Hr Patel Institute Of Pharmaceutical Education And Research

Shirpur, India

Hr Patel Institute Of Pharmaceutical Education And Research

Shirpur, India
SEARCH FILTERS
Time filter
Source Type

Firke S.D.,Rc Patel Institute Of Pharmaceutical Education And Research | Patel N.A.,Hr Patel Institute Of Pharmaceutical Education And Research | Patil R.R.,Rc Patel Institute Of Pharmaceutical Education And Research
International Journal of Pharmaceutical Quality Assurance | Year: 2017

A simple, precise, accurate high performance thin layer chromatographic (HPTLC) method has been developed for estimation of cyamemazine tartrate from a bulk drug and combined dosage form. The separation of drugs was carried out on Merck HPTLC aluminium sheets of Silica gel 60 F254 TLC plates as stationary phase and the chromatogram was developed using Benzene: Methanol (4.2:0.8v/v) as the mobile phase. Cyamemazine tartrate showed Rf values 0.45, when scanned densitometrically at 260 nm using Camag TLC Scanner. The described method was linear over a concentration range of 200 ng/spot to 1200 ng/spot for cyamemazine tartrate. Results of analysis were validated according to International Conference on Harmonization ICH Q2B guidelines statistically, and by recovery studies. The limit of detection (LOD) and limit of quantification (LOQ) for cyamemazine tartrate was found to be 28.47 ng/spot 86.29 ng/spot respectively. The results of the study showed that the proposed HPTLC method is simple, rapid, precise and accurate, which is useful for the routine determination of cyamemazine tartrate bulk drug and in its pharmaceutical dosage form. © 2017, International Journal of Pharmaceutical Quality Assurance. All rights reserved.


Tatiya A.U.,R C Patel Institute Of Pharmaceutical Education And Research | Puranik P.M.,R C Patel Institute Of Pharmaceutical Education And Research | Surana S.J.,R C Patel Institute Of Pharmaceutical Education And Research | Patil Y.S.,R C Patel Institute Of Pharmaceutical Education And Research | Mutha R.E.,Hr Patel Institute Of Pharmaceutical Education And Research
Bangladesh Journal of Pharmacology | Year: 2013

The tuber of Eulophia herbacea is widely used in the treatment of obesity in traditional medicine. Methanolic extract, aqueous extract and isolated glucomannan were tested for triton WR-1339 induced hyperlipidemia and alloxaninduced diabetes in rats. Blood samples were collected and analysed for lipid profile and blood glucose. Glucomannan was isolated and characterised. Antioxidant activity of test sample was determined by superoxide radical and lipid peroxidation assay and compared it with standards ascorbic acid. The findings showed that folk medicinal claim of E. herbacea tubers possess hypolipidemic, hypoglycemic and antioxidant effects.


Pande V.,Hr Patel Institute Of Pharmaceutical Education And Research | Patel S.,Hr Patel Institute Of Pharmaceutical Education And Research | Patil V.,Hr Patel Institute Of Pharmaceutical Education And Research | Sonawane R.,Hr Patel Institute Of Pharmaceutical Education And Research
Advanced Pharmaceutical Bulletin | Year: 2014

Purpose: The objective of this work was to develop a bioadhesive topical gel of sertaconazole nitrate with the help of response-surface approach. Methods: Experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of Carbapol 934 = X1) and Sodium carboxymethylcellulose (NaCMC) = X2)] on the bioadhesive character of gel, rheological property of gel (consistency index), and in-vitro drug release. The best model was selected to fit the data. Results: Mathematical equation was generated by Design Expert® software for the model which assists in determining the effect of independent variables. Response surface plots were also generated by the software for analyzing effect of the independent variables on the response. The effect of formulation variables on the product characteristics can be easily predicted and precisely interpreted by using a 3-level factorial design and generated quadratic mathematical equations. Conclusion: On the basis of product characteristics viscosity, bioadhesiveness, permeation study, in-vitro release, in-vivo studies, TPA and spreadability it can be concluded that the best batch of topical bioadhesive gel of Sertaconazole nitrate would be with 1% Carbopol 934 and 1% NaCMC. © 2014 by Tabriz University of Medical Sciences.


Bari S.B.,Hr Patel Institute Of Pharmaceutical Education And Research | Haswani N.G.,Rc Patel Institute Of Pharmaceutical Education And Research
Journal of Saudi Chemical Society | Year: 2014

In an attempt to find a new class of antimicrobial agents, a series of thienopyrimidin-4(3H)-thiones 4(H1-H36) were synthesized and evaluated for in vitro antifungal activity against Candida albicans (NCIM 3471), Aspergillus niger (NCIM 545), and Penicillium chrysogenum (NCIM 709). The title compounds were synthesized by thionation of thienopyrimidin-4(3H)-ones 3(H1-H36) using Lawesson's reagent. All the compounds were characterized using elemental analytical (C, H, and N) and spectral (FT-IR, 1H NMR, 13C NMR and MS) data. Among the tested compounds, 5-(4-chlorophenyl)-2-(pyridin-3-yl)thieno[2,3-d]pyrimidine-4(3H)-thione 4(H11), 2-sulfanyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-4(3H)-thione 4(H18), and 2-(butylsulfanyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-4(3H)-thione 4(H32) were identified as potentially excellent antifungal agents. They exhibited potent antifungal activity against C. albicans (MIC; 4 μg/mL), A. niger (MIC; 2 μg/mL), and P. chrysogenum (MIC; 2 μg/mL) comparable with that of ketoconazole. The binding mode of compounds by SP docking studies shows that it fits well into the active site cavity of DHFR. Lipinski's rule and in silico ADME pharmacokinetic parameters are within the acceptable range defined for human use thereby indicating their potential as drug-like molecules. © 2014.


Patil P.O.,Rc Patel Institute Of Pharmaceutical Education And Research | Bari S.B.,Hr Patel Institute Of Pharmaceutical Education And Research
Arabian Journal of Chemistry | Year: 2014

The present review highlights the synthetic methods of monoamine oxidase inhibitors (MAO) belonging to a group of nitrogen heterocycles such as pyrazoline, indole, xanthine, oxadiazole, benzimidazole, pyrrole, quinoxaline, thiazole and other related compounds (1990-2012). Moreover, it emphasizes salient findings related to chemical structures and the bioactivities of these heterocycles as MAO inhibitors. The aim of this review is to find out different methods for the synthesis of nitrogen containing heterocycles and their bioactivity related aspects as MAO inhibitors. © 2013.


Patil P.O.,Rc Patel Institute Of Pharmaceutical Education And Research | Bari S.B.,Hr Patel Institute Of Pharmaceutical Education And Research | Firke S.D.,Hr Patel Institute Of Pharmaceutical Education And Research | Deshmukh P.K.,Hr Patel Institute Of Pharmaceutical Education And Research | And 2 more authors.
Bioorganic and Medicinal Chemistry | Year: 2013

Monoamine oxidase (MAO) enzyme inhibition is a crucial target for the management of depression and Alzheimer disease and inhibitors of MAO are the most important drugs for their management. Coumarins are a large family of compounds, of natural and synthetic origin, that exhibit a variety of pharmacological activities, including MAO inhibition. The current review highlights the design and synthetic methods of coumarin derivatives as well as coumarins obtained from plant source as MAO inhibitors for treatment of depression and Alzheimer disease with salient finding related to structure-activity relationship. The aim of present review is to find out natural as well as synthetic coumarins as MAO inhibitors. © 2013 Elsevier Ltd. All rights reserved.


Firake S.D.,Rc Patel Institute Of Pharmaceutical Education And Research | Bari S.B.,Hr Patel Institute Of Pharmaceutical Education And Research
Current Enzyme Inhibition | Year: 2015

Benzenesulfonamide is versatile motif employed for the discovery in the field of medicinal and pharmaceutical chemistry. Over the years of active research, sulfonamide has evolved as important privileged pharmacophore in medicinal chemistry, encompassing a diverse range of biological activities including antiviral, carbonic anhydrase inhibitors, diuretic, and a protease inhibitor, hypoglycemic, anticancer and anti-inflammatory. On the other hand, owing to the fast development of new drugs possessing sulfonamide pharmacophore many research reports generated in a short span of time. Thus, there is a need to couple the most recent data with the prior data to comprehend the present status of benzenesulfonamide as anti-inflammatory agent. The present review highlights the molecular modeling and synthetic methods of benzenesulfonamide scaffold bearing various heterocyclic or carbocyclic rings such as thiazole, triazole, imidazole, isoxazoline, pyridine, pyranone, pyridazone, pyrimidine, pyran, indole, benzothiazole, benzotriazole, benzimidazole and benzopyran as central ring scaffold. In addition to this, the manuscript will be a guideline to medicinal chemists for rationally designing a novel benzenesulfonamide bearing compounds as COX-2 inhibitors. © 2015 Bentham Science Publishers.


Redasani V.K.,Rc Patel Institute Of Pharmaceutical Education And Research | Bari S.B.,Hr Patel Institute Of Pharmaceutical Education And Research
Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry | Year: 2015

The present work is an agreement with simple and efficient method of improving the therapeutic efficacy of ibuprofen by masking its acidic moiety. It aims to reduce gastrointestinal side effects by controlling the rate, duration and site of release. This is achieved by synthesis and evaluation of polymeric prodrug of ibuprofen with natural polymer sodium alginate. The synthesis was supported by N-protected serine as spacer due to chemical incompatibility of drug and polymer. Synthesized prodrug was characterized for confirmation of said structures. The in-vitro dissolution profile of ibuprofen-alginate prodrug showed that the release of the drug is significantly higher in case of pH 7.2 buffer as compared to ibuprofen, which might be due to ester group adjacent to drug get hydrolyzed. The hydrolysis was found to be with faster rate in alkaline media than that of in acidic media. © 2015 Bentham Science Publishers.


Sonawane R.O.,Hr Patel Institute Of Pharmaceutical Education And Research | Patil S.D.,Hr Patel Institute Of Pharmaceutical Education And Research
Polymer - Plastics Technology and Engineering | Year: 2016

Nowadays, pellets are playing a dominating role in the world of multiparticulate oral drug delivery. These pellets have many advantages over single-unit dosage forms like extended release. The present review highlights various formulation aspects for the designing of extended release pellets with a special emphasis on effect of key formulation variables. Design includes pellets–matrix and pellets–reservoir systems. Formulation variables such as effect of polymer, plasticizer, pore former, pH adjuster, antitacking agents, and wetting liquids are considered as key formulation variables. The authors lead to a conclusion that designing approaches and formulation factors should be considered and will assist while preparing extended release pellets. © 2016, Copyright © Taylor & Francis Group, LLC.


PubMed | Hr Patel Institute Of Pharmaceutical Education And Research
Type: Journal Article | Journal: Current drug delivery | Year: 2016

In present investigation, an innovative attempt has been made to enhance the solubility and dissolution rate of Repaglinide (RPGD) using hydrothermally treated water insoluble dietary bamboo fibers (HVBF) as potential nutraceutical used in the treatment of diabetes mellitus. RPGD was selected as a model drug due to its low aqueous solubility and dissolution rate. Characterization of HVBF demonstrated the outstanding features like high surface area, maximum drug loading and increase dissolution rate and making HVBF as an excellent drug carrier. RHVBF (Repaglinide loaded HVBF) tablets were prepared using direct compression method. Pre and post-compression parameters for blend and tablets were studied and found within acceptable limits. RHVBF and tablet showed significantly improved dissolution rate, when compared with pure crystalline RPGD, physical mixture, RVBF and commercial marketed tablet. This fact was further supported by FT-IR, DSC, XRPD and FESEM studies followed by in-vitro drug release profile. Stability studies showed no changes after exposing to accelerated conditions for a period of 3 months with respect to physical characteristics and in-vitro drug release studies. In a nut shell, it can be concluded that HVBF is a novel, smart and promising carrier for poorly water soluble drugs, when administered orally.

Loading Hr Patel Institute Of Pharmaceutical Education And Research collaborators
Loading Hr Patel Institute Of Pharmaceutical Education And Research collaborators