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Yan J.-L.,Ren County Hospital | Li M.,Hotan Detachment of the Xinjiang Armed Police Corps | Li R.-Y.,Institute for Integrated Traditional and Western Medicine | Wu L.-P.,Hebei Medical University | And 2 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2013

Background: Compound Chinese medicine is a kind of compound drugs with the combination of minerals, plants and animals, which play the multi-target integrated treatment effects in the treatment of bone metabolic disease through various methods. Objective: To research the effect of compound traditional Chinese medicine on the proliferation and bone mineral density of osteoblasts, and to explore the pharmacological effect of compound traditional Chinese medicine in the treatment of osteoporosis. Methods: A retrospective analysis was performed to analyze the effect of some compound traditional Chinese medicines on the proliferation and bone mineral density of osteoblasts that identified in the previous studies, in order to analyze the factors of compound traditional Chinese medicines that can promote the bone formation. The appropriate dose of the drugs that can promote cell proliferation and differentiation and improve the bone mineral density was screened out through the in vitro culture of osteoblasts, and then compared with the results of chemical medicines. Results and Conclusion: Compound traditional Chinese medicines can promote the proliferation and differentiation of osteoblasts and improve the bone mineral density, and have the advantages of full treatment and less side effect in the treatment of osteoporosis. But the effect of compound traditional Chinese medicines in improving the bone mineral density is less than the chemical drugs. The long-term and large-sample clinical studies should be performed to decrease the risk of osteoporotic fracture. Source


Wei S.-P.,Xingtai Medical College | Li M.,Hotan Detachment of the Xinjiang Armed Police Corps | Li R.-Y.,Institute for Integrated Traditional and Western Medicine | Wu L.-P.,Hebei Medical University | And 2 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2013

BACKGROUND: In vitro culture of osteoblasts and its Chinese medicine intervention is one of the important means for the research and development of osteoporosis treated with traditional Chinese medicine. OBJECTIVE: To observe the effect of Chinese medicine on the proliferation and differentiation of osteoblasts and the synthesis of osteocalcin. METHODS: The researches on the effect of different kinds of Chinese medincine-loaded serum on the secretion of osteoblasts and osteocalcin were collected for the data analysis. The effect of traditional Chinese medicine on osteocalcin synthesis of osteoblasts was observed from the level of molecular cell biology. RESULTS AND CONCLUSION: Some single Chinese herbs and Chinese herbal compounds could promote the proliferation and differentiation of osteoblasts and the synthesis of osteocalcin, and different Chinese medicines had different effects in promoting the proliferation and differentiation of osteoblasts and expression level of osteocalcin, which was positively correlated with the concentration of Chinese medicine-loaded serum. Through screening with the in vitro culture of osteoblasts, the drugs and appropriate dose for promoting the proliferation and differentiation were founded, which could positively promote the development of drugs used for the treatment of osteoporosis. Source


Li H.-Z.,Institute of Integrative Medicine | Li M.,Hotan Detachment of the Xinjiang Armed Police Corps | Li R.-Y.,Institute of Integrative Medicine | Wu L.-P.,Hebei Medical University
Chinese Journal of Tissue Engineering Research | Year: 2014

Background: Epimedium has been used in the treatment of osteoporosis and repair of bone defects. Objective: To explore the effects of epimedium on the osteogenic differentiation of bone marrow mesenchymal stem cells. Methods: A database search was performed to retrieve literatures addressing epimedium effects on the osteogenic differentiation of bone marrow mesenchymal stem cells. Then, the papers meeting the criteria were selected for in-depth analysis. During the osteogenic differentiation induced by epimedium, alkaline phosphatase, osteocalcin, osteopontin, transforming growth factor β, bone morphogenetic proteins, osteocalcin, bone sialoprotein were detected in the bone marrow mesenchymal stem cells to understand the underlying mechanism of epimedium in proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells. Results and Conclusion: Epimedium effects on bone marrow mesenchymal stem cells are shown in a dose-dependent manner. During the early induction, icariin can increase cell phosphatase activity; in the late induction, icariin can increase calcified nodules, promote osteocalcin secretion, significantly improve the expressions of transforming growth factor β1, bone morphogenetic protein 2, insulin-like growth factor-1, osteopontin and bone sialoprotein. Epimedium, which can be used as an excellent osteoinductive factor, improves the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells. Source


Ruiyu L.,Institute for Integrated Traditional and Western Medicine | Xueyu M.,Xingtai University | Meng L.,Hotan Detachment of the Xinjiang Armed Police Corps | Kaoshan G.,Institute for Integrated Traditional and Western Medicine | Jinjie H.,Institute for Integrated Traditional and Western Medicine
BioTechnology: An Indian Journal | Year: 2013

Objective: Talk about the change of cilium's function and the ostiomcatal complexmucosal ultrestructure aftermaxillary sinus cyst operation treatment and nonoperational treatment methods: choose 63 patients and divided theminto 2 groups. then cut down the tumor. Then inject the medicine and observe the patient of the two groups use some methods to observe the changes. Results: in surgical treatment group, nasal mucosa cilia propagation velocity is 4.08±1.26 mm/min. In the other group, the space is 8.23±2.13 mm/min. The difference is obvious between the two groups. According to the electronic microscope cilium is less and chaos arranged, parts of cells come off, local edema,minor Neutrogena. and goblet cells. In cross-section contains: 9+2microtubules in contrast group, ciliumis ciliaarrangement and thickness, abundant and intensive. 9+2microtub is clearly built. Conclusion: nonoperational treatment doesn't affect the transfer rate of cilia propagation velocity and cilium's physical function. © 2013 Trade Science Inc. - INDIA. Source


Li R.,Institute for Integrated Traditional and Western Medicine | Ma X.,Xingtai University | Li M.,Hotan Detachment of the Xinjiang Armed Police Corps | Wu L.,Hebei Medical University | And 2 more authors.
Proceedings - 2015 7th International Conference on Information Technology in Medicine and Education, ITME 2015 | Year: 2015

Objection: the research of The effect of nasal septum deviation on the new technology of the treatment of maxillary sinus cyst. Way: 61 patients with maxillary sinus cyst were selected from patients with CT scan, and were divided into two groups. Group one includes 32 patients with Maxillary sinus cyst(treatment group). Group two uses 29 Patients with nasal septum deviation of maxillary sinus cyst as a comparison(matched group). These two group Adopt the surface anesthesia or local anesthesia, Under the conventional via nasal passages or labial gingival sulcus second incisor puncture, let the needle get into the cyst and then extract the fluid. According to the number of the fluid, inject our invention patent medicine by the ratio of 2:1(the fluid was 2ml, the drug was 1ml, and the main component of the drug was the super oxidation of iodine atoms). After two months' treatment, taking the CT scan for the two groups' patients in order to observe their effect respectively. Results: the patients in treatment group were all cured by taking 1-2 times' new way. Among the matched group, 5 patients were cured and 25 patients get better. The cure rate and the effective rate of the treatment group and the control group have the statistically significance (p<0.05, p<0.01). conclusion: The research shows that the nasal septum is an important factor that affects the curative effect of the treatment of maxillary sinus cyst. Before treatment, the treatment and correction of nasal septum deviation should be first considered to provide ideas and methods for the comprehensive treatment of the relevant deviation of nasal septum, maxillary sinus cyst. © 2015 IEEE. Source

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