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Maniyar Y.,Hsk Hospital And Research Center | Bhixavatimath P.,Hsk Hospital And Research Center
Journal of Clinical and Diagnostic Research | Year: 2012

Objective: To evaluate the hypoglycaemic and the hypolipidaemic activity of the aqueous extract of the leaves of Ixora Coccinea Linn in alloxan induced diabetic albino rats. Materials and methods: Diabetes was induced in the albino rats by the administration of alloxan monohydrate (120 mg/kg, i.p.). The rats were divided into five groups of six animals each. The first group served as the non-diabetic control, the second group as the diabetic control and the third group as the standard and it was treated with 0.1 mg/kg/ day of glibenclamide. Groups four, five and six received 100, 200 and 400 mg/kg body weight of the aqueous extract. The blood samples were analyzed for blood glucose on days 0, 1, 7, 14 and 21 and the lipid profile was assessed on day 21. Results: The aqueous extract of leaves of Ixora Coccinea showed significant reduction (p<0.01) in the blood glucose levels and the serum lipid profile levels, with 400 mg/kg of body weight in the alloxan induced diabetic rats as compared to the controls. Conclusion: It was concluded that the aqueous extract of the leaves of Ixora Coccinea was effective in controlling the blood glucose levels and in improving the lipid profile in diabetic rats. Source


Kora S.A.,Hsk Hospital And Research Center | Kulkarni K.,Hsk Hospital And Research Center
Journal of Clinical and Diagnostic Research | Year: 2012

This study was conducted to know the various reasons for donor blood wastage and how to prevent the donor blood wastage. This study was conducted for a period of 2 years from Jan 2009 to Dec 2010 in H.S.K. Blood Bank attached to S.N. Medical College and H.S.K. Hospital, Bagalkot (Karnataka) in southern India. All blood units collected during study period were included. Total blood units collected during study period was 6129 units and total blood units discarded were 263. Voluntary blood donation (VBD) was 3.99%. In the discarded blood units majority were HbsAg Positives (179 Units) and second was due to outdating (38 units). To conclude, we require blood donor awareness programs for public to increase VBD & screening for HbsAg & HIV by rapid tests before bleeding, follow type and screen protocol, to arrange near expiry blood units in front shelves of freezers, not to bleed the rare & Rh negative blood when not required & to have proper inventory management in blood bank to prevent donor blood wastage. Regular audit of blood issue and discard is essential by hospital transfusion committee. Source


Maniyar Y.,Hsk Hospital And Research Center | Bhixavatimath P.,Hsk Hospital And Research Center
Journal of Ayurveda and Integrative Medicine | Year: 2012

Background: India is considered as the diabetic capital of the world. The study of plants having antihyperglycemic and hypolipidemic activities may give a new approach in the treatment of diabetes mellitus. Objective: The study was intended to evaluate the antihyperglycemic and hypolipidemic activity of aqueous extract of leaves of Carica papaya Linn. (AECPL) in alloxan-induced diabetic albino rats. Materials and Methods: Diabetes was induced in albino rats by administration of alloxan monohydrate (120 mg/kg, i.p.). Rats were divided into 6 groups of 6 animals each. First group served as non-diabetic control, second group as diabetic control, third group as standard and was treated with 0.1 mg/kg/day of glibenclamide. Group 4, 5, and 6 received 100, 200, and 400 mg/kg body weight of AECPL. Blood samples were analyzed for blood glucose on day 0, 1, 7, 14, 21 and lipid profile on day 21. Results: The AECPL showed significant reduction (P<0.01) in blood glucose level and serum lipid profile levels with 400 mg/kg body weight in alloxan-induced diabetic rats as compared with the control. Conclusion: It is concluded that AECPL is effective in controlling blood glucose levels and in improving lipid profile in diabetic rats. Source


Maniyar Y.,Hsk Hospital And Research Center | Bhixavatimath P.,Hsk Hospital And Research Center | Agashikar N.V.,Jawaharlal Nehru Medical College
Journal of Ayurveda and Integrative Medicine | Year: 2010

Ixora coccinea Linn (Rubiaceae), a small shrub cultivated throughout India, has been reported to possess a number of medicinal properties. It has traditionally been used for the treatment of diarrhea and dysentery. However the claims of Ayurveda have to be validated by suitable experimental models. The present study was therefore undertaken to evaluate the effect of aqueous extract of I. coccinea for its antidiarrheal potential against several experimental models of diarrhea in albino Wistar rats. Here, we report the effects of aqueous extracts of flowers of I. coccinea in the castor oil induced diarrhea model. The gastrointestinal transit rate was expressed as the percentage of the longest distance traversed by charcoal divided by the total length of the small intestine. Weight and volume of intestinal content induced by castor oil were studied by the enteropooling method. Loperamide was used as a positive control. The plant-extract showed significant (P<0.001) inhibitor activity against castor oil induced diarrhea and castor oil induced enteropooling in rats at the dose of 400 mg/kg. There was also significant reduction in gastrointestinal motility in the charcoal meal test. Results obtained in this study substantiate the antidiarrheal effect of the aqueous extract and its use by traditional practitioners in the treatment of diarrhea. Source


Kora S.A.,Hsk Hospital And Research Center | Devi P.,Hsk Hospital And Research Center | Malgi S.,Hsk Hospital And Research Center | Satish B.,Hsk Hospital And Research Center | Ugale M.,Hskhospital And Research Center
Journal of Clinical and Diagnostic Research | Year: 2011

Aim & Introduction: The present study has been undertaken at a tertiary care centre in rural India to know about the Clinical and Radiological (CT Scan) co-relation of Posterior Circulation Stroke as CT Scan is cheaper, easily available and faster compared to MRI. Material And Methods: A total number of 25 cases were studied during the period from Jan 2010 to Dec 2010, from among those who were admitted to department of Medicine and Neurology in S.Nijalingappa Medical College and HSK Hospital & Research Center. Detailed clinical history was taken in all patients with general physical examination, CBC, urine analysis, random blood sugar, blood urea, serum electrolytes, lipid profile, ECG, CXR, and CT scan were done. In some selected cases CSF analysis, EEG and ECHO were done. Results & Conclusion: Infra tentorial infarcts (83.3%) were seen more frequently than supra tentorial infarcts (16.6%) in this study. CT scan was 100% positive in supra tentorial ischemic strokes and in both infra & supra tentorial hemorrhage. CT scan was only 43% positive in cases of infra tentorial ischemic infarct especially in brain stem infarct. To summarize we recommend CT scan is the first option in critically ill, poor rural Indian population. Source

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