Tianjin, China
Tianjin, China

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Zhang Y.,Huanhu Hospital | Gao C.,Tianjin University | Li X.,Tianjin Orthopedic Hospital | Xu C.,Beijing 302 Hospital | And 4 more authors.
Carbohydrate Polymers | Year: 2014

Thermosensitive methyl cellulose (MC)-based injectable hydrogels for post-operation anti-adhesion were prepared by integrating polyethylene glycol (PEG), carboxymethyl cellulose (CMC) and chitosan sulfate (CS-SO3) with MC sols. The viscosity of the MC-based sols depended on the sol composition, especially the amount of CMC. The gelation temperature of the sols was tuned by adjusting the concentrations of K+ and other components to obtain an MC-based sol that transformed to a gel at body temperature. The composition of the sol also affected the gel strength. Adding PEG decreased the repulsions between the CMC and CS-SO3 macromolecules and thus increased the gel strength. The efficacy of the MC-based injectable hydrogels as barriers for reducing postsurgical adhesions was evaluated using a rat cecal abrasion model. The PEG and CS-SO3 loaded MC-based injectable hydrogels were effective in reducing adhesion formation and reduced adhesiolysis difficulties. © 2013 Published by Elsevier Ltd.


Wang Z.,Huanhu Hospital | Jiang W.,Huanhu Hospital | Feng Y.,Tianjin Medical University | Guo Y.,Huanhu Hospital | And 3 more authors.
Radiation Oncology | Year: 2013

Purpose: To develop a new IMRT technique to simplify the process and improve efficiency in radiotherapy treatment planning for craniospinal irradiation (CSI) treatment.Methods: Image data of 9 patients who received CSI treatment in 2012 were used, the prescription was 36Gy in 20 fractions. Two treatment plans were created for each patient, one was with the new technique called three-isocenter overlap-junction (TIOJ) IMRT and the other was with the three-isocenter jagged-junction (TIJJ) IMRT technique. The comparative study was conducted using the parameters of heterogeneity index (HI), conformity index (CI), and doses to the organs at risk (OARs).Results: Comparing the TIOJ IMRT plans with the TIJJ IMRT plans, the average homogeneity index is 0.071 ± 0.003 and 0.077 ± 0.002, respectively, and the averaged conformity number is 0.80 ± 0.012 and 0.80 ± 0.009, respectively. There are no significant differences (p > 0.05). Both plans provide satisfactory sparing for the OARs.Conclusions: The TIOJ IMRT technique for CSI treatment planning can create similar plans as with the TIJJ IMRT technique, but the new technique greatly simplifies the steps required to manually set field widths and boundaries and improved efficiency. © 2013 Wang et al.; licensee BioMed Central Ltd.


Zhang Y.,Huanhu Hospital | Liu Y.,Tianjin University | Wang X.,Tianjin University | Sun Z.,Huanhu Hospital | And 4 more authors.
Carbohydrate Polymers | Year: 2014

Orderly porous graphene oxide/carboxymethyl cellulose (GO/CMC) monoliths were prepared by a unidirectional freeze-drying method. The porous monoliths were characterized by Fourier transform infrared spectra, X-ray diffraction and scanning electron microscopy. Their properties including compressive strength and moisture adsorption were measured. The incorporation of GO changed the porous structure of the GO/CMC monoliths and significantly increased their compressive strength. The porous GO/CMC monoliths exhibited a strong ability to adsorb metal ions, and the Ni2+ ions adsorbed on GO/CMC monolith were reduced by NaBH4 to obtain Ni GO/CMC monolith which could be used as catalyst in the reduction of 4-nitrophenol to 4-aminophenol. Since CMC is biodegradable and non-toxic, the porous GO/CMC monoliths are potential environmental adsorbents. © 2013 Elsevier Ltd. All rights reserved.


Liu P.,Huanhu Hospital | Liu P.,New York University | Li Y.-S.,New York University | Quartermain D.,New York University | And 2 more authors.
Brain Research | Year: 2013

Although the mechanisms underlying mild traumatic brain injury (mTBI) are becoming well understood, treatment options are still limited. In the present study, mTBI was induced by a weight drop model to produce a closed head injury to mice and the effect of inhaled nitric oxide (INO) was evaluated by a short term memory task (object recognition task) and immunohistochemical staining of glial fibrillary acidic protein (GFAP) and CD45 for the detection of reactive astrocytes and microglia. Results showed that mTBI model did not produce brain edema, skull fracture or sensorimotor coordination dysfunctions. Mice did however exhibit a significant deficit in short term memory (STM) and strong inflammatory reaction in the ipsilateral cortex and hippocampus compared to sham-injured controls 24 h after mTBI. Additional groups of untreated mice tested 3 and 7 days later, demonstrated that recognition memory had recovered to normal levels by Day 3. Mice treated with 10 ppm INO for 4 or 8 h, beginning immediately after TBI demonstrated significantly improved STM at 24 h when compared with room air controls (p<0.05). Whereas mice treated with 10 ppm INO for 24 h showed no improvement in STM. Mice treated with INO 10 ppm for 8 h exhibited significantly reduced microglia and astrocyte activation compared with room air controls. These data demonstrate that mTBI produces a disruption of STM which is evident 24 h after injury and persists for 2 - 3 days. Treatment with low concentration or short durations of INO prevents this memory loss and also attenuates the inflammatory response. These findings may have relevance for the treatment of patients diagnosed with concussion. © 2013 Elsevier B.V.


Jing H.,Huanhu Hospital | Lin M.,PLA General Hospital
Journal of Magnetic Resonance Imaging | Year: 2010

Purpose: To study the features of proton magnetic resonance spectroscopy (1H-MRS) on amyotrophic lateral sclerosis (ALS) and its relation with clinical scale. Materials and Methods: Fifteen patients with definite or probable ALS and 15 age- and gender-matched normal controls were enrolled. 1H-MRS was performed on a 3.0 Tesla GE imaging system (GE Healthcare, Milwaukee, WI). TE-averaged Point Resolved Selective Spectroscopy was used. N-acetylaspartate (NAA), creatine (Cr), Glu, and Glx (glutamate + glutamine) values of the motor cortex and posterior limb of internal capsule were acquired. The t-test was used to compare differences between groups, and the correlations between the above values and clinical scale were analyzed. Results: The motor area and posterior limb of the internal capsule of ALS patients had lower NAA/Cr (1.91 ± 0.34, 1.53 ± 0.17) compared with normal subjects (2.23 ± 0.33, 1.66 ± 0.07), and the differences between groups were statistically significant (P < 0.01, 0.01). ALS patients had higher Glu/Cr (0.34 ± 0.05, 0.29 ± 0.06) and Glx/Cr (0.40 ± 0.04, 0.33 ± 0.06) compared with normal subjects (0.30 ± 0.03, 0.25 ± 0.04) and (0.32 ± 0.05, 0.26 ± 0.03), and the differences between groups were statistically significant (P < 0.01, 0.01). The Norris scale was negatively correlated with Glx/Cr of primary motor cortex by lineal correlation analysis (r = -0.75), and this correlation had statistical significance (F = 16.60; P = 0.001). Conclusion: Neuronal loss and Glu+Gln increase can be detected by using proton MRS in ALS patients. 1H-MRS is an useful tool in reflecting the characteristic changes of metabolite in ALS. © 2010 Wiley-Liss, Inc.


PURPOSE: The aim of this study was to evaluate the effects of an aquatic exercise program designed to enhance muscular strength in paretic lower limbs in subacute stroke patients. METHOD: Thirty-six subacute stroke patients were randomly divided to a conventional or an aquatic group (n = 18 each). Outcome measures were assessed at baseline and after 8 wks of training. For the paretic lower limbs, maximum isometric voluntary contraction strength of the rectus femoris and biceps femoris caput longus and the tibialis anterior and lateral gastrocnemius was measured. Cocontraction ratios during knee extension and flexion and ankle dorsiflexion and plantarflexion were calculated respectively. In addition, Modified Ashworth Scale, Functional Ambulation Category, and Barthel Index were assessed. RESULTS: Compared with the conventional intervention, the aquatic intervention resulted in significantly higher knee extension (P = 0.002) and ankle plantarflexion torque (P = 0.002), accompanied with a significantly lower knee extension cocontraction ratio in the paretic limb (P = 0.000). Functional Ambulation Category (P = 0.009) and Barthel Index (P = 0.024) were greater in aquatic group than conventional group posttreatment. Modified Ashworth Scale scores did not show any differences between groups. CONCLUSIONS: Aquatic exercise enhanced muscle strength in paretic lower limbs and improved muscle cocontraction without increasing spasticity in subacute stroke patients. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.


Hang W.,Huanhu Hospital
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery | Year: 2013

To evaluate the effectiveness of transsphenoidal endoscopic endonasal approach for the resection of Rathke cleft cysts (RCC). Thirty-five pathologically diagnosed RCCs were resected throuth transsphenoidal endoscopic endonasal approach at the HuanHu hospital between January 2000 and December 2011. The clinical data were retrospectively analysed. There were 12 male and 23 female. The average age was 45.7 years and the average disease course was 4.6 years. The typical clinical manifestations included headache (26 cases), visual interference (11 cases) and pituitary dysfunction (8 cases). The postoperative symptoms and follow-up results were recorded. All of the patients underwent complete removal of the cyst contents, complete removal of the cyst wall in 20, fenestration and aspiration of the RCC with partial excision of the cyst wall in 15. The mean cyst volume was (1145.3 ± 12.1) mm(3) [range (121 - 4586) mm(3)]. One patient had cerebrospinal fluid leak, which was repaired using artificial dura mate of brain and gelatin sponge intraoperatively. No postoperative complications were found. Follow-up time ranged from half a year to 11 years. Headache resolved in 100% (26/26), visual interference resolved in 90.9% (10/11), pituitary dysfunction resolved in 62.5% (5/8). No patient recurred. It is concluded that the transsphenoidal endoscopic endonasal approach is microinvasive, safe and effective in the treatment of RCC.


OBJECTIVE: To explore the prevention and effective treatment of opposite subdural effusion after decompressive cranium.METHODS: Retrospective analyses were conducted for 79 cases of opposite subdural effusion after decompressive cranium. And the efficacies of various methods were compared.RESULTS: Among them, 78 cases were cured by enswathing with elastic bondage. And one case improved through cavity fluid drainage catheter.CONCLUSION: Enswathing with elastic bondage is an effective, simple and economic method of managing opposite subdural effusion after decompressive cranium.


Guo X.-B.,Tianjin Medical University | Fan Y.-M.,Huanhu Hospital | Zhang J.-N.,Tianjin Medical University
European Journal of Radiology | Year: 2011

Background and purpose: The HydroCoil Embolic System (HES) was developed to reduce recurrences of aneurysms relative to platinum coils. But the HydroCoil Embolic System was characterized with many limitations. The manufacturer had recognized the challenge and recently a new design of hydrogel-coated coil - HydroSoft has become available in the market as the new generation HydroCoil. We reported our initial experience using HydroSoft coil versus HydroCoil in our center. Methods: 75 aneurysms embolized primarily using HydroSoft Coils from July 2008 to May 2009 were compared with 66 volume- and shape-matched aneurysms treated with HydroCoils from March 2006 to August 2008. Outcome measures included length and number of coils used, contrast volume, and length of hospital stay. During embolization, a stable framework was first established with bare coils, and hydrogel-coated coils were used subsequently to increase the packing density. Follow-up angiographic results 6 months after treatment were evaluated among some of the patients. Results: Successful coil embolization was achieved in all patients. There were no differences in average total coil length used per aneurysm. There were no differences in length of hospital stay and packing density. HydroSoft coils were more suitable using as the finishing or final coil. HydroSoft coil decreased the procedure-related retreated rates, and aneurysm packing was finished with soft, flexible HydroSoft coil and decreased the neck remnant rates. Follow-up angiography in HydroSoft-treated patients at 6 months revealed aneurysm stability without significant residual neck. Conclusions: HydroSoft coil allowed us to deploy coated coils with good packing density. A slight expansion of these coils at the neck can be expected to reduce neck remnant and potentially inhibit recurrence. © 2010 Elsevier Ireland Ltd.


Chen H.,Tianjin Medical University | Liu S.,Huanhu Hospital | Ji L.,Tianjin Medical University | Wu T.,Tianjin Medical University | And 6 more authors.
Current Alzheimer Research | Year: 2015

Background: There is a growing focus on nutritional therapy for Alzheimer’s disease (AD), and controversy exists regarding the association between AD and homocysteine (Hcy), vitamin B12, and folate levels. Objective: The present study evaluated the association between AD and the combined levels of Hcy, vitamin B12, and folate. Methods: This case-control study consisted of 115 patients with AD and 115 matched controls. Serum folate and vitamin B12 were measured using an automated immunoassay analyzer. Plasma Hcy was measured using high-performance liquid chromatography. The association between AD and Hcy, vitamin B12, and folate was analyzed using binary logistic regression, adjusted for age and sex. Results: With the combination of normal blood Hcy, vitamin B12, and folate levels as the reference category, low vitamin B12 in subjects with normal Hcy and folate was associated with AD (adjusted odds ratio [OR], 4.6; 95% confidence interval [CI]: 1.6–13.2). The combination of low vitamin B12 and folate in subjects with normal Hcy was associated with AD (adjusted OR, 4.3; 95% CI: 1.3–14.6). The combination of high Hcy and low folate levels in patients with normal vitamin B12 was associated with AD (adjusted OR, 17.0; 95% CI: 5.4– 53.4). The combination of high Hcy, low vitamin B12, and any folate level was associated with AD (adjusted OR, 30.5; 95% CI: 9.7–95.9). Conclusion: Vitamin B12 was directly associated with AD. The combination of high Hcy, low vitamin B12, and any folate level represented the poorest association with AD. © 2015 Bentham Science Publishers.

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