Hospital Universitario Reina Sofia Of Cordoba

Hospital de Órbigo, Spain

Hospital Universitario Reina Sofia Of Cordoba

Hospital de Órbigo, Spain
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Ruiz M.A.M.,Hospital Universitario Reina Sofia Of Cordoba
Revista de la Sociedad Espanola de Enfermeria Nefrologica | Year: 2017

Introduction: Patients with advanced chronic kidney disease suffer various changes in their lives, due to their own illness and treatment, which cause anxietydepressive disorders and alterations in emotional state. Objective: The aim of the present study was to assess the emotional state of patients on hemodialysis and to identify emotional support needs. Patients and Method: We studied 66 patients, 68.2% men and the mean age was 65.5 ± 16.25 years. A descriptive cross-sectional observational study was carried out at the Clinical Management Unit (CMU) of Nephrology at the Reina Sofía University Hospital (HURS) in Córdoba. The demographic variables added in the study were: age, sex, marital status, other associated pathologies, economic level and occupation. The outcome variable was the emotional state, as measured by the Tool for Detection of the Emotional State of Patients in Dialysis (EE-D). Results: Of the total number of patients, 86.3% were retired and the average monthly income was 878.79 ± 533.35 €. More than 42% had at least 2 or more pathologies associated with their underlying disease and 62.1% were married. Regarding the variables of sadness and nervousness, 54.5% were sad, and 59.1% were nervous. On the other hand, 92.4% had altered to a greater or lesser extent the emotional state. Conclusions: There is a high prevalence of altered emotional state in the studied patients and a high number of them need emotional support. © 2017, Sociedad Espanola de Enfermeria Nefrologica. All rights reserved.

Tasset I.,University of Cordoba, Spain | Medina F.J.,University of Cordoba, Spain | Jimena I.,University of Cordoba, Spain | Aguera E.,Hospital Universitario Reina Sofia Of Cordoba | And 7 more authors.
Neuroscience | Year: 2012

There is evidence to suggest that the neuroprotective effect of exposure of extremely low-frequency electromagnetic fields (ELF-EMF) may be due, at least in part, to the effect of these fields on neurotrophic factors levels and cell survival, leading to an improvement in behavior. This study was undertaken to investigate the neuroprotective effects of ELFEF in a rat model of 3-nitropropionic acid (3NP)-induced Huntington's disease. Behavior patterns were evaluated, and changes in neurotrophic factor, cell damage, and oxidative stress biomarker levels were monitored in Wistar rats. Rats were given 3NP over four consecutive days (20 mg/kg body weight), whereas ELFEF (60 Hz and 0.7 mT) was applied over 21 days, starting after the last injection of 3NP. Rats treated with 3NP exhibited significantly different behavior in the open field test (OFT) and the forced swim test (FST), and displayed significant differences in neurotrophic factor levels and oxidative stress biomarkers levels, together with a neuronal damage and diminished neuronal density, with respect neuronal controls. ELFEF improved neurological scores, enhanced neurotrophic factor levels, and reduced both oxidative damage and neuronal loss in 3NP-treated rats. ELFEF alleviates 3NP-induced brain injury and prevents loss of neurons in rat striatum, thus showing considerable potential as a therapeutic tool. © 2012 IBRO.

Ferrandiz C.,Autonomous University of Barcelona | Fonseca-Capdevila E.,Complejo Hospitalario Universitario Of runa | Garcia-Diez A.,Hospital Universitario Of La Princesa | Guillen-Barona C.,Instituto Valenciano Of Oncologia | And 3 more authors.
Actas dermo-sifiliográficas | Year: 2014

Current trends in our setting indicate that the prevalence of actinic keratosis and similar diseases will increase in coming years and impose a greater burden on health care resources. A long list of clinical features must be taken into account when approaching the treatment of actinic keratosis. Until recently, therapeutic approaches focused solely on ablative procedures and the treatment of individual lesions and did not take into account areas of field cancerization. Now that the therapeutic arsenal has grown, standardized criteria are needed to guide the optimal choice of treatment for each patient. The elaboration of evidence-based consensus recommendations for the diagnosis and treatment of actinic keratosis generates knowledge that will help clinicians to deliver the highest level of care possible, standardizing decision-making processes and enhancing awareness among all the health professionals involved in the care pathway. Copyright © 2013 Elsevier España, S.L. and AEDV. All rights reserved.

PubMed | Hospital U Reina Sofia, Fundacio Puig Vert. Barcelona., Hospital Universitari Arnau Of Villanova Of Lleida, Hospital Universitario Reina Sofia Of Cordoba and 10 more.
Type: | Journal: American journal of physiology. Renal physiology | Year: 2017

Patients with stage 5 chronic kidney disease who are on hemodialysis (HD) remain in a chronic inflammatory state, characterized by the accumulation of uremic toxins that induce endothelial damage and cardiovascular disease (CVD). Our aim was to examine microvesicles (MVs), monocyte subpopulations, and angiopoietins to identify prognostic markers in HD patients with or without diabetes mellitus (DM). A total of 160 prevalent HD patients from 10 centers across Spain were obtained from the Biobank of the Nephrology Renal Network (REDinREN, Madrid): 80 patients with diabetes mellitus (DM) and 80 patients without DM who were matched for clinical and demographic criteria. MVs from plasma and several monocyte subpopulations (CD14++/CD16+, CD14+/CD16++) were analyzed by flow cytometry, and the plasma concentrations of angiopoietin (Ang)1 and Ang2 were quantified by ELISA. Data on cardiovascular disease were gathered over the 5.5 years after these samples were obtained. MV level, monocyte subpopulations (CD14+/CD16++ and CD14++/CD16+), and Ang2/Ang1 ratios increased in HD patients with DM compared with non-DM patients. Moreover, MV level above the median (264 MVs/l) were associated independently with greater mortality. MVs, monocyte subpopulations, and Ang2/Ang1 ratio can be used as predictors for CVD. In addition, MV level have potential predictive value in the prevention of CVD in HD patients. These parameters undergo more extensive changes in patients with DM.

Tunez I.,University of Cordoba, Spain | Sanchez-Lopez F.,Hospital Universitario Reina Sofia Of Cordoba | Aguera E.,Hospital Universitario Reina Sofia Of Cordoba | Fernandez-Bolanos R.,Hospital Universitario Nuestra Senora Of Valme | And 2 more authors.
Journal of Medicinal Chemistry | Year: 2011

This study examined global oxidative stress (GOS) and antioxidant system and their correlation with disease stage in 19 patients with HD. The results revealed an increase in oxidative stress biomarkers and a reduction in antioxidant systems in HD patients. The effects were more intense in HD1 than in HD2 patients. Additionally, carbonylated proteins and GOS were correlated with disease stage. These findings suggest that oxidative stress plays an important role in the pathogenesis of HD. © 2011 American Chemical Society.

Valenzuela-Salas B.,Hospital Universitario Reina Sofia Of Cordoba | Dean-Ferrer A.,University of Cordoba, Spain | Alamillos-Granados F.-J.,University of Cordoba, Spain
Medicina Oral, Patologia Oral y Cirugia Bucal | Year: 2010

Burkitt's lymphoma (BL) is a neoplasm which, despite its very aggressive behaviour is potentially curable. It typically affects the paediatric population. BL belongs to the non-Hodgkin lymphomas group, and is the first human tumour undoubtedly related to a viral origin (Epstein-Barr virus). Two main clinical subtypes are recognized: endemic or African type, and sporadic type; HIV associated BL constitutes a third type. Although common in endemic BL, maxillary involvement is rare in sporadic cases. This, together with the clinical lack of specificity associated to this location, makes diagnosis difficult. New chemotherapeutic protocols achieve a high survival rate. Most important prognostic factors are location and tumour stage. We report a paediatric case of BL presenting in the maxilla, with a review and a description of the characteristics of the disease. © Medicina Oral S. L.

Vicente A.,Hospital Virgen Of La Salud | Lecumberri B.,Hospital Universitario La Paz | Galvez M.T.,Hospital Universitario Reina Sofia Of Cordoba
Endocrinologia y Nutricion | Year: 2013

Classic pituitary apoplexy (PA) is an acute, life-threatening clinical syndrome caused by acute hemorrhage and/or infarction of the pituitary gland. PA is considered a neuroendocrinological emergency. However, there is no consensus about the best options for PA diagnosis and management. Objective: To develop a clinical practice guideline with a number of recommendations for diagnosis and treatment of patients with PA based on the medical evidence available, in order to help clinicians involved in their care. Methods: The clinical guideline for diagnosis and treatment of pituitary apoplexy issued in 2006 by the Neuroendocrinology Working Group of the Spanish Society of Endocrinology and Nutrition (SEEN) and the British Clinical Practice Guideline published in 2011 were taken as the basis. The text has been adapted to the format used in most international medical journals. For this, after updated medical literature, the quality of evidence and the strength of the recommendations were evaluated using the system proposed by the Agency for Health Care Policy and Research (AHCPR). Conclusions: Diagnosis of pituitary apoplexy should be considered in all patients with acute severe headache with or without neuro-ophthalmic signs. Patients with PA must undergo a complete history and physical examination. All patients with suspected pituitary apoplexy should have urgent blood samples drawn to test electrolytes, renal function, liver function, coagulation screen, complete blood count, and basal levels of pituitary and peripheral hormones, and to rule out adrenocorticotropic hormone (ACTH) deficiency. Formal visual field assessment should be performed when the patient is clinically stable. Magnetic resonance imaging (MRI) is the imaging test of choice to confirm diagnosis. Indications for empirical urgent corticosteroid therapy in patients with PA include hemodynamic instability, impaired consciousness, reduced visual acuity, and severe visual field defects. In patients with these severe neuro-ophthalmic signs, surgery should be considered. Surgery should preferably be performed within seven days of the onset of symptoms. Patients with mild and stable signs may be managed conservatively with careful monitoring. Treatment and long-term follow-up of patients with PA should be conducted by a multidisciplinary team consisting, amongst others, of an experienced pituitary neurosurgeon, an ophthalmologist, and an endocrinologist. © 2012 SEEN.

Rivero-Juarez A.,Hospital Universitario Reina Sofia Of Cordoba | Camacho A.,Hospital Universitario Reina Sofia Of Cordoba | Rivero A.,Hospital Universitario Reina Sofia Of Cordoba
Expert Opinion on Drug Metabolism and Toxicology | Year: 2015

Introduction: Telaprevir is one of the first direct-acting antiviral drugs approved for the treatment of the hepatitis C virus (HCV) genotype 1. Following its approval in 2011, new data regarding the pharmacokinetics and pharmacodynamics were reported, leading to important clinical applications.Areas covered: This article reviews the pharmacokinetic and pharmacodynamic properties of telaprevir for the treatment of the HCV. The areas covered include data regarding the drug's absorption, distribution, metabolism and excretion, in addition to the antiviral activity strategy such as the clinical dose selection and treatment duration.Expert opinion: Telaprevir presents several pharmacological properties that could limit its administration such a high-fat, high-calorie meal; the need to be administrated with pegylated IFN plus ribavirin; and the drug-drug interaction profile. As a consequence and considering the new therapeutic arsenal against the HCV, the use of telaprevir as part of HCV therapy will be limited. © Informa UK, Ltd.

PubMed | Hospital Universitario Reina Sofia Of Cordoba
Type: Journal Article | Journal: Revista espanola de cirugia ortopedica y traumatologia | Year: 2016

Reverse shoulder arthroplasty is becoming a useful tool for many diseases of the shoulder. Any severe glenoid bone defect may affect the fixing of the glenoid component. The aim of this paper is to evaluate the medium-term outcomes of reverse shoulder arthroplasty associated with a glenoplasty.A retrospective study was conducted on 5 patients from our hospital, selected due to glenoid defects of different etiology. All of them where treated with reverse shoulder arthroplasty associated with glenoplasty with bone graft.The minimum follow-up was one year (mean 30.4 months). All grafts were radiologically integrated, with no signs of resorption or necrosis being observed. At 12 months, the Constant score was 66.75 and the mean EVA score was 1.Glenoplasty surgery is technically demanding for restoring original bone size in patients with glenoid structural defects, enabling a reverse shoulder arthroplasty to be implanted. Thus improving both the function and clinical outcomes in selected patients with glenohumeral pathology and providing them with a solution.

Delgado I.Z.,Hospital Universitario Reina Sofia Of Cordoba | Villarraso M.T.C.,Hospital Universitario Reina Sofia Of Cordoba | Garcia M.R.,Hospital Universitario Reina Sofia Of Cordoba
Revista de la Sociedad Espanola de Enfermeria Nefrologica | Year: 2014

Introduction: Poor adherence to treatment in chronic diseases such as hypertension currently remains a latent problem in our country. Although the Health Education is been used in different levels of health care to improve adherence to drug therapy and acquisition of healthy lifestyles, there is little evidence of their effectiveness, especially in hypertensive patients, refractory to change their hygienic-dietary habits. Objective: This study was realized with the aim of learning personal motivations involved in changing habits, adherence and knowledge of the disease in a group of hypertensive patients. Method: Phenomenological study in the hospital setting, using semi- structured interviews. The sample was made of eighteen patients with uncontrolled levels of blood pressure associated with metabolic syndrome and / or obesity (BMI>30). These patients are been visited by the health care team of Nephrology UGC/Hypertension, in the Hospital Universitario Reina Sofía of Córdoba, since last January. Results: Three thematic categories with which to answer our study objectives, have been found: Raising awareness about cardiovascular risk to which they are exposed and knowledge of the disease itself, justifying the reasons which motivate or retract the hypertensive patient to adhere to treatment, and relationship between compliance pharmacological and non-pharmacological treatment. Conclusion: The lack of adherence to treatment is showed up by unwillingness among hypertensive patients refractory, rather than an information problem. For this reason, a nursing intervention focused on solving the problem, is necessary. © 2014, Sociedad Espanola de Enfermeria Nefrologica. All rights reserved.

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