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Martinez-Ramirez A.,Public University of Navarra | Lecumberri P.,Public University of Navarra | Gomez M.,Public University of Navarra | Rodriguez-Manas L.,Hospital Universitario Of Getafe | And 2 more authors.
Journal of Biomechanics | Year: 2011

Background: A standard phenotype of frailty was independently associated with an increased risk of adverse outcomes including comorbidity, disability and with increased risks of subsequent falls and fractures. Postural control deficit measurement during quiet standing has been often used to assess balance and fall risk in elderly frail population. Real time human motion tracking is an accurate, inexpensive and portable system to obtain kinematic and kinetic measurements. The aim of this study was to examine orientation and acceleration signals from a tri-axial inertial magnetic sensor during quiet standing balance tests using the wavelet transform in a frail, a prefail and a healthy population. Methods: Fourteen subjects from a frail population (79±4 years), eighteen subjects from a prefrail population (80±3 years) and twenty four subjects from a healthy population (40±3 years) volunteered to participate in this study. All signals were analyzed using time-frequency information based on wavelet decomposition and principal component analysis. Findings: The absolute sum of the coefficients of the wavelet details corresponding to the high frequencies component of orientation and acceleration signals were associated with frail syndrome. Interpretation: These parameters could be of great interest in clinical settings and improved rehabilitation therapies and in methods for identifying elderly population with frail syndrome. © 2011 Elsevier Ltd.


Vina J.,University of Valencia | Gambini J.,University of Valencia | Garcia-Garcia F.J.,Hospital Virgen Del Valle | Rodriguez-Manas L.,Geriatria Hospital Universitario Of Getafe | Borras C.,University of Valencia
Hormone Molecular Biology and Clinical Investigation | Year: 2013

Females live longer than males. We have shown that this could be in part due to the higher levels of oestrogens in females, which protect them against ageing, by upregulating the expression of antioxidant, longevity-related genes. However, the low concentration of oestrogens makes it unlikely that they exhibit significant antioxidant capacity in the organism. Our results show that physiological concentrations of oestrogens activate the expression of manganese superoxide dismutase and glutathione peroxidase by oestrogen receptors and the mitogen-activated protein kinase and nuclear factor kappa B pathway. Moreover, when considering oestrogen replacement therapy, it is of utmost importance to take into account when to start the therapy after menopause. We have shown that only early-onset administration of oestrogen replacement therapy is effective on oestrogen deprivation associated with oxidative and metabolic stress. This is due to a change in oestrogen receptor distribution after oestrogen deprivation. Oestrogens are also involved in inflammatory processes. Their role on inflammation is very complex, because their effects are different depending on the doses and also on the oestrogen receptor distribution.


Millor N.,Research and Sport Medicine Center | Millor N.,Public University of Navarra | Lecumberri P.,Public University of Navarra | Gomez M.,Public University of Navarra | And 4 more authors.
IEEE Journal of Biomedical and Health Informatics | Year: 2013

The aim of this study was to evaluate the inertial measures of the 30-s chair stand test using modern body-fixed motion sensors. Polynomial data fitting was used to correct the drift effect in the position estimation. Thereafter, the three most important test cycles phases ("impulse," "stand up," and "sit down") were characterized and automatically analyzed. Automated test control is provided, making it possible for researchers without engineering knowledge to run the test. A collection of meaningful data based on kinematic variables is selected for further research. The proposed methodology for data analysis is a feasible tool for use in clinical settings. This method may not only improve rehabilitation therapies but also identify people at risk for falls more accurately than simply evaluating the number of cycles. © 2013 IEEE.


Panizo C.,Hospital Nuestra Senora del Prado | Cimarra M.,Hospital Clinico San Carlos | Gonzalez-Mancebo E.,Hospital Fuenlabrada | Vega A.,Hospital Universitario Of Guadalajara | And 2 more authors.
Journal of Investigational Allergology and Clinical Immunology | Year: 2010

Background: The fast-dissolving grass allergy immunotherapy tablet (grass AIT), Grazax, has proven effective in grass pollen-induced rhinoconjunctivitis. Objective: To investigate the immunological and cutaneous changes induced after a short course with grass AIT. Methods: We performed a randomized, double-blind placebo-controlled trial with 78 patients randomly assigned to receive either grass AIT or placebo in a 2:1 ratio. Treatment lasted at least 8 weeks before the grass pollen season (GPS), and continued until the season finished. Specific immunoglobulin (Ig) G4, IgE, and IgE-blocking factor to Phleum pratense were measured at the beginning of the trial and at different intervals during treatment. Immediate and delayed skin tests with P pratense were also performed. Safety endpoints were defi ned in terms of adverse events reported. Results: A total of 75 patients completed the trial (50 active and 25 placebo). P pratense IgG4, IgE, and IgE-blocking factor in actively treated patients increased significantly from baseline to the start of the GPS compared to placebo (P>.001, P=.017, and P=.005, respectively) The immediate cutaneous response was reduced during therapy in actively treated subjects, whereas placebo-treated subjects showed a decrease only after the start of the GPS. The delayed response to the intradermal test in grass AIT-treated subjects diminished, although not in a significantly different way from the placebo-treated subjects. Conclusion: Treatment with grass AIT for grass pollen allergic rhinoconjunctivitis induces immunological changes after only 1 month of treatment. © 2010 Esmon Publicidad.


Garcia-Garcia F.J.,Hospital Virgen Del Valle | Gutierrez Avila G.,University of Castilla - La Mancha | Alfaro-Acha A.,Hospital Virgen Del Valle | Amor Andres M.S.,Hospital Virgen Del Valle | And 7 more authors.
Journal of Nutrition, Health and Aging | Year: 2011

Objective: To assess the prevalence of the frailty syndrome and its associated variables among the older adult population in the province of Toledo (Spain). Methods: Data were taken from the Toledo Study for Healthy Aging, a population-based study conducted on 2,488 individuals aged 65 years and older. Study participants were selected by a two-stage random sampling from the municipal census of Toledo, covering both institutionalized and community dwelling persons from rural and urban settings. Data were collected from 2006 to 2009, and included information on social support, activities of daily living, comorbidity, physical activity, quality of life, depressive symptoms, and cognitive function. In addition, a nurse collected anthropometric data, conducted tests of physical performance (walk speed, upper and lower extremities strength, and the stand-and-sit from a chair test) and obtained a blood sample. The diagnosis of the frailty syndrome was based on the Fried criteria (weakness, low speed, low physical activity, exhaustion, and weight loss). Results: In total, 41.8% (95% confidence interval [CI] 39.4-44.2%) of the study participants were prefrail, and 8.4% (95% CI 7.1-9.8%) were frail. There were no differences in the prevalence of frailty by sex, level of education, occupation, marital status, or place of residence. The frequency of the frailty syndrome increased with age, and was higher in those with disability, depression, hip fracture and other comorbidity, such as cardiovascular disease and disorders of the central nervous system. Conclusions: The prevalence of the frailty syndrome in older Spanish adults is high and similar to that reported in other populations in the Mediterranean basin. © 2011 Serdi and Springer Verlag France.

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