Zhang Y.,Huanhu Hospital |
Gao C.,Tianjin University |
Li X.,Tianjin Orthopedic Hospital |
Xu C.,Beijing 302 Hospital |
And 4 more authors.
Carbohydrate Polymers | Year: 2014
Thermosensitive methyl cellulose (MC)-based injectable hydrogels for post-operation anti-adhesion were prepared by integrating polyethylene glycol (PEG), carboxymethyl cellulose (CMC) and chitosan sulfate (CS-SO3) with MC sols. The viscosity of the MC-based sols depended on the sol composition, especially the amount of CMC. The gelation temperature of the sols was tuned by adjusting the concentrations of K+ and other components to obtain an MC-based sol that transformed to a gel at body temperature. The composition of the sol also affected the gel strength. Adding PEG decreased the repulsions between the CMC and CS-SO3 macromolecules and thus increased the gel strength. The efficacy of the MC-based injectable hydrogels as barriers for reducing postsurgical adhesions was evaluated using a rat cecal abrasion model. The PEG and CS-SO3 loaded MC-based injectable hydrogels were effective in reducing adhesion formation and reduced adhesiolysis difficulties. © 2013 Published by Elsevier Ltd.
Hang W.,Huanhu Hospital
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery | Year: 2013
To evaluate the effectiveness of transsphenoidal endoscopic endonasal approach for the resection of Rathke cleft cysts (RCC). Thirty-five pathologically diagnosed RCCs were resected throuth transsphenoidal endoscopic endonasal approach at the HuanHu hospital between January 2000 and December 2011. The clinical data were retrospectively analysed. There were 12 male and 23 female. The average age was 45.7 years and the average disease course was 4.6 years. The typical clinical manifestations included headache (26 cases), visual interference (11 cases) and pituitary dysfunction (8 cases). The postoperative symptoms and follow-up results were recorded. All of the patients underwent complete removal of the cyst contents, complete removal of the cyst wall in 20, fenestration and aspiration of the RCC with partial excision of the cyst wall in 15. The mean cyst volume was (1145.3 ± 12.1) mm(3) [range (121 - 4586) mm(3)]. One patient had cerebrospinal fluid leak, which was repaired using artificial dura mate of brain and gelatin sponge intraoperatively. No postoperative complications were found. Follow-up time ranged from half a year to 11 years. Headache resolved in 100% (26/26), visual interference resolved in 90.9% (10/11), pituitary dysfunction resolved in 62.5% (5/8). No patient recurred. It is concluded that the transsphenoidal endoscopic endonasal approach is microinvasive, safe and effective in the treatment of RCC.
Zhang Y.,Huanhu Hospital
American Journal of Physical Medicine and Rehabilitation | Year: 2016
PURPOSE: The aim of this study was to evaluate the effects of an aquatic exercise program designed to enhance muscular strength in paretic lower limbs in subacute stroke patients. METHOD: Thirty-six subacute stroke patients were randomly divided to a conventional or an aquatic group (n = 18 each). Outcome measures were assessed at baseline and after 8 wks of training. For the paretic lower limbs, maximum isometric voluntary contraction strength of the rectus femoris and biceps femoris caput longus and the tibialis anterior and lateral gastrocnemius was measured. Cocontraction ratios during knee extension and flexion and ankle dorsiflexion and plantarflexion were calculated respectively. In addition, Modified Ashworth Scale, Functional Ambulation Category, and Barthel Index were assessed. RESULTS: Compared with the conventional intervention, the aquatic intervention resulted in significantly higher knee extension (P = 0.002) and ankle plantarflexion torque (P = 0.002), accompanied with a significantly lower knee extension cocontraction ratio in the paretic limb (P = 0.000). Functional Ambulation Category (P = 0.009) and Barthel Index (P = 0.024) were greater in aquatic group than conventional group posttreatment. Modified Ashworth Scale scores did not show any differences between groups. CONCLUSIONS: Aquatic exercise enhanced muscle strength in paretic lower limbs and improved muscle cocontraction without increasing spasticity in subacute stroke patients. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
Jing H.,Huanhu Hospital |
Lin M.,Chinese PLA General Hospital
Journal of Magnetic Resonance Imaging | Year: 2010
Purpose: To study the features of proton magnetic resonance spectroscopy (1H-MRS) on amyotrophic lateral sclerosis (ALS) and its relation with clinical scale. Materials and Methods: Fifteen patients with definite or probable ALS and 15 age- and gender-matched normal controls were enrolled. 1H-MRS was performed on a 3.0 Tesla GE imaging system (GE Healthcare, Milwaukee, WI). TE-averaged Point Resolved Selective Spectroscopy was used. N-acetylaspartate (NAA), creatine (Cr), Glu, and Glx (glutamate + glutamine) values of the motor cortex and posterior limb of internal capsule were acquired. The t-test was used to compare differences between groups, and the correlations between the above values and clinical scale were analyzed. Results: The motor area and posterior limb of the internal capsule of ALS patients had lower NAA/Cr (1.91 ± 0.34, 1.53 ± 0.17) compared with normal subjects (2.23 ± 0.33, 1.66 ± 0.07), and the differences between groups were statistically significant (P < 0.01, 0.01). ALS patients had higher Glu/Cr (0.34 ± 0.05, 0.29 ± 0.06) and Glx/Cr (0.40 ± 0.04, 0.33 ± 0.06) compared with normal subjects (0.30 ± 0.03, 0.25 ± 0.04) and (0.32 ± 0.05, 0.26 ± 0.03), and the differences between groups were statistically significant (P < 0.01, 0.01). The Norris scale was negatively correlated with Glx/Cr of primary motor cortex by lineal correlation analysis (r = -0.75), and this correlation had statistical significance (F = 16.60; P = 0.001). Conclusion: Neuronal loss and Glu+Gln increase can be detected by using proton MRS in ALS patients. 1H-MRS is an useful tool in reflecting the characteristic changes of metabolite in ALS. © 2010 Wiley-Liss, Inc.
Wang H.,Huanhu Hospital
Zhonghua yi xue za zhi | Year: 2014
OBJECTIVE: To explore the prevention and effective treatment of opposite subdural effusion after decompressive cranium.METHODS: Retrospective analyses were conducted for 79 cases of opposite subdural effusion after decompressive cranium. And the efficacies of various methods were compared.RESULTS: Among them, 78 cases were cured by enswathing with elastic bondage. And one case improved through cavity fluid drainage catheter.CONCLUSION: Enswathing with elastic bondage is an effective, simple and economic method of managing opposite subdural effusion after decompressive cranium.