HU University of Applied Sciences Utrecht
Apeldoorn, Netherlands

The HU University of Applied science Utrecht is a vocational university in the city of Utrecht and one of the largest educational institutions in the Netherlands. It shares its main campus, the Uithof, with the largest university of the Netherlands, Utrecht University. It also has buildings in Amersfoort, 25 km from Utrecht.Funded by the state, it has over 38,000 students with more than one hundred different nationalities. It offers about 70 different degree courses in a wide range of subjects: Communication and Journalism, Economics and Management, Science and Technology, Health care, Education and Social Professions. HU also participates in the Utrecht Summer School, which offers 130 short courses in July and August. Wikipedia.

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Van Hoof J.,HU University of Applied Sciences Utrecht | Mazej M.,University of Ljubljana | Hensen J.L.M.,TU Eindhoven
Frontiers in Bioscience | Year: 2010

Thermal comfort -the state of mind, which expresses satisfaction with the thermal environment- is an important aspect of the building design process as modern man spends most of the day indoors. This paper reviews the developments in indoor thermal comfort research and practice since the second half of the 1990s, and groups these developments around two main themes; (i) thermal comfort models and standards, and (ii) advances in computerization. Within the first theme, the PMV-model (Predicted Mean Vote), created by Fanger in the late 1960s is discussed in the light of the emergence of models of adaptive thermal comfort. The adaptive models are based on adaptive opportunities of occupants and are related to options of personal control of the indoor climate and psychology and performance. Both models have been considered in the latest round of thermal comfort standard revisions. The second theme focuses on the ever increasing role played by computerization in thermal comfort research and practice, including sophisticated multi-segmental modeling and building performance simulation, transient thermal conditions and interactions, thermal manikins.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: SEC-2009-6.1-01 | Award Amount: 3.62M | Year: 2010

The goal of SAFIRE is to improve fundamental understanding of radicalisation processes and use this knowledge to develop principles to improve (the implementation) of interventions designed to prevent, halt and reverse radicalisation. SAFIRE will develop a process model of radicalisation, describing the process from moderation to extremism, based on a non-linear dynamic systems approach and a typology of radical groups. This is an innovative approach that has not been explicitly applied to this area up until now. Principles regarding interventions will be developed in close concert with the models, and will be applied in a longitudinal, empirical study. Important aspects of radicalisation that will also be addressed are: the relationship between national culture and radicalisation, radicalisation on the Internet, and defining observable indicators of the radicalisation process. The main deliverable is a CD containing on one hand a detailed description of the work done in SAFIRE and on the other an interactive, accessible overview of the project designed for quick, user-friendly accessibility to the main points. Envisaged end-users are policy makers, researchers in the field of radicalisation and professionals who work with high-risk individuals. The results of this project will increase the understanding of both conceptual aspects of radicalisation (e.g. the psycho-social dynamics of radical groups and individuals), and practical characteristics and modus operandi of radical groups (e.g. recruitment techniques). In addition, the results will increase understanding of field efforts and interventions when, why and how they work thus helping focus the allocation of resources and the implementation of interventions.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SEC-2012.6.1-1 | Award Amount: 3.54M | Year: 2014

IMPACT Europe will develop an evaluation toolkit to help professionals in the public and voluntary sectors design and implement an evaluation of their programmes tackling violent radicalisation, whether policies or interventions. The toolkit will also help professionals go beyond the evaluation of a single project by integrating best practice into the design and implementation of future programmes. This evaluation toolkit will be composed of four elements: 1) A standardised methodology, to provide professionals with a tool to conduct robust evaluations; 2) An evaluation results database, to allow professionals to analyse these results over time, identify best practice and develop a more informed understanding of violent radicalisation; 3) A training course (including a train-the-trainer component), to build professionals capacity to design, carry out and learn from appropriate evaluations; 4) A training manual, to provide easy reference for professionals applying the toolkit.

Agency: European Commission | Branch: FP7 | Program: JTI-CP-ARTEMIS | Phase: SP1-JTI-ARTEMIS-2013-ASP4;SP1-JTI-ARTEMIS-2013-ASP1 | Award Amount: 13.01M | Year: 2014

European manufacturing industry faces increasing product variances resulting as a consequence of frequent innovation, short product lifecycles, small series production, and shrinking production cycles. At the same time, production cost must be continuously reduced. Agile, transformable and re-usable automation and robotics is be a key enabler to manage those trends. However, few robotic components are designed for easy adaptation and reuse. To overcome those shortcomings, R5-COP focuses on agile manufacturing paradigms and specifically on modular robotic systems. Based on existing and newly developed methods for a formal modeling of hardware and software components, R5-COP will support model-based design, engineering, validation, and fast commissioning. Furthermore, using existing interface and middleware standards such as ROS, R5-COP will strongly facilitate integration of components from various suppliers. The proposed modular approach will not only be more flexible than state-of-the-art solutions, but will also reduce design, setup, and maintenance costs. Flexible use of robots naturally includes their close cooperation with humans. Therefore, robustness and safety are crucial requirements which will be assured by dedicated verification and validation methodologies. The formal specification framework will support component suppliers in efficiently verifying and certifying their modules. R5-COP will help to identify and develop reconfigurable key hardware and software components, and to show the feasibility and capability of the approach in living labs in manufacturing and service demonstrator environments. Date of approval by ECSEL JU: 22/07/2015

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: EURO-3-2014 | Award Amount: 2.38M | Year: 2015

There is growing consensus in Europe that an active set of approaches to welfare known as Social Investment will improve human capital, enable more people to participate in society, and reduce intergenerational deprivation, yet implementation has been uneven across member states and much remains to be learned, especially with regard to regional and local realities of Social Investment. This proposal is for EURO-3-2014: European societies after the crisis. Within that call its focus is on Innovative social investment approaches for the modernisation of social policies and services. We will deploy multidisciplinary research on innovative ways of implementing and financing social welfare that promise lasting benefits. Our aims are threefold: -Identify and evaluate existing innovative and strategic approaches to social welfare reform at a regional and local level; -Explore social and psychological impact of these innovations on individuals and communities; -Collate useful, practical learning from this new body of evidence and mobilise it to inform policy and practice across the EU. We will deliver on our first two aims through: Macro and micro-level research on social investment policies and initiatives; Mixed method case studies in ten member states, taking account of local and regional networks, institutions and assets, as well as national and European policies; A distinct understanding of Social Investment utilizing social innovation as a key concept; A strong user voice, ensured throughout the project by recruiting and training Community Reporters Approximately a third of the resource on this project is devoted to impact generation (Aim 3). Results from the research will be assimilated in a Foresight Analysis where we will work with policy makers, user-led organizations and social entrepreneurs to consider options for innovative ways of implementing and financing social welfare systems in the future. 10 impact partners will assist us.

Van Der Zand A.,University Utrecht | Gent J.,University Utrecht | Gent J.,HU University of Applied Sciences Utrecht | Braakman I.,University Utrecht | Tabak H.F.,University Utrecht
Cell | Year: 2012

As a rule, organelles in eukaryotic cells can derive only from pre-existing organelles. Peroxisomes are unique because they acquire their lipids and membrane proteins from the endoplasmic reticulum (ER), whereas they import their matrix proteins directly from the cytosol. We have discovered that peroxisomes are formed via heterotypic fusion of at least two biochemically distinct preperoxisomal vesicle pools that arise from the ER. These vesicles each carry half a peroxisomal translocon complex. Their fusion initiates assembly of the full peroxisomal translocon and subsequent uptake of enzymes from the cytosol. Our findings demonstrate a remarkable mechanism to maintain biochemical identity of organelles by transporting crucial components via different routes to their final destination. © 2012 Elsevier Inc.

Hammer A.,HU University of Applied Sciences Utrecht | Coene M.,VU University Amsterdam
Ear and Hearing | Year: 2016

Objective: In this study, the acquisition of Dutch finite verb morphology is investigated in children with cochlear implants (CIs) with profound hearing loss and in children with hearing AIDS (HAs) with moderate to severe hearing loss. Comparing these two groups of children increases our insight into how hearing experience and audibility affect the acquisition of morphosyntax. Design: Spontaneous speech samples were analyzed of 48 children with CIs and 29 children with HAs, ages 4 to 7 years. These language samples were analyzed by means of standardized language analysis involving mean length of utterance, the number of finite verbs produced, and target-like subject verb agreement. The outcomes were interpreted relative to expectations based on the performance of typically developing peers with normal hearing. Outcomes of all measures were correlated with hearing level in the group of HA users and age at implantation in the group of CI users. Results: For both groups, the number of finite verbs that were produced in 50-utterance sample was on par with mean length of utterance and at the lower bound of the normal distribution. No significant differences were found between children with CIs and HAs on any of the measures under investigation. Yet, both groups produced more subject verb agreement errors than are to be expected for typically developing hearing peers. No significant correlation was found between the hearing level of the children and the relevant measures of verb morphology, both with respect to the overall number of verbs that were used and the number of errors that children made. Within the group of CI users, the outcomes were significantly correlated with age at implantation. Conclusion: When producing finite verb morphology, profoundly deaf children wearing CIs perform similarly to their peers with moderate-tosevere hearing loss wearing HAs. Hearing loss negatively affects the acquisition of subject verb agreement regardless of the hearing device (CI or HA) that the child is wearing. The results are of importance for speech-language pathologists who are working with children with a hearing impairment indicating the need to focus on subject verb agreement in speech-language therapy. © 2015 Wolters Kluwer Health, Inc. All rights reserved.

Smakman M.,HU University of Applied Sciences Utrecht
Frontiers in Artificial Intelligence and Applications | Year: 2016

Using Roger Crisp's [1] arguments for well-being as the ultimate source of moral reasoning, this paper argues that there are no ultimate, non-derivative reasons to program robots with moral concepts such as moral obligation, morally wrong or morally right. Although these moral concepts should not be used to program robots, they are not to be abandoned by humans since there are still reasons to keep using them, namely: as an assessment of the agent, to take a stand or to motivate and reinforce behaviour. Because robots are completely rational agents they do not need these additional motivations, they can suffice with a concept of what promotes well-being. How a robot knows which action promotes well-being to the greatest degree is still up for debate, but a combination of top-down and bottom-up approaches seem to be the best way. © 2016 The authors and IOS Press. All rights reserved.

Background: The aims of the study were to investigate the effects of different tasks on determination of the speaking fundamental frequency (SFF) using acoustic measurements and to formulate a tentative proposal based on the results of the current and other studies on this topic. Methods: A total of 36 normophonic German subjects were examined. Nine different tasks commonly used in science and in clinical work for determination of the SFF were used. Results: The maximum deviation in F0 across all methods was 18 Hz in women and 8 Hz in men. Women revealed significantly lower F0 values in spontaneous speech, reading, counting from both 1-10 and 1-60, as well as in the vowel [i:] and the "um Hm" utterances, when compared with the vowel [a:] using the procedure of Awan (p < 0.05). Furthermore, significantly lower F0 values were found in the reading and the picture storytelling task (p < 0.05). Men revealed significantly higher F0 values in spontaneous speech, reading and the picture storytelling task in comparison to the vowel [a:] and the counting tasks (p < 0.05). Conclusions: In line with findings of other recent studies, this study confirms the validity of the proposal that there is a significant difference in F0 values as it pertains to vowels, counting, and continuous speech. Thus, it follows that continuous speech should be used for determining the SFF. © 2013 Springer-Verlag Berlin Heidelberg.

De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Volksgezondheid and HU University of Applied Sciences Utrecht | Date: 2014-02-26

The invention is in the field of medicinal chemistry and provides methods and means for determining whether a composition comprises pertussis toxin activity. More specifically, the invention relates to an in vitro method for determining pertussis toxin activity in a composition, comprising the steps of providing dendritic cells (DCs), contacting the cells with the composition in a culture medium, determining the expression level of at least one gene selected from the group consisting of IL2, IFNg, XCL1, CD69, CSF2 and CXCL10, wherein the composition is likely to contain pertussis toxin activity if the expression level of at least one gene selected from the group consisting of IL2, IFNg, XCL1, CD69, CSF2 and CXCL10 is more than two times a predetermined reference value.

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