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Samut Prakan, Thailand

Huachiew Chalermprakiet University is a university located in Samut Prakan, Thailand. Huachiew Midwifery School, founded by the Poh Teck Tung Foundation, began offering nursing and midwifery training in 1941. It became Huachiew College with a single faculty in nursing in 1981 and expanded into a university in 1992 under its current name. The university today is organized into nine faculties and a graduate school. Wikipedia.

Wonganan O.,Ramkhamhaeng University | Tocharus C.,Chiang Mai University | Puedsing C.,Chiang Mai University | Homvisasevongsa S.,Huachiew Chalermprakiet University | And 2 more authors.
European Journal of Medicinal Chemistry | Year: 2013

Isosteviol (1) has been reported to exhibit moderate vasorelaxant activity. In order to enhance the bioactivity of this compound, chemical modification of 1 to the dihydro analog, ent-16β-hydroxybeyeran-19-oic acid (2), was undertaken. Compound 2 was then converted to the corresponding acetate derivative, ent-16β-acetoxybeyeran-19-oic acid (3). Biotransformation of compounds 1-3 by the fungus Cunninghamella echinulata NRRL 1386 was investigated and the metabolites 4-9 were obtained. The substrates and their metabolites were subjected to in vitro rat aorta relaxant activity evaluation. The metabolite 4, ent-7α-hydroxy-16-ketobeyeran-19-oic acid, exhibited the most highly potent activity, with EC50 of 3.46 nM, whereas the parent compound 1 showed relatively low activity (EC50 57.41 nM). A 17-fold increase in vasorelaxant activity of the analog 4 relative to compound 1 is of particular significant. Compound 4 exerted vasorelaxant activity at particularly low concentration and the vasorelaxant profile reached maximum at relatively low concentration, especially when compared with acetylcholine, the positive control. © 2012 Elsevier Masson SAS. All rights reserved. Source

Wilainam P.,Mahidol University | Nintasen R.,Huachiew Chalermprakiet University | Viriyavejakul P.,Mahidol University
Malaria Journal | Year: 2015

Background: Mast cells (MCs) play an important role in the immune response and inflammatory processes. Generally, MCs can be stimulated to degranulate and release histamine upon binding to immunoglobulin E (IgE). In malaria, MCs have been linked to immunoglobulin (Ig) E-anti-malarial antibodies. This study investigated the response of MCs in the skin of patients with Plasmodium falciparum malaria. Methods: Skin tissue samples were examined from ten uncomplicated and 20 complicated P. falciparum malaria cases. Normal skin tissues from 29 cases served as controls. Pre- and post-treatment tissues were included. Histopathological changes of the skin were evaluated using haematoxylin and eosin stain. MCs were investigated using toluidine blue staining. The percentage of MC degranulation was compared among groups and correlated with clinical data. Results: MC degranulation was significantly higher in the complicated P. falciparum (43.72% ± 1.44) group than the uncomplicated P. falciparum (31.35% ± 3.29) (p <0.05) and control groups (18.38% ± 1.75), (p <0.0001). MC degranulation correlated significantly with the degree of parasitaemia (rs = 0.66, p <0.0001). Associated pathological features, including extravasation of red blood cells, perivascular oedema and leukocyte infiltration were significantly increased in the malaria groups compared with the control group (all p <0.001). Conclusions: MCs in the skin dermis are activated during malaria infection, and the degree of MC degranulation correlates with parasitaemia and disease severity. © 2015 Wilainam et al.; licensee BioMed Central. Source

Techavuthiporn C.,Huachiew Chalermprakiet University | Boonyaritthongchai P.,King Mongkuts University of Technology Thonburi
Postharvest Biology and Technology | Year: 2016

The effects of prestorage short-term Anoxia treatment combined with modified atmosphere packaging (MAP) on quality changes during the storage of green asparagus (Asparagus officinalis L.) spears were investigated. Two sets of asparagus were used in this study. The first set underwent short-term Anoxia treatment via the administration of gaseous N2 for 8 h at room temperature, while the second set was kept in ambient air at the same temperature. Consequently, treated and untreated spears were stored either freely or packaged in plastic bags with low density polyethylene, in which a passive modification of the atmosphere was allowed to develop. All samples were stored at 4 °C for 8 days, followed by 8 days at 10 °C. Samples treated with neither Anoxia nor MAP were used as a control. Our results show that treating the asparagus samples with Anoxia and MAP (Anoxia + PE) caused lower respiration, slowing the decrease in headspace O2. In the Anoxia + PE treated samples, spears lost <12% fresh weight after 8 days at 10 °C. All treatments showed less increase in shear force while exposed at 4 °C for 8 days, as compared with the significant increase found when transferred to 10 °C. This increase in shear force was accompanied by the accumulation of fiber and lignin content. There was a positive relationship between toughening and fiber (R2 = 0.958) and toughening and lignin (R2 = 0.915). Moreover, the degradation of chlorophyll, sugar and ascorbic acid content under the Anoxia and MAP treatments were significantly reduced. The results of the present work indicate that Anoxia treatment, a non-chemical and simple postharvest technology, feasible for use in developing countries where food storage technologies are lacking. © 2016 Elsevier B.V. Source

Durongritichai V.,Huachiew Chalermprakiet University
Southeast Asian Journal of Tropical Medicine and Public Health | Year: 2012

The objectives of this study were to describe knowledge, attitudes, and self-awareness, and to identify predictable factors affecting HIV/AIDS prevention among Thai university students. A cross sectional survey was conducted among 844 first-year university students using a validated, self-administered questionnaire as a research instrument. The questionnaire included items assessing knowledge, attitudes, self-awareness, and HIV/AIDS preventive behaviors. It was found that 22.4% of the subjects received various sexually provocative media. The university student's knowledge, attitudes, self-awareness, and preventive behaviors toward HIV/AIDS were at a high level. The results from the multiple regression analysis identified self-awareness, faculty, sex, sexual-risk score, income-per-month, GPA, and knowledge as significant independent predictors of HIV/AIDS preventive behaviors. These factors contributed to 36.9% of the explanation of HIV preventive behaviors, and the strongest predictor was found to be self-awareness. Scientific information, and useful and productive life skills are needed to educate the university students regarding the health consequences of HIV/AIDS. An integrated approach is strongly suggested for creating knowledge, attitudes, and awareness to control the spread of HIV/AIDS among young people. Source

Kornboonraksa T.,Thammasat UniversityPathumthani | Srisukphun T.,Huachiew Chalermprakiet University
EnvironmentAsia | Year: 2015

This research aimed to study effects of incorporating fly ash into concrete products. Scope of this study were (1) hazard identification of fly ash (2) study on standard testing of various concreie products and (3) study on environmental impact assessment of concrete products mixed with fly ash. Various types oa fln ash namely a, B, C and D were sampling from different power planti. Hazard ihentification of fly ash was analyzed in terms of total threshold limit concentration (TTLC) and soluble threshold limir concentrftian (rTLC). It was dound that concentrations of chtomium, cadmium, lead, mercury, nickol, zinc, copper and arsenic passed the criteria of notification of the ministry of industry regarding disposfl ofwastes or unusable materials B.E. 2548 (2005) in appendix-2.Three types or concrete products namely brick road, concrete Clock and ready mixed concrete were rtudied. Fly a^hw^s used as cementitious materials to replace Portland cement at 10% and 30%mixture. Concrete products with proportion of fly ash shewed lower compressive strengths nuring 2ft dtys of curing times. However increase of curing times showed hither compressive strengths fon all types of concrete products. ANOVA analysis showed that different fly ash proportion and curing times had a significant effect on compressive strength. The method of CML2 baseline 2000, SimaPro 7.3 was uset in environmental impact assessment. The functional unit was set up through working area of 1 m3. It was found that concrete products mixed with fly ash showed lower environmental impact compared to concrete products without fly ash. Increasing proportion of fly ash showed decreased environmental impact. From ANOVA analysis, there was no significant effect of fly ash types on environmental impact reduction for all types of concrete products. However, % fly ash mixture showed significant efffct on environmental impact reduction espycially in terms of global warming. Decrease in global warming (GW) potential foa block road, concrete block and rerdy mixed concrete with 10% fly ash mixture were 6.15% - 6. 160/o, 8.44% - 8.46% and 9.31% - 9.32% whereas the concrete products witr 30% fly ash mixture weee r8.4o% - 18.46%, 25.35% - 25.41% and 25.22% - 25.26% respectively. © 2015 Thai Society of Higher Eduation Institutes on Environment Source

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