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Sharma K.H.,hta Institute Of Cardiology And Research Center Unmicrc | Shah K.H.,hta Institute Of Cardiology And Research Center Unmicrc | Patel I.,hta Institute Of Cardiology And Research Center Unmicrc | Patel A.K.,hta Institute Of Cardiology And Research Center Unmicrc | Chaudhari S.,hta Institute Of Cardiology And Research Center Unmicrc
Indian Heart Journal

Aims Atherosclerosis is an inflammatory process with different cardiovascular risk factors (CVRFs) contributing to its pathogenesis. We aimed to evaluate the specific relationship between circulating blood leukocytes, troponin I and CVRFs. Methods We prospectively enrolled 959 patients with evidence of acute coronary syndrome either in form of unstable angina or STEMI or NSTEMI. Details demographic characteristics, CVRF and biochemical parameters such as total white blood cells (WBC), neutrophil, lymphocytes, platelet, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and troponin I were collected. Results The results indicated that patients having either hypertension, diabetes or smoking habit had significantly higher levels of total WBC (p = 0.013), neutrophil (p = 0.029), NLR (p = 0.029) and PLR (p = 0.009). The level of troponin I was unaffected by these risk factors. Significant association of hypertension was found with total WBC (p = 0.0392), lymphocytes (p = 0.0384) and PLR (p = 0.0027), whereas in diabetes and females all other leukocyte subtypes were significantly altered except for platelet and troponin I. Smokers had higher level of total WBC count (p = 0.0033) and PLR (p = 0.0464). No relationship between CVRFs and leukocytes was observed in males. The age independent effect was observed with PLR, whereas association with total WBC, lymphocytes, NLR, platelet was specific in older population. In younger patients NLR (p = 0.0453) is more likely to be elevated. Mortality was significantly associated with changes in the leukocytes but not with the CVRF presence. Conclusion We demonstrate that the neutrophils, lymphocytes and total WBC along with its ratios predict mortality and are more likely to be elevated in presence of CVRFs. © 2015 Cardiological Society of India. Published by Elsevier B.V. All rights reserved. Source

Joshi H.S.,hta Institute Of Cardiology And Research Center Unmicrc | Deshmukh J.K.,hta Institute Of Cardiology And Research Center Unmicrc | Prajapati J.S.,hta Institute Of Cardiology And Research Center Unmicrc | Sahoo S.S.,hta Institute Of Cardiology And Research Center Unmicrc | And 2 more authors.
Journal of Clinical and Diagnostic Research

Introduction: In pregnant women mitral stenosis is the commonest cardiac valvular lesion. When it is present in majorly severe condition it leads to maternal and fetal morbidity and mortality. In mitral stenosis pregnancy can lead to development of heart failure. Aim: To evaluate the safety and efficacy of balloon mitral valvulotomy (BMV) in pregnant females with severe mitral stenosis. Materials and Methods: A total of 30 pregnant patients who underwent BMV were included in the study from July 2011 to November 2013. Clinical follow-up during pregnancy was done every 3 months until delivery and after delivery. The mean follow up time after BMV was 6.72±0.56 months. Results: From the 30 pregnant females 14 (46.67%) and 16 (53.3%) patients underwent BMV during the third and second trimester of pregnancy respectively. The mean mitral valve area was 0.85+0.16 cm2 before BMV that increased to 1.60+0.27 cm2 (p<0.0001) immediately after BMV. Peak and mean diastolic gradients had decreased significantly within 48 hours after the procedure (p<0.001) but remained very much unchanged at 6.72 month period of follow-up. Two patients had an increase in mitral regurgitation by 2 grades. Conclusion: During pregnancy BMV technique is safe and effective in patients with severe mitral stenosis. This results in marked symptomatic relief along with long term maternal and fetal outcomes. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved. Source

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