He Q.,Beijing Shijitan Hospital |
Yang Y.,Beijing Cancer Hospital |
Xia M.,Beijing Shijitan Hospital |
Li G.-Z.,Beijing Jishuitan Hospital |
And 4 more authors.
Surgical Practice | Year: 2015
Aim: The aim of the present study was to identify sex differences of risk factors for interstitial cystitis (IC)/painful bladder syndrome (PBS) in patients with lower urinary tract symptoms (LUTS) without urinary tract infection or benign prostate hyperplasia in China. Patients and Methods: A total of 954 outpatients with LUTS presenting for care to urology clinics in many hospitals on a national scale were surveyed using a standardized questionnaire. The definitions for PBS, based on the O'Leary-Sant IC symptom and problem indices, was used. The prevalence of possible risk factors was analysed using the Fisher's exact test, Pearson's χ2-test and binary logistic regression methods. Results: Of the multicentre patients surveyed (491 women and 463 men), 44.7 per cent (427/954) met the criteria for PBS. There was a significant difference between women and men [51.7 per cent (254/491) vs 37.3 per cent (173/463), P>0.05]. After adjusting for confounding factors, bladder pain was found to be significantly associated with the consumption of stimulatory foods [odds ratio (OR): 3.85, 95 per cent confidence interval (CI): 1.58-9.36, P=0.003] and anorectal disease (OR: 2.76, 95 per cent CI: 1.09-7.04, P=0.03) in women. Caffeine beverage intake (OR: 3.54, 95 per cent CI: 1.54-8.12, P=0.003) was identified the only modifiable association noted in a multivariate analysis of men. Factors in men significantly associated with an increased risk of IC/PBS were the consumption of caffeinated beverages (OR: 1.43, 95 per cent CI: 1.16-1.75, P=0.001) and holding in urine (OR: 1.18, 95 per cent CI: 1.03-1.36, P=0.034). Conclusions: A higher incidence of IC was founded in LUTS outpatients without urinary tract infection or benign prostate hyperplasia in China. Stimulating foods, irritable bowel, gynaecologically-infected diseases and anorectal disease are potential risk factors for IC/PBS in women. Caffeinated beverages and holding in urine are potential risk factors for IC/PBS in men. © 2015 College of Surgeons of Hong Kong.
Pan Y.,Tianjin Medical University |
Pan Y.,Sino American Diagnostic and Therapeutic Center for Hematological Malignancies |
Meng B.,Shandong University |
Zhang H.,Tianjin Medical University |
And 16 more authors.
Leukemia and Lymphoma | Year: 2013
The purpose of this study was to examine the incidence of Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma of the elderly in a representative northern Chinese population. Overall, 212 cases of primary diffuse large B-cell lymphoma were analyzed for EBV-positive status by detection of EBV-encoded RNA using in situ hybridization. Immunophenotypic identity was verified by a streptavidin-biotin peroxidase detection system using the markers CD20, CD3, CD10, BCL6 and MUM1. The prevalence of EBV-positive diffuse large B-cell lymphoma in elderly northern Chinese patients was 3.8% (eight of 212). All eight cases were negative for CD10 and BCL6 immunostaining. The incidence is less frequent than that of southern China and other East-Asian countries. Patients tend to be older, present with a non-germinal center B-cell-like immunophenotype and have a poor outcome. © 2012 Informa UK, Ltd.
Shen Y.,Shanghai JiaoTong University |
Huang X.-J.,Beijing City University |
Wang J.-X.,Peking Union Medical College |
Jin J.,Zhejiang University |
And 11 more authors.
International Journal of Clinical Pharmacology and Therapeutics | Year: 2013
Background: Invasive fungal infection (IFI) is common in neutropenic patients with acute myelogenous leukemia (AML) or myelodysplastic syndrome (MDS). Posaconazole is a broad-spectrum triazole antifungal drug with efficacy in prevention of IFI; however, it has not been previously studied as prophylaxis in a Chinese population. Methods: This multicenter, randomized study in China enrolled AML and MDS patients with persistent chemotherapy-induced neutropenia. Prophylaxis with posaconazole or fluconazole was administered for a maximum of 12 weeks, or until patients recovered from neutropenia and achieved complete remission or an IFI occurred. The primary endpoint was incidence of proven, probable, or possible IFI during treatment. Clinical failure rate, all-cause mortality and time to first systemic antifungal treatment were secondary endpoints. Results: Patients were randomized to receive posaconazole (n = 129) or fluconazole (n = 123); 117 patients in each group were included in the statistical analysis. The incidence of proven, probable or possible IFI was 9.4% (11/117) and 22.2% (26/117) in the posaconazole and fluconazole groups, respectively (p = 0.0114). The clinical failure rate was numerically lower in the posaconazole group (37/117 (31.6%; 95%CI: 23.3-40.9)) than in the fluconazole group (49/117 (41.88%; 95% CI: 32.8-51.4)) (p = 0.168). Patients receiving posaconazole had a later onset of first systematic antifungal treatment than those receiving fluconazole (p = 0.0139). The most common important adverse events were liver function abnormalities (11 patients (8.8%) on posaconazole and 6 (5.0%) on fluconazole (p = 0.221)). Conclusions: Posaconazole demonstrates ef-ficacy as prophylaxis against IFI in high-risk neutropenic Chinese patients and is well tolerated during long-term use (ClinicalTrials. gov number, NCT00811928). © 2013 Dustri-Verlag Dr. K. Feistle.
Ding D.,Fudan University |
Zhang Q.,Ningxia Medical University |
Zhou D.,Huaxi Hospital |
Lin W.,Jilin University |
And 15 more authors.
Journal of Neurology, Neurosurgery and Psychiatry | Year: 2012
Background: Phenobarbital is an effective treatment for epilepsy but concerns remain over its potential neurocognitive toxicity. This prospective study evaluated the effects of phenobarbital treatment on cognition and mood in people with epilepsy in rural China. Methods: We recruited 144 adults with convulsive seizures and 144 healthy controls from six sites in rural China. People with epilepsy were treated with phenobarbital monotherapy for 12 months. At baseline, and at 3, 6 and 12 months, cases and controls were evaluated with a battery of neuropsychological tests: the Mini-Mental State Examination, the Hamilton Depression Rating Scale, a digit span test, a verbal fluency test, an auditory verbal learning test and a digit cancellation test. Efficacy of phenobarbital treatment was evaluated at the end of follow-up for those with epilepsy. Results: Cognitive test scores and mood ratings were available for 136 (94%) people with epilepsy and 137 (95%) controls at the 12 month follow-up. Both groups showed slightly improved performance on a number of neuropsychological measures. The people with epilepsy showed greater performance gains (p=0.012) in verbal fluency. Nine people with epilepsy complained of memory problems during the treatment period. Conclusion: In this study, phenobarbital was not found to have a major negative impact on cognitive function of people with convulsive seizures and some cognitive gains were observed, possibly due to improved seizure control.
Zhang Q.,Fudan University |
Zhang Q.,Ningxia Medical University |
Ding D.,Fudan University |
Zhou D.,Huaxi Hospital |
And 9 more authors.
Epilepsy and Behavior | Year: 2012
One hundred and forty-four people with convulsive seizures (CS) and 144 healthy controls were evaluated for cognitive function, using a battery of neuropsychological tests. People with CS performed significantly worse than the controls on the Mini-Mental State Examination, Hamilton Depression Rating Scale, auditory verbal learning test, digit span test, verbal fluency test, and digit cancellation test. The percentage of patients who had abnormal scores on the Hamilton Depression Rating Scale was higher than that of controls (54.9% vs. 7.6%, p < 0.001). Cognitive functional impairment was detected in 65.3% of the patients and 29.2% of the controls (p < 0.001). People with CS presented with depressive mood and a wide range of cognitive deficits, particularly deficits in episodic declarative memory, attentional capacity, semantic memory, and mental speed. Years in education were positively associated with the cognitive performance of people with CS (OR = 0.655, 95% CI: 0.486-0.882, p = 0.005). © 2012 Elsevier Inc.
Zuo G.-W.,Chongqing Medical University |
Zuo G.-W.,University of Chicago |
Kohls C.D.,University of Chicago |
Kohls C.D.,Miami University Ohio |
And 27 more authors.
Histology and Histopathology | Year: 2010
The CCN proteins contain six members, namely CCN1 to CCN6, which are small secreted cysteine-rich proteins. The CCN proteins are modular proteins, containing up to four functional domains. Many of the CCN members are induced by growth factors, cytokines, or cellular stress. The CCNs show a wide and highly variable expression pattern in adult and in embryonic tissues. The CCN proteins can integrate and modulate the signals of integrins, BMPs, VEGF, Wnts, and Notch. The involvement of integrins in mediating CCN signaling may provide diverse contextdependent responses in distinct cell types. CCN1 and CCN2 play an important role in development, angiogenesis and cell adhesion, whereas CCN3 is critical to skeletal and cardiac development. CCN4, CCN5 and CCN6 usually inhibit cell growth. Mutations of Ccn6 are associated with the progressive pseudorheumatoid dysplasia and spondyloepiphyseal dysplasia tarda. In stem cell differentiation, CCN1, CCN2, and CCN3 play a principal role in osteogenesis, chondrogenesis, and angiogenesis. Elevated expression of CCN1 is associated with more aggressive phenotypes of human cancer, while the roles of CCN2 and CCN3 in tumorigenesis are tumor type-dependent. CCN4, CCN5 and CCN6 function as tumor suppressors. Although CCN proteins may play important roles in fine-tuning other major signaling pathways, the precise function and mechanism of action of these proteins remain undefined. Understanding of the biological functions of the CCN proteins would not only provide insight into their roles in numerous cellular processes but also offer opportunities for developing therapeutics by targeting CCN functions.
Zou B.,Huaxi Hospital |
Xu Y.,Huaxi Hospital |
Li T.,Sichuan Provincial Cancer Hospital |
Li W.,Yunnan Provincial Cancer Hospital |
And 14 more authors.
International Journal of Radiation Oncology Biology Physics | Year: 2010
Purpose: To retrospectively evaluate the role of postoperative chemoradiotherapy (POCRT) in patients with completely resected non-small-cell lung cancer (NSCLC) with N2 lymph node involvement. Methods and Materials: This study included 183 patients from four centers in southwest China who underwent radical section of Stage III-N2 NSCLC without any preoperative therapy. One hundred and four were treated with POCRT and 79 with postoperative chemotherapy (POCT) alone. The median radiation dose to clinical target volume (CTV) was 50 Gy (varying between 48 and 54 Gy), whereas the cycles of platinum-based chemotherapy ranged from two to six with a median of four. Results: The median duration of follow-up was 72 months. The 5-year overall survival rate (OS) was 30.5% in the POCRT group, and 14.4% in the POCT group (p = 0.007). The 5-year disease-free survival rate (DFS) was 22.2% in POCRT group and 9.3% in POCT group (p = 0.003). In a multivariate analysis, N1 nodal involvement (N1+/N2+) was associated with significantly worse OS (HR = 1.454, 95% CI, 1.012-2.087, p = 0.043) and DFS (HR = 1.685, 95% CI, 1.196-2.372, p = 0.003). Absence of radiotherapy and treatment with fewer than three cycles of chemotherapy both were poor prognostic factors for both OS and DFS. Conclusions: As compared with chemotherapy alone, adjuvant treatment with both radiotherapy and chemotherapy improves survival in patients with completely resected Stage III-N2 nodal disease in NSCLC. Future study of treatment modality with radiotherapy and chemotherapy is warranted, especially focusing on both N1 and N2 nodal status. © 2010 Elsevier Inc. All rights reserved.
Lu H.,Philips |
Li J.,Philips |
Lu Q.,Huaxi Hospital |
Bharat S.,Philips |
And 5 more authors.
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2014
2D Ultrasound (US) is becoming the preferred modality for image-guided interventions due to its low cost and portability. However, the main limitation is the limited visibility of surgical tools. We present a new sensor technology that can easily be embedded on needles that are used for US-guided interventions. Two different types of materials are proposed to be used as sensor - co-polymer and PZT. The co-polymer technology is particularly attractive due to its plasticity, allowing very thin depositions (10-20 μm) on a variety of needle shapes. Both sensors receive acoustic energy and convert it to an electrical signal. The precise location of the needle can then be estimated from this signal, to provide real-time feedback to the clinician. We evaluated the feasibility of this new technology using (i) a 4DOF robot in a water tank; (ii) extensive ex vivo experiments; and (iii) in vivo studies. Quantitative robotic studies indicated that the co-polymer is more robust and stable when compared to PZT. In quantitative experiments, the technology achieved a tracking accuracy of 0.14 ± 0.03mm, significantly superior to competing technologies. The technology also proved success in near-real clinical studies on tissue data. This sensor technology is non-disruptive of existing clinical workflows, highly accurate, and is cost-effective. Initial clinician feedback shows great potential for large scale clinical impact. © 2014 Springer International Publishing.
You X.,Huaxi Hospital |
Liao Z.-Y.,Huaxi Hospital |
Teng H.-Q.,Huaxi Hospital
Journal of Interventional Radiology (China) | Year: 2012
Objective: To evaluate the feasibility, safety and effectiveness of CT-guided percutaneous ganglion impar block and neuroablation in treating sacrocoxalgia caused by benign or malignant lesions. Methods: Percutaneous ganglion impar block and neuroablation under the guidance of CT scanning was performed in 18 patients with intractable sacrocoxalgia. All patients were followed up for two months, and the visual analogue scale (VAS) for pain was recorded at different points of time. Results: CT-guided percutaneous ganglion impar block and neuroablation was successfully accomplished in 18 patients. After the treatment, effective pain relief was obtained in all patients (100%). Complete relief of pain was seen in 5 patients (27.8%) and partial relief of pain was seen in 13 patients (72.2%). Eight out of the 18 patients had to receive a second injection two weeks after the treatment, and complete relief of pain was obtained in two patients. No severe complications occurred in this series. Conclusion: CT-guided percutaneous ganglion impar block and neuroablation can reduce the severity of sacrocoxalgia caused by benign or malignant lesions. This technique is safe, reliable and effective. It is worthwhile employing this method in clinical practice.