Shen Y.,Shanghai JiaoTong University |
Huang X.-J.,Beijing City University |
Wang J.-X.,Peking Union Medical College |
Jin J.,Zhejiang University |
And 11 more authors.
International Journal of Clinical Pharmacology and Therapeutics | Year: 2013
Background: Invasive fungal infection (IFI) is common in neutropenic patients with acute myelogenous leukemia (AML) or myelodysplastic syndrome (MDS). Posaconazole is a broad-spectrum triazole antifungal drug with efficacy in prevention of IFI; however, it has not been previously studied as prophylaxis in a Chinese population. Methods: This multicenter, randomized study in China enrolled AML and MDS patients with persistent chemotherapy-induced neutropenia. Prophylaxis with posaconazole or fluconazole was administered for a maximum of 12 weeks, or until patients recovered from neutropenia and achieved complete remission or an IFI occurred. The primary endpoint was incidence of proven, probable, or possible IFI during treatment. Clinical failure rate, all-cause mortality and time to first systemic antifungal treatment were secondary endpoints. Results: Patients were randomized to receive posaconazole (n = 129) or fluconazole (n = 123); 117 patients in each group were included in the statistical analysis. The incidence of proven, probable or possible IFI was 9.4% (11/117) and 22.2% (26/117) in the posaconazole and fluconazole groups, respectively (p = 0.0114). The clinical failure rate was numerically lower in the posaconazole group (37/117 (31.6%; 95%CI: 23.3-40.9)) than in the fluconazole group (49/117 (41.88%; 95% CI: 32.8-51.4)) (p = 0.168). Patients receiving posaconazole had a later onset of first systematic antifungal treatment than those receiving fluconazole (p = 0.0139). The most common important adverse events were liver function abnormalities (11 patients (8.8%) on posaconazole and 6 (5.0%) on fluconazole (p = 0.221)). Conclusions: Posaconazole demonstrates ef-ficacy as prophylaxis against IFI in high-risk neutropenic Chinese patients and is well tolerated during long-term use (ClinicalTrials. gov number, NCT00811928). © 2013 Dustri-Verlag Dr. K. Feistle. Source
Pan Y.,Tianjin Medical University |
Pan Y.,Sino American Diagnostic and Therapeutic Center for Hematological Malignancies |
Meng B.,Shandong University |
Zhang H.,Tianjin Medical University |
And 16 more authors.
Leukemia and Lymphoma | Year: 2013
The purpose of this study was to examine the incidence of Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma of the elderly in a representative northern Chinese population. Overall, 212 cases of primary diffuse large B-cell lymphoma were analyzed for EBV-positive status by detection of EBV-encoded RNA using in situ hybridization. Immunophenotypic identity was verified by a streptavidin-biotin peroxidase detection system using the markers CD20, CD3, CD10, BCL6 and MUM1. The prevalence of EBV-positive diffuse large B-cell lymphoma in elderly northern Chinese patients was 3.8% (eight of 212). All eight cases were negative for CD10 and BCL6 immunostaining. The incidence is less frequent than that of southern China and other East-Asian countries. Patients tend to be older, present with a non-germinal center B-cell-like immunophenotype and have a poor outcome. © 2012 Informa UK, Ltd. Source
Lu H.,Philips |
Li J.,Philips |
Lu Q.,Huaxi Hospital |
Bharat S.,Philips |
And 5 more authors.
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2014
2D Ultrasound (US) is becoming the preferred modality for image-guided interventions due to its low cost and portability. However, the main limitation is the limited visibility of surgical tools. We present a new sensor technology that can easily be embedded on needles that are used for US-guided interventions. Two different types of materials are proposed to be used as sensor - co-polymer and PZT. The co-polymer technology is particularly attractive due to its plasticity, allowing very thin depositions (10-20 μm) on a variety of needle shapes. Both sensors receive acoustic energy and convert it to an electrical signal. The precise location of the needle can then be estimated from this signal, to provide real-time feedback to the clinician. We evaluated the feasibility of this new technology using (i) a 4DOF robot in a water tank; (ii) extensive ex vivo experiments; and (iii) in vivo studies. Quantitative robotic studies indicated that the co-polymer is more robust and stable when compared to PZT. In quantitative experiments, the technology achieved a tracking accuracy of 0.14 ± 0.03mm, significantly superior to competing technologies. The technology also proved success in near-real clinical studies on tissue data. This sensor technology is non-disruptive of existing clinical workflows, highly accurate, and is cost-effective. Initial clinician feedback shows great potential for large scale clinical impact. © 2014 Springer International Publishing. Source
Zhang Q.,Fudan University |
Zhang Q.,Ningxia Medical University |
Ding D.,Fudan University |
Zhou D.,Huaxi Hospital |
And 9 more authors.
Epilepsy and Behavior | Year: 2012
One hundred and forty-four people with convulsive seizures (CS) and 144 healthy controls were evaluated for cognitive function, using a battery of neuropsychological tests. People with CS performed significantly worse than the controls on the Mini-Mental State Examination, Hamilton Depression Rating Scale, auditory verbal learning test, digit span test, verbal fluency test, and digit cancellation test. The percentage of patients who had abnormal scores on the Hamilton Depression Rating Scale was higher than that of controls (54.9% vs. 7.6%, p < 0.001). Cognitive functional impairment was detected in 65.3% of the patients and 29.2% of the controls (p < 0.001). People with CS presented with depressive mood and a wide range of cognitive deficits, particularly deficits in episodic declarative memory, attentional capacity, semantic memory, and mental speed. Years in education were positively associated with the cognitive performance of people with CS (OR = 0.655, 95% CI: 0.486-0.882, p = 0.005). © 2012 Elsevier Inc. Source
He Q.,Beijing Shijitan Hospital |
Yang Y.,Beijing Cancer Hospital |
Xia M.,Beijing Shijitan Hospital |
Li G.-Z.,Beijing Jishuitan Hospital |
And 4 more authors.
Surgical Practice | Year: 2015
Aim: The aim of the present study was to identify sex differences of risk factors for interstitial cystitis (IC)/painful bladder syndrome (PBS) in patients with lower urinary tract symptoms (LUTS) without urinary tract infection or benign prostate hyperplasia in China. Patients and Methods: A total of 954 outpatients with LUTS presenting for care to urology clinics in many hospitals on a national scale were surveyed using a standardized questionnaire. The definitions for PBS, based on the O'Leary-Sant IC symptom and problem indices, was used. The prevalence of possible risk factors was analysed using the Fisher's exact test, Pearson's χ2-test and binary logistic regression methods. Results: Of the multicentre patients surveyed (491 women and 463 men), 44.7 per cent (427/954) met the criteria for PBS. There was a significant difference between women and men [51.7 per cent (254/491) vs 37.3 per cent (173/463), P>0.05]. After adjusting for confounding factors, bladder pain was found to be significantly associated with the consumption of stimulatory foods [odds ratio (OR): 3.85, 95 per cent confidence interval (CI): 1.58-9.36, P=0.003] and anorectal disease (OR: 2.76, 95 per cent CI: 1.09-7.04, P=0.03) in women. Caffeine beverage intake (OR: 3.54, 95 per cent CI: 1.54-8.12, P=0.003) was identified the only modifiable association noted in a multivariate analysis of men. Factors in men significantly associated with an increased risk of IC/PBS were the consumption of caffeinated beverages (OR: 1.43, 95 per cent CI: 1.16-1.75, P=0.001) and holding in urine (OR: 1.18, 95 per cent CI: 1.03-1.36, P=0.034). Conclusions: A higher incidence of IC was founded in LUTS outpatients without urinary tract infection or benign prostate hyperplasia in China. Stimulating foods, irritable bowel, gynaecologically-infected diseases and anorectal disease are potential risk factors for IC/PBS in women. Caffeinated beverages and holding in urine are potential risk factors for IC/PBS in men. © 2015 College of Surgeons of Hong Kong. Source