixed P > P c), there are two zeroth order phase transition points but no first order phase transition points. The systems favors large pressure states at constant T, or high temperature states at constant P. © 2014 The Authors. Source

McCracken R.A.,Heriot - Watt University | Sun J.,Huazhong University of Science and Technology | Leburn C.G.,Heriot - Watt University | Reid D.T.,Heriot - Watt University
Optics Express | Year: 2012

The carrier-envelope-offset frequencies of the pump, signal, idler and related second-harmonic and sum-frequency mixing pulses have been locked to 0 Hz in a 20-fs-Ti:sapphire-pumped optical parametric oscillator satisfying a critical prerequisite for broadband optical pulse synthesis. With outputs spanning 400 -3200 nm, this result represents the broadest zerooffset comb demonstrated to date. ©2012 Optical Society of America. Source

Wang H.,Huazhong University of Science and Technology
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban | Year: 2010

In coal mines, main occupational hazard is coal-mine dust, which can cause health problem including coal workers' pneumoconiosis and lung cancer. Some heat shock proteins (Hsps) have been reported as an acute response to a wide variety of stressful stimuli. Whether Hsps protect against chronic environmental coal-mine dust over years is unknown. It is also interesting to know that whether the expression of Hsp27 and Hsp70 proteins as a marker for exposure is associated risk of lung cancer among coal miners. We investigated the association between levels of Hsp27 and Hsp70 expression in lymphocytes and plasma and levels of coal-mine dust exposure in workplace or risk of lung cancer in 42 cancer-free non-coal miners, 99 cancer-free coal miners and 51 coal miners with lung cancer in Taiyuan city in China. The results showed that plasma Hsp27 levels were increased in coal miners compared to non-coal miners (P<0.01). Except high cumulative coal-mine dust exposure (OR=13.62, 95%CI=6.05-30.69) and amount of smoking higher than 24 pack-year (OR=2.72, 95% CI=1.37-5.42), the elevated levels of plasma Hsp70 (OR=13.00, 95% CI=5.14-32.91) and plasma Hsp27 (OR=2.97, 95% CI=1.40-6.32) and decreased expression of Hsp70 in lymphocytes (OR=2.36, 95% CI=1.05-5.31) were associated with increased risk of lung cancer. These findings suggest that plasma Hsp27 may be a potential marker for coal-mine dust exposure. And the expression of Hsp27 and Hsp70 levels in plasma and lymphocytes may be used as biomarkers for lung cancer induced by occupational coal-mine dust exposure. Source

Huang G.,Huazhong University of Science and Technology
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban | Year: 2010

The value of the left atrial volume tracking (LAVT) method in the evaluation of left atrial (LA) function in patients with diabetes mellitus (DM) was examined in this study. Fifty-eight DM patients as DM group and 40 healthy people as normal control group were enrolled in this study. EUB-6500 echocardiographic imaging system with LAVT was applied to display and analyze the LA volume curve imaging on LV apical two and four chamber views. The maximal LA volume at end-systole (LAV(max)), LA volume at the onset of ECG-P wave (LAV(p)), the minimal LA volume at end-diastole (LAV(min)) from the LA volume curve were acquired and recorded. All values above were standardized by body surface area (BSA). Then the passive, active and total LA volume (LAVIpass, LAVIact, LAVItotal) and empting rate (%LAVIpass, %LAVIact, %LAVItotal), effective passive and active empting rate (%eLAVIpass, %eLAVIact), and the proportionality of passive empting volume and active empting volume were calculated. The LAVIp, LAVIact, LAVItotal, %LAVIact, %LAVItotal and %eLAVIact were significantly higher in the DM group than those in the control group, whereas the LAVIpass, %LAVIpass, %eLAVIpass and LAVIpass/act were lower (all P<0.05). For the LA volume change in DM, the active empting volume was enhanced at end-diastole. It was concluded that LAVT is a potentially useful tool to evaluate the function of LA. Source

Yang Y.,Huazhong University of Science and Technology
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban | Year: 2010

This study was designed to determine the impact of chrysoeriol on proliferation and cell cycle progression in the human multiple myeloma cell lines RPMI 8226 and KM3, and its related molecular mechanisms. Chryseoriol was identified by using the phosphorylated AKT-specific cytoblot high throughput assay. CCK-8 assay was employed to examine the growth inhibition rate and IC(50) (48 h) in peripheral blood mononuclear cells (PBMNCs), RPMI 8226 and KM3 cells treated with chrysoeriol at various concentrations. Cells were labeled with 5-6-carboxyfluorescein diacetate succinimidyl ester (CFSE), and the proliferation dynamics was detected by flow cytometry and analyzed with ModFit software. The cell cycles of RPMI 8226 and KM3 cells were measured by flow cytometry when the IC(50) concentration of chrysoeriol was adopted. The alterations in cell-cycle related proteins (Cyclin B1, Cyclin D1, p21) and proteins in PI3K-AKT-mTOR pathway were determined by Western blot analysis. The results showed the proliferation of multiple myeloma cells was significantly inhibited by chrysoeriol, resulting in cell cycle arrest in G(2)/M phase. Chrysoeriol could significantly reduce the expression of p-AKT (s473) and p-4eBP1 (t37/46) protein, meanwhile enhanced Cyclin B1 and p21 protein expression. Similar effects were not observed in PBMNCs from normal donors. It was concluded that chrysoeriol was a selective PI3K-AKT-mTOR pathway inhibitor. It restrained the proliferation of human multiple myeloma cells, but didn't affect proliferation of PBMNCs from normal donors. It might exhibit the cell cycle regulatory effect via the inhibition of PI3K-AKT-mTOR signal pathway. Source

Yang K.,Huazhong University of Science and Technology
Immunology and Cell Biology | Year: 2015

Post-infarction inflammatory response results in worse remodeling and dysfunction following myocardial infarction (MI). Supression of post-infarction inflammation would be a logical approach of alleviating post-infarction injury and promoting cardiac repair. In this study, we investigated the significance of mTORC1 signaling in the anti-inflammatory activity of regulatory T cells (Tregs) after MI. Using the murine MI model with wild type and Rag1-/- mice, we found that the mechanistic target of rapamycin compex 1 (mTORC1) signaling was upregulated in Tregs infiltrating into the infarcted myocardium, rather than in circulating Tregs after MI. The anti-inflammatory activity of infiltrating Tregs was significantly stronger than that of circulating Tregs. This was demonstrated by a higher expression of anti-inflammatory cytokines in the infiltrating Tregs and a robust suppression of proinflammatory cytokine production by macrophages. In an adoptive transfer analysis, compared with normal splenic Tregs, rapamycin-treated splenic Tregs ineffectively suppressed the post-infarction inflammatory response of infiltrating macrophages. In addition, in vitro cultured primary cardiomyocytes treated with mild oxygen glucose deprivation induced mTORC1 activation and a higher anti-inflammatory activity of Tregs in a coculture assay. Our study identified a new mechanism by which infiltrating Tregs subdue post-infarction inflammation. Understanding and utilizing this information would be helpful for designing new therapeutic interventions for MI.Immunology and Cell Biology advance online publication, 27 October 2015; doi:10.1038/icb.2015.88. © 2015 Australasian Society for Immunology Inc. Source

Liu W.-H.,Tianjin University | Xie D.,Tianjin University | Xu X.-C.,Huazhong University of Science and Technology
International Journal of Production Economics | Year: 2013

Quality supervision and coordination are critical in realising successful cooperation in the logistics service supply chain (LSSC). To build a closer partnership in the supply chain, collaboration in the LSSC presents multi-period features. Therefore, the study on the quality of decision-making problems under multi-period conditions in the LSSC is practical. Logistic service quality is not easy to measure. Hence, this paper proposes a multi-period quality coordination model based on the single-period quality coordination model in a two-echelon LSSC, and establishes a new model in a three-echelon LSSC when the logistics service integrator (LSI) is punished. Simulation results indicate that under multi-period cooperation conditions, the LSI tends to make rapid decisions when punishment intensity is below the critical value. Moreover, for the three-echelon LSSC, the final equilibrium between sub-LSI and ultimate FLSP is not associated with punishment intensity that the LSI sets against the sub-LSI. © 2012 Elsevier B.V. Source

Ouyang L.,Huazhong University of Science and Technology
Medical oncology (Northwood, London, England) | Year: 2013

Osteosarcoma is the most common human primary malignant bone tumor in children and young adults. Sensitive and non-invasive biomarkers that can facilitate disease detection at early stage are highly desirable to improve survival rate and help to determine optimized treatment for osteosarcoma. The small non-coding RNAs, microRNAs (miRNAs), have recently been identified as critical regulators for various diseases including cancer and may represent a novel class of cancer biomarkers. In this study, we aimed to detect the potential of circulating miRNAs as biomarkers for osteosarcoma. Levels of six candidate miRNAs (miR-21, miR-199a-3p, miR-143, miR-34, miR-140, and miR-132) that were previously demonstrated to be regulated in osteosarcoma were examined in plasma of 40 osteosarcoma patients and 40 matched healthy controls by quantitative reverse-transcription polymerase chain reaction assays. The results showed that circulating levels of miR-21 were significantly higher in osteosarcoma patients than controls, while miR-199a-3p and miR-143 were decreased in osteosarcoma patients. We replicated the findings in an independent study of 40 osteosarcoma patients and 40 matched controls and confirmed the results. Receiver operating characteristics curve analysis of the combined populations demonstrated that the three-miRNA signature could discriminate cases from controls with an area under the curve of 0.953 (95 % CI 0.924-0.984). In addition, circulating miR-21 and miR-143 were correlated with both metastasis status and histological subtype of the patients, while miR-199a-3p only correlated with histological subtype. Our data suggest that altered levels of circulating miRNAs might have great potential to serve as novel, non-invasive biomarkers for osteosarcoma. Source

Xiao B.,Hong Kong Polytechnic University | Hua Y.,Huazhong University of Science and Technology
IEEE Transactions on Parallel and Distributed Systems | Year: 2010

One widely used mechanism for representing membership of a set of items is the simple space-efficient randomized data structure known as Bloom filters. Yet, Bloom filters are not entirely suitable for many new network applications that support network services like the representation and querying of items that have multiple attributes as opposed to a single attribute. In this paper, we present an approach to the accurate and efficient representation and querying of multiattribute items using Bloom filters. The approach proposes three variant structures of Bloom filters: Parallel Bloom Filter (referred as PBF) structure, PBF with a hash table (PBF-HT), and PBF with a Bloom filter (PBF-BF). PBF stores multiple attributes of an item in parallel Bloom filters. The auxiliary HT and BF provide functions to capture the inherent dependency of all attributes of an item. Compared to standard Bloom filters to represent items with multiple attributes, the proposed PBF facilitates much faster query service and both PBF-HT and PBF-BF structures achieve much lower false positive probability with a result to save storage space. Simulation and experimental results demonstrate that the new space-efficient Bloom filter structures can efficiently and accurately represent multiattribute items and quickly respond queries at the cost of a relatively small false positive probability. © 2010 IEEE. Source

Shi S.,Huazhong University of Science and Technology | Klotz U.,Robert Bosch GmbH | Klotz U.,University of Tubingen
Current Drug Metabolism | Year: 2011

Ageing is characterized by a progressive decline in the functional reserve of multiple organs and systems, which can influence drug disposition. In addition, comorbidity and polypharmacy are highly prevalent in the elderly. As ageing is associated with some reduction in first-pass metabolism, bioavailability of a few drugs can be increased. With ageing body fat increases and total body water as well as lean body mass decrease. Consequently, hydrophilic drugs have a smaller apparent volume of distribution (V) and lipophilic drugs have an increased V with a prolonged half-life. Drugs with a high hepatic extraction ratio display some age-related decrease in systemic clearance (CL), but for most drugs with a low hepatic extraction ratio, CL is not reduced with advancing age. In general, activities of cytochrome P450 enzymes are preserved in normal ageing and the genetic influence is much more striking than age effects. Drug transporters play an important role in pharmacokinetic processes, but their function and pharmacology have not yet been fully examined for agerelated effects. One third of elderly persons show no decrease in renal function (GFR>70 mL/min/1.73 m 2). In about two thirds of elderly subjects, the age-related decline of renal function was associated with coexisting cardiovascular diseases and other risk factors. In the elderly a large interindividual variability in drug disposition is particularly prominent. In conclusion, the complexity of interactions between comorbidity, polypharmacy, and age-related changes in pharmacokinetics (and pharmacodynamics) justify the old and well-known dosing aphorism "start low, go slow" for aged individuals. © 2011 Bentham Science Publishers. Source

Lu S.,Huazhong University of Science and Technology | Braunstein S.L.,University of York
Quantum Information Processing | Year: 2014

We study the quantum version of a decision tree classifier to fill the gap between quantum computation and machine learning. The quantum entropy impurity criterion which is used to determine which node should be split is presented in the paper. By using the quantum fidelity measure between two quantum states, we cluster the training data into subclasses so that the quantum decision tree can manipulate quantum states. We also propose algorithms constructing the quantum decision tree and searching for a target class over the tree for a new quantum object. © 2013 Springer Science+Business Media New York. Source

Keil M.,Georgia State University | Rai A.,Georgia State University | Liu S.,Huazhong University of Science and Technology
European Journal of Information Systems | Year: 2013

Improving the management of information technology (IT) projects is of prime concern to both IS researchers and practitioners, as IT projects are notorious for poor process performance, frequently running over budget and behind schedule. Over the years, at least two separate streams of research have emerged with the aim of contributing to our understanding of IT project management. One of these focuses on the exercise of formal and informal controls, while another focuses on identifying and managing key risks such as those associated with requirements and users. Proponents of the control stream would argue that the exercise of formal and informal controls can improve process performance and there is some evidence that this is so. An obvious question that emerges, however, is how effective these controls are in the presence of particular risks. In this study, we seek to answer this question by developing and testing a research model that integrates these two streams of research. On the basis of data collected from 63 completed IT projects in China, we examine the moderating effects of requirements risk and user risk on the relationship between control (both formal and informal) and the process performance of IT projects. We contribute to the current state of knowledge by clearly demonstrating that both types of risk moderate the effects of formal and informal controls on performance. Specifically, both requirements risk and user risk were found to reduce the positive influence of controls on process performance, implying that implementing solid controls is a necessary, but not sufficient, condition to ensure good process performance. © 2013 Operational Research Society Ltd. All rights reserved. Source

Zhu X.-F.,Huazhong University of Science and Technology
Physics Letters, Section A: General, Atomic and Solid State Physics | Year: 2013

Here in locally resonant acoustic material, it is shown that effective zero refractive index can be constructed by the resonant unit-cells with coherent degenerate monopole-dipole momenta. Due to strong local resonances, the material layers with effective zero refractive index can function as a resonant cavity of high Q factor, where a subtle deviation from the resonant frequency may result in distinct increase of reflection. Full-wave simulations are performed to demonstrate some unusual wave transport properties such as invisibility cloaking, super-reflection, local field enhancement, and wavefronts rotation. © 2013 Elsevier B.V. Source

Wang H.,Huazhong University of Science and Technology
Nucleic Acids Research | Year: 2012

Transcription factors (TFs) are proteins that bind to specific DNA sequences, thereby playing crucial roles in gene-expression regulation through controlling the transcription of genetic information from DNA to RNA. Transcription cofactors and chromatin remodeling factors are also essential in the gene transcriptional regulation. Identifying and annotating all the TFs are primary and crucial steps for illustrating their functions and understanding the transcriptional regulation. In this study, based on manual literature reviews, we collected and curated 72 TF families for animals, which is currently the most complete list of TF families in animals. Then, we systematically characterized all the TFs in 50 animal species and constructed a comprehensive animal TF database, AnimalTFDB. To better serve the community, we provided detailed annotations for each TF, including basic information, gene structure, functional domain, 3D structure hit, Gene Ontology, pathway, protein-protein interaction, paralogs, orthologs, potential TF-binding sites and targets. In addition, we collected and annotated transcription cofactors and chromatin remodeling factors. AnimalTFDB has a user-friendly web interface with multiple browse and search functions, as well as data downloading. It is freely available at http://www.bioguo.org/AnimalTFDB/. © The Author(s) 2011. Published by Oxford University Press. Source

Li H.J.,Huazhong University of Science and Technology
Zhongguo zhen jiu = Chinese acupuncture & moxibustion | Year: 2011

To explore the efficacy and safety of acupuncture for post-stroke depression (PSD). The randomized, double-blind control study was designed. 43 post-stroke patients with current major depression episode (DSM-IV) were randomly assigned to an observation group (23 cases) and a control group (20 cases). The conventional symptomatic, supportive and anti-infection treatment in neurological internal medicine was applied to all of the cases in two groups. In observation group, acupuncture was applied to Baihui (GV 20), Yintang (EX-HN 3), Sishencong (EX-HN 1), Taichong (LR 3), etc. Additionally, the placebo was taken orally. In control group, acupuncture was applied to non-acupoint spots (5 mm lateral to the acupoints selected in observation group) with shallow needling technique. Moreover, Fluoxetine was taken orally. The treatment lasted for 6 weeks. Hamilton Depression Scale (HAMD), Asberg antidepressant side effect scale (ASES), adverse response of acupuncture and efficacy were compared between two groups. The total effective rate was 73.9% (17/23) in observation group and was 80.0% (16/20) in control group, indicating equivalent efficacy between two groups. After treatment, HAMD score was reduced remarkably as compared with that before treatment in two groups (P < 0.05). ASES scores in 4 weeks of treatment and after treatment in observation group and ASES score after treatment in control group were reduced remarkably as compared with those before treatment (all P < 0.05). ASES scores in 4 weeks of treatment and after treatment in observation group were reduced much more remarkably as compared with those in control group (both P < 0.05). The incidences of adverse response of acupuncture were 13.0% (3/23) and 15.0% (3/20) respectively in observation group and control group, indicating that the adverse response was transient and had not recurred after symptomatic measures. Acupuncture for PSD is as effective as fluoxetine, without obvious drug-induced adverse reaction involved. Source

Gong Y.,Huazhong University of Science and Technology | Gong Y.,CAS Institute of Theoretical Physics
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2014

We discuss the general dynamical behaviors of quintessence field, in particular, the general conditions for tracking and thawing solutions are discussed. We explain what the tracking solutions mean and in what sense the results depend on the initial conditions. Based on the definition of tracking solution, we give a simple explanation on the existence of a general relation between wφ and Ωφ which is independent of the initial conditions for the tracking solution. A more general tracker theorem which requires large initial values of the roll parameter is then proposed. To get thawing solutions, the initial value of the roll parameter needs to be small. The power-law and pseudo-Nambu Goldstone boson potentials are used to discuss the tracking and thawing solutions. A more general wφ-Ωφ relation is derived for the thawing solutions. © 2014 The Authors. Source

Xu H.,Nankai University | Xu W.,Nankai University | Xu W.,Huazhong University of Science and Technology | Zhao L.,Nankai University
European Physical Journal C | Year: 2014

Treating the cosmological constant as thermodynamic pressure and its conjugate as thermodynamic volume, we investigate the critical behavior of the third-order Lovelock black holes in diverse dimensions. For black hole horizons with different normalized sectional curvature k = 0, ± 1, the corresponding critical behaviors differ drastically. For k=0, there is no critical point in the extended thermodynamic phase space. For k=-1, there is a single critical point in any dimension d ≥ 7, and for k=+1, there is a single critical point in 7 dimensions and two critical points in 8, 9, 10, 11 dimensions. We studied the corresponding phase structures in all possible cases. © 2014, The Author(s). Source

Wang L.,Huazhong University of Science and Technology | Wang L.,Center for Fusion Theory | Diamond P.H.,Center for Fusion Theory | Diamond P.H.,University of California at San Diego
Physical Review Letters | Year: 2013

A mechanism for turbulent acceleration of parallel rotation is discovered using gyrokinetic theory. This new turbulent acceleration term cannot be written as a divergence of parallel Reynolds stress. Therefore, turbulent acceleration acts as a local source or sink of parallel rotation. The physics of turbulent acceleration is intrinsically different from the Reynolds stress. For symmetry breaking by positive intensity gradient, a positive turbulent acceleration, i.e., cocurrent rotation, is predicted. The turbulent acceleration is independent of mean rotation and mean rotation gradient, and so constitutes a new candidate for the origin of spontaneous rotation. A quasilinear estimate for ion temperature gradient turbulence shows that the turbulent acceleration of parallel rotation is explicitly linked to the ion temperature gradient scale length and temperature ratio Ti0/Te0. Methods for testing the effects of turbulent parallel acceleration by gyrokinetic simulation and experiment are proposed. © 2013 American Physical Society. Source

Wu J.,Wuhan University | Ding X.-H.,Huazhong University of Science and Technology
Scientometrics | Year: 2013

Scientists generally do scientific collaborations with one another and sometimes change their affiliations, which leads to scientific mobility. This paper proposes a recursive reinforced name disambiguation method that integrates both coauthorship and affiliation information, especially in cases of scientific collaboration and mobility. The proposed method is evaluated using the dataset from the Thomson Reuters Scientific "Web of Science". The probability of recall and precision of the algorithm are then analyzed. To understand the effect of the name ambiguation on the h-index and g-index before and after the name disambiguation, calculations of their distribution are also presented. Evaluation experiments show that using only the affiliation information in the name disambiguation achieves better performance than that using only the coauthorship information; however, our proposed method that integrates both the coauthorship and affiliation information can control the bias in the name ambiguation to a higher extent. © 2013 Akadémiai Kiadó, Budapest, Hungary. Source

Chow E.K.-H.,University of California at San Francisco | Fan L.-L.,University of California at San Francisco | Fan L.-L.,Huazhong University of Science and Technology | Chen X.,University of California at San Francisco | Bishop J.M.,University of California at San Francisco
Hepatology | Year: 2012

At least some cancer stem cells (CSCs) display intrinsic drug resistance that may thwart eradication of a malignancy by chemotherapy. We explored the genesis of such resistance by studying mouse models of liver cancer driven by either MYC or the combination of oncogenic forms of activation of v-akt murine thymoma viral oncogene homolog (AKT) and NRAS. A common manifestation of chemoresistance in CSCs is efflux of the DNA-binding dye Hoechst 33342. We found that only the MYC-driven tumors contained a subset of cells that efflux Hoechst 33342. This "side population" (SP) was enriched for CSCs when compared to non-SP tumor cells and exhibited markers of hepatic progenitor cells. The SP cells could differentiate into non-SP tumor cells, with coordinate loss of chemoresistance, progenitor markers, and the enrichment for CSCs. In contrast, non-SP cells did not give rise to SP cells. Exclusion of Hoechst 33342 is mediated by ATP binding cassette drug transporter proteins that also contribute to chemoresistance in cancer. We found that the multidrug resistance gene 1 (MDR1) transporter was responsible for the efflux of Hoechst from SP cells in our MYC-driven model. Accordingly, SP cells and their tumor-initiating subset were more resistant than non-SP cells to chemotherapeutics that are effluxed by MDR1. Conclusion: The oncogenotype of a tumor can promote a specific mechanism of chemoresistance that can contribute to the survival of hepatic CSCs. Under circumstances that promote differentiation of CSCs into more mature tumor cells, the chemoresistance can be quickly lost. Elucidation of the mechanisms that govern chemoresistance in these mouse models may illuminate the genesis of chemoresistance in human liver cancer. © 2012 American Association for the Study of Liver Diseases. Source

Liu Y.,Huazhong University of Science and Technology
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2011

The aim of the study was to understand the quality of life and the related factors of farmer workers in the countryside of Hubei province. Purposive sampling was used to select 529 farmer workers and another 326 government workers were served as controls. 'Group investigation' method was used in this study. t-test was used to compare the quality of life among farmer workers and the Chinese norm. SF-36 was used to measure the quality of life. Generalized linear regression model (GLM) and structural equation model (SEM) were applied to test the related factors. Quality of life among farmer workers in Hubei was significantly different from the norm of residents in Hangzhou. The quality of life among migrant workers was significantly lower than the government staff (P(RP) < 0.05, P(BP) < 0.05, P(VT) < 0.05) after controlling the confounding factors. Factors as age (B = -0.33), sex (B = -0.07), marital status (B = -0.10), sleeping habits (B = -0.16), fatigue (B = -0.12), life style (B = -0.05) and social status (B = 0.93) etc. were related to the quality of life. The quality of life among farmer workers was poor, and mainly affected by age, sex, marital status, sleeping habits, fatigue, lifestyle and social status. It is important to reduce the work load and making the work status and life style reasonable to better the quality of life among the farmer workers. Source

Gong Y.-G.,Huazhong University of Science and Technology | Gong Y.-G.,CAS Institute of Theoretical Physics
Communications in Theoretical Physics | Year: 2013

We argue that more cosmological solutions in massive gravity can be obtained if the metric tensor and the tensor Σμν defined by Stückelberg fields take the homogeneous and isotropic form. The standard cosmology with matter and radiation dominations in the past can be recovered and ΛCDM model is easily obtained. The dynamical evolution of the universe is modified at very early times. © 2013 Chinese Physical Society and IOP Publishing Ltd. Source

Li Z.,Huazhong University of Science and Technology
Journal of Vibration and Acoustics, Transactions of the ASME | Year: 2012

A radial unbalanced magnetic pull (UMP) can be produced by an eccentric rotor and leads vibrations in large hydro-turbine generators. The influence of nonlinear UMP on the radial vibration of a large hydro-turbine generator is analyzed in this paper. The UMP is determined as a function of eccentricities and field currents by means of a simple analytical method instead of the finite element (FE) method. The analytical method employs the no-load characteristic curve of an electrical machine and saturation effects of the ferromagnetic materials are taken into consideration. FE rotor model of a large hydro-turbine generator unit, taking account of guide bearings, thrust bearing and periodic forces, is developed to investigate the influence of UMP on radial vibrations. The FE rotor model and the analytical method for UMP constitute the computational model. UMP is calculated under different rotor eccentricities and field currents by the proposed method. Comparing with other analytical methods, the effectiveness of the proposed method is verified. Dynamic responses of the FE model under different analytical methods for UMP are calculated to investigate the difference in vibration between different analytical methods. A simulated excitation test is performed and a comparative analysis between the calculated results and the field data is provided. The computational model is proved to be reasonable according to the analysis. © 2012 American Society of Mechanical Engineers. Source

Naradikian M.S.,University of Pennsylvania | Hao Y.,Huazhong University of Science and Technology | Cancro M.P.,University of Pennsylvania
Immunological Reviews | Year: 2016

A subset of B cells with unique phenotypic and functional features-termed Age-associated B cells (ABCs)-has recently been identified in both mice and humans. These cells are characterized by a T-BET driven transcriptional program, robust responsiveness to TLR7 and TLR9 ligands, and a propensity for IgG2a/c production. Beyond their age-related accumulation, these cells play roles in both normal and pathogenic humoral immune responses regardless of host age. Thus, B cells with the ABC phenotype and transcriptional signature appear during viral, bacterial, and parasitic infections, but also arise during humoral autoimmune disease in both mouse models and humans. These observations suggest that both autoantigens and certain classes of pathogens provide the signals required for ABC differentiation. Herein, we review the discovery and features of ABCs, and propose that they are a memory subset generated by nucleic acid-containing antigens in the context of a promoting inflammatory cytokine milieu. © 2016 John Wiley & Sons A/S. Source

Ge G.,Hong Kong Polytechnic University | Xiao F.,Hong Kong Polytechnic University | Xu X.,Huazhong University of Science and Technology
Applied Energy | Year: 2011

This study presents a model-based control strategy for a novel dedicated outdoor air-chilled ceiling (DOAS-CC) system with the aim of optimizing the overall system performance. The DOAS-CC system incorporates liquid desiccant dehumidification and membrane-based total heat recovery technologies. Simplified but reliable models of major components in the DOAS-CC system are firstly developed to predict the system performance. A cost function is then constructed to minimize total energy consumption while properly maintaining thermal comfort reflected by indoor air temperature and relative humidity. Genetic algorithm is used to search for optimal set-points of the supply air temperature and humidity ratio of the dedicated outdoor air subsystem as well as the supply water temperature. The performance of this strategy is tested and evaluated with different control settings in a simulated multi-zone space served by the DOAS-CC system under various weather conditions. The results show that optimized control variables produced by the optimal strategy can improve the system energy performance and maintain indoor thermal comfort. © 2011 Elsevier Ltd. Source

Ding N.,Huazhong University of Science and Technology
International journal of nanomedicine | Year: 2011

Receptor-targeted delivery of imaging and therapeutic agents can lead to enhanced efficacy for both. Multimodality imaging offers unique advantages over traditional single modality imaging. Tumor marker folate receptor (FR)-targeted fluorescent paramagnetic bimodal liposomes were synthesized to co-deliver paramagnetic and fluorescence agents for magnetic resonance (MR) and optical bimodal imaging contrast enhancement. Fluorescent and paramagnetic bimodal liposomes were synthesized with a mean diameter of 136 nm and a low polydispersity index. The liposomes incorporated folate-PEG(3350)-CHEMS for FR targeting, Gd(III)[N,N-Bis-stearylamidomethyl-N'-amidomethyl]diethylenetriamine tetraacetic acid (Gd-DTPA-BSA) for MR contrast, and calcein for fluorescence. To determine the specificity and efficiency of delivery, the liposomes were evaluated in FR-positive KB and HeLa cells and FR-negative A549 cells, which were analyzed by fluorescence microscopy, magnetic resonance imaging (MRI), and flow cytometry (FCM). FR-specific and efficient cellular uptake of the FR-targeted bimodal liposomes was confirmed by fluorescence microscopy and by FCM. The mean fluorescence intensity (MFI) of KB cells treated with FR-targeted liposomes was 45× that of cells treated with nontargeted liposomes, and 18× that of cells treated with FR-targeted liposomes and excess folic acid (FA). The MFI of HeLa cells treated with targeted liposomes was 33× that of nontargeted liposomes, and was 16× that of the mixture of targeted liposomes and free FA. In contrast, the MFI of A549 cells treated with FR-targeted liposomes was nearly the same as those treated with nontargeted liposomes. The T(1)-weighted MR images of HeLa and KB cells incubated with FR-targeted liposomes had much higher signal intensity than those treated with nontargeted liposomes or free Gd-DTPA. Furthermore, the FR-targeting effect could be blocked by excess free FA. FR-targeted fluorescent paramagnetic bimodal liposomes provided a novel platform for bimodal tumor imaging and theranostic delivery. Source

Lu X.-P.,Huazhong University of Science and Technology
Gaodianya Jishu/High Voltage Engineering | Year: 2011

Plasma jet devices generate plasma plumes in open space (surrounding air) rather than in confined discharge gaps only. Thus, they can be used for direct treatment and there is no limitation on the size of the object to be treated. This characteristic is very attractive for various applications, such as plasma medicine. Consequently, the states of atmospheric pressure non-equilibrium plasma jets are overviewed. Several typical plasma jet devices, which use noble gas, nitrogen and air as working gases respectively, are discussed. The history of plasma medicine is briefly introduced. Two research topics of plasma medicine, i.e. decontamination of oral bacteria and inducing apoptosis of cancer cells by using plasma jets, are focused on. Finally, some suggestions on plasma jets and plasma medicine research are presented. Source

Zhang X.,Huazhong University of Science and Technology | Zhang X.,Hubei Key Laboratory of Engineering Structural Analysis and Safety Assessment | Zhang H.,Wuhan Textile University
International Journal of Impact Engineering | Year: 2012

Honeycomb cellular structures and multi-cell prismatic columns are highly efficient and effective energy dissipating components and are widely used in the crashworthiness design of vehicles. Due to the complex features during large plastic deformation, only few special sections have been theoretical modeled for their energy absorption capacity under axial compression. In this paper, based on a simplified FE model, the energy absorption characteristics of angle elements with three panels are investigated by using the non-linear finite element code LS-DYNA. Theoretical models are proposed to predict the crush resistance of three-panel angle elements with different angles. Numerical results show that the proposed theoretical model can predict the energy absorption of these angle elements with good accuracy. © 2012 Elsevier Ltd. All rights reserved. Source

Zhang X.,Huazhong University of Science and Technology | Huang G.Q.,University of Hong Kong
International Journal of Production Economics | Year: 2010

This paper deals with simultaneous configuration of platform products and supply chains. The supply chain consists of one manufacturer and multiple cooperative suppliers. A common platform is shared for developing/configuring the product family with variant modules which are substitutable in the sense that high-performance module options can replace low-performance ones. As the customer in the supply chain, the manufacturer takes its leading role by making the first move to produce decisions on platform products configuration (PPC) and supplier selection. The manufacturer and concerned suppliers then move cooperatively to make their ordering and pricing decisions with a common objective to maximize their joint payoffs. We derive the optimal solution ranges for this two-moves dynamic game according to Nash's bargaining model. An iterative algorithm is developed to find the subgame perfect equilibrium. A numerical study is conducted through a series of simulation experiments to illustrate how useful insights about the mutual impacts between the PPC and SCC (supply chain configuration) decisions can be obtained from the proposed game models and solution procedure. The results are further compared with those obtained in a previous study with non-cooperative suppliers. The comparative study allows us to appreciate managerial measures under different supply chain coordination schemes. It is found that a supply chain with cooperative suppliers is more effective by using the lot-for-lot policy and more competitive by accommodating higher product variety. © 2009 Elsevier B.V. All rights reserved. Source

Li J.,Huazhong University of Science and Technology | Yu R.,Wuhan Institute of Technology
Optics Express | Year: 2011

We investigate the scattering properties of a single surface plasmon in metal nanowire coupled to a nitrogen-vacancy (NV) center in diamond nanocrystal under optical excitation. We demonstrate that, by spatially modulating a classical control beam, alternating regions of high reflection and absorption as well as high transmission and absorption of a single plasmon can be created in the left-and right-going directions that act as a kind of scattering grating. Such approach to induce grating gets out the well investigating region in which the weak interactions between single atoms and light is often used. The proposal may be used for chip-integrated grating, switcher and multi-channel drop filter. © 2011 Optical Society of America. Source

Chen C.,Huazhong University of Science and Technology
Journal of Physical Chemistry B | Year: 2016

The free energy landscape is the most important information in the study of the reaction mechanisms of the molecules. However, it is difficult to calculate. In a large collective variable space, a molecule must take a long time to obtain the sufficient sampling during the simulation. To save the calculation quantity, decreasing the sampling region and constructing the local free energy landscape is required in practice. However, the restricted region in the collective variable space may have an irregular shape. Simply restricting one or more collective variables of the molecule cannot satisfy the requirement. In this paper, we propose a modified tomographic method to perform the simulation. First, it divides the restricted region by some hyperplanes and connects the centers of hyperplanes together by a curve. Second, it forces the molecule to sample on the curve and the hyperplanes in the simulation and calculates the free energy data on them. Finally, all the free energy data are combined together to form the local free energy landscape. Without consideration of the area outside the restricted region, this free energy calculation can be more efficient. By this method, one can further optimize the path quickly in the collective variable space. (Graph Presented). © 2016 American Chemical Society. Source

Xu W.,Huazhong University of Science and Technology
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2014

We consider three dimensional Einstein gravity non-minimally coupled to a real scalar field with a self-interacting scalar potential and present the exact black hole formation in three dimensions. Firstly we obtain an exact time-dependent spherically symmetric solution describing the gravitational collapse to a scalar black hole at the infinite time, i.e. in the static limit. The solution can only be asymptotically AdS because of the No-Go theorem in three dimensions which is resulting from the existence of a smooth black hole horizon. Then we analyze their geometric properties and properties of the time evolution. We also get the exact time-dependent solution in the minimal coupling model after taking a conformal transformation. © 2014 The Author. Source

Ouyang M.,Huazhong University of Science and Technology
Reliability Engineering and System Safety | Year: 2014

Modern societies are becoming increasingly dependent on critical infrastructure systems (CISs) to provide essential services that support economic prosperity, governance, and quality of life. These systems are not alone but interdependent at multiple levels to enhance their overall performance. However, recent worldwide events such as the 9/11 terrorist attack, Gulf Coast hurricanes, the Chile and Japanese earthquakes, and even heat waves have highlighted that interdependencies among CISs increase the potential for cascading failures and amplify the impact of both large and small scale initial failures into events of catastrophic proportions. To better understand CISs to support planning, maintenance and emergency decision making, modeling and simulation of interdependencies across CISs has recently become a key field of study. This paper reviews the studies in the field and broadly groups the existing modeling and simulation approaches into six types: empirical approaches, agent based approaches, system dynamics based approaches, economic theory based approaches, network based approaches, and others. Different studies for each type of the approaches are categorized and reviewed in terms of fundamental principles, such as research focus, modeling rationale, and the analysis method, while different types of approaches are further compared according to several criteria, such as the notion of resilience. Finally, this paper offers future research directions and identifies critical challenges in the field. © 2013 Elsevier Ltd. Source

Xu M.,Huazhong University of Science and Technology
Telematics and Informatics | Year: 2013

Zhang G.,Southwest Jiaotong University | Gheorghe M.,University of Sheffield | Pan L.,Huazhong University of Science and Technology | Perez-Jimenez M.J.,University of Seville
Information Sciences | Year: 2014

Evolutionary membrane computing is an important research direction of membrane computing that aims to explore the complex interactions between membrane computing and evolutionary computation. These disciplines are receiving increasing attention. In this paper, an overview of the evolutionary membrane computing state-of-the-art and new results on two established topics in well defined scopes (membrane-inspired evolutionary algorithms and automated design of membrane computing models) are presented. We survey their theoretical developments and applications, sketch the differences between them, and compare the advantages and limitations. © 2014 Elsevier Inc. All rights reserved. Source

Xiang X.,Huazhong University of Science and Technology
Chaos (Woodbury, N.Y.) | Year: 2010

Based on the chaotic oscillator, a method for weak signal detection using information fusion technology is proposed in this paper. On the one hand, various methods are employed to the amplitude detection of the same weak periodic signal, then the detection outcomes are fused by the adaptive weighted fusion method. On the other hand, during the detection course, information entropy, statistic distance, and Walsh transform are, respectively, used in the state recognition of chaotic oscillator from the viewpoint of time domain or frequency domain, then the recognition results are fused by the k/l fusion method. Numerical results show that the proposed approach detects signal more precisely, identifies state more accurately, and represents information more completely compared with traditional methods. Source

Yu F.,Jianghan University | Li B.,Huazhong University of Science and Technology
CrystEngComm | Year: 2011

Solvothermal reactions of tetrakis(4-pyridyloxymethylene)methane (TPOM) with deprotonated benzoate (L1) in the presence of acetate (L2) of copper in H2O/CH3OH with reactant ratio 1:2:2 under different synthesis temperatures produced two new complexes, namely, {[Cu 2(TPOM)2(L1)2(L2)2]·Guest} n (1), and {[Cu4(TPOM)(L1)2(L2) 4(OH)2]·6H2O}n (2). These complexes were characterized by elemental analysis, IR spectroscopy, and X-ray single-crystal diffraction. Complex 1 reveals a 3D crystal structure with a novel 2,3,4-connected 3-nodal topology constructed from the connection of Cu centers and TPOM ligands, which neutralized the mono-dentate carboxylates from different ligands coordinated to Cu ions. Complex 2 exhibits a distinct 3D framework with 2-nodal PtS topology, constructed from the connection of neutral Cu4 SBUs and TPOM ligands. The increasing reaction temperature must be responsible for the versatile coordination modes of carboxylates in 2 compared to the ones in 1, resulting in the formation of the distinct crystal structure. In addition, magnetic investigations on complex 2 revealed antiferromagnetic intra-tetramer interactions through the mixed hydroxo and carboxylato bridges. This journal is © The Royal Society of Chemistry. Source

Xu L.,Huazhong University of Science and Technology | Shi Z.-G.,Wuhan University | Feng Y.-Q.,Wuhan University
Analytical and Bioanalytical Chemistry | Year: 2011

In this review the focus is on application of porous monoliths to miniaturized extraction of biological analysis, with emphasis on porous monolithic materials and different miniaturized extraction formats. The general approaches used to synthesize organic polymer and silica monolithic materials are highlighted, and their properties and applicability are described and compared. Several extraction formats, including in-tube microextraction, chip-based microextraction, tip-based microextraction, among others, are reviewed in depth. © 2010 Springer-Verlag. Source

Wang Y.,Tulane University | Wang Y.,Huazhong University of Science and Technology | Han C.,Tulane University | Lu L.,Tulane University | And 2 more authors.
Hepatology | Year: 2013

Hedgehog (Hh) signaling plays an important role in embryonic development and in the regulation of a variety of cellular functions. Aberrant activation of Hh signaling has been implicated in several human cancers including hepatocellular carcinoma (HCC). In this study we examined the pathobiological functions and molecular mechanisms of the Hh signaling pathway in HCC cells. Treatment of cultured human HCC cells (Huh7, Hep3B, and HepG2) with the Hh signaling ligand (recombinant Shh) or agonist, SAG and purmorphamine, prevented the induction of autophagy. In contrast, GANT61 (a small molecule inhibitor of Gli1 and Gli2) induced autophagy, as determined by immunoblotting for microtubule-associated protein light chain 3 (LC3) and p62, GFP-LC3 puncta, monodansylcadaverine (MDC) staining, and transmission electron microscopy. Hh inhibition-induced autophagy was associated with up-regulation of Bnip3, as determined by immunoblotting and real-time polymerase chain reaction (PCR) assay. Knockdown of Bnip3 by RNAi impaired GANT61-induced autophagy. Additionally, Hh inhibition-induced autophagy was associated with Bnip3-mediated displacement of Bcl-2 from Beclin-1, as determined by immunoblotting and immunoprecipitation assays. Furthermore, inhibition of Hh signaling increased HCC cell apoptosis and decreased cell viability, as determined by caspase and WST-1 assays. Pharmacological or genetic inhibition of autophagy by 3-methyladenine (3-MA) or Beclin-1 small interfering RNA (siRNA) partially suppressed GANT61-induced cell apoptosis and cytotoxicity. In a tumor xenograft model using SCID mice inoculated with Huh7 cells, administration of GANT61 inhibited tumor formation and decreased tumor volume; this effect was partially blocked by the autophagy inhibitor, 3-MA. Conclusion: These findings provide novel evidence that Hh inhibition induces autophagy through up-regulation of Bnip3 and that this mechanism contributes to apoptosis. Therefore, the status of autophagy is a key factor that determines the therapeutic response to Hh-targeted therapies. (Hepatology 2013;53:995-1010). © 2013 by the American Association for the Study of Liver Diseases. Source

Song H.,Huazhong University of Science and Technology
Applied Immunohistochemistry and Molecular Morphology | Year: 2016

Increasing evidences suggest that transforming acidic coiled-coil protein 3 (TACC3) is associated with various types of human cancer. However, the expression of TACC3 in breast cancer tissues remains largely unknown. To identify whether TACC3 can serve as a biomarker for the diagnosis and prognosis of breast cancer, quantitative polymerase chain reaction, western blotting, and immunohistochemistry staining were utilized to detect the expression of TACC3. The mRNA and protein levels of TACC3 in breast cancer samples were novelty higher compared with nontumorous breast tissues. Immunohistochemistry results revealed TACC3 expression was significantly correlated to lymphoid nodal metastasis (P=0.035) and HER-2 status (P=0.021). The patients with high expression of TACC3 had a significantly poor prognosis compared with patients with low expression (P=0.017), especially in the patients with pathological tumor size 2-4 status (P=0.028). Furthermore, multivariate analysis indicated that TACC3 expression was an independent prognostic factor for breast cancer patients (P=0.029). This study, first, suggested TACC3 might be an important molecular marker for diagnosis and prognosis of breast cancer. Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved. Source

Li J.,University of Hong Kong | Liu S.,Huazhong University of Science and Technology | Lam E.Y.,University of Hong Kong
Optics Express | Year: 2013

Source mask optimization (SMO) is a powerful and effective technique to obtain sufficient process stability in optical lithography, particularly in view of the challenges associated with 22nm process technology and beyond. However, SMO algorithms generally involve computationintensive nonlinear optimization. In this work, a fast algorithm based on augmented Lagrangian methods (ALMs) is developed for solving SMO. We first convert the optimization to an equivalent problem with constraints using variable splitting, and then apply an alternating minimization method which gives a straightforward implementation of the algorithm. We also use the quasi-Newton method to tackle the sub-problem so as to accelerate convergence, and a tentative penalty parameter schedule for adjustment and control. Simulation results demonstrate that the proposed method leads to faster convergence and better pattern fidelity. © 2013 Optical Society of America. Source

Lee W.B.,Hong Kong Polytechnic University | Chen Y.P.,Hong Kong Polytechnic University | Chen Y.P.,Huazhong University of Science and Technology
International Journal of Plasticity | Year: 2010

The size effect observed in the micro-indentation of FCC single crystal copper is modelled by the employment of mechanism-based strain gradient crystal plasticity (MSG-CP). The total slip resistance in each active system is assumed to be due to a mixed population of forest obstacles arising from both statistically stored and geometrically necessary dislocations. The MSG-CP constitutive model is implemented into the Abaqus/Standard FE platform by developing the User MATerial subroutine UMAT. The simulation of micro-indentation hardness on (0 0 1) and (1 1 1) single crystal copper, with a conical indenter having a sharp tip, a conical indenter with a spherical tip and a three-sided Berkovich indenter, is undertaken. The phenomena of pile-up and sink-in have been observed in the simulation and dealt with by appropriate use of the contact analysis function in Abaqus. These phenomena have been taken into account in the determination of the contact areas and hence the average indentation depth for anisotropic single crystals. The depth dependence of the micro-indentation hardness, the size effect, is calculated. The micro-hardness results from the simulation are compared with those of the published experimental ones in the literature and a good agreement is found. © 2010 Elsevier Ltd. All rights reserved. Source

Ding Y.,Technical University of Denmark | Xu J.,Technical University of Denmark | Da Ros F.,Technical University of Denmark | Huang B.,Technical University of Denmark | And 3 more authors.
Optics Express | Year: 2013

We demonstrate a novel on-chip two-mode division multiplexing circuit using a tapered directional coupler-based TE0&TE1 mode multiplexer and demultiplexer on the silicon-on-insulator platform. A low insertion loss (0.3 dB), low mode crosstalk (< -16 dB), wide bandwidth (∼100 nm), and large fabrication tolerance (20 nm) are measured. An onchip mode multiplexing experiment is carried out on the fabricated circuit with non return-to-zero (NRZ) on-off keying (OOK) signals at 40 Gbit/s. The experimental results show clear eye diagrams and moderate power penalty for both TE0 and TE1 modes. © 2013 Optical Society of America. Source

Li Q.,Chongqing University of Posts and Telecommunications | Zeng H.,Chongqing University of Posts and Telecommunications | Yang X.-S.,Chongqing University of Posts and Telecommunications | Yang X.-S.,Huazhong University of Science and Technology
Nonlinear Dynamics | Year: 2014

Recently a new attractor, called hidden attractor, has been found in the well-known Chua's circuit, whose basin of attraction does not contain neighborhood of any equilibrium. This paper will restudy this circuit, showing that two hidden attractors can coexist in this circuit for some parameters, and characterizes the basins of these two attractors by means of computer method as well. In addition, a computer-assisted proof of the chaoticity of these attracters is presented by a topological horseshoe theory. © 2014 Springer Science+Business Media Dordrecht. Source

Zou Y.-C.,Hebrew University of Jerusalem | Zou Y.-C.,Huazhong University of Science and Technology | Piran T.,Hebrew University of Jerusalem
Monthly Notices of the Royal Astronomical Society | Year: 2010

While it is generally agreed that the emitting regions in gamma-ray bursts move ultra-relativistically towards the observer, different estimates of the initial Lorentz factors, Γ0, lead to different at times conflicting estimates. We show here that the quiet periods in which the signals goes down below the instrumental thresholds put strong upper limits on the values of Γ0. According to the standard internal-external shock model, an external shock should develop during the prompt stage. This external shock radiates in the hard X-rays to soft gamma-rays bands and this emission should be seen as a smooth background signal. The observed deep minima indicate that this contribution is negligible. This limits, in turn, Γ0. We obtain upper limits on Γ0 for several bursts with typical values around hundreds. We compare these values with those obtained by the other methods, which typically yield lower limits. The results are marginally consistent leaving only a narrow range of allowed values for Γ0. © 2009 The Authors. Journal compilation © 2009 RAS. Source

Chen M.,Huazhong University of Science and Technology | Chen M.,Seoul National University
Multimedia Tools and Applications | Year: 2013

Recent advances in the fields of wireless technology have exhibited a strong potential and tendency on improving human life by means of ubiquitous communications devices that enable smart, distributed services. In fact, traditional human to human (H2H) communications are gradually falling behind the scale of necessity. Consequently, machine to machine (M2M) communications have surpassed H2H, thus drawing significant interest from industry and the research community recently. This paper first presents a four-layer architecture for internet of things (IoT). Based on this architecture, we employ the second generation RFID technology to propose a novel intelligent system for M2M communications. © 2012 The Author(s). Source

Liu F.,Huazhong University of Science and Technology
Pancreas | Year: 2016

OBJECTIVES: Proinsulin is the first autoantigen in type 1 diabetes (T1D). We reasoned that coupling hematopoietic stem cells (HSCs) transplantation with ex vivo transduction of syngeneic HSCs with lentiviral vectors to express proinsulin II could prevent T1D in nonobese diabetic (NOD) mice. METHODS: Hematopoietic stem cells were isolated from 6- to 8-week-old NOD female mice and transduced in vitro with lentiviral vectors encoding proinsulin II. Preconditioned 3- to 4-week-old female NOD mice were transplanted with transduced or nontransduced HSCs and compared with age-matched unmanipulated control. The insulitis, T1D development, and immune reconstitution were assessed. RESULTS: The mean (SD) insulitis score was significantly reduced (1.156 [0.575] vs 2.156[0.892] or 3.043[0.728], P = 0.009 or <0.001), and diabetes was nearly completely prevented (1/13 vs 5/12 or 4/9, P = 0.031 or 0.013) in recipients of transduced HSCs expressing proinsulin II as compared with recipients of nontransduced HSCs or unmanipulated control. Sialitis, reconstitution of peripheral blood leukocytes, and in vitro recall responses to ovalbumin were not different between 3 groups of mice. CONCLUSIONS: Syngeneic transplantation of HSCs transduced ex vivo with lentiviral vectors to encode proinsulin II is a novel strategy to prevent T1D. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. Source

Shi C.,Huazhong University of Science and Technology
Cancer biology & therapy | Year: 2010

Cancer stem cells (CSCs)/tumor-initiating cells have been defined as a subset of tumor cells responsible for initiating and sustaining tumor development. Emerging evidence strongly supports the existence of CSCs in various solid tumors, but they have not yet been identified in human gallbladder carcinomas (GBC). In this study, we identified CSCs in primary GBC and in the cell line GBC-SD using the cell surface markers CD44 and CD133. The percentages of CD44+CD133+ cells were 1.76-3.05% in primary tumors and 40.29% in GBC-SD cells. These cells showed stem cell properties, including self-renewal, differentiation potential, and high tumorigenicity. In vitro culture experiments revealed that CD44+CD133+ GBC cells possessed a higher spheroid-colony forming ability in serum-free media than other subpopulations. When injected into nonobese diabetic/severe combined immunodeficient mice, these cells formed new tumors and generated CD44+CD133+, CD44-, and CD133- progeny. CD44+CD133+ cells also showed a high degree of chemoresistance, possibly due to upregulation of the breast cancer resistance protein (ABCG2) and the transcription factor Gli1 in these highly tumorigenic cells. These results suggest that the CD44+CD133+ population exhibited CSC-like characteristics and may thus provide a novel approach to the diagnosis and treatment of GBC. Source

Rao L.,McGill University | Liu X.,McGill University | Xie L.,Texas A&M University | Liu W.,Huazhong University of Science and Technology
IEEE Transactions on Smart Grid | Year: 2012

This paper addresses the problem of electricity cost management for Internet service providers with a collection of spatially distributed data centers. As the demand on Internet services drastically increases in recent years, the electricity consumed by Internet data centers (IDCs) has been skyrocketing. While most existing research focuses on reducing electric energy consumption of IDCs at one specific location, the problem of reducing the total electricity cost has been overlooked. This is an important problem faced by service providers, especially in the present multi-electricity-market environment, where the price of electricity may exhibit temporal and spatial diversities. Further, for these service providers, guaranteeing the quality of service (i.e., service level objectives) such as service delay guarantees to the end users is of critical importance. This paper studies the problem of minimizing the total electricity cost under multiple electricity markets environment while guaranteeing the quality of service geared to the location diversity and time diversity of electricity price. The problem is modeled as a constrained mixed-integer programming and an efficient solution algorithm is proposed. Extensive evaluations based on real-world electricity price data for multiple IDC locations illustrate the efficiency and efficacy of our approach. © 2011 IEEE. Source

Deng R.,Hubei Key Laboratory Of Materials Chemistry And Service Failure | Liu S.,Hubei Key Laboratory Of Materials Chemistry And Service Failure | Li J.,Hubei Key Laboratory Of Materials Chemistry And Service Failure | Liao Y.,Hubei Key Laboratory Of Materials Chemistry And Service Failure | And 2 more authors.

A simple, yet robust route to prepare polymer nanoparticles with tunable internal structures through supramolecular assembly within emulsion droplets is presented. Nanoparticles with various internal morphologies, including dispersed spheres, dispersed spirals, stacked toroids, and concentric lamellae, are obtained due to the 3D confinement and variation of hydrogen-bonding agent. This method also allows us to form mesoporous particles through further disassembly of the supramoleclar assemblies by rupturing the hydrogen bonding. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

Huang X.W.,Huazhong University of Science and Technology
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery | Year: 2011

To establish a preliminary foundation for developing a serum proteomics diagnostic model of nasopharyngeal carcinoma (NPC) by comparing the differences in serum protein fingerprints between patients with NPC and healthy subjects and between different types of NPC. The serum samples of 41 patients with different types of NPC and 20 healthy subjects were collected. Surface-enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI-TOF-MS) were used to detect the blood samples to obtain serum protein mass spectrum, i.e. serum protein fingerprinting. Biomarker Wizard and Biomarker Patterns system software were used to compare the differences in serum protein mass spectrum between NPC patients and healthy subjects and between different types of NPC, and to screen out the NPC-related serum proteins. Compared with the healthy control, NPC patients emerged 9 very prominent protein peaks (P < 0.001), with the combined differential peaks. No significant difference was found in relative amount of serum proteins with different molecular mass between different types of NPC (P > 0.05). The serum marker proteins and specific protein fingerprints of NPC can be screened out by SELDI-TOF-MS, which could be used to develop a serum proteomics model for clinical screening and early diagnosis of NPC. Source

Cao N.,Hubei University | Su J.,Huazhong University of Science and Technology | Luo W.,Hubei University | Cheng G.,Hubei University
International Journal of Hydrogen Energy | Year: 2014

Ru@Ni core-shell nanoparticles (NPs) supported on graphene have been synthesized by one-step in situ co-reduction of aqueous solution of ruthenium (III) chloride, nickel (II) chloride, and graphene oxide (GO) with ammonia borane (AB) as the reducing agent under ambient condition. The as-synthesized NPs exhibit much higher catalytic activity for hydrolytic dehydrogenation of AB than the monometallic, bimetallic alloy (RuNi/graphene), and graphene-free core-shell (Ru@Ni) counterparts. Additionally, the Ru@Ni/graphene NPs facilitate the hydrolysis of AB, with the turnover frequency (TOF) value of 340 mol H 2 min-1 (mol Ru)-1, which is among the highest value reported on Ru-based NPs so far, and even higher than the reversed Ni@Ru NPs. Furthermore, the as-prepared NPs exert satisfied durable stability and magnetically recyclability for the hydrolytic dehydrogenation of AB and methylamine borane (MeAB). Moreover, this simple synthetic method can be extended to other Ru-based bimetallic core-shell systems for more applications. Copyright © 2013, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved. Source

Wang B.,Huazhong University of Science and Technology
ACM Computing Surveys | Year: 2011

Sensor networks, which consist of sensor nodes each capable of sensing environment and transmitting data, have lots of applications in battlefield surveillance, environmental monitoring, industrial diagnostics, etc. Coverage which is one of the most important performance metrics for sensor networks reflects how well a sensor field is monitored. Individual sensor coverage models are dependent on the sensing functions of different types of sensors, while network-wide sensing coverage is a collective performance measure for geographically distributed sensor nodes. This article surveys research progress made to address various coverage problems in sensor networks. We first provide discussions on sensor coverage models and design issues. The coverage problems in sensor networks can be classified into three categories according to the subject to be covered. We state the basic coverage problems in each category, and review representative solution approaches in the literature. We also provide comments and discussions on some extensions and variants of these basic coverage problems. © 2011 ACM. Source

Lu X.,Huazhong University of Science and Technology | Naidis G.V.,RAS Joint Institute for High Temperatures | Laroussi M.,Old Dominion University | Ostrikov K.,CSIRO | Ostrikov K.,University of Sydney
Physics Reports | Year: 2014

This review focuses on one of the fundamental phenomena that occur upon application of sufficiently strong electric fields to gases, namely the formation and propagation of ionization waves-streamers. The dynamics of streamers is controlled by strongly nonlinear coupling, in localized streamer tip regions, between enhanced (due to charge separation) electric field and ionization and transport of charged species in the enhanced field. Streamers appear in nature (as initial stages of sparks and lightning, as huge structures-sprites above thunderclouds), and are also found in numerous technological applications of electrical discharges. Here we discuss the fundamental physics of the guided streamer-like structures-plasma bullets which are produced in cold atmospheric-pressure plasma jets. Plasma bullets are guided ionization waves moving in a thin column of a jet of plasma forming gases (e.g.,He or Ar) expanding into ambient air. In contrast to streamers in a free (unbounded) space that propagate in a stochastic manner and often branch, guided ionization waves are repetitive and highly-reproducible and propagate along the same path-the jet axis. This property of guided streamers, in comparison with streamers in a free space, enables many advanced time-resolved experimental studies of ionization waves with nanosecond precision. In particular, experimental studies on manipulation of streamers by external electric fields and streamer interactions are critically examined. This review also introduces the basic theories and recent advances on the experimental and computational studies of guided streamers, in particular related to the propagation dynamics of ionization waves and the various parameters of relevance to plasma streamers. This knowledge is very useful to optimize the efficacy of applications of plasma streamer discharges in various fields ranging from health care and medicine to materials science and nanotechnology. © 2014 Elsevier B.V. Source

Jiang H.,Huazhong University of Science and Technology | Jin S.,Case Western Reserve University | Wang C.,NEC Laboratories America Inc.
IEEE Transactions on Parallel and Distributed Systems | Year: 2011

For many applications in wireless sensor networks (WSNs), users may want to continuously extract data from the networks for analysis later. However, accurate data extraction is difficultit is often too costly to obtain all sensor readings, as well as not necessary in the sense that the readings themselves only represent samples of the true state of the world. Clustering and prediction techniques, which exploit spatial and temporal correlation among the sensor data provide opportunities for reducing the energy consumption of continuous sensor data collection. Integrating clustering and prediction techniques makes it essential to design a new data collection scheme, so as to achieve network energy efficiency and stability. We propose an energy-efficient framework for clustering-based data collection in wireless sensor networks by integrating adaptively enabling/disabling prediction scheme. Our framework is clustering based. A cluster head represents all sensor nodes in the cluster and collects data values from them. To realize prediction techniques efficiently in WSNs, we present adaptive scheme to control prediction used in our framework, analyze the performance tradeoff between reducing communication cost and limiting prediction cost, and design algorithms to exploit the benefit of adaptive scheme to enable/disable prediction operations. Our framework is general enough to incorporate many advanced features and we show how sleep/awake scheduling can be applied, which takes our framework approach to designing a practical algorithm for data aggregation: it avoids the need for rampant node-to-node propagation of aggregates, but rather it uses faster and more efficient cluster-to-cluster propagation. To the best of our knowledge, this is the first work adaptively enabling/disabling prediction scheme for clustering-based continuous data collection in sensor networks. Our proposed models, analysis, and framework are validated via simulation and comparison with competing techniques. © 2011 IEEE. Source

Ni Z.,University of Rhode Island | He H.,University of Rhode Island | Wen J.,Huazhong University of Science and Technology
IEEE Transactions on Neural Networks and Learning Systems | Year: 2013

In this paper, we present a new adaptive dynamic programming approach by integrating a reference network that provides an internal goal representation to help the systems learning and optimization. Specifically, we build the reference network on top of the critic network to form a dual critic network design that contains the detailed internal goal representation to help approximate the value function. This internal goal signal, working as the reinforcement signal for the critic network in our design, is adaptively generated by the reference network and can also be adjusted automatically. In this way, we provide an alternative choice rather than crafting the reinforcement signal manually from prior knowledge. In this paper, we adopt the online action-dependent heuristic dynamic programming (ADHDP) design and provide the detailed design of the dual critic network structure. Detailed Lyapunov stability analysis for our proposed approach is presented to support the proposed structure from a theoretical point of view. Furthermore, we also develop a virtual reality platform to demonstrate the real-time simulation of our approach under different disturbance situations. The overall adaptive learning performance has been tested on two tracking control benchmarks with a tracking filter. For comparative studies, we also present the tracking performance with the typical ADHDP, and the simulation results justify the improved performance with our approach. © 2012 IEEE. Source

Bernardes M.A.D.S.,Centro Universitario | Zhou X.,Huazhong University of Science and Technology
Solar Energy | Year: 2013

This paper evaluates the Solar Chimney Power Plant performance subject to adverse solar radiance conditions. For that, numerical simulations are performed to estimate the optimal ratio of the turbine pressure drop to the total pressure potential (. x-factor) as an independent control variable. The results show that x-factor values remain around 0.8 for periods with sufficient heat gain from sun or ground. Otherwise, x-factor values have a tendency to drop to zero. In winter, due to lower system heat gains, this trend is more accentuated. © 2013 Elsevier Ltd. Source

Zeng T.,Huazhong University of Science and Technology | Zeng T.,FiberHome Technologies Group
Optics Express | Year: 2013

We proposed a new method for superchannel transmission based on the newly proposed multi-channel equalization technique. This method allows us to realize tight channel spacing (equal to the baud rate) without using frequency-locked lasers and complex spectral shaping techniques at the transmitter. The inter-channel interference originated from the tight channel spacing is removed at the receiver by joint equalization of multiple adjacent channels. When the channel spacing is equal to the baud rate, our simulation results show that, with conventional oversample ratio (2 samples per symbol), realistic laser frequency offset and laser linewidth, the proposed multi-channel-equalization based method can achieve better performance than the traditional method using spectral shaping plus single channel equalization, although at the expense of a moderate increase in DSP complexity. The paper also gives a simple method to process the data after conventional chromatic dispersion compensation, which enables subsequent multi-channel equalization for long-haul transmissions. © 2013 Optical Society of America. Source

Gai S.,Nanjing Southeast University | Gai S.,Huazhong University of Science and Technology | Da F.,Nanjing Southeast University
Optics Express | Year: 2010

A novel phase-analysis method is proposed. To get the fringe order of a fringe image, the amplitude-modulation fringe pattern is carried out, which is combined with the phase-shift method. The primary phase value is obtained by a phase-shift algorithm, and the fringe-order information is encoded in the amplitude-modulation fringe pattern. Different from other methods, the amplitude-modulation fringe identifies the fringe order by the amplitude of the fringe pattern. In an amplitudemodulation fringe pattern, each fringe has its own amplitude; thus, the order information is integrated in one fringe pattern, and the absolute fringe phase can be calculated correctly and quickly with the amplitude-modulation fringe image. The detailed algorithm is given, and the error analysis of this method is also discussed. Experimental results are presented by a full-field shape measurement system where the data has been processed using the proposed algorithm. © 2010 Optical Society of America. Source

Lin K.,Dalian University of Technology | Chen M.,Huazhong University of Science and Technology | Zeadally S.,University of the District of Columbia | Rodrigues J.J.P.C.,University of Beira Interior
Future Generation Computer Systems | Year: 2012

For Wireless Sensor Networks (WSNs), an unbalanced energy consumption will decrease the lifetime of network. In this paper, we leverage mobile agent technology to investigate the problem of how to balance the energy consumption during data collection in WSNs. We first demonstrate that for a sensor network with uniform node distribution and constant data reporting, balancing the energy of the whole network cannot be realized when the distribution of data among sensor nodes is unbalanced. We design a method to mitigate the uneven energy dissipation problem by controlling the mobility of agents, which is achieved by an energy prediction strategy to find their positions. Finally, we propose energy balancing cluster routing based on a mobile agent (EBMA) for WSNs. To obtain better performance, the cluster structure is formed based on cellular topology taking into consideration the energy balancing of inter-cluster and intra-cluster environments. Extensive simulation experiments are carried out to evaluate EBMA with several performance criteria. Our simulation results show that EBMA can effectively balance energy consumption and perform high efficiency in large-scale network deployment. © 2011 Elsevier B.V. All rights reserved. Source

Xu Q.,Huazhong University of Science and Technology
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference | Year: 2011

Epidural spinal cord stimulation (ESCS) combined with partial weight bearing therapy (PWBT) has been reported to facilitate recovery of functional walking for individuals after chronic incomplete spinal cord injury. This paper describes a low cost, fully implantable, advanced ESCS stimulator that can be manufactured in a research laboratory for use in small animals. The system is composed of four main parts: an external personal digital assistant (PDA), an external controller, an implantable pulse generator (IPG), lead extension and electrode. The PDA allows the experimenter to program the stimulation parameters through a user-friendly graphical interface. The external controller placed on the rat back communicates with PDA via RF telemetry. The IPG generates the biphasic charge-balanced voltage-regulated pulses, which are delivered to the bipolar electrode by the lead extension to achieve chronic ESCS in freely moving rats. A RF carrier from the Class-E amplifier in the external controller provides both data and power for the implanted circuitry through a closely coupled inductive link. The IPG is hermetically packaged using a silicon elastomer and measures 22 mm × 23 mm × 7 mm with a mass of ~3.78 g. Source

Guo Y.,Huazhong University of Science and Technology
Journal of Occupational and Environmental Medicine | Year: 2016

OBJECTIVE:: This study is aimed to analyze the relationship between occupational CS2 exposure and reproductive impairments. METHODS:: Seventy-six CS2-exposed (9.73?±?2.76?mg/m) male workers and 94 unexposed workers were selected for study. Worker demographics were assessed with a customized questionnaire. Sexual hormones and sperm-related parameters were measured by biochemical or morphological analysis. RESULTS:: The CS2-exposed workers had significantly higher serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and lower levels of testosterone (T). Significant decrements were also identified in sperm viability and motility, chromatin, antioxidant capacity, mitochondrial membrane potential, mitochondrial membrane permeability transition pore (MPTP), and respiratory chain Complexes II and IV. CONCLUSIONS:: Our data indicated that occupational CS2 exposure can exert deleterious effects on male sexual hormones and sperm quality, and mitochondrial dysfunction may play a vital role in this process. Copyright © 2016 by the American College of Occupational and Environmental Medicine Source

Chen L.,Huazhong University of Science and Technology
Hepato-Gastroenterology | Year: 2013

Pancreatic leakage after pancreaticoduodenectomy is not fully prevented despite pancreaticojejunostomy or pancreaticogastrostomy being applied. Here, a new type of transductal invaginational pancreaticojejunostomy (TDI) was devised to prevent pancreatic leakage. Briefly, prolene was penetrated from inside the pancreatic duct through the pancreatic stump at ventral and dorsal sides, respectively, and penetrated from the jejunal cavity outwards; so the pancreatic duct was kept patently and pancreaticojejunostomy was fixed by the prolene stitches. From August 2009 to March 2012, 29 patients received TDI with their consent. No pancreatic leakage was found postoperatively. The postoperative complications included 1 instance of biliojejunostomy leakage, 1 abscess and 2 incision infections. Our primary experience of applying TDI suggests that it is a simple and effective technique to prevent pancreatic leakage after pancreatoduodenectomy, especially in those cases with soft pancreas and normal pancreatic duct diameter. © H.G.E. Update Medical Publishing S.A. Source

Wang X.,Huazhong University of Science and Technology
PloS one | Year: 2013

Tu Z.,University of California at Los Angeles | Bai X.,Huazhong University of Science and Technology
IEEE Transactions on Pattern Analysis and Machine Intelligence | Year: 2010

The notion of using context information for solving high-level vision and medical image segmentation problems has been increasingly realized in the field. However, how to learn an effective and efficient context model, together with an image appearance model, remains mostly unknown. The current literature using Markov Random Fields (MRFs) and Conditional Random Fields (CRFs) often involves specific algorithm design in which the modeling and computing stages are studied in isolation. In this paper, we propose a learning algorithm, auto-context. Given a set of training images and their corresponding label maps, we first learn a classifier on local image patches. The discriminative probability (or classification confidence) maps created by the learned classifier are then used as context information, in addition to the original image patches, to train a new classifier. The algorithm then iterates until convergence. Auto-context integrates low-level and context information by fusing a large number of low-level appearance features with context and implicit shape information. The resulting discriminative algorithm is general and easy to implement. Under nearly the same parameter settings in training, we apply the algorithm to three challenging vision applications: foreground/background segregation, human body configuration estimation, and scene region labeling. Moreover, context also plays a very important role in medical/brain images where the anatomical structures are mostly constrained to relatively fixed positions. With only some slight changes resulting from using 3D instead of 2D features, the auto-context algorithm applied to brain MRI image segmentation is shown to outperform state-of-the-art algorithms specifically designed for this domain. Furthermore, the scope of the proposed algorithm goes beyond image analysis and it has the potential to be used for a wide variety of problems for structured prediction problems. © 2006 IEEE. Source

Hu Y.,University of Hong Kong | Su H.,Huazhong University of Science and Technology | Lam J.,University of Hong Kong
International Journal of Robust and Nonlinear Control | Year: 2013

This paper is concerned with the second-order consensus problem of multi-agent systems with a virtual leader, where all agents and the virtual leader share the same intrinsic dynamics with a locally Lipschitz condition. It is assumed that only a small fraction of agents in the group are informed about the position and velocity of the virtual leader. A connectivity-preserving adaptive controller is proposed to ensure the consensus of multi-agent systems, wherein no information about the nonlinear dynamics is needed. Moreover, it is proved that the consensus can be reached globally with the proposed control strategy if the degree of the nonlinear dynamics is smaller than some analytical value. Numerical simulations are further provided to illustrate the theoretical results. Copyright © 2012 John Wiley & Sons, Ltd. Source

Peng C.,Nanjing Normal University | Tian Y.-C.,Queensland University of Technology | Yue D.,Huazhong University of Science and Technology
IEEE Transactions on Systems, Man, and Cybernetics Part A:Systems and Humans | Year: 2011

This correspondence paper addresses the problem of output feedback stabilization of control systems in networked environments with quality-of-service (QoS) constraints. The problem is investigated in discrete-time state space using Lyapunov's stability theory and the linear inequality matrix technique. A new discrete-time modeling approach is developed to describe a networked control system (NCS) with parameter uncertainties and nonideal network QoS. It integrates a network-induced delay, packet dropout, and other network behaviors into a unified framework. With this modeling, an improved stability condition, which is dependent on the lower and upper bounds of the equivalent network-induced delay, is established for the NCS with norm-bounded parameter uncertainties. It is further extended for the output feedback stabilization of the NCS with nonideal QoS. Numerical examples are given to demonstrate the main results of the theoretical development. © 2006 IEEE. Source

Pan Y.,Huazhong University of Science and Technology
Southern Medical Journal | Year: 2011

OBJECTIVES: Differentiation between pulmonary tuberculoma and malignancy by preoperative diagnostic imaging sometimes proves difficult. The purpose of this study is to investigate variable manifestations of pulmonary tuberculoma mimicking lung cancer on fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) image and pathologic correlation. PATIENTS AND METHODS: Twenty-five patients with a high suspicion of malignancy and histopathologically diagnosed as pulmonary tuberculoma were included. Their FDG PET/CT images, clinical data, and pathologic findings were investigated. RESULTS: There were 18 men and seven women. The mean age was 52 ± 8.8 years. The maximal diameter of pulmonary tuberculoma ranged from 1.7 to 4.2 cm. CT scan revealed that abnormal signs associated with malignancy such as spicular radiation, notching, and pleural indentation also frequently manifested in tuberculoma. During early imaging, positive FDG uptake was identified in 21 patients (84%), intermediate uptake in 3 patients (12%) and negative uptake in 1 patient (4%). During delayed imaging, 16 patients (64%) showed persistent elevated FDG accumulation and 8 patients (32%) experienced a slight drop of FDG accumulation. Pathologically active tuberculoma showed significantly higher FDG radioactivity during both early and delayed imaging than inactive lesion (P < 0.05). Lymphadenopathy with positive FDG uptake was identified in nine patients (36%). CONCLUSION: Pulmonary tuberculomas mimicking lung cancer, most of which were pathologically active lesions, commonly displayed abnormal appearances in CT scan and an increase in FDG uptake, similar to changes seen on malignancy. Coexistent lymphadenopathy made differential diagnosis even more complicated. These results suggested that positive FDG PET/CT findings should be interpreted with caution in tuberculosis-endemic regions. Copyright © 2011 by The Southern Medical Association. Source

Yin X.,Huazhong University of Science and Technology | Hu S.,Hubei University of Arts and Science
Asian Journal of Control | Year: 2013

This paper is devoted to the consensus protocol design for a set of agents with fractional-order uncertainty dynamics where the fractional order α satisfies 0 < α < 2. For multi-agent systems (MASs) with fixed undirected topology, a distributed static output feedback protocol is proposed with an undetermined system matrix. Based on model transformation and fractional-order stability theory, sufficient conditions are derived to ensure the consensus of MASs in terms of linear matrix inequalities (LMIs). Finally, a simulation example is employed to validate the effectiveness of the proposed consensus protocol. © 2013 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society. Source

Chen Z.,University of Newcastle | Zhang H.-T.,Huazhong University of Science and Technology
Automatica | Year: 2011

In this paper, a decentralized control algorithm is proposed for a group of nonholonomic vehicles to form a class of collective circular motion behavior. Without the guidance of a global beacon, the desired collective behavior occurs provided that the multi-agent system is jointly connected. Moreover, a repulsion mechanism is considered to improve the distribution evenness of the agents' circular motion phases and hence to avoid collision. The effectiveness of the approach is verified through both theoretical analysis and numerical simulation. Moreover, some interesting variations of the circular motion model are investigated to enrich the collective behaviors. © 2011 Elsevier Ltd. All rights reserved. Source

Lu X.,Rensselaer Polytechnic Institute | Zhang X.-C.,Huazhong University of Science and Technology | Zhang X.-C.,Rensselaer Polytechnic Institute
Physical Review Letters | Year: 2012

By applying a helical electric field along a plasma region, a revolving electron current is formed along the plasma and an elliptically polarized far-field terahertz wave pattern is observed. The observed terahertz wave polarization reveals the remarkable role of velocity retardation between optical pulses and generated terahertz pulses in the generation process. Extensive simulations, including longitudinal propagation effects, are performed to clarify the mechanisms responsible for polarization control of air-plasma-based terahertz sources. © 2012 American Physical Society. Source

Zhang X.,Huazhong University of Science and Technology | Zhang X.,Hubei Key Laboratory of Engineering Structural Analysis and Safety Assessment | Zhang H.,Wuhan Textile University
Thin-Walled Structures | Year: 2013

Multi-cell metal columns were found to be much more efficient in energy absorption than single-cell columns under axial compression. However, the experimental investigations and theoretical analyses of them are relatively few. In this paper, the quasi-static axial compression tests are carried out for multi-cell columns with different sections. The significant advantage of multi-cell sections over single cell in energy absorption efficiency is investigated and validated. Numerical simulations are also conducted to simulate the compression tests and the numerical results show a very good agreement with experiment. Theoretial analyses based on constitutive element method are proposed to predict the crush resistance of multi-cell columns and the theoretical predictions compare very well with the experimental and numerical results. © 2013 Elsevier Ltd. Source

Zhu H.X.,University of Cardiff | Chen C.Y.,Huazhong University of Science and Technology
Mechanics of Materials | Year: 2011

This paper presents the combined effects of relative density and material distribution on the elastic constants and the yield strengths of metallic honeycombs. Periodic regular hexagonal cell is employed as the structural model. Cell wall bending, transverse shear and axial stretching/compression are taken as the deformation mechanisms in the analysis. Closed-form solutions for the yield strengths and all the five independent elastic constants are obtained for honeycombs with cell walls of uniform thickness. For honeycombs with cell walls of non-uniform thickness, the closed-form solutions would be too lengthy to use in practical applications. We instead provide numerical results to show the combined effects of relative density and material distribution on the initial and full yield strengths and all the five independent elastic constants of metallic honeycombs. The results can serve as a guide for the optimal design of metallic honeycombs. Crown Copyright © 2011 Published by Elsevier Ltd. All rights reserved. Source

Qiu X.,Huazhong University of Science and Technology
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban | Year: 2011

To observe the effects of Huanglian Jiedu Decoction (HLJDT) on the metabolism of free radicals, the morphology and histopathology of hippocampal CA1 neurons in PS1/APP double transgenic mice of Alzheimer's disease (AD), and to study its possible mechanisms, thus providing experimental evidence for treating AD by HLJDT. The APP/PS1 double transgenic mouse model was used. Mice were randomly divided into five groups, i. e., the model control group, the positive control group (Aricept), high-, middle-, and low-dose HLJDT group (at the daily dose of 865 mg*kg(-1), 433 mg*kg(-1), and 216 mg*kg(-1), respectively). Corresponding medication was daily given by gastrogavage. Seven months later superoxide dismutase (SOD) and malondialdehyde (MDA) were detected at the ten-month old mice, thus observing the effects on the morphology of CA1 hippocampal neurons and the senile plaques (SP). HLJDT and Aricept could obviously increase the SOD contents and lower the MDA contents (P<0.05), attenuate the destroy of neurocytes and the formation of SP, effectively hinder the degeneration of hippocampal neurons. Better results were obtained in the middle-dose HLJDT group than in the positive control group (P<0.05). The mechanism of HLJDT in treating AD might be possibly correlated with improving anti-oxygenation, protecting hippocampal neurocytes, and reducing the formation of SP. Source

Cheng M.,Huazhong University of Science and Technology | Qin G.,Northwestern University
Progress in Molecular Biology and Translational Science | Year: 2012

Progenitor cell retention and release are largely governed by the binding of stromal-cell-derived factor 1 (SDF-1) to CXC chemokine receptor 4 (CXCR4) and by α4-integrin signaling. Both of these pathways are dependent on c-kit activity: the mobilization of progenitor cells in response to either CXCR4 antagonism or α4-integrin blockade is impaired by the loss of c-kit kinase activity; and c-kit-kinase inactivation blocks the retention of CXCR4-positive progenitor cells in the bone marrow. SDF-1/CXCR4 and α4-integrin signaling are also crucial for the retention of progenitor cells in the ischemic region, which may explain, at least in part, why clinical trials of progenitor cell therapy have failed to display the efficacy observed in preclinical investigations. The lack of effectiveness is often attributed to poor retention of the transplanted cells and, to date, most of the trial protocols have mobilized cells with injections of granulocyte colony-stimulating factor (G-CSF), which activates extracellular proteases that irreversibly cleave cell-surface adhesion molecules, including α4-integrin and CXCR4. Thus, the retention of G-CSF-mobilized cells in the ischemic region may be impaired, and the mobilization of agents that reversibly disrupt SDF-1/CXCR4 binding, such as AMD3100, may improve patient response. Efforts to supplement SDF-1 levels in the ischemic region may also improve progenitor cell recruitment and the effectiveness of stem cell therapy. © 2012 Elsevier Inc. Source

Tian E.,Nanjing Normal University | Yue D.,Huazhong University of Science and Technology
International Journal of Robust and Nonlinear Control | Year: 2013

This paper investigates robust and reliable H∞ filter design for a class of nonlinear networked control systems: (i) a T-S fuzzy model with its own uncertainties is used to approximate the nonlinear dynamics of the plant, (ii) a new sensor failure model with uncertainties is proposed, and (iii) the signal transfer of the closed-loop system is under a networked communication scheme and therefore is subject to time delay, packet loss, and/or packet out of order. Four new theorems are proved to cover the conditions for the robust mean square stability of the systems under study in terms of LMIs, and a decoupling method for the filter design is developed. Two examples, one of them is based on a model of an inverted pendulum, are provided to demonstrate the design method. Copyright © 2011 John Wiley & Sons, Ltd. Source

Tan W.-W.,Central China Normal University | Cao X.-F.,Huazhong University of Science and Technology | Yu Y.-W.,Central China Normal University
Astrophysical Journal Letters | Year: 2013

The determination of the luminosity function (LF) of gamma-ray bursts (GRBs) is an important role for the cosmological applications of the GRBs, which, however, is seriously hindered by some selection effects due to redshift measurements. In order to avoid these selection effects, we suggest calculating pseudo-redshifts for Swift GRBs according to the empirical L-Ep relationship. Here, such a L-Ep relationship is determined by reconciling the distributions of pseudo- and real redshifts of redshift-known GRBs. The values of Ep taken from Butler's GRB catalog are estimated with Bayesian statistics rather than observed. Using the GRB sample with pseudo-redshifts of a relatively large number, we fit the redshift-resolved luminosity distributions of the GRBs with a broken-power-law LF. The fitting results suggest that the LF could evolve with redshift by a redshift-dependent break luminosity, e.g., Lb = 1.2 × 1051(1 + z) 2 erg s-1. The low- and high-luminosity indices are constrained to 0.8 and 2.0, respectively. It is found that the proportional coefficient between the GRB event rate and the star formation rate should correspondingly decrease with increasing redshifts. © 2013. The American Astronomical Society. All rights reserved. Source

Wu X.-F.,Chinese Academy of Sciences | Wu X.-F.,Nanjing University | Hou S.-J.,Xiamen University | Lei W.-H.,Huazhong University of Science and Technology
Astrophysical Journal Letters | Year: 2013

A particularly interesting discovery in observations of GRB 121027A is that of a giant X-ray bump detected by the Swift/X-Ray Telescope. The X-ray afterglow re-brightens sharply at ≃103 s after the trigger by more than two orders of magnitude in less than 200 s. This X-ray bump lasts for more than 104 s. It is quite different from typical X-ray flares. In this Letter we propose a fall-back accretion model to interpret this X-ray bump within the context of the collapse of a massive star for a long-duration gamma-ray burst. The required fall-back radius of ≃3.5 × 10 10 cm and mass of ≃0.9-2.6 M imply that a significant part of the helium envelope should survive through the mass loss during the last stage of the massive progenitor of GRB 121027A. © 2013. The American Astronomical Society. All rights reserved.. Source

Zhang X.,Huazhong University of Science and Technology | Zhang X.,Hubei Key Laboratory of Engineering Structural Analysis and Safety Assessment | Zhang H.,Wuhan Textile University
International Journal of Impact Engineering | Year: 2013

The present work is aimed at finding the maximum energy absorption efficiency of plates in thin-walled structures under compression. In thin-walled structures, the plates are connected with different angles and by different edge connectivity. The influences of these two major factors on the crush resistance of structures are investigated numerically by nonlinear finite element code. Two extreme modes: uniform mode and opposite mode are defined for the angle elements with different edge connectivity. The energy absorption characteristics of these two modes are investigated and a theoretical model is established to predict the energy absorption capacity of elements deforming in uniform mode. Experimental tests of multi-cell columns are conducted to validate the numerical analyses and theoretical models for angle elements. The numerical simulations and theoretical predictions of the crush resistance of multi-cell columns show a very good agreement with the experimental results. © 2013 Elsevier Ltd. All rights reserved. Source

Zhang C.,Huazhong University of Science and Technology
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban | Year: 2012

Carboxylesterases (CESs) play important roles in the metabolism of endogenous and foreign compounds in physiological and pharmacological responses. The aim of this study was to investigate the effect of dexamethasone at different doses on the expression of CES1 and CES2. Imidapril and irinotecan hydrochloride (CPT-11) were used as special substrates for CES1 and CES2, respectively. Rat hepatocytes were cultured and treated with different concentrations of dexamethasone. The hydrolytic activity of CES1 and CES2 was tested by incubation experiment and their expression was quantitated by real-time PCR. A pharmacokinetic study was conducted in SD rats to further evaluate the effect of dexamethasone on CESs activity in vivo. Western blotting was performed to investigate the regulatory mechanism related to pregnane X receptor (PXR) and glucocorticoid receptor (GR). The results showed that exposure of cultured rat hepatocytes to nanomolar dexamethasone inhibited the imidapril hydrolase activity, which was slightly elevated by micromolar dexamethasone. For CES2, CPT-11 hydrolase activity was induced only when dexamethasone reached micromolar levels. The real-time PCR demonstrated that CES1 mRNA was markedly decreased by nanomolar dexamethasone and increased by micromolar dexamethasone, whereas CES2 mRNA was significantly increased by micromolar dexamethasone. The results of a complementary animal study showed that the concurrent administration of dexamethasone significantly increased the plasma concentration of the metabolite of imidapril while the ratio of CPT-11 to its metabolite SN-38 was significantly decreased. PXR protein was gradually increased by serial concentrations of dexamethasone. However, only nanomolar dexamethasone elevated the level of GR protein. The different concentrations of dexamethasone required suggested that suppression of CES1 may be mediated by GR whereas the induction of CES2 may result from the role of PXR. It was concluded that dexamethasone at different concentrations can differentially regulate CES1 and CES2. Source

Lai S.,Huazhong University of Science and Technology
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban | Year: 2012

This study examined the role of EMP-1 in tumorigenesis of non-small cell lung carcinoma (NSCLC) and the possible mechanism. Specimens were collected from 28 patients with benign lung diseases and 28 with NSCLC, and immunohistochemically detected to evaluate the correlation of EMP-1 expression to the clinical features of NSCLC. Recombinant adenovirus was constructed to over-express EMP-1 and then infect PC9 cells. Cell proliferation was measured by Ki67 staining. Western blotting was performed to examine the effect of EMP-1 on the PI3K/AKT signaling. Moreover, tumor xenografts were established by subcutaneous injection of PC9 cell suspension (about 5×10(7)/mL in 100 μL of PBS) into the right hind limbs of athymic nude mice. The results showed EMP-1 was significantly up-regulated in NSCLC patients as compared with those with benign lung diseases. Over-expression of EMP-1 promoted proliferation of PC9 cells, which coincided with the activation of the PI3K/AKT pathway. EMP-1 promoted the growth of xenografts of PC9 cells in athymic nude mice. It was concluded that EMP-1 expression may contribute to the development and progress of NSCLC by activating PI3K/AKT pathway. Source

Yin X.,Huazhong University of Science and Technology | Yue D.,Nanjing University of Posts and Telecommunications | Hu S.,Hubei University of Arts and Science
Journal of the Franklin Institute | Year: 2013

This paper investigates the consensus problem for a set of discrete-time heterogeneous multi-agent systems composed of two kinds of agents differed by their dynamics. The consensus control is designed based on the event-triggered communication scheme, which can lead to a significant reduction of the information communication burden in the multi-agent network. Meanwhile, only the communication between the agent and its local neighbors is needed, therefore, the designed control is essentially distributed. Based on the Lyapunov functional method and the Kronecker product technique, a sufficient condition is obtained to guarantee the consensus of heterogeneous multi-agent systems in terms of linear matrix inequality (LMI). Simulation results illustrate the effectiveness of the developed theory in the last. Source

Zhou D.,Huazhong University of Science and Technology
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban | Year: 2012

Dai R.,Huazhong University of Science and Technology
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban | Year: 2012

The Sonic hedgehog (SHH) signaling pathway plays a pivotal role in neurogenesis and brain damage repair. Our previous work demonstrated that the SHH signaling pathway was involved in the neuroprotection of cortical neurons against oxidative stress. The present study was aimed to further examine the underlying mechanism. The cortical neurons were obtained from one-day old Sprague-Dawley neonate rats. Hydrogen peroxide (H(2)O(2), 100 μmol/L) was used to treat neurons for 24 h to induce oxidative stress. Exogenous SHH (3 μg/mL) was employed to activate the SHH pathway, and cyclopamine (20 μmol/L), a specific SHH signal inhibitor, to block SHH pathway. LY294002 (20 μmol/L) were used to pre-treat the neurons 30 min before H(2)O(2) treatment and selectively inhibit the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. The cell viability was measured by MTT and apoptosis rate by flow cytometry analysis. The expression of p38, p-p38, ERK, p-ERK, Akt, p-Akt, Bcl-2, and Bax in neurons was detected by immunoblotting. The results showed that as compared with H(2)O(2) treatment, exogenous SHH could increase the expression of p-Akt by 20% and decrease the expression of p-ERK by 33%. SHH exerted no significant effect on p38 mitogen-activated protein kinase (p38 MAPK) pathway. Blockade of PI3K/Akt pathway by LY294002 decreased the cell viability by 17% and increased the cell apoptosis rate by 2-fold. LY294002 treatment could up-regulate the expression of the pro-apoptotic gene Bax by 12% and down-regulate the expression of the anti-apoptotic gene Bcl-2 by 54%. In conclusion, SHH pathway may activate PI3K/Akt pathway and inhibit the activation of the ERK pathway in neurons under oxidative stress. The PI3K/Akt pathway plays a key role in the neuroprotection of SHH. SHH/PI3K/Bcl-2 pathway may be implicated in the protection of neurons against H(2)O(2)-induced apoptosis. Source

Shi X.,Huazhong University of Science and Technology
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban | Year: 2012

This study investigated the effect of epigenetic modification of maspin on extravillous trophoblastic function. The mRNA expression of maspin in placentae from normotensive and preeclamptic pregnant women was detected by RT-PCR. TEV-1 cells, a human first-trimester extravillous trophoblast cell line, were cultured and treated with CoCl(2) (300 μmol/L) to induce chemical hypoxia and with 5-aza (500 nmol/L) to induce demethylation. The mRNA expression of maspin in TEV-1 cells subjected to different treatments was determined by RT-PCR, and the proliferative and migratory abilities of TEV-1 cells were assessed by cell counting kit-8 (CCK-8) and Transwell assays. Our results showed that the maspin mRNA expression level in placentae from preeclamptic women was much higher than that from normotensive women. CoCl(2) or 5-aza could up-regulate the mRNA expression of maspin and significantly suppress the proliferation and migration of TEV-1 cells. It was concluded that the epigenetic modification in promoter region of maspin contributes to incomplete trophoblast invasion, which offers a novel approach for predicting and treating placental dysfunction. Source

Wang Q.,Huazhong University of Science and Technology
Applied Optics | Year: 2011

This investigation analyzes random errors in interferometric surface profilers using the least-squares method when random noises are present. Two types of random noise are considered here: intensity noise and position noise. Two formulas have been derived for estimating the standard deviations of the surface height measurements: one is for estimating the standard deviation when only intensity noise is present, and the other is for estimating the standard deviation when only position noise is present. Measurements on simulated noisy interferometric data have been performed, and standard deviations of the simulated measurements have been compared with those theoretically derived. The relationships have also been discussed between random error and the wavelength of the light source and between random error and the amplitude of the interference fringe. © 2011 Optical Society of America. Source

Li Z.M.,Huazhong University of Science and Technology
Zhonghua fu chan ke za zhi | Year: 2010

To investigate the expression of microRNA 27a (miR-27a) and relationship with drug resistance in human ovarian cancer A2780/Taxol cells. A stem-loop-mediated real-time PCR was used to detect miR-27a expression in A2780 and A2780/Taxol cells. The cells were transfected with the mimics or inhibitors of miR-27a or negative control RNA (NC) by lipofectamine 2000. The expressions of MDR1 gene, P-glycoprotein (P-gp) and homeodomain-interacting protein kinase 2 (HIPK2) protein levels were measured by real-time PCR and western blot respectively. Methyl thiazolyl tetrazolium (MTT) assay was used to analyze drug sensitivity. Apoptosis analysis was measured by fluorescence activated cell sorter (FACS). (1) miR-27a was an average of 2.2-fold higher expression level in A2780/Taxol cells than that in A2780 cells, with a significant difference between the two groups (P<0.05). (2) A2780/Taxol cells transfection with inhibitors of miR-27a showed that the levels of MDR1 mRNA was decreased by 39%, P-gp protein level [(26+/-5)%] decreased than that in the NC group [(43+/-7)%], HIPK2 protein level [(30+/-6)%] increased than that in the NC group [(19+/-4)%], the 50% inhibition concentration (0.5 micromol/L) was less than that in the NC group (6.8 micromol/L), apoptosis rate [(32.5+/-3.6)%] was higher than that in the NC group [(5.6+/-2.1)%], and there were significant differences between two groups (all P<0.05). (3) Transfection of A2780 cells with mimics of miR-27a led to increase MDR1 mRNA expression by 121% as compared with one transfection with NC (P<0.05). The expression of miR-27a is upregulated in A2780/Taxol cells, which may regulate MDR1 and P-gp expression by targeting HIPK2. Source

Zhang Y.,Huazhong University of Science and Technology
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban | Year: 2012

This study examined the incidence, neuropsychological characteristics and risk factors of cognitive impairment 3 months after stroke in China. Five regions that differed in geography and economy in China were selected. Patients from the hospitals located in the five regions were prescreened at admission, and the demographic data, vascular risk factors and clinical characteristics of stroke were obtained. A battery of cognitive-specific domain tests was performed in the patients who failed to pass cognitive screening 3 months post stroke. Patients were diagnosed as having post-stroke cognitive impairment (PSCI) or no cognitive impairment (NCI) based on the results of the neuropsychological tests. Univariate analysis was performed for suspect risk factors, and significant variables were entered in multivariable logistic regression analysis. Our results showed that a total of 633 patients were recruited 3 months after stroke; complete cognitive tests were performed in 577 of the stroke patients. The incidence of PSCI in these Chinese patients was 30.7%. There were 129 (22.4%) patients with visuospatial impairment, 67 (11.6%) with executive impairment, 60 (10.4%) with memory impairment and 18 (3.1%) with attention impairment. The risk factors associated with PSCI were older age (odds ratio [OR] 1.76, 95% confidence interval [CI] 1.20-2.58), low education level (OR 2.45, 95% CI 1.65-3.64), depressive symptom (OR 1.69, 95% CI 1.09-2.61), obesity (OR 2.57, 95% CI 1.41-4.71), stroke severity 3 months post stroke (OR 1.62, 95%CI 1.10-2.37) and cortex lesion (OR 1.55, 95% CI 1.04-2.31). It was concluded that PSCI occurs commonly 3 months after first-ever stroke in Chinese patients. Visuospatial ability may be the most frequently impaired cognitive domain for the patients with stroke. The critical risk factors of PSCI are older age, low education level, depressive symptom, obesity, stroke severity 3 months post stroke and cortex lesion. Source

Li Z.,Huazhong University of Science and Technology | Li Z.,City University of Hong Kong | Li Y.,City University of Hong Kong
Optics Letters | Year: 2011

In fast phase-measuring profilometry, phase error caused by gamma distortion is the dominant error source. Previous phase-error compensation or gamma correction methods require the projector to be focused for best performance. However, in practice, as digital projectors are built with large apertures, they cannot project ideal focused fringe images. In this Letter, a thorough theoretical model of the gamma-distorted fringe image is derived from an optical perspective, and a highly accurate and easy to implement gamma correction method is presented to reduce the obstinate phase error. With the proposed method, high measuring accuracy can be achieved with the conventional three-step phase-shifting algorithm. The validity of the technique is verified by experiments. © 2011 Optical Society of America. Source

Xinpeng T.,Huazhong University of Science and Technology
SAE Technical Papers | Year: 2013

This paper establishes a chassis multi-body dynamics model for integrated chassis control system with ABS (Anti-lock Brake System), ESP (Electronic Stability Program) and ARC (Active Roll Controller), using ADAMS/Mechatronics modules in ADAMS/Car, And a co-simulation is carried out in ADAMS and MATLAB/Simulink for the integrated control system with single lane change on both dry and wet sliding roads. The simulation results show that the integrated chassis control system is effective and necessary. In addition, the co-simulation method with ADAMS/Mechatronics and MATLAB can be an effective way for the study of integrated chassis control system, providing a reference for future researches. Copyright © 2013 SAE International. Source

Lu X.-Y.,Ludong University | Lu X.-Y.,Huazhong University of Science and Technology | Wu J.,Zhejiang University
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2010

A simple scheme is proposed to achieve three-mode continuous-variable (CV) entanglement in a coupled triple-semiconductor quantum-well (TSQW) structure via tunneling-induced interference. In the present scheme, the TSQW structure is trapped into a triply resonant cavity, and the tunneling-induced interference effects considered here are the key to realizing entanglement. By numerically simulating the dynamics of the system, we show that the strength of tunneling-induced interference can effectively influence the period of entanglement, and the generation of entanglement does not depend intensively on the initial condition of the cavity field in our scheme. As a result, the present research provides an efficient approach to achieve three-mode CV entanglement in a semiconductor nanostructure, which may have an impact on the progress of solid-state quantum-information theory. © 2010 The American Physical Society. Source

Zhou T.,Hangzhou Dianzi University | Lu Y.,Huazhong University of Science and Technology
International Journal of Human-Computer Interaction | Year: 2011

Existing research on user acceptance of mobile commerce has found that technological perceptions-such as perceived usefulness, perceived ease of use, and perceived compatibility-had significant effects on user behavior. However, the effects of personality traits have seldom been examined. The purpose of this research is to examine the effects of five personality traits of extraversion, agreeableness, openness to experience, conscientiousness, and neuroticism on user adoption of mobile commerce. Partial least squares was employed to conduct data analysis. The results show that extraversion has a strong effect on trust, whereas neuroticism has significantly negative effects on trust and perceived usefulness, both of which determine user intention to adopt mobile commerce. © Taylor & Francis Group, LLC. Source

Wang D.,Huazhong University of Science and Technology | Peng F.Z.,Michigan State University
IEEE Transactions on Smart Grid | Year: 2012

This paper presents a smart residential electric power supply system, which is named smart gateway grid (SGG). It can enable residential distributed generations (DGs) and energy storage system (ESS) to participate in system operation, which will improve the reliability of power supply and help households secure a high quality service while reducing the cost of consumption. The SGG operation modes and associated transition strategies are analyzed in the paper. And the control strategy is developed to guarantee the whole system operating satisfactorily. To meet the demand of the typical U.S. household, a low cost and high efficiency SGG configuration is designed as a case study. Finally, analysis, simulation, and experimental results are presented and they show that the proposed SGG has the attractive features. © 2010-2012 IEEE. Source

Wu J.,Huazhong University of Science and Technology
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2012

To understand the relationship between negative life events and suicide ideation, and how it was influenced by the mediating effect of depression. 1145 college students from one university were selected using cluster sampling. Both Symptom Check List (SCL-90) and Questionnaire were administered to measure depression and suicide ideation in the past week and on the prevalence of negative life events and related information. Recent negative life events would include physical illness, academic problem, financial problem and interpersonal conflict etc. Multiple logistic regressions were used to identify the mediating effect of depression. Physical illness (OR = 2.5, P = 0.028), interpersonal conflict (OR = 7.2, P = 0.002) and financial problem (OR = 1.6, P = 0.026) were significantly associated with suicide ideation, but academically-related problems did not seem to be significantly associated with suicide ideation (OR = 1.8, P = 0.090). After adjusted for depression, both physical illness and interpersonal conflicts were not but financial problem remained significantly associated with suicide ideation (OR = 1.7, P = 0.014). Our data showed that depression fully mediated the relationship between physical illness, interpersonal conflict and suicide ideation, but did not mediate the relationship between financial problem and suicide ideation. Depression played different mediating roles between different negative life events and suicide ideation. The findings from this study might be able to provide some clues for the prevention interventions on college students. Source

Zhou T.,Hangzhou Dianzi University | Lu Y.,Huazhong University of Science and Technology
Computers in Human Behavior | Year: 2011

Due to the intense competition and low switching cost, building user loyalty is critical for mobile instant messaging (IM) service providers. Integrating both perspectives of network externalities and flow experience, this research identified the factors affecting mobile IM user loyalty. Network externalities include referent network size and perceived complementarity. Flow experience includes perceived enjoyment and attention focus. We conducted data analysis with structural equation modeling (SEM). The results show that both network externalities and flow experience significantly affect perceived usefulness and satisfaction, further determining user loyalty. Thus mobile service providers need to improve their IM platforms, and deliver positive network externalities and good usage experience to users. Then they can facilitate users' loyalty. © 2010 Elsevier Ltd. All rights reserved. Source

Li S.,Temple University | Li S.,Huazhong University of Science and Technology | Yang L.,Temple University | Selzer M.E.,Temple University | Hu Y.,Temple University
Annals of Neurology | Year: 2013

Injuries to central nervous system axons result not only in Wallerian degeneration of the axon distal to the injury, but also in death or atrophy of the axotomized neurons, depending on injury location and neuron type. No method of permanently avoiding these changes has been found, despite extensive knowledge concerning mechanisms of secondary neuronal injury. The autonomous endoplasmic reticulum (ER) stress pathway in neurons has recently been implicated in retrograde neuronal degeneration. In addition to the emerging role of ER morphology in axon maintenance, we propose that ER stress is a common neuronal response to disturbances in axon integrity and a general mechanism for neurodegeneration. Thus, manipulation of the ER stress pathway could have important therapeutic implications for neuroprotection. Ann Neurol 2013;74:768-777 © 2013 American Neurological Association. Source

Song T.,Huazhong University of Science and Technology | Wang X.,University of Tsukuba
Neural Processing Letters | Year: 2015

Spiking neural P systems with inhibitory synapses (ISN P systems, for short) are a class of discrete neural-like computing models, which are inspired by the way of biological neurons storing and processing information and communication by means of excited and inhibitory impulses. In this work, we prove that ISN P systems can compute and accept any set of Turing computable numbers by using one type of neurons, thus can achieve Turing universality. Such systems are called homogenous ISN P systems. The results give a positive answer to an open problem left in (Pan and Păun, Int J Comput Commun 4(3):273–282, 2009) that “whether the number of types of neurons in universal SN P systems can be decreased by using inhibitory synapses”. The obtained result is optimal in the sense of having minimal number of types of neurons in Turing universal SN P systems. © 2014, Springer Science+Business Media New York. Source

Chen G.,Huazhong University of Science and Technology
Information Technology Journal | Year: 2011

Dynamic Optimal Power Flow (DOPF) is a typical complex multi-constrained non-convex non-linear programming problem when considering the valve-point effect of conventional generators. Moreover, it is mixed integer when considering the discreteness of reactive compensation devices for power system with Fixed Speed Wind Generators (FSWGs). DOPF model in FSWGs integrated power system is established in this study and then a hybrid Taguchi-Particle Swarm Optimization (TPSO) algorithm is proposed for solving the established DOPF model. This hybrid algorithm combines the well-known Particle Swarm Optimization (PSO) algorithm with the established Taguchi method which has been a important tool for robust design. This study clearly presents the improvements obtained despite the simplicity of the hybridization process. The Taguchi method is run only once in every iteration and therefore does not give significant impact in terms of computational cost. The method creates a more diversified population, which also contributes to the success of avoiding premature convergence. IEEE 39-bus system is used to illustrate the effectiveness of the proposed method compared with those obtained from PSO algorithm. The test results show that the proposed method is effective and has a certain practicality. © 2011 Asian Network for Scientific Information. Source

Bo Z.,Zhejiang University | Yang Y.,Huazhong University of Science and Technology | Chen J.,University of Wisconsin - Milwaukee | Yu K.,Case Western Reserve University | And 2 more authors.
Nanoscale | Year: 2013

Vertically oriented graphene (VG) nanosheets have attracted growing interest for a wide range of applications, from energy storage, catalysis and field emission to gas sensing, due to their unique orientation, exposed sharp edges, non-stacking morphology, and huge surface-to-volume ratio. Plasma-enhanced chemical vapor deposition (PECVD) has emerged as a key method for VG synthesis; however, controllable growth of VG with desirable characteristics for specific applications remains a challenge. This paper attempts to summarize the state-of-the-art research on PECVD growth of VG nanosheets to provide guidelines on the design of plasma sources and operation parameters, and to offer a perspective on outstanding challenges that need to be overcome to enable commercial applications of VG. The review starts with an overview of various types of existing PECVD processes for VG growth, and then moves on to research on the influences of feedstock gas, temperature, and pressure on VG growth, substrate pretreatment, the growth of VG patterns on planar substrates, and VG growth on cylindrical and carbon nanotube (CNT) substrates. The review ends with a discussion on challenges and future directions for PECVD growth of VG. © 2013 The Royal Society of Chemistry. Source

Huang Z.,Huazhong University of Science and Technology
Environmental Impact Assessment Review | Year: 2012

The values, concepts and approaches of health impact assessment (HIA) were outlined in the Gothenburg consensus paper and some industrialized countries have implemented HIA for many years. HIA has played an important role in environmental protection in China, however, the emergence, progress and challenges of HIA in China have not been well described. In this paper, the evolution of HIA in China was analyzed and the challenges of HIA were presented based on the author's experiences. HIA contributed to decision-making for large capital construction projects, such as the Three Gorges Dam project, in its emergence stage. Increasing attention has been given to HIA in recent years due to supportive policies underpinning development of the draft HIA guidelines in 2008. However enormous challenges lie ahead in ensuring the institutionalization of HIA into project, program and policy decision-making process due to limited scope, immature tools and insufficient professionals in HIA practice. HIA should broaden its horizons by encompassing physical, chemical, biological and socio-economic aspects and constant attempts should be made to integrate HIA into the decision-making process, not only for projects and programs but also for policies as well. © 2011 Elsevier Inc. Source

She W.B.,Huazhong University of Science and Technology
Zhonghua nei ke za zhi [Chinese journal of internal medicine] | Year: 2012

To investigate the expression of macrophage migration inhibition factor (MIF) in pulmonary tissues of the smokers with and without chronic obstructive pulmonary disease (COPD). The subjects were assigned into three groups: non-smokers without COPD (control group, n = 12), smokers without COPD (smoker group, n = 13) and smokers with COPD (COPD group, n = 16). The specimens were obtained from lung tissues as far away from cancer focus as possible (> 5 cm). Real-time quantitative PCR and immunohistochemistry were used to investigate the expression and distribution of MIF in pulmonary tissues. The relationship between the severity of airflow obstruction and the differential expressions of MIF in lung tissues of the smokers with or without COPD was analyzed. (1) MIF mRNA expression in COPD group (4.87 ± 1.79) was higher than that in the smoker group (2.16 ± 0.72; P < 0.01), which was higher than that in the control group (1.09 ± 0.48; P < 0.01). (2) Immunohistochemistry analysis showed that MIF protein expression in lung tissues of the COPD group (0.277 ± 0.025) was higher than that in the smokers group (0.199 ± 0.034; P < 0.01), which was significantly higher than that in control group (0.130 ± 0.021; P < 0.01). (3) Correlation analysis of MIF mRNA expression in the lung tissues and pulmonary function parameters of forced expired volume in one second (FEV(1)) percentage of predicted (FEV(1) pred)and ratio of FEV(1) to forced vital capacity (FEV(1)/FVC) suggested that MIF mRNA expression in the lung tissues was negatively related with FEV(1) pred (r = -0.578, P < 0.01) and FEV(1)/FVC (r = -0.607, P < 0.01). MIF expression significantly increases in the smokers with COPD, and MIF level in the lung is positively correlated with airflow limitation. The results suggest that MIF may play an important role in the pathogenesis of smoking-induced COPD. Source

Zhu S.,Huazhong University of Science and Technology
The journal of headache and pain | Year: 2013

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary small vascular disease and its mainly clinical manifestations are ischemic events. Spontaneous intracerebral hemorrhage (ICH) involvement in patients with CADASIL is extremely uncommon. A 46-year-old normotensive Chinese man developed a large hematoma in the left basal ganglia after he was diagnosed with CADASIL 2 months ago, the patient did not take any antithrombotics. Susceptibility weighted imaging at pre-ICH showed multiple cerebral microbleeds (CMBs) in the bilateral basal ganglia. He experienced migraine at about 10 months post-ICH. To our knowledge, this is the first report of ICH in CADASIL patients with Arg90Cys mutation in exon 3. ICH should be considered when evaluating new attacks in CADASIL patients. Thus, MRI screening for CMBs might be helpful in predicting the risk of ICH and guiding antithrombotic therapy. In addition, strict control of hypertension and cautious use of antithrombotics may be important in this context. Source

Li Q.,Chongqing University | Yang X.-S.,Huazhong University of Science and Technology
International Journal of Bifurcation and Chaos | Year: 2010

This paper presents an efficient method for finding horseshoes in dynamical systems by using several simple results on topological horseshoes. In this method, a series of points from an attractor of a map (or a Poincaré map) are firstly computed. By dealing with the series, we can not only find the approximate location of each short unstable periodic orbit (UPO), but also learn the dynamics of almost every small neighborhood of the attractor under the map or the reverse map, which is very helpful for finding a horseshoe. The method is illustrated with the Hénon map and two other examples. Since it can be implemented with a computer software, it becomes easy to study the existence of chaos and topological entropy by virtue of topological horseshoe. © 2010 World Scientific Publishing Company. Source

Pan A.,Huazhong University of Science and Technology | Wang Y.,National University of Singapore | Talaei M.,National University of Singapore | Hu F.B.,Harvard University
Circulation | Year: 2015

Background - The prevalence of smoking in diabetic patients remains high, and reliable quantification of the excess mortality and morbidity risks associated with smoking is important for diabetes management. We performed a systematic review and meta-analysis of prospective cohort studies to evaluate the relation of active smoking with risk of total mortality and cardiovascular events among diabetic patients. Methods and Results - We searched Medline and Embase databases through May 2015, and multivariate-adjusted relative risks were pooled by using random-effects models. A total of 89 cohort studies were included. The pooled adjusted relative risk (95% confidence interval) associated with smoking was 1.55 (1.46-1.64) for total mortality (48 studies with 1 132 700 participants and 109 966 deaths), and 1.49 (1.29-1.71) for cardiovascular mortality (13 studies with 37 550 participants and 3163 deaths). The pooled relative risk (95% confidence interval) was 1.44 (1.34-1.54) for total cardiovascular disease (16 studies), 1.51 (1.41-1.62) for coronary heart disease (21 studies), 1.54 (1.41-1.69) for stroke (15 studies), 2.15 (1.62-2.85) for peripheral arterial disease (3 studies), and 1.43 (1.19-1.72) for heart failure (4 studies). In comparison with never smokers, former smokers were at a moderately elevated risk of total mortality (1.19; 1.11-1.28), cardiovascular mortality (1.15; 1.00-1.32), cardiovascular disease (1.09; 1.05-1.13), and coronary heart disease (1.14; 1.00-1.30), but not for stroke (1.04; 0.87-1.23). Conclusions - Active smoking is associated with significantly increased risks of total mortality and cardiovascular events among diabetic patients, whereas smoking cessation is associated with reduced risks in comparison with current smoking. The findings provide strong evidence for the recommendation of quitting smoking among diabetic patients. © 2015 American Heart Association, Inc. Source

Wang L.,Huazhong University of Science and Technology | Wang L.,Hubei Key Laboratory for Engineering Structural Analysis and Safety Assessment
JVC/Journal of Vibration and Control | Year: 2012

Wang L.,Huazhong University of Science and Technology | Wang L.,Hubei Key Laboratory for Engineering Structural Analysis and Assessment
Physica E: Low-Dimensional Systems and Nanostructures | Year: 2012

In this paper, the post-buckling behavior of supported nanobeams containing internal flowing fluid with two surface layers is studied based on a nonlinear theoretical model. The nonlinear governing equation, in which the surface effect and stretching-related nonlinearity are accounted for, is analytically solved for both clampedclamped and pinnedpinned systems. The effects of nanobeam length, bulk thickness and several dimensionless parameters on the post-buckling behavior are analyzed. It is found that, the nanobeam with low flow velocity is stable at its original static equilibrium position and then undergoes a buckling instability at a critical flow velocity, which depends on the system parameters. When buckled, in all cases, the amplitude of the resultant buckling increases with the increasing flow velocity. Typically, the surface effect is explored by considering different nanobeam lengths and bulk thicknesses. The buckling amplitude is found to be length-dependent and thickness-dependent, showing that the effect of surface layers is considerably strong. © 2011 Elsevier B.V. All rights reserved. Source

Wang C.,Huazhong University of Science and Technology
Transplantation | Year: 2016

BACKGROUND: The long-term outcome of lung transplantation is impeded by the development of obliterative bronchiolitis (OB). We sought to investigate the relationship between the apoptosis of tracheal epithelial cells and bone marrow–derived myofibroblasts in the process of OB. METHODS: The mouse orthotopic tracheal transplant model was established. The allografts and syngrafts were harvested at 1, 2, 3, and 4 weeks after tracheal transplant. The percentage of tracheal lumen occlusion was assayed via histology and morphometry. Immunofluorescence staining was used to detect the apoptotic epithelial cells and recipient-derived myofibroblasts. The expression of SDF-1α and TGF-β and the infiltrations of CD4 and CD8 T cells in the grafts were detected using immunohistochemical staining. RESULTS: We found that there were more apoptotic epithelia in the allograft group than in the syngraft group and that the level of tracheal lumen occlusion was higher at different time points. Moreover, the increase in the apoptosis of the tracheal epithelium occurred earlier than that of occlusion of the tracheal lumen. There were more myofibroblasts derived from the recipient’s bone marrow and more CD4 and CD8 T cells in the allografts. The expression of SDF-1α and TGF-β was higher in the epithelium from allografts than in those of the syngrafts. CONCLUSIONS: Our study indicated that the apoptotic tracheal epithelia in the OB model might increase the amount of myofibroblasts derived from the recipient’s bone marrow. Therapeutic methods aimed at preventing apoptosis of the tracheal epithelium may improve the outcome of lung transplantation. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. Source

Leung C.C.,Center for Health Protection | Yu I.T.S.,Chinese University of Hong Kong | Chen W.,Huazhong University of Science and Technology
The Lancet | Year: 2012

Silicosis is a fibrotic lung disease caused by inhalation of free crystalline silicon dioxide or silica. Occupational exposure to respirable crystalline silica dust particles occurs in many industries. Phagocytosis of crystalline silica in the lung causes lysosomal damage, activating the NALP3 inflammasome and triggering the inflammatory cascade with subsequent fibrosis. Impairment of lung function increases with disease progression, even after the patient is no longer exposed. Diagnosis of silicosis needs carefully documented records of occupational exposure and radiological features, with exclusion of other competing diagnoses. Mycobacterial diseases, airway obstruction, and lung cancer are associated with silica dust exposure. As yet, no curative treatment exists, but comprehensive management strategies help to improve quality of life and slow deterioration. Further efforts are needed for recognition and control of silica hazards, especially in developing countries. Source

Long X.B.,Huazhong University of Science and Technology
PloS one | Year: 2012

Clara cell 10-kDa protein (CC10) is a multifunctional protein with anti-inflammatory and immunomodulatory effects. Induction of CC10 expression by gene transfection may possess potential therapeutic effect. Nuclear factor κB (NF-κB) plays a key role in the inflammatory processes of airway diseases. To investigate potential therapeutic effect of CC10 gene transfection in controlling airway inflammation and the underlying intracellular mechanisms, in this study, we constructed CC10 plasmid and transfected it into bronchial epithelial cell line BEAS-2B cells and CC10 knockout mice. In BEAS-2B cells, CC10's effect on interleukin (IL)-1β induced IL-8 expression was explored by means of RT-PCR and ELISA and its effect on NF-κB classical signaling pathway was studied by luciferase reporter, western blot, and immunoprecipitation assay. The effect of endogenous CC10 on IL-1β evoked IL-8 expression was studied by means of nasal explant culture. In mice, CC10's effect on IL-1β induced IL-8 and nuclear p65 expression was examined by immunohistochemistry. First, we found that the CC10 gene transfer could inhibit IL-1β induced IL-8 expression in BEAS-2B cells. Furthermore, we found that CC10 repressed IL-1β induced NF-κB activation by inhibiting the phosphorylation of IκB-α but not IκB kinase-α/β in BEAS-2B cells. Nevertheless, we did not observe a direct interaction between CC10 and p65 subunit in BEAS-2B cells. In nasal explant culture, we found that IL-1β induced IL-8 expression was inversely correlated with CC10 levels in human sinonasal mucosa. In vivo study revealed that CC10 gene transfer could attenuate the increase of IL-8 and nuclear p65 staining in nasal epithelial cells in CC10 knockout mice evoked by IL-1β administration. These results indicate that CC10 gene transfer may inhibit airway inflammation through suppressing the activation of NF-κB, which may provide us a new consideration in the therapy of airway inflammation. Source

Hu L.,Huazhong University of Science and Technology
Clinical biochemistry | Year: 2014

OBJECTIVES: Aiming to develop potential noninvasive biomarkers for male infertility, the present study is designed to identify cell-free seminal piRNAs (PIWI-interacting RNA), and microRNAs predominately derived from testis and epididymis in human semen, which is secreted from the male accessory reproductive organs.DESIGN AND METHODS: The ejaculate of successfully vasectomized men does not contain any secretion from the testis or epididymis. We screened cell-free seminal piRNAs, and microRNAs that predominately derived from testis/epididymis by comparing Solexa sequencing of seminal RNA of normozoospermic donors and vasectomized men, followed by quantitative PCR validation in individuals.RESULTS: Totally 84 seminal microRNAs exhibited levels >4-fold higher in normozoospermic donors than in vasectomized men. Subsequent quantitative PCR validation in individuals confirmed 61 microRNAs predominately secreted from testis/epididymis. Of these miRNAs, the lowest level in normozoospermic donors is ≥2-fold (24 miRNAs) or 0-2-fold (37 miRNAs) more than the highest level in vasectomized men. Interestingly, 28 microRNAs, which contain 5 microRNA clusters (18 microRNAs), reside on the X-chromosome. Some microRNAs have been shown or predicted to target important genes in spermatogenesis or sperm maturation. At least 995 seminal piRNAs were identified in normozoospermic donors while were absent in vasectomized men.CONCLUSIONS: The present study identified cell-free seminal piRNAs, and microRNAs that predominately derived from testis and epididymis. These small noncoding RNAs might be useful noninvasive epigenetic markers for human male infertility researches on revealing the etiology and physiopathological status of impaired sperm production and maturation. Copyright © 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. Source

Lu X.,Huazhong University of Science and Technology | Lu X.,University of Tsukuba | Feng L.,University of Tsukuba | Feng L.,Soochow University of China | And 2 more authors.
Chemical Society Reviews | Year: 2012

Endohedral metallofullerenes (EMFs), a new class of hybrid molecules formed by encapsulation of metallic species inside fullerene cages, exhibit unique properties that differ distinctly from those of empty fullerenes because of the presence of metals and their hybridization effects via electron transfer. This critical review provides a balanced but not an exhaustive summary regarding almost all aspects of EMFs, including the history, the classification, current progress in the synthesis, extraction, isolation, and characterization of EMFs, as well as their physiochemical properties and applications in fields such as electronics, photovoltaics, biomedicine, and materials science. Emphasis is assigned to experimentally obtained results, especially the X-ray crystallographic characterizations of EMFs and their derivatives, rather than theoretical calculations, although the latter has indeed enhanced our knowledge of metal-cage interactions. Finally, perspectives related to future developments and challenges in the research of EMFs are proposed. (381 references) This journal is © The Royal Society of Chemistry 2012. Source

Gu Y.,Huazhong University of Science and Technology | Jerome F.,University of Poitiers
Green Chemistry | Year: 2010

Glycerol, an organic waste generated by the biodiesel industry, has been recently proposed as a valuable green solvent. This review summarizes the advantages, disadvantages and potential uses of glycerol as a green solvent for catalysis, organic synthesis, separations and materials chemistry. In particular, through selected examples we show here that glycerol may combine the advantages of water (low toxicity, low price, large availability, renewability) and ionic liquids (high boiling point, low vapour pressure, low solubility in scCO 2). More generally, all these reported works contribute to increase the portfolio of available green solvents and afford innovative solutions to the substitution of the conventionally used volatile organic solvents. © The Royal Society of Chemistry 2010. Source

Zhang C.,U.S. National Institutes of Health | Bao W.,U.S. National Institutes of Health | Rong Y.,Huazhong University of Science and Technology | Yang H.,Peking University | And 3 more authors.
Human Reproduction Update | Year: 2013

Background: Several studies have examined associations between genetic variants and the risk of gestational diabetes mellitus (GDM). However, inferences from these studies were often hindered by limited statistical power and conflicting results. We aimed to systematically review and quantitatively summarize the association of commonly studied single nucleotide polymorphisms (SNPs) with GDM risk and to identify important gaps that remain for consideration in future studies. Methods: Genetic association studies of GDM published through 1 October 2012 were searched using the HuGE Navigator and PubMed databases. A SNP was included if the SNP-GDM associations were assessed in three or more independent studies. Two reviewers independently evaluated the eligibility for inclusion and extracted the data. The allele-specific odds ratios (ORs) and 95% confidence intervals (CIs) were pooled using random effects models accounting for heterogeneity. Results: Overall, 29 eligible articles capturing associations of 12 SNPs from 10 genes were included for the systematic review. The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (230G/A, GCK), rs5219 (E23K, KCNJ11), rs7754840 (CDKAL1), rs4402960 (IGF2BP2), rs10830963 (MTNR1B), rs1387153 (MTNR1B) and rs1801278 (Gly972Arg, IRS1) were significantly associated with a higher risk of GDM. Among them, genetic variants in TCF7L2 showed the strongest association with GDM risk, with ORs (95% CIs) of 1.44 (1.29-1.60, P , 0.001) per T allele of rs7903146 and 1.46 (1.15-1.84, P 1/4 0.002) per T allele of rs12255372. Conclusions: In this systematic review, we found significant associations of GDM risk with nine SNPs in seven genes, most of which have been related to the regulation of insulin secretion. Source

Derichter R.K.,National Graduate School of Chemistry, Montpellier | Ming T.,Huazhong University of Science and Technology | Caillol S.,National Graduate School of Chemistry, Montpellier
Renewable and Sustainable Energy Reviews | Year: 2013

Over the last decades, fighting global warming has become the most important challenge humanity has to face. Therefore technologies of carbon dioxide capture, sequestration and recycling are equally important in order to tackle the global climate change stakes. Among recycling technologies, photocatalytic processes reducing CO2 with H2O back to fuels or to other useful organic compounds, have the potential to be part of a renewable energy system. Indeed these processes can help to control CO 2 emissions and eventually eliminate CO2 in excess. This perspective paper describes a large size device, able simultaneously: • to proceed to direct air capture (DAC) of CO2; • to transform part of it into useful chemicals, like hydrocarbons or syngas; • and to produce renewable energy, thus preventing future CO2 emissions. Synergies between solar chimney power plants (SCPPs) and semiconductor photocatalysis in order to create giant photocatalytic reactors for artificial photosynthesis are discussed, as well as scale economies for unconventional carbon capture directly from the atmosphere. This paper presents a carbon negative emission technology obtained by coupling SCPPs with DAC systems which allows many scale economies, and also synergies to proceed to solar-to-chemical energy-conversion process by photocatalytic reduction of atmospheric CO2 under sunlight. © 2012 Elsevier Ltd. Source

Akhmat G.,Huazhong University of Science and Technology | Zaman K.,COMSATS Institute of Information Technology
Renewable and Sustainable Energy Reviews | Year: 2013

The objective of the study is to investigate the causal relationship among nuclear energy consumption, commercial energy consumption (i.e., oil consumption, gas consumption, electricity consumption and coal consumption) and economic growth in South Asian countries; namely, Afghanistan, Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan and Sri Lanka; over the period of 1975 to 2010. Data is analyzed by bootstrap panel Granger causality method. The results reveal that nuclear energy consumption Granger causes economic growth in Nepal and Pakistan; while, commercial energy consumption i.e., oil consumption Granger causes economic growth in Bangladesh, Bhutan, Maldives, Nepal and Srilanka; gas consumption Granger causes economic growth in Bangladesh, Bhutan, India and Maldives; electricity consumption Granger causes economic growth in India and Srilanka, finally, coal consumption Granger causes economic growth in Bangladesh, Bhutan, Nepal and Srilanka. On the other side, economic growth Granger causes nuclear energy consumption in Pakistan; economic growth Granger causes oil consumption in Bhutan, Maldives and Srilanka; economic growth Granger causes gas consumption in Nepal, Srilanka and Pakistan; finally, economic growth Granger causes electricity consumption. Economic growth Granger causes coal consumption in all South Asian countries. The findings show that the nature of causality between nuclear energy consumption & economic growth; and commercial energy consumption & economic growth is in favor of the neutrality hypothesis in most of the countries. © 2013 Elsevier Ltd. Source

Du W.,Nanjing Normal University | Jiang X.,Nanjing Normal University | Zhu L.,Huazhong University of Science and Technology
Journal of Materials Chemistry A | Year: 2013

Graphene, a two-dimensional crystalline form of carbon, has attracted wide and intense interest owing to its excellent physical properties and because its surface and edges can be chemically modified readily. Development of a method for producing high-quality graphene in large quantities is essential for further investigation of its properties and applications. The direct liquid-phase exfoliation of graphite to produce graphene is a convenient method for generating ideal graphene samples in large quantities. This direct method, which involves the use of colloidal suspensions, is based on the one-step physical transformation of graphite into graphene and has many unique advantages. A large number of liquids have been employed as exfoliation media and show a range of exfoliation efficiencies. In this review, we highlight the recent progress made on the exfoliation of bulky graphite powders or flakes into single- and few-layered graphene sheets in various liquids, including organic solvents, ionic liquids, and water/surfactant solutions. The qualities and yields of the exfoliated graphene samples, as well as their use in various applications, are also reviewed. Furthermore, future research directions for the development of novel exfoliation media and more efficient techniques for producing well-exfoliated pristine graphene are proposed. © 2013 The Royal Society of Chemistry. Source

Chen Y.,Huazhong University of Science and Technology
Rheumatology (Oxford, England) | Year: 2013

High mobility group box chromosomal protein 1 (HMGB1) is a ubiquitous highly conserved single polypeptide in all mammal eukaryotic cells. HMGB1 exists mainly within the nucleus and acts as a DNA chaperone. When passively released from necrotic cells or actively secreted into the extracellular milieu in response to appropriate signal stimulation, HMGB1 binds to related cell signal transduction receptors, such as RAGE, TLR2, TLR4 and TLR9, and becomes a proinflammatory cytokine that participates in the development and progression of many diseases, such as arthritis, acute lung injury, graft rejection immune response, ischaemia reperfusion injury and autoimmune liver damage. Only a small amount of HMGB1 release occurs during apoptosis, which undergoes oxidative modification on Cys106 and delivers tolerogenic signals to suppress immune activity. This review focuses on the important role of HMGB1 in the pathogenesis of RA, mainly manifested as the aberrant expression of HMGB1 in the serum, SF and synovial tissues; overexpression of signal transduction receptors; abnormal regulation of osteoclastogenesis and bone remodelling leading to the destruction of cartilage and bones. Intervention with HMGB1 may ameliorate the pathogenic conditions and attenuate disease progression of RA. Therefore administration of an HMGB1 inhibitor may represent a promising clinical approach for the treatment of RA. Source

Cheng Z.,Huazhong University of Science and Technology
Foundations of Physics | Year: 2016

The Hartree–Fock–Popov theory of interacting Bose particles is generalized to the Cooper-pair system with a screened Coulomb repulsive interaction in high-temperature superconductors. At zero temperature, it is found that the condensate density nc(0) of Cooper pairs is of the order nc(0) ≃ 10 18 cm-3, consistently with the fact that a small fraction of the total p holes participate in pairing. We find that the phonon velocity c(0) at zero temperature is of the order c(0) ≃ 10 km s-1. The computation shows that the transition temperature Tc is a dome-shaped function of the p hole concentration δ, which is consistent with experiments. At finite temperature, we find that the condensate fraction nc(T) / n decreases continuously from nc(0) / n to zero as the temperature increases from zero to the transition temperature Tc. For higher temperatures, we find that the repulsive interaction between Cooper pairs drives more Cooper pairs into the condensate. The computation reveals that the phonon velocity c(T) decreases continuously from c(0) to zero as the temperature increases from zero to the transition temperature Tc. The Cooper-pair system undergoes a first-order phase transition from the normal state to the BEC state. © 2016, Springer Science+Business Media New York. Source

Li K.,Huazhong University of Science and Technology | Schneider M.,University of Marburg
Journal of biomedical optics | Year: 2014

With ever-increasing applications of nanoscale materials in the biomedical field, the impact of nanoparticle size on cellular uptake efficiency, dynamics, and mechanism has attracted numerous interests but still leaves many open questions. A combined "multiphoton imaging-UV/Vis spectroscopic analysis" method was applied for the first time for quantitative visualization and evaluation of the cellular uptake process of different-sized (15-, 30-, 50-, and 80-nm) gold nanoparticles (AuNPs). Quantitative analysis of the size effect on cellular uptake behavior of AuNPs from a stack of three-dimensional multiphoton laser scanning microscopy images is obtained. The technique allows for differentiating AuNPs present in external and internal subcellular components, giving detailed information for elucidating cellular uptake dynamics without particle labeling. The data show that the internalization extent of AuNPs is highly dependent on particles' sizes and incubation time. Due to sedimentation, 50- and 80-nm AuNPs are taken up to a greater extent than 15- and 30-nm particles after exposure for 24 h. However, the smaller particles' uptake velocity is significantly faster in the first 10 h, indicating a disparity in uptake kinetics for different-sized AuNPs. The finding from this study will improve our understanding of the cellular uptake mechanisms of different-sized nanoparticles and has great implications in developing AuNP-based drug carriers with various sizes for different purposes. Source

Tong Y.,Huazhong University of Science and Technology
Gaodianya Jishu/High Voltage Engineering | Year: 2010

Traditional current transformer is being replaced by electronic current transformer in power system and other industrial field. Nevertheless, the use of power supply circuit and signal processing circuit brings new challenge to the stability of electronic current transformer, so the calibration and monitoring of electronic current transformer is more important. We presented a calibration system based on a virtual instrument, which can calibrate the electronic current transformer with digital output on site. The experimental results show that this system has high precision to meet the requirements of calibrating 0.2 s class electronic current transformer. Source

Chen H.,Massachusetts General Hospital | Chen H.,Huazhong University of Science and Technology | Weng Q.Y.,Massachusetts General Hospital | Fisher D.E.,Massachusetts General Hospital
Journal of Investigative Dermatology | Year: 2014

The effects of UVR on the skin include tanning, carcinogenesis, immunomodulation, and synthesis of vitamin D, among others. Melanocortin 1 receptor polymorphisms correlate with skin pigmentation, UV sensitivity, and skin cancer risk. This article reviews pathways through which UVR induces cutaneous stress and the pigmentation response. Modulators of the UV-tanning pathway include sunscreen agents, melanocortin 1 receptor activators, adenylate cyclase activators, phosphodiesterase 4D3 inhibitors, T-oligos, and microphthalmia-associated transcription factor regulators such as histone deacetylase inhibitors. UVR, as one of the most ubiquitous carcinogens, represents both a challenge and an enormous opportunity in skin cancer prevention. © 2014 The Society for Investigative Darmatology. Source

Xu K.,Huazhong University of Science and Technology | Xu K.,Beth Israel Deaconess Medical Center | Liu P.,Beth Israel Deaconess Medical Center | Wei W.,Beth Israel Deaconess Medical Center
Biochimica et Biophysica Acta - Reviews on Cancer | Year: 2014

mTOR (the mechanistic target of rapamycin) is an atypical serine/threonine kinase involved in regulating major cellular functions including growth and proliferation. Deregulation of the mTOR signaling pathway is one of the most commonly observed pathological alterations in human cancers. To this end, oncogenic activation of the mTOR signaling pathway contributes to cancer cell growth, proliferation and survival, highlighting the potential for targeting the oncogenic mTOR pathway members as an effective anti-cancer strategy. In order to do so, a thorough understanding of the physiological roles of key mTOR signaling pathway components and upstream regulators would guide future targeted therapies. Thus, in this review, we summarize available genetic mouse models for mTORC1 and mTORC2 components, as well as characterized mTOR upstream regulators and downstream targets, and assign a potential oncogenic or tumor suppressive role for each evaluated molecule. Together, our work will not only facilitate the current understanding of mTOR biology and possible future research directions, but more importantly, provide a molecular basis for targeted therapies aiming at key oncogenic members along the mTOR signaling pathway. © 2013 Elsevier B.V. Source

Lu B.,Nanchang Hangkong University | Li N.,Huazhong University of Science and Technology
Applied Surface Science | Year: 2015

Various geometric microstructures on aluminum alloy surfaces were fabricated simply through SiC paper rubbing, and the wettability of the obtained surfaces was investigated thoroughly. The water contact angle increased firstly with the increasing particle size of the sandpaper, and then declined with further increase of the grits size, exhibiting a hydrophilic-hydrophobic-hydrophilic transition. The effect of surface geometric microstructure on the wetting behavior of aluminum alloy can be well rationalized in terms of the Cassie-Baxter model by considering the surface energy gradient. The present results not only enhance the in-depth understanding of the mechanism for the significant role of surface microstructure on the wettability of aluminum alloy, but also explore promising applications of versatile metallic surface in industries. © 2014 Elsevier B.V. Source

Jiang T.,Huazhong University of Science and Technology | Li X.,Beijing Institute of Technology
IEEE Transactions on Vehicular Technology | Year: 2010

In this paper, we apply fountain codes to control the peak-to-average power ratio (PAPR) of orthogonal frequency-division multiplexing (OFDM) signals. The main key idea of the proposed scheme is based on the fact that the best fountain-coded OFDM packets can be generated with a low PAPR. Both theoretical analysis and simulation results prove that the proposed scheme can effectively obtain the desirable PAPR and good throughput with rateless codes. Moreover, the flexibility of controlling PAPR makes the proposed scheme more suitable for implementing random frame sizes and providing effective error detection. © 2006 IEEE. Source

Yu H.,Huazhong University of Science and Technology
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban | Year: 2010

The role of interleukin-17 (IL-17) in autoimmune hepatitis (AIH) was investigated. A mouse model of experimental autoimmune hepatitis was established, and the syngeneic S-100 antigen emulsified in complete Freud's adjuvant was injected intraperitoneally into adult male C57BL/6 mice. The IL-17 expression in serum and the livers of the mice models was detected by using ELISA and immunohistochemistry, respectively. IL-17 neutralizing antibody was used to study the biological effect of IL-17 in the experimental AIH. IL-17 neutralizing antibody in vivo administration alleviated the hepatic inflammation and ALT level in the AIH model. IL-17 in the peripheral blood mononuclear cells (PBMC) of AIH patients was measured by using real-time PCR method. The results showed that IL-17 level was significantly up-regulated in AIH patients and mice models. It was concluded that IL-17 contributed to the development of AIH and might be a potential therapeutic target of AIH. Source

Xu W.,Huazhong University of Science and Technology | Wang J.,Nankai University | Meng X.-H.,Nankai University | Meng X.-H.,CAS Institute of Theoretical Physics
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2015

We revisit the entropy product, entropy sum and other thermodynamic relations of charged and rotating black holes. Based on these relations, we derive the entropy (area) bound for both event horizon and Cauchy horizon. We establish these results for variant class of 4-dimensional charged and rotating black holes in Einstein(-Maxwell) gravity and higher derivative gravity. We also generalize the discussion to black holes with NUT charge. The validity of this formula, which seems to be universal for black holes with two horizons, gives further clue on the crucial role that the thermodynamic relations of multi-horizons play in black hole thermodynamics and understanding the entropy at the microscopic level. © 2015 The Authors. Source

Wu Q.,Huazhong University of Science and Technology | Hao J.-K.,University of Angers
Expert Systems with Applications | Year: 2015

Combinatorial auctions (CAs) where bidders can bid on combinations of items is an important model in many application areas. CAs attract more and more attention in recent years due to its relevance to fast growing electronic business applications. In this paper, we study the winner determination problem (WDP) in CAs which is known to be NP-hard and thus computationally difficult in the general case. We develop a solution approach for the WDP by recasting the WDP into the maximum weight clique problem (MWCP) and solving the transformed problem with a recent heuristic dedicated to the MWCP. The computational experiments on a large range of 530 benchmark instances show that the clique-based approach for the WDP not only outperforms the current best performing WDP heuristics in the literature both in terms of solution quality and computation efficiency, but also competes very favorably with the powerful CPLEX solver. © 2014 Elsevier Ltd. All rights reserved. Source

Li J.,Huazhong University of Science and Technology
Database : the journal of biological databases and curation | Year: 2014

Post-translational modifications (PTMs) of proteins play essential roles in almost all cellular processes, and are closely related to physiological activity and disease development of living organisms. The development of tandem mass spectrometry (MS/MS) has resulted in a rapid increase of PTMs identified on proteins from different species. The collection and systematic ordering of PTM data should provide invaluable information for understanding cellular processes and signaling pathways regulated by PTMs. For this original purpose we developed SysPTM, a systematic resource installed with comprehensive PTM data and a suite of web tools for annotation of PTMs in 2009. Four years later, there has been a significant advance with the generation of PTM data and, consequently, more sophisticated analysis requirements have to be met. Here we submit an updated version of SysPTM 2.0 (http://lifecenter.sgst.cn/SysPTM/), with almost doubled data content, enhanced web-based analysis tools of PTMBlast, PTMPathway, PTMPhylog, PTMCluster. Moreover, a new session SysPTM-H is constructed to graphically represent the combinatorial histone PTMs and dynamic regulation of histone modifying enzymes, and a new tool PTMGO is added for functional annotation and enrichment analysis. SysPTM 2.0 not only facilitates resourceful annotation of PTM sites but allows systematic investigation of PTM functions by the user. Database URL: http://lifecenter.sgst.cn/SysPTM/. Source

Yang X.H.,Huazhong University of Science and Technology
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases | Year: 2013

To observe the change of the cognitive function and the serum level of advanced oxidation protein products (AOPP) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS), and then to investigate the correlation between them. Sixty seven patients with OSAHS, 20 healthy controls with matched age, BMI, and education, 15 patients with OSAHS after effective treatment of continuous positive airway pressure (CPAP) with matched age, BMI, and education were enrolled. Polysomnography (PSG), Epworth sleepiness scale (ESS), mini-mental state examination (MMSE), and clock drawing test (CDT) were performed in these groups. The serum level of AOPP, superoxide dismutase (SOD), and malondialdehyde (MDA) were measured. The MMSE and CDT scores of patients with OSAHS were decreased compared to those in healthy controls [(4.73 ± 0.81) vs (2.69 ± 1.38), (2.85 ± 0.61) vs (1.92 ± 0.62)], but the scores improved after effective CPAP treatment. The serum levels of AOPP [(78 ± 20) vs (117 ± 20) μmol/L] and MDA [(2.9 ± 1.0) vs (6.1 ± 3.0) μmol/L] in patients with OSAHS were increased compared to those in healthy controls, but the levels decreased after effective CPAP treatment. The serum SOD level in patients with OSAHS was decreased compared to that in healthy controls [(89 ± 8) vs (57 ± 9) U/ml], but it was increased after effective CPAP treatment. The MMSE and CDT scores of all the subjects including the 2 groups (the OSAHS group and the effective CPAP-treatment group) were correlated with the results of PSG (baseline SaO2, lowest SaO2, AHI, LA/HT, SLT90%). The serum levels of AOPP, MDA and SOD of all the subjects were also correlated with the results of PSG (lowest SaO2, AHI, LA/HT, SLT90%). The serum levels of AOPP, MDA and SOD of all the subjects were correlated with the MMSE and CDT scores. The serum level of AOPP of all the subjects was also correlated with the serum levels of MDA and SOD. Cognitive impairment in patients with OSAHS is correlated with the severity of the disease. AOPP is a useful marker for oxidative stress and protein injury, and closely correlated with the cognitive impairment in patients with OSAHS. Source