Hospital Universitario Of La Santa Creu nt Pau

Barcelona, Spain

Hospital Universitario Of La Santa Creu nt Pau

Barcelona, Spain
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Gonzalez-Vilchez F.,Registro Espanol de Trasplante Cardiaco | Gonzalez-Vilchez F.,Hospital Universitario Marques Of Valdecilla | Gomez-Bueno M.,Servicio de Cardiologia | Almenar L.,Polytechnic University of Valencia | And 7 more authors.
Revista Espanola de Cardiologia | Year: 2013

Introduction and objectives The present article reports the characteristics and results of heart transplantation in Spain since this therapeutic modality was first used in May 1984. Methods We summarize the main features of recipients, donors, and surgical procedures, as well as the results of all heart transplantations performed in Spain until December 31, 2012. Results A total of 247 heart transplantations were performed in 2012. The whole series consisted of 6775 procedures. Recent years have seen a progressive worsening in the clinical characteristics of recipients (34% aged over 60 years, 22% with severe kidney failure, 17% with insulin-dependent diabetes, 29% with previous heart surgery, 16% under mechanical ventilation) and donors (38% aged over 45 years, 26% with recipient: donor weight mismatch>20%), and in surgical conditions (29% of procedures at >4 h ischemia and 36% as emergency transplantations). The probability of survival at 1, 5, 10, and 15 years of follow-up was 78%, 67%, 53%, and 38%, respectively. These results have remained stable since 1995. Conclusions In recent years, the number of heart transplantations/year in Spain has remained stable at around 250. Despite the worsening of recipient and donor clinical characteristics and of time-to-surgery, the results in terms of mortality have remained stable and compare favorably with those of other countries. © 2013 Sociedad Espanola de Cardiologa. Published by Elsevier Espana, S.L. All rights reserved.


Gonzalez-Vilchez F.,Registro Espanol de Trasplante Cardiaco | Gonzalez-Vilchez F.,Hospital Universitario Marques Of Valdecilla | Gomez-Bueno M.,Servicio de Cardiologia | Almenar L.,Polytechnic University of Valencia | And 7 more authors.
Revista Espanola de Cardiologia | Year: 2014

Introduction and objectives The present article reports the characteristics and outcome of heart transplantation in Spain since it was first performed in May 1984. Methods We provide a descriptive analysis of the characteristics of the recipients, the donors, the surgical procedure, and results of the heart transplantations performed in Spain until 31 December 2013. Results During 2013, a total of 248 transplantation procedures were carried out, bringing the time series to a total of 7023 transplantations. The temporal analysis confirms a significant deterioration in the clinical profile of the recipients (higher percentage of older patients, severe renal failure, insulin-dependent diabetes mellitus, previous heart surgery, mechanical ventilation), of the donors (higher proportion of older donors and greater weight mismatch), and of the procedure (higher percentage of emergency transplantations which, in 2013, reached 49%, and with ischemia times > 240 min). There was a marked increase in the use of circulatory assist devices prior to transplantation which, in 2013, were employed in 25.2% of all the patients. The survivals at 1, 5, 10, and 15 years were 76%, 65%, 52%, and 37%, respectively, and have remained stable since 1995. Conclusions Heart transplantation activity in Spain remains stable in recent years, with around 250 procedures a year. Despite the clear deterioration in the clinical characteristics of the donors and recipients, and lengthening of the operative times, the results in terms of mortality continue to be comparable to those reported in our neighboring countries, and a growing use of circulatory assist devices prior to transplantation is confirmed. Full English text available from: www.revespcardiol.org/en © 2014 Sociedad Española de Cardiología.


PubMed | Servicio de Cardiologia, Hospital Universitario 12 Of Octubre, Hospital Universitario Gregorio Maranon, Hospital Universitario Marques Of Valdecilla and 6 more.
Type: Journal Article | Journal: Revista espanola de cardiologia (English ed.) | Year: 2015

We present the characteristics and outcomes of heart transplantation in Spain since it was first performed in 1984.A descriptive analysis of the characteristics of recipients, donors, the surgical procedure, and the outcomes of heart transplantations performed in Spain until 31 December 2014.In 2014, 266 procedures were performed, making a time series of 7289 transplantations. The temporal analysis confirmed a significant worsening of the clinical profile of recipients (higher percentage of older patients, patients with severe renal failure, insulin-dependent diabetes, previous cardiac surgery, and previous mechanical ventilation), of donors (higher percentage of older donors and greater weight mismatch), and of the procedure (higher percentage of emergency transplantations, reaching 41.4% in 2014, and ischemia time>240min). Mechanical assist devices were used less than in 2013; in 2014 they were used in 18.8% of all transplant recipients. Survival at 1, 5, 10, and 15 years was 76%, 65%, 52%, and 38%, respectively, and has remained stable since 1995.Cardiac transplantation activity in Spain has remained stable in recent years, at around 250 procedures per year. Despite a clear deterioration in donor and recipient characteristics and surgical times, the mortality outcomes have remained comparable to those of previous periods in our environment. The growing use of circulatory assist devices before transplantation is also confirmed.


PubMed | Servicio de Cardiologia, Hospital Universitario 12 Of Octubre, Hospital Universitario Gregorio Maranon, Hospital Universitario Marques Of Valdecilla and 6 more.
Type: Journal Article | Journal: Revista espanola de cardiologia (English ed.) | Year: 2016

The present article reports the characteristics and results of heart transplants in Spain since this therapeutic modality was first used in May 1984.We describe the main features of recipients, donors, surgical procedures, and results of all heart transplants performed in Spain until December 31, 2015.A total of 299 cardiac transplants were performed in 2015, with the whole series comprising 7588 procedures. The main transplant features in 2015 were similar to those observed in recent years. A remarkably high percentage of transplants were performed under emergency conditions and there was widespread use of circulatory assist devices, particularly continuous-flow left ventricular assist devices prior to transplant (16% of all transplants). Survival has significantly improved in the last decade compared with previous time periods.During the last few years, between 250 and 300 heart transplants have consistently been performed each year in Spain. Despite a more complex clinical context, survival has increased in recent years.


Sionis A.,Hospital Universitario Of La Santa Creu nt Pau | Ruiz-Nodar J.M.,Hospital General Universitario Of Alicante | Fernandez-Ortiz A.,Complutense University of Madrid | Marin F.,Hospital Clinico Universitario Virgen Of La Arrixaca | And 4 more authors.
Revista Espanola de Cardiologia | Year: 2015

This article summarizes the main developments reported in 2014 on ischemic heart disease, together with the most important innovations in intensive cardiac care. Full English text available from: www.revespcardiol.org/en © 2014 Sociedad Española de Cardiología.


Marin F.,Hospital Clinico Universitario Virgen Of La Arrixaca | Diaz-Castro O.,Complejo Hospitalario Universitario Of Pontevedra | Ruiz-Nodar J.M.,Hospital General Universitario Of Alicante | De La Villa B.G.,Hospital Of Manacor | And 4 more authors.
Revista Espanola de Cardiologia | Year: 2014

This article summarizes the main developments reported in 2013 on ischemic heart disease, together with the most important innovations in the management of acute cardiac patients. © 2013 Sociedad Española de Cardiología.


PubMed | Hospital Clinico, University of Verona, Hospital Valle Of Hebron, University Paris Diderot and 21 more.
Type: Journal Article | Journal: Clinical and experimental rheumatology | Year: 2015

The current knowledge of the influence of systemic sclerosis (SSc) risk loci in the clinical sub-phenotypes is still limited. The main limitation lies in the low frequency of some sub-phenotypes which could be solved by replication studies in independent cohorts and meta-analysis between studies. In this regard, CCR6 gene variants have been recently associated with anti-topoisomerase I positive (ATA+) production in SSc patients in a candidate gene study. This gene has been proposed to have a critical role in IL-17-driven autoimmunity in human diseases.In order to confirm the association between CCR6 and ATA+ SSc patients, we performed an independent replication study in populations of European ancestry. We studied two CCR6 genetic variants (rs968334 and rs3093024) in a total of 901 ATA+ SSc cases, 3,258 ATA- SSc cases and 7,865 healthy controls and compared allelic frequencies for those SNPs in ATA+ SSc with healthy controls and also with ATA- SSc patients.The comparison performed between ATA+ SSc patients and healthy controls showed significant association with SNP rs968334 (p=4.88x10(-2), OR=1.11). When we compared ATA+ SSc cases with ATA- SSc, both SNPs, rs3093024 and rs968334, showed significant associations (p=2.89x10(-2), OR=1.13; p=1.69x10(-2), OR=1.15). Finally, in order to increase even more sample size and statistical power, we meta-analysed our study with the previous reported and found a significant association between SNP rs3093024 and ATA+ SSc patients (p=1.00x10(-4), OR=1.16) comparing with healthy controls.Our work confirms the association of CCR6 gene and ATA+ SSc patients.


PubMed | Complutense University of Madrid, Hospital Clinico Universitario, Complejo Hospitalario Universitario Of Pontevedra, Hospital Universitario ValldHebron and 3 more.
Type: Journal Article | Journal: Revista espanola de cardiologia (English ed.) | Year: 2015

This article summarizes the main developments reported in 2014 on ischemic heart disease, together with the most important innovations in intensive cardiac care.


Asencio-Cortes C.,Hospital Universitario Of La Santa Creu nt Pau | De Quintana-Schmidt C.,Hospital Universitario Of La Santa Creu nt Pau | Clavel-Laria P.,Hospital Quiron | Antunez I.C.,Hospital Universitario Of La Santa Creu nt Pau | And 3 more authors.
Neurocirugia | Year: 2014

Introduction: Gliosarcoma is a rare neoplasm of the central nervous system, similar to glio-blastoma multiforme. In contrast to glioblastoma, it is characterised by its propensity forextracranial metastasis (11% of the cases) due to its sarcomatous component. Intramedu-llary metastasis from primary gliosarcoma is extremely rare.Case report: A patient who had surgery for primary cerebral gliosarcoma developed parapare-sis during the course of the disease. A magnetic resonance image showed an intramedullaryspinal cord metastasis requiring surgical treatment. This article reviews the literature on intramedullary spinal cord metastasis from gliosarcoma, and highlights the characteristics, treatment and overall survival. Conclusions: Only 4 cases of intramedullary gliosarcoma metastasis are described in the literature. This extremely rare entity should be suspected with the onset of spinal cord symptoms during the course of primary cerebral gliosarcoma. © 2013 Sociedad Espãnola de Neurocirugía. Published by Elsevier España, S.L. All rights reserved.

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