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Hospital de Órbigo, Spain

Garcia-Diaz B.,Hospitales Universitarios Regional Of Malaga rgen Of La Victoria | Garcia-Diaz B.,Columbia University | Riquelme R.,Autonomous University of Madrid | Varela-Nieto I.,Autonomous University of Madrid | And 12 more authors.
Brain Structure and Function | Year: 2015

Lysophosphatidic acid (LPA) is an intercellular signaling lipid that regulates multiple cellular functions, acting through specific G-protein coupled receptors (LPA1–6). Our previous studies using viable Malaga variant maLPA1-null mice demonstrated the requirement of the LPA1 receptor for normal proliferation, differentiation, and survival of the neuronal precursors. In the cerebral cortex LPA1 is expressed extensively in differentiating oligodendrocytes, in parallel with myelination. Although exogenous LPA-induced effects have been investigated in myelinating cells, the in vivo contribution of LPA1 to normal myelination remains to be demonstrated. This study identified a relevant in vivo role for LPA1 as a regulator of cortical myelination. Immunochemical analysis in adult maLPA1-null mice demonstrated a reduction in the steady-state levels of the myelin proteins MBP, PLP/DM20, and CNPase in the cerebral cortex. The myelin defects were confirmed using magnetic resonance spectroscopy and electron microscopy. Stereological analysis limited the defects to adult differentiating oligodendrocytes, without variation in the NG2+ precursor cells. Finally, a possible mechanism involving oligodendrocyte survival was demonstrated by the impaired intracellular transport of the PLP/DM20 myelin protein which was accompanied by cellular loss, suggesting stress-induced apoptosis. These findings describe a previously uncharacterized in vivo functional role for LPA1 in the regulation of oligodendrocyte differentiation and myelination in the CNS, underlining the importance of the maLPA1-null mouse as a model for the study of demyelinating diseases. © 2014, Springer-Verlag Berlin Heidelberg. Source


Garcia A.M.C.,Hospital Universitario Regional Of Malaga
Nutricion Hospitalaria | Year: 2015

Introduction: Normalization can be understood as the establishing measures against repetitive situations through the development, dissemination, and application of technical design documents called standards. In Andalusia there are 45 public hospitals with 14,606 beds, and in which 11,700 full pensions / day are served. The Working Group on Hospital Food Standardization of the Andalusian Society for Clinical Nutrition and Dietetics, started in 2010, working on the certification of suppliers, product specifications, and meals technical card. Aims: –– Develop a specific tool to help improving food safety through the certification of their suppliers. –– Develop a standardized technical specifications of foodstuffs necessary for the development of menus established codes diets Andalusian hospitals document. –– Develop a catalog of data sheets plates of hospital meals, to homogenize menus, respecting local and unifying criteria for qualitative and quantitative ingredients. Methods: –– Providing documentation and studying of several public hospitals in Andalusia: • Product specifications and certification of suppliers. • International standards certification and distribution companies. • Legislation. • Data sheets for the menu items. • Specifications of different product procurement procedures. –– Development of the draft standard HOSPIFOOD®, and approval of the version “0.0”. –– Training course for auditors to this standard. –– Development of a raw materials catalog as technical cards. –– Meals Technical cards review and election of the ones which will be part of the document. Results: After nearly three years of work, we have achieved the following products: –– Standardized database of technical specifications for the production of food dietary codes for: fish, seafood, meat and meat products, meats and pates, ready meals, bread and pastries, preserves, milk and dairy products, oils, cereals, legumes , vegetables, fruits, fresh and frozen vegetables, condiments and spices. –– Standardized database of technical cards for meals containing the following data: SAS Code, Province, Hospital, name plate, ingredients (g), edible ingredients (g) kcal, Proteins, HC, Fat and Fiber. –– HOSPIFOOD® standard certification for food providers in hospitals, school cafeterias and other institutions of social restoration. Conclusion: Patients expect food that is offered during the stay in the hospital, meet basic standards of quality and safety, and therefore it is necessary to design and develop control systems from the award and / or acquisition of food (raw materials and finished) products which subsequently become part of the menu that is offered as part of their treatment. To avoid the effect of fraudulent practice in public health, it’s needed to ensure the quality and safety of the food from the origin and establish the standards for acquisition and subsequent use of it. © 2015, Grupo Aula Medica S.A. All rights reserved. Source


Martinez-Selles M.,Complutense University of Madrid | Gomez Huelgas R.,Hospital Universitario Regional Of Malaga | Abu-Assi E.,Hospital Clinico Universitario Of Santiago Of Compostela | Vidan M.T.,Complutense University of Madrid
Medicina Clinica | Year: 2016

It is the aim of this manuscript to take into account the peculiarities and specific characteristics of elderly patients with chronic ischaemic heart disease from a multidisciplinary perspective, with the participation of the Spanish Society of Cardiology (sections of Geriatric Cardiology and Ischaemic Heart Disease/Acute Cardiovascular Care), the Spanish Society of Internal Medicine, the Spanish Society of Primary Care Physicians and the Spanish Society of Geriatrics and Gerontology. This consensus document shows that in order to adequately address these elderly patients a comprehensive assessment is needed, which includes comorbidity, frailty, functional status, polypharmacy and drug interactions. We conclude that in most patients medical treatment is the best option and that this treatment must take into account the above factors and the biological changes associated with aging. © 2016 Elsevier España, S.L.U. All rights reserved. Source


Martinez-Selles M.,European University at Madrid | Gomez Huelgas R.,Hospital Universitario Regional Of Malaga | Abu-Assi E.,Hospital Clinico Universitario Of Santiago Of Compostela | Vidan M.T.,Complutense University of Madrid
Semergen | Year: 2016

It is the aim of this manuscript to take into account the peculiarities and specific characteristics of elderly patients with chronic ischaemic heart disease from a multidisciplinary perspective, with the participation of the Spanish Society of Cardiology (sections of Geriatric Cardiology and Ischaemic Heart Disease/Acute Cardiovascular Care), the Spanish Society of Internal Medicine, the Spanish Society of Primary Care Physicians and the Spanish Society of Geriatrics and Gerontology.This consensus document shows that in order to adequately address these elderly patients a comprehensive assessment is needed, which includes comorbidity, frailty, functional status, polypharmacy and drug interactions. We conclude that in most patients medical treatment is the best option and that this treatment must take into account the above factors and the biological changes associated with aging. © 2016 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Source


Martinez-Selles M.,European University at Madrid | Gomez Huelgas R.,Hospital Universitario Regional Of Malaga | Abu-Assi E.,University of Santiago de Compostela | Vidan M.T.,Complutense University of Madrid
Revista Espanola de Geriatria y Gerontologia | Year: 2016

It is the aim of this manuscript to take into account the peculiarities and specific characteristics of elderly patients with chronic ischaemic heart disease from a multidisciplinary perspective, with the participation of the Spanish Society of Cardiology (sections of Geriatric Cardiology and Ischaemic Heart Disease/Acute Cardiovascular Care), the Spanish Society of Internal Medicine, the Spanish Society of Primary Care Physicians and the Spanish Society of Geriatrics and Gerontology.This consensus document shows that in order to adequately address these elderly patients a comprehensive assessment is needed, which includes comorbidity, frailty, functional status, polypharmacy and drug interactions. We conclude that in most patients medical treatment is the best option and that this treatment must take into account the above factors and the biological changes associated with aging. © 2016 SEGG. Source

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