Concepcion-Medina T.,Hospital Universitario Of La Candelaria |
Rodriguez-Hernandez O.,Hospital Universitario Of Canarias
Rehabilitacion | Year: 2011
Charcot's neuroarthropathy is a progressive disease. It is associated with severe peripheral neuropathy. It is characterized by inflammation, joint dislocation and bone destruction with subsequent foot deformity. It should be suspected in any diabetic patient who has swelling, heat and redness in the ankle or foot, with absence of vibratory sensation, to monofilament and patellar and Achilles reflexes. Its prevalence is low. Currently the most common cause is diabetes mellitus. The goal is to reach the stage of consolidation with a plantigrade foot and the possibility of wearing shoes. © 2010 Elsevier España, S.L. and SERMEF. All rights reserved.
Hueso-Falcon I.,University of La Laguna |
Hueso-Falcon I.,Hospital Universitario Of La Candelaria |
Giron N.,Complutense University of Madrid |
Velasco P.,Complutense University of Madrid |
And 6 more authors.
Bioorganic and Medicinal Chemistry | Year: 2010
Thirty one ent-kaurane derivatives were prepared from kaurenoic acid (1), grandiflorenic acid (16), 15α-acetoxy-kaurenoic acid (26) and 16α-hydroxy-kaurenoic acid (31). They were tested for their ability to inhibit cell viability in the mouse leukemic macrophagic RAW 264.7 cell line. The most effective compounds were 12, 20, 21, and 23. These were selected for further evaluation in other human cancer cell lines such as Hela, HepG2, and HT-29. Similar effects were obtained although RAW 264.7 cells were more sensitive. In addition, these compounds were significantly less cytotoxic in non-transformed cells. The apoptotic potential of the most active compounds was investigated and they were able to induce apoptosis with compound 12 being the best inducer. The caspase-3, -8 and -9 activities were measured. The results obtained showed that compounds 12, 21, and 23 induce apoptosis via the activation of caspase-8, whereas compound 20 induces apoptosis via caspase-9. Immunoblot analysis of the expression of p53, Bax, Bcl-2, Bcl-xl, and IAPs in RAW 264.7 cells was also carried out. When cells were exposed to 5 μM of the different compounds, expression levels of p53 and Bax increased whereas levels of antiapoptotic proteins such as Bc1-2, Bc1-x1, and IAPs decreased. In conclusion, kaurane derivatives (12, 20, 21, and 23) induce apoptosis via both the mitochondrial and membrane death receptor pathways, involving the Bcl-2 family proteins. Taken together these results provide a role of kaurane derivatives as apoptotic inducers in tumor cells. © 2009 Elsevier Ltd. All rights reserved.
Casanova C.,Hospital Universitario Ntra Sra Of La Candelaria |
Marin J.M.,Hospital Universitario Miguel Servet |
Marin J.M.,CIBER ISCIII |
Martinez-Gonzalez C.,Hospital Central Of Asturias |
And 46 more authors.
Respiratory Research | Year: 2014
Rationale: Little is known about the longitudinal changes associated with using the 2013 update of the multidimensional GOLD strategy for chronic obstructive pulmonary disease (COPD).Objective: To determine the COPD patient distribution of the new GOLD proposal and evaluate how this classification changes over one year compared with the previous GOLD staging based on spirometry only.Methods: We analyzed data from the CHAIN study, a multicenter observational Spanish cohort of COPD patients who are monitored annually. Categories were defined according to the proposed GOLD: FEV1%, mMRC dyspnea, COPD Assessment Test (CAT), Clinical COPD Questionnaire (CCQ), and exacerbations-hospitalizations. One-year follow-up information was available for all variables except CCQ data.Results: At baseline, 828 stable COPD patients were evaluated. On the basis of mMRC dyspnea versus CAT, the patients were distributed as follows: 38.2% vs. 27.2% in group A, 17.6% vs. 28.3% in group B, 15.8% vs. 12.9% in group C, and 28.4% vs. 31.6% in group D. Information was available for 526 patients at one year: 64.2% of patients remained in the same group but groups C and D show different degrees of variability. The annual progression by group was mainly associated with one-year changes in CAT scores (RR, 1.138; 95%CI: 1.074-1.206) and BODE index values (RR, 2.012; 95%CI: 1.487-2.722).Conclusions: In the new GOLD grading classification, the type of tool used to determine the level of symptoms can substantially alter the group assignment. A change in category after one year was associated with longitudinal changes in the CAT and BODE index. © 2014 Casanova et al.; licensee BioMed Central Ltd.
Parra-Blanco A.,Bernardo O'Higgins University |
Ruiz A.,Bernardo O'Higgins University |
Alvarez-Lobos M.,Bernardo O'Higgins University |
Amoros A.,Hospital Universitario Of La Candelaria |
And 4 more authors.
World Journal of Gastroenterology | Year: 2014
Bowel preparation is a core issue in colonoscopy, as it is closely related to the quality of the procedure. Patients often find that bowel preparation is the most unpleasant part of the examination. It is widely accepted that the quality of cleansing must be excellent to facilitate detecting neoplastic lesions. In spite of its importance and potential implications, until recently, bowel preparation has not been the subject of much study. The most commonly used agents are high-volume polyethylene glycol (PEG) electrolyte solution and sodium phosphate. There has been some confusion, even in published meta-analyses, regarding which of the two agents provides better cleansing. It is clear now that both PEG and sodium phosphate are effective when administered with proper timing. Consequently, the timing of administration is recognized as one of the central factors to the quality of cleansing. The bowel preparation agent should be administered, at least in part, a few hours in advance of the colonoscopy. Several low volume agents are available, and either new or modified schedules with PEG that usually improve tolerance. Certain adjuvants can also be used to reduce the volume of PEG, or to improve the efficacy of other agents. Other factors apart from the choice of agent can improve the quality of bowel cleansing. For instance, the effect of diet before colonoscopy has not been completely clarified, but an exclusively liquid diet is probably not required, and a low-fiber diet may be preferable because it improves patient satisfaction and the quality of the procedure. Some patients, such as diabetics and persons with heart or kidney disease, require modified procedures and certain precautions. Bowel preparation for pediatric patients is also reviewed here. In such cases, PEG remains the most commonly used agent. As detecting neoplasia is not the main objective with these patients, less intensive preparation may suffice. Special considerations must be made for patients with inflammatory bowel disease, including safety and diagnostic issues, so that the most adequate agent is chosen. Identifying neoplasia is one of the main objectives of colonoscopy with these patients, and the target lesions are often almost invisible with white light endoscopy. Therefore excellent quality preparation is required to find these lesions and to apply advanced methods such as chromoendoscopy. Bowel preparation for patients with lower gastrointestinal bleeding represents a challenge, and the strategies available are also reviewed here. © 2014 Baishideng Publishing Group Inc. All rights reserved.
PubMed | Hospital Universitario Of La Candelaria and University Hospital Nuestra Senora Of La Candelaria
Type: | Journal: Case reports in oncological medicine | Year: 2016
Secondary or metastatic cardiac tumors are much more common than primary benign or malignant cardiac tumors. Any tumor can cause myocardial or pericardial metastasis, although isolated or combined tumor invasion of the pericardium is more common. Types of neoplasia with the highest rates of cardiac or pericardial involvement are melanoma, lung cancer, and breast and mediastinal carcinomas. Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. Initial treatment involves chemotherapy followed by consolidation treatment to reduce the risk of relapse. In high-risk patients, the treatment of choice for consolidation is hematopoietic stem cell transplantation (HSCT). Relapse of AML is the most common cause of HSCT failure. Extramedullary relapse is rare. The organs most frequently affected, called sanctuaries, are the testes, ovaries, and central nervous system. We present a case with extramedullary relapse in the form of a solid cardiac mass.
Henriquez-Hernandez L.A.,University of Las Palmas de Gran Canaria |
Henriquez-Hernandez L.A.,Instituto Canario Of Investigacion Del Cancer Icic |
Murias-Rosales A.,Instituto Canario Of Investigacion Del Cancer Icic |
Murias-Rosales A.,Hospital Universitario Insular Of Gran Canaria |
And 8 more authors.
Cancer Epidemiology | Year: 2010
Purpose To investigate the role of TSER (TYMS), C677T (MTHFR), Arg72Pro (p53) and C3435T (MDR1) gene polymorphisms in breast cancer patients treated with 5-fluorouracil and cyclophosphamide-based neoadjuvant chemotherapy. Results Observed allelic frequencies were: TSER, (2) 0.54 and (3) 0.46; MTHFR C677T, (C) 0.59 and (T) 0.41; p53 Arg72Pro, (Arg) 0.73 and (Pro) 0.27; MDR1 C3435T, (C) 0.52 and (T) 0.48. MTHFR allele T and p53 allele Pro were strongly associated with toxicity due to chemotherapy (odds ratio, 7.1 (95% confidence interval, 1.4-36.1; p= 0.018) and 7.0 (95% confidence interval, 1.2-40.5; p= 0.029), respectively). Conclusion We introduced new data related to the contribution of p53 codon 72 to toxicity due to 5-fluorouracil and cyclophosphamide-based neoadjuvant chemotherapy in patients with breast cancer. © 2010 Elsevier Ltd.
Henriquez-Hernandez L.A.,University of Las Palmas de Gran Canaria |
Henriquez-Hernandez L.A.,Canary Institute for Cancer Research ICIC |
Perez L.F.,University of Las Palmas de Gran Canaria |
Perez L.F.,Canary Institute for Cancer Research ICIC |
And 8 more authors.
Cancer Epidemiology | Year: 2010
Purpose: The distribution of TSER (TYMS), C677T (MTHFR), Arg72Pro (p53) and C3435T (MDR1) gene polymorphisms was investigated in 80 consecutive breast cancer patients treated with adjuvant chemotherapy. Results: Observed allelic frequencies were: TSER, (2) 0.55 and (3) 0.45; MTHFR C677T, (C) 0.65 and (T) 0.35; p53 Arg72Pro, (Arg) 0.76 and (Pro) 0.24; MDR1 C3435T, (C) 0.51 and (T) 0.49. MTHFR C677T was found to be a strong predictor of the presence of multifocal tumour (odds ratio, 4.1; 95% CI, 1.1-15.7; P=0.035). Conclusion: Our data indicate that breast cancer patients with the C/C variant may present multifocal tumour most frequently. © 2010 Elsevier Ltd.
Martin-Viota L.,Hospital Universitario Of La Candelaria |
Garcia-Conde M.,Hospital Universitario Of Canarias |
Solis-Reyes C.,Hospital Universitario Of La Candelaria |
Rosario Duque-Fernandez M.,Hospital Universitario Of La Candelaria |
Lopez-Mendoza S.,Hospital Universitario Of La Candelaria
Revista de Neurologia | Year: 2012
Introduction. Encephalitis due to NMDA receptors antibodies is a relatively common condition but it was under diagnosed until recently. It courses predictably and similarly in adults and children, although there are some differences, still less its association with tumours. Case report. A 3 years-old girl who was admitted to our hospital with symptoms compatible with acute encephalitis, so we started treatment with acyclovir. During admission she was alterning periods of poor response to stimuli with periods of agitation, and progressed to complete silence, adding sleep problems. She suffered epileptic seizures, dystonic movements and autonomic disturbances. Cranial MRI showed mild cortical atrophy and EEG generalized slowing of base tracing. Repeated samples of cerebral spinal fluid were normal from cytological and biochemical point of view. In view of the torpid evolution she began methylprednisolone therapy and later inmunoglobulins with no improvement. Upon confirmation of the positivity for NMDA receptors antibodies in cerebral spinal fluid and serum, cyclophosphamide was administered, with gradual improvement of symptoms until full recovery. After ten months of follow-up without treatment she has not presented relapses and has ruled out the presence of tumours. Conclusions. It is important to recognize encephalitis with behavioural changes and abnormal movements, because early diagnosis and the beginning of appropriate therapy could improve the prognosis. © 2012 Revista de Neurología.