Hospital Universitario Of La Ribera
Hospital Universitario Of La Ribera
Gomez-Cabrera M.C.,University of Valencia |
Garcia-Valles R.,University of Valencia |
Rodriguez-Manas L.,Hospital Universitario Of Getafe |
Olaso-Gonzalez G.,University of Valencia |
And 4 more authors.
Journals of Gerontology - Series A Biological Sciences and Medical Sciences | Year: 2017
The development of animal models to study human frailty is important to test interventions to be translated to the clinical practice. The aim of this work was to develop a score for frailty in experimental animals based in the human frailty phenotype. We also tested the effect of physical inactivity in the development of frailty as determined by our score. Male C57Bl/6J mice, individually caged, were randomly assigned to one of two groups: sedentary (inactive) or spontaneous wheel-runners. We compared the sedentary versus the active lifestyle in terms of frailty by evaluating the clinical criteria used in humans: unintentional weight loss; poor endurance (running time); slowness (running speed); weakness (grip strength), and low activity level (motor coordination) at five different ages: 17, 20, 23, 26 and 28 months of age. Each criterion had a designated cut-off point to identify the mice with the lowest performance. Lifelong spontaneous exercise significantly retards frailty. On the contrary sedentary animals become frail as they age. Thus, physical inactivity is a model of frailty in experimental animals. Our frailty score provides a tool to evaluate interventions in mice prior to translating them to clinical practice. © The Author 2016.
Marti J.L.P.,Hospital Universitario Of La Ribera |
Ituren A.G.,Hospital Universitario Of La Ribera |
Gonzalez L.V.,Hospital Universitario Of La Ribera
Archivos Espanoles de Urologia | Year: 2017
OBJECTIVES: The objective of this article is to show the current situation regarding two surgical techniques for the treatment of renal lithiasis, RIRS (Retrograde intrarenal surgery) and PCNL (Percutaneous nephrolithotomy), specially concerning the larger size stones. We perform a literature review on the topic and add the experience with both techniques at our center. Besides, we also analyze the role of RIRS in comparison with the percutaneous techniques in smaller size lithiasis. METHODS: We review the results obtained in the literature and our experience. We offer our opinion in reference to the indications of RIRS in these cases based on such review and our experience. RESULTS/CONCLUSIONS: RIRS is a safe and effective technique, with a similar success rate to PCNL if one assumes the possibility of retreatment in stones >2cm. Its low complication rate, fast postoperative recovery and short hospital stay make this technique a therapeutic alternative to PCNL in this type of patients. Compared with percutaneous techniques less invasive than classical 24 to 30 Ch. accesses (miniperc or microperc), RIRS offers a higher stone free rate. If we also consider that RIRS is associated with shorter hospital stay and lower bleeding risk, even without significant differences in the global complication rate we could consider RIRS as the first line endourological treatment in stones <2cm.
Domingo Benito C.,Hospital Universitario Of La Ribera
Boletin de AELFA | Year: 2012
The audiology is a discipline that since its inception has sought in technology resources to address communication problems resulting from hearing disorders. Among the different possibilities that enhance auditory perception, cochlear implants are an important milestone as it is indicated in the bilateral profound sensorineural hearing loss involving major problem for human communication. Currently, the widespread use of cochlear implants can raise new perspectives in the study of hearing and communication disorders associated with this loss. The voice is one of the aspects of communication that are most altered in relation to the degree of hearing loss. Although there are many studies that relate speech and hearing, yet little literature studying this relationship in adult patients with cochlear implants. The aim of this paper is to raise this ratio in patients with post-lingual profound bilateral sensorineural hearing loss that after undergoing cochlear implant surgery are able to reflect through a subjective assessment by the Voice Handicap Index an evolution in the perception of their own voice. The results regarding the perception of voice before and after cochlear implant by study subjects correlated with the publications to date and reflect a subjective improvement in this perception. © 2012 AELFA. Published by Elsevier Espãa, S.L. All rights reserved.
Manas A.,Hospital Universitario La Paz |
Monroy J.L.,Hospital Universitario Of La Ribera |
Ramos A.A.,Hospital Txagorritxu |
Cano C.,Hospital Of Torrecardenas |
And 3 more authors.
International Journal of Radiation Oncology Biology Physics | Year: 2011
Purpose: Neuropathic pain (NP) in cancer patients severely impacts quality of life. Radiotherapy (RT) may cause NP, and at the same time, cancer patients visit RT units for pain relief. NP prevalence at these sites and current analgesic treatment should be assessed to improve management. Methods and Materials: This epidemiological, prospective, multicenter study was undertaken to assess NP prevalence, according to Douleur Neuropathique 4 questions questtionaire (DN4) test results, and analgesic management in cancer pain patients visiting RT oncologic units. Secondary analyses assessed NP etiology and pain intensity (using the Brief Pain Inventory - Short Form) and impact (using the Hospital Anxiety and Depression Scale (HADS), Medical Outcomes Study [MOS] for Sleep, and the Health Survey Short Form-12). Results: A total of 1,098 patients with any kind of pain were registered. NP prevalence was 31.1% (95% confidence interval, 28.4% - 33.9%); 291 NP patients (mean age, 62.2 ±12.5 years and 57.7% men) were eligible for study; 49% of patients were overweight. The most frequent tumors were those of breast and lung, and stage IIIB was the most common cancer stage. The tumors caused 75% of NP cases. Anxiety, sleepiness, and depression were common. At 8 weeks, pain intensity and interference with daily activities decreased significantly for 50.8% of responders. Depression and anxiety (p < 0.0001) scores on the Physical Component Summary and Mental Component Summary measures (p < 0.0001) and all MOS-Sleep subscales, except for snoring, improved significantly. The percentage of satisfied patients increased from 13.8% to 87.4% (p < 0.0001) with the current analgesic treatment, which meant a 1.2- and 6-fold increase (p < 0.0001) in narcotic analgesics and anticonvulsants, respectively, compared to previous treatment. Conclusions: NP is highly prevalent at RT oncology units, with sleepiness, anxiety, and depression as frequent comorbidities. There is a need to improve management of NP with increased use of more specific NP-targeting drugs. © 2011 Elsevier Inc.
Qureshi M.M.,Aga Khan University |
Qureshi M.M.,Kenyatta National Hospital |
Piquer J.,Hospital Universitario Of La Ribera |
Young P.H.,Washington University in St. Louis
World Neurosurgery | Year: 2013
Background Hydrocephalus, largely a disease of poverty in many developing regions such as Sub-Saharan Africa, becomes even more challenging to treat because of lack of trained neurosurgical personnel, inadequately equipped public health care facilities, meager resource allocation, high rates of neonatal infection, difficulty of access to tertiary care hospitals able to treat hydrocephalus, and high complication rates in patients who are able to access and receive shunting procedures. Furthermore, conventional methods of training of neurosurgeons and nursing staff to become proficient in neuroendoscopic procedures involve a lengthy period of training, often at specialized centers in Western or local Western-style institutions. Methods The novel approach promoted by volunteer neurosurgical teams from Neurosurgery Education Development Foundation is described, and its potential role in successfully providing neuroendoscopic ventriculostomy at hospitals in regional sites away from main referral tertiary hospitals is outlined. The impact on the training of local neurosurgical specialists and residents in training as well as nursing staff is highlighted. Results With the use of a single portable neuroendoscopy system and a versatile free-hand, single-operator neuroendoscope, this outreach, mobile, and readily portable model has been successfully used to perform more than 250 procedures in 21 different hospital sites around seven different countries in two continents. The local courses have imparted hands-on training to 62 neurosurgeons and trainee residents and a further 110 operating room nurses at these 21 institutions. Conclusions Neuroendoscopy is not only a priority surgical tool for East Africa. It offers a medical philosophy as an application that serves as an art and a science dedicated to the development of a complex surgical specialty: neurosurgery. © 2013 Elsevier Inc. All rights reserved.
Aguilella L.,Hospital Universitario Of La Ribera |
Aguilella L.,Institute Kaplan |
Garcia-Elias M.,Hospital Universitario Of La Ribera |
Garcia-Elias M.,Institute Kaplan
Journal of Hand Surgery | Year: 2012
As a source of corticocancellous grafts for treating scaphoid nonunions, the anterolateral corner of the distal radial metaphysis has several advantages over other alternatives: it provides good-quality corticocancellous bone, it allows one to harvest the graft and treat the scaphoid through the same incision, it does not require general anesthesia, and it has less morbidity than occurs when obtaining the graft from the iliac crest. © 2012 ASSH Published by Elsevier, Inc. All rights reserved.
Perez-Jorge E.V.,Hospital Universitario Of La Ribera |
Burdette S.D.,Wright State University
Molecular Diagnosis and Therapy | Year: 2010
This case report describes the differential diagnosis of cutaneous ulcerations and the utility of the interferon-γ release assays as a tool to aid in the diagnosis. These new assays can be used to identify mycobacterial infections (specifically Mycobacterium marinum) as the etiologic agents. © 2010 Adis Data Information BV. All rights reserved.
Tarazona-Santabalbina F.J.,Hospital Universitario Of La Ribera |
Aguilella-Fernandez L.,Hospital Universitario Of La Ribera
Aging Clinical and Experimental Research | Year: 2013
Long-term treatment with biphosphonates has been related to atypical femoral fractures. We report the clinical case of a woman who suffered a proximal diaphyseal oblique fracture of the left femur after uninterrupted 13-year treatment with alendronate. Shortly after surgery, a painful lytic image in the external cortex of her right femur diaphysis was detected. Some papers have suggested surgical treatment to repair femur fractures after long-term treatment with bisphosphonates. Otherwise, two studies have shown healing acceleration of bone fractures with teriparatide. A lytic lesion was treated with teriparatide obtaining progressive disappearance of symptoms as well as bone healing. This outcome may suggest a way of prevention of complete fractures in symptomatic patients with long-term treatment with bisphosphonates. © 2013 Springer International Publishing Switzerland.
Gorriz Pintado S.,Hospital Universitario Of La Ribera |
Estela Burriel P.L.,Hospital Universitario Of La Ribera
Endocrinologia y Nutricion | Year: 2014
Introduction: Serum 25-hydroxyvitamin D [25(OH)D] levels are the best indicator of vitamin D levels in the body. Precision, reproducibility, and lack of standardization are the main problems in such measurements. The aim of this study was to compare the 25(OH)D levels measured using Elecsys Vitamin D Total (Roche) and ADVIA Centaur Vitamin D Total (Siemens). Material and methods: 25(OH)D levels were tested in 166 patients using both methods. Patients were subsequently divided into two groups: a supplemented group consisting of patients receiving vitamin D supplements, and an untreated group consisting of the rest of patients. Results: 25(OH)D mean levels measured by the Roche and Siemens methods in the overall group were 33.6. ±. 16.0 and 19.8. ±. 12.4 ng/mL respectively. 54.2% of patients were receiving vitamin D supplements. In this group, mean 25(OH)D levels measured by the Roche and Siemens methods were 40.6. ±. 14.5 and 25.4. ±. 13.1 ng/mL respectively. In the untreated group, the respective values were 24.9. ±. 13.2 and 12.8. ±. 6.6 ng/mL. Prevalence of vitamin D deficiency (serum 25(OH)D levels less than 20 ng/mL) was higher in samples analyzed using the Siemens method (60.2%) as compared to those tested using the Roche method (23.5%). Conclusion: The assays evaluated are not comparable to each other. Laboratory specialists should inform clinicians of the features of the method used for measuring 25(OH)D because this will have a direct impact on interpretation of the results and medical decisions. © 2013 SEEN.
Navarrete-Sanchis J.,Hospital Universitario Of La Ribera |
Zarco-Bosquets J.,Hospital Universitario Of La Ribera |
Tomas-Torrent J.M.,Hospital Universitario Of La Ribera |
Diago T.,Hospital Universitario Of La Ribera |
Ortega-Evangelio L.,Hospital Universitario Of La Ribera
Graefe's Archive for Clinical and Experimental Ophthalmology | Year: 2015
Background: The aim of this study is to assess whether the outcome of pars plana vitrectomy for the treatment of cystoid non-tractional diabetic macular edema is stable and durable. Methods: A prospective longitudinal analysis of central macular thickness and visual acuity was performed, using repeated-measures ANOVA, in 22 subjects with cystoid diabetic macular edema. Results: Of the patients, 45.5 % met the criteria for surgical success at 6 months (achieving a reduction of central macular thickness of over 20 %, without associated loss of vision and central macular thickness less than 300 μm), of which 70 % remained stable at 1 year. A significant outcome of the intervention was found on central macular thickness (p < 0.01), but not on visual acuity (p = 0.159). This change occurred in the immediate postoperative period to remain stable thereafter. Conclusions: Vitreoretinal surgery can be an alternative treatment option in cases that do not respond to other types of treatment provided. Its expected benefit is observed in most cases in the immediate postoperative period, and is usually stable and sustained over 1-year follow-up. © 2014, Springer-Verlag Berlin Heidelberg.