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Kawaguchi I.,Houju Memorial Hospital | Kawaguchi I.,Kanazawa University | Higashide T.,Kanazawa University | Ohkubo S.,Kanazawa University | And 2 more authors.
Japanese Journal of Ophthalmology | Year: 2012

Purpose: To compare the drug efficacy of four prostaglandin analogues (PGAs) by bilateral treatment in normal subjects. Methods: Three consecutive studies comparing latanoprost to three other PGAs (travoprost, tafluprost and bimatoprost) were performed in 24 healthy subjects. Each study was separated by a washout period of over 6 weeks. In each study, two drugs were randomly assigned to one eye of each subject. Study subjects instilled the assigned medication at 9:00 p.m. every day for 2 weeks. The same masked investigator measured intraocular pressure (IOP) at 9:00 a.m., 1:00 p.m. and 5:00 p.m. at baseline and repeated measurements on days 7 and 14. The differences in IOP reduction were compared between the drugs. Results: Mean diurnal IOP reduction with latanoprost on days 7 and 14 was similar to that with travoprost and tafluprost, but was significantly lower than that with bimatoprost. The association of the mean diurnal IOP reduction between latanoprost and bimatoprost on day 14 (r 2 = 0.25) was weak, in remarkable contrast to the strong association between latanoprost and travoprost (r 2 = 0.81) and between latanoprost and tafluprost (0.82). Conclusions: The short-term bilateral treatment revealed a different IOP-lowering efficacy of bimatoprost compared to other PGAs in healthy subjects. © Japanese Ophthalmological Society 2012. Source

Yoshioka K.,Kanazawa University | Matsuda E.,Houju Memorial Hospital | Murakami H.,Kanazawa University | Tsuchiya H.,Kanazawa University
Asian Spine Journal | Year: 2015

We present a rare case of a patient who underwent complete microendoscopic excision of an osteoid osteoma, which induced radiculopathy without nerve root compression. A 20-year-old man presented severe right groin pain that was temporarily relieved by nonsteroidal anti-inflammatory drugs. A computed tomography (CT) scan showed typical features of a nidus located in the inferior cortex of the right L3 pedicle. We performed surgery using a posterior microendoscopic approach. We drilled vertically along the line of the cortex of the caudal pedicle using a high-speed drill. After identifying the tumor, en bloc resection of the nidus was achieved. Immediately after surgery, pain in the right groin disappeared. A CT scan showed that most of the right L3 pedicle remained. This minimally invasive technique preserves spinal structures, including the facet and pedicle, and is a viable option for the treatment of spinal osteoid osteomas located close to vital structures. Source

Miyashita T.,Kanazawa University | Miwa K.,Houju Memorial Hospital | Fujimura T.,Kanazawa University | Ninomiya I.,Kanazawa University | And 5 more authors.
International Journal of Cancer | Year: 2013

The mechanism through which each histological type of carcinoma arises from the esophageal mucosa remains unknown. This study was designed to investigate whether there is an association between the severity of duodeno-esophageal reflux and the histological type of esophageal cancer. A series of 120 male Fischer rats, weighing ∼180 g, were randomized to receive one of the following procedures: duodeno-forestomach reflux (DFR) with reduced exposure to duodenal contents, duodeno-esophageal reflux (DER) with increased exposure to duodenal contents and three control operations (DFR, DER control and sham). The reflux of bile was estimated with 99mTc-PMT scintigraphy. All animals were fed a standard diet without carcinogen. The esophageal mucosa was assessed 50 weeks after surgery for carcinoma. The median scanned fraction rate of duodeno-esophageal reflux was significantly lower for the rodents in the DFR group than those in the DER group. Five of 28 rodents in the DFR group and 17 of the 22 rodents in the DER group developed esophageal carcinoma. None of the controls developed carcinoma. The five rodents in the DFR group developed SCC. Of 22 esophageal carcinomas for the DER group, nine were SCC, 12 ADC and one was adenosquamous carcinoma. The fraction of esophageal SCC for the DFR group was significantly higher than that for the DER group, while the fraction of esophageal ADC for the DFR group was significantly lower than that for the DER group. These observations suggest that the severity of duodeno-esophageal reflux in rodents is related to the development of different histological types of esophageal carcinoma. What's new? How do different types of esophageal cancer get started? This study looked at whether the severity of reflux influenced the type of cancer in a rat model. The authors found that high exposure to duodenal contents leads to esophageal adenocarcinoma, while low exposure leads to esophageal squamous cell carcinoma. Because obesity can lead to increased reflux, these findings suggest that obesity could be the driving force behind increased rates of these esophageal cancers. Copyright © 2012 UICC. Source

Suzuki N.,Kanazawa University | Takimoto Y.,Kanazawa University | Suzuki R.,Kanazawa University | Arai T.,Kanazawa University | And 4 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2013

Extract of Lentinula edodes mycelia (LEM) is currently utilized as an oral biological response modifier (BRM) medicine for cancer patients. However, its effectiveness for breast cancer patients with postoperative adjuvant hormone therapy has not yet been scientifically verified. In this study, we investigated the influence of LEM on the quality of life (QOL) and immune response in breast cancer patients undergoing postoperative adjuvant hormone therapy. Twenty patients were studied in total. They received only hormone therapy in the ?rst 4 weeks followed by hormone therapy and LEM during the next 8 weeks. Laboratory tests, QOL score and peripheral blood cytokine production levels were evaluated during the study period. No changes in QOL or cytokines were noted after the ?rst 4 weeks. In contrast, during the following combined therapy period, improvements were noted in QOL and cytokine levels. Although a future large-scale investigation is necessary to confirm these results, these data suggest that the concomitant use of LEM with postoperative adjuvant hormone therapy improves the QOL and immune function of patients. Source

Sagawa M.,Kanazawa Medical University | Maeda T.,Houju Memorial Hospital | Yoshimitsu Y.,Houju Memorial Hospital | Sakuma T.,Kanazawa Medical University
European Journal of Cardio-thoracic Surgery | Year: 2014

Two patients were admitted to our hospital due to giant bullae. During thoracoscopic surgery, saline-cooled radiofrequency coagulation devices were used to shrink the wall of the bulla. In each case, the volume of the bulla was gradually reduced and the boundary between the lung and bulla was clearly delineated. This method is considered to be useful for performing thoracoscopic surgery of giant bulla. © The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. Source

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