Samut Prakan, Thailand

Huachiew Chalermprakiet University

www.hcu.ac.th
Samut Prakan, Thailand

Huachiew Chalermprakiet University is a university located in Samut Prakan, Thailand. Huachiew Midwifery School, founded by the Poh Teck Tung Foundation, began offering nursing and midwifery training in 1941. It became Huachiew College with a single faculty in nursing in 1981 and expanded into a university in 1992 under its current name. The university today is organized into nine faculties and a graduate school. Wikipedia.

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Janyou A.,Chiang Mai University | Changtam C.,Huachiew Chalermprakiet University | Suksamrarn A.,Ramkhamhaeng University | Tocharus C.,Chiang Mai University | Tocharus J.,Chiang Mai University
NeuroToxicology | Year: 2015

Endoplasmic reticulum (ER) stress is involved in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Therefore, interventions that attenuate ER stress may contribute to induction in apoptotic cell death. This study aimed to evaluate the potential involvement of O-demethyldemethoxycurcumin, an analog of curcuminoids, on thapsigargin-induced apoptosis in cultured neuroblastoma (SK-N-SH) cells through the ER stress signaling pathway. The results showed that O-demethyldemethoxycurcumin reduced thapsigargin induced cell death in SK-N-SH cells and the release of lactate dehydrogenase (LDH) by decreasing the apoptotic cell death induced by thapsigargin. Consistent with these findings, O-demethyldemethoxycurcumin inhibited the thapsigargin-induced activation of cleavagecaspase-12. Moreover, O-demethyldemethoxycurcumin attenuated the intracellular Ca2+ level and the expression of the calpain protein. O-demethyldemethoxycurcumin also downregulated the expression of ER stress signaling proteins, including the phosphorylation of PKR-like endoplasmic reticulum kinase (p-PERK), the phosphorylation of inositol-requiring enzyme 1 (p-IRE1), activating transcription factor 6 (ATF6), binding immunoglobulin protein (BiP) and C/EBP homologous protein (CHOP). Our findings suggest that O-demethyldemethoxycurcumin could protect against thapsigargin-induced ER stress in SK-N-SH cells. © 2015 Elsevier Inc.


Nimmanee P.,Huachiew Chalermprakiet University | Tam E.W.T.,University of Hong Kong | Woo P.C.Y.,University of Hong Kong | Vanittanakom P.,University of Phayao | Vanittanakom N.,Chiang Mai University
FEMS Microbiology Letters | Year: 2017

Stress-activated MAPK pathways are systems used to regulate the stress adaptation of most fungi. It has been shown that in Talaromyces marneffei (Penicillium marneffei), a pathogenic dimorphic fungus, the sakA gene is involved, not only in tolerance against oxidative and heat stresses, but also in playing a role in asexual development, yeast cell generation in vitro and survival inside macrophage cell lines. In this study, the role of the T. marneffei sakA gene on the nitrosative stress response and the regulation of gene expression were investigated. The susceptibility of the sakA mutant to NaNO2 was investigated using drop dilution assay and the expression of genes of interest were determined by RT-PCR, comparing them to the wild-type and complemented strains. The results demonstrated that the T. marneffei sakA gene played a role in the stress response to NaNO2, the expression of genes functioning in conidial development (brlA, abaA and wetA) and red pigment biosynthesis (pks3, rp1, rp2 and rp3). These findings suggest that T. marneffei sakA is broadly involved in a wide variety of cell activities, including stress response, cell morphogenesis, asexual development and pigmentation. © FEMS 2016. All rights reserved.


Siricharoen W.V.,Burapha University | Siricharoen N.,Huachiew Chalermprakiet University
Mobile Networks and Applications | Year: 2017

Context is critical Delivering messages to the audience is also the important matter. The visualization of the information is significant in term of perceiving the knowledge. The brain of humans are able to identify and understand the pattern and their relationships especially in visual forms. The infographic is the meaningful and easily sharable tool for deliver the messages through the social media and other new media forms. The communication theories are also support the use of infographics to help increasing the recognition of human brain and help fasten digesting of information through the flood of information. The result of the case studies and practices can support the significant of how the visuals help the audience in any ages effective perceiving messages in one form of digital content (photo and data) through social media, also case studies that are applied the proper infographics to trigger the audience’s intention to raising the health care awareness. The experimental of how five users perceive the knowledge through infographics and how much it can improve the communication are also discussed. © 2017 Springer Science+Business Media, LLC


Pinkaew D.,Chiang Mai University | Changtam C.,Huachiew Chalermprakiet University | Tocharus C.,Chiang Mai University | Govitrapong P.,Mahidol University | And 3 more authors.
Neurotoxicity Research | Year: 2016

Amyloid-β peptides (Aβ), a major component of senile plaques, play an important role in the development and progression of Alzheimer’s disease. Several lines of evidence have demonstrated that Aβ-induced neuronal death is mediated by oxidative stress. The present study aimed to evaluate the potential involvement of di-O-demethylcurcumin, an analog of curcuminoid, on Aβ-induced neurotoxicity in culture neuroblastoma cells (SK-N-SH cells) through the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway and the suppression of nuclear factor-κB (NF-κB) signaling pathway and their downstream targets. The results showed that pretreatment with di-O-demethylcurcumin elevated cell viability and decreased the level of reactive oxygen species. Moreover, treatment with di-O-demethylcurcumin promoted the translocation of Nrf2 protein from the cytoplasm to the nucleus, increased the expression of Nrf2-ARE pathway-related downstream proteins including heme oxygenase (HO-1), NAD(P)H:quinone oxidoreductase 1 and glutamate-cysteine ligase catalytic subunit, and increased the activity of superoxide dismutase enzymes. On the other hand, di-O-demethylcurcumin suppressed the degradation of IκBα, translocation of the p65 subunit of NF-κB from cytoplasm to nucleus and thereby, attenuated the expression of inducible nitric oxide synthase protein and nitric oxide production. Taken together, these results suggest that neuroinflammatory effect of di-O-demethylcurcumin might potentially be due to inhibit NF-κB and activate Nrf2 signaling pathways induced by Aβ25–35. © 2015, Springer Science+Business Media New York.


Wilainam P.,Mahidol University | Nintasen R.,Huachiew Chalermprakiet University | Viriyavejakul P.,Mahidol University
Malaria Journal | Year: 2015

Background: Mast cells (MCs) play an important role in the immune response and inflammatory processes. Generally, MCs can be stimulated to degranulate and release histamine upon binding to immunoglobulin E (IgE). In malaria, MCs have been linked to immunoglobulin (Ig) E-anti-malarial antibodies. This study investigated the response of MCs in the skin of patients with Plasmodium falciparum malaria. Methods: Skin tissue samples were examined from ten uncomplicated and 20 complicated P. falciparum malaria cases. Normal skin tissues from 29 cases served as controls. Pre- and post-treatment tissues were included. Histopathological changes of the skin were evaluated using haematoxylin and eosin stain. MCs were investigated using toluidine blue staining. The percentage of MC degranulation was compared among groups and correlated with clinical data. Results: MC degranulation was significantly higher in the complicated P. falciparum (43.72% ± 1.44) group than the uncomplicated P. falciparum (31.35% ± 3.29) (p <0.05) and control groups (18.38% ± 1.75), (p <0.0001). MC degranulation correlated significantly with the degree of parasitaemia (rs = 0.66, p <0.0001). Associated pathological features, including extravasation of red blood cells, perivascular oedema and leukocyte infiltration were significantly increased in the malaria groups compared with the control group (all p <0.001). Conclusions: MCs in the skin dermis are activated during malaria infection, and the degree of MC degranulation correlates with parasitaemia and disease severity. © 2015 Wilainam et al.; licensee BioMed Central.


Techavuthiporn C.,Huachiew Chalermprakiet University | Boonyaritthongchai P.,King Mongkut's University of Technology Thonburi
Postharvest Biology and Technology | Year: 2016

The effects of prestorage short-term Anoxia treatment combined with modified atmosphere packaging (MAP) on quality changes during the storage of green asparagus (Asparagus officinalis L.) spears were investigated. Two sets of asparagus were used in this study. The first set underwent short-term Anoxia treatment via the administration of gaseous N2 for 8 h at room temperature, while the second set was kept in ambient air at the same temperature. Consequently, treated and untreated spears were stored either freely or packaged in plastic bags with low density polyethylene, in which a passive modification of the atmosphere was allowed to develop. All samples were stored at 4 °C for 8 days, followed by 8 days at 10 °C. Samples treated with neither Anoxia nor MAP were used as a control. Our results show that treating the asparagus samples with Anoxia and MAP (Anoxia + PE) caused lower respiration, slowing the decrease in headspace O2. In the Anoxia + PE treated samples, spears lost <12% fresh weight after 8 days at 10 °C. All treatments showed less increase in shear force while exposed at 4 °C for 8 days, as compared with the significant increase found when transferred to 10 °C. This increase in shear force was accompanied by the accumulation of fiber and lignin content. There was a positive relationship between toughening and fiber (R2 = 0.958) and toughening and lignin (R2 = 0.915). Moreover, the degradation of chlorophyll, sugar and ascorbic acid content under the Anoxia and MAP treatments were significantly reduced. The results of the present work indicate that Anoxia treatment, a non-chemical and simple postharvest technology, feasible for use in developing countries where food storage technologies are lacking. © 2016 Elsevier B.V.


Thongkanluang T.,Suratthani Rajabhat University | Chirakanphaisarn N.,Huachiew Chalermprakiet University
Key Engineering Materials | Year: 2016

Light green pigments based on Cr2O3, TiO2, Al2O3 and SiO2were prepared for reflective heat from solar radiation. The prepared pigment powders were mixed with ceramic glaze and sprayed onto ceramic substrates and then calcining accordance with ceramic processing for the reflectance measurement. The results show that the ceramic glaze 100 g mixed with the prepared pigment 5 g gives a maximum near infrared solar reflective of 70.94 %. The comparisons of performance test between prepared pigment and commercial green pigment that use for ceramic coating tile roof were covered two test boxes for temperature measurement. The results shown that the prepared pigment using make decrease the middle - room temperature less than commercial pigment using about 0.8 °C. It can be concluded that the prepared pigment is suitable to be used as a coating ceramic-based roofs for reducing the heat penetrating into the building. © 2016 Trans Tech Publications, Switzerland.


Durongritichai V.,Huachiew Chalermprakiet University
Southeast Asian Journal of Tropical Medicine and Public Health | Year: 2012

The objectives of this study were to describe knowledge, attitudes, and self-awareness, and to identify predictable factors affecting HIV/AIDS prevention among Thai university students. A cross sectional survey was conducted among 844 first-year university students using a validated, self-administered questionnaire as a research instrument. The questionnaire included items assessing knowledge, attitudes, self-awareness, and HIV/AIDS preventive behaviors. It was found that 22.4% of the subjects received various sexually provocative media. The university student's knowledge, attitudes, self-awareness, and preventive behaviors toward HIV/AIDS were at a high level. The results from the multiple regression analysis identified self-awareness, faculty, sex, sexual-risk score, income-per-month, GPA, and knowledge as significant independent predictors of HIV/AIDS preventive behaviors. These factors contributed to 36.9% of the explanation of HIV preventive behaviors, and the strongest predictor was found to be self-awareness. Scientific information, and useful and productive life skills are needed to educate the university students regarding the health consequences of HIV/AIDS. An integrated approach is strongly suggested for creating knowledge, attitudes, and awareness to control the spread of HIV/AIDS among young people.


Kongmaroeng C.,Huachiew Chalermprakiet University | Kumkaen K.,Rayong Hospital
Tissue Antigens | Year: 2015

The FCGR3B gene encodes three human neutrophil antigens which consist of HNA-1a, HNA-1b, and HNA-1c. These antigens are encoded by three alleles in the FCGR3B locus: FCGR3B*01, FCGR3B*02, and FCGR3B*03 alleles, respectively. The frequencies of FCGR3B alleles have been reported in different ethnic populations. This study compared the FCGR3B gene frequencies among 230 unrelated healthy Eastern Thai blood donors in Rayong hospital with the previously published studies. The polymerase chain reaction-sequence-specific primers method was performed to determine FCGR3B genotypes. The results showed that the allele frequencies of FCGR3B*01, FCGR3B*02, and FCGR3B*03 were 0.722, 0.274, and 0.009, respectively. The FCGR3B*01 and FCGR3B*02 frequencies found in the Eastern Thais were similar to the previous reports investigating in Northern Thais, Chinese Han, Taiwanese, and Japanese populations. Interestingly, our data showed statistically significant difference (P<0.05) to Central Thais, Korean, Indian, Turkish, Australian, Tunisian, American, German, and Italian populations. In addition, one FCGR3Bnull, which represents a gene deletion, was also found in this study. This information is important not only for the assessment of neutrophil antibody-mediated clinical conditions and for disease association studies but also for anthropological studies. © 2015 John Wiley & Sons A/S.


Chuprajob T.,Ramkhamhaeng University | Changtam C.,Huachiew Chalermprakiet University | Chokchaisiri R.,University of Phayao | Chunglok W.,Walailak University | And 2 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2014

A general method for the synthesis of substituted (1E,4E,6E)-1,7- diphenylhepta-1,4,6-trien-3-ones, based on the aldol condensations of substituted 4-phenylbut-3-en-2-ones and substituted 3-phenylacrylaldehydes, was achieved. The natural trienones 4 and 5 have been synthesized by this method, together with the trienone analogues 9-20. These analogues were evaluated for their cytotoxic activity against human oral cancer KB cell line. The structure-activity relationship study has indicated that the analogues with the 1,4,6-trien-3-one function are more potent than the curcuminoid-type function. Analogues with meta-oxygen function on the aromatic rings are more potent than those in the ortho- and para-positions. Free phenolic hydroxy group is more potent than the corresponding methyl ether analogues. Among the potent trienones, compounds 11, 18 and 20 were more active than the anticancer drug ellipticine. All compounds were also evaluated against the non-cancerous Vero cells and it was found that compounds 11, 12 and 17 were much less toxic than curcumin (1); they showed high selectivity indices of 35.46, 33.46 and 31.68, respectively. These analogues are regarded as the potent trienones for anti-oral cancer study. © 2014 Elsevier Ltd. All rights reserved.

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