Hospital Universitario Of Gran Canaria

Las Palmas de Gran Canaria, Spain

Hospital Universitario Of Gran Canaria

Las Palmas de Gran Canaria, Spain
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Kechida M.,Fattouma Bourguiba Hospital | Villalba N.L.,Hospital Universitario Of Gran Canaria
Egyptian Rheumatologist | Year: 2017

Background: Sarcoidosis is a clinically heterogenous disease of unknown etiology with a hallmark of the development and accumulation of non-caseating granulomas in any organ. The antiphospholipid syndrome (APS) is an autoimmune disorder characterized by an elevated risk for arterial and venous thrombosis and pregnancy-related morbidity. Celiac disease (CD) is a chronic, immune-mediated form of enteropathy that is now presenting later in life and often with extraintestinal manifestations. Co-existence of sarcoidosis, CD and APS is extremely rare. Case presentation: We describe a 27-year-old Tunisian woman with a history of non-explored superficial vein thrombosis and 4 successive miscarriages, who was explored for abdominal pain, vomiting, hypercalcemia, hepatic cytolyses and cholestasis and was complicated later with pancreatitis and anterior uveitis. Hepatic biopsy revealed noncaseating-granulomas, a high serum angiotensin converting enzyme activity was detected and the diagnosis of sarcoidosis was considered. A high titer of antiphopsholipid antibodies concluded the diagnosis of APS. Duodenal biopsies showed a total villous atrophy indicative of CD, confirmed by positivity of serum anti-endomisium and anti-transglutaminase antibodies. She had normocytic anemia (hemoglobin 9. g/dl) and elevated transaminases. Thorough investigation established the diagnosis of extra pulmonary sarcoidosis associated with CD and APS. Conclusion: Co-existence of sarcoidosis, CD and APS is extremely rare. APS should be recognized as an accompanying disorder of sarcoidosis and antiphospholipids measured especially when there is a history of thrombosis or miscarriages. CD should not be overlooked in association to sarcoidosis, given the shared immunological and genetic background, even in the absence of a typical presentation of the disease. © 2017 Egyptian Society of Rheumatic Diseases.


Cabrera Mateos J.L.,Consultorio Local de Puerto del Carmen | Tourino Gonzalez R.,Hospital Universitario Of Gran Canaria | Nunez Gonzalez E.,University of Las Palmas de Gran Canaria
Semergen | Year: 2016

Despite its high prevalence, mental disorders are often underdiagnosed. Objective: To determine the magnitude of the underdiagnosis mental disorders and its associated characteristics. Methodology: A descriptive cross-sectional study performed in Lanzarote (2011) on 310 patients selected by cluster random sampling. A self-completed questionnaire was used that contained the General Health Questionnaire-28, as well as structured interview using the Mini International Neuropsychiatric Interview to confirm the diagnosis of mental disorder. The current diagnosis registered in the DRAGO-AP electronic medical record was also recorded. Results: Of the 75 patients detected with the interview, 14 (18.67%) had a diagnosis recorded in the medical record (sensitivity = 0.19; IC 95% CI; 0.09-28). The positive predictive value of being in the medical record was 0.56.With respect to sensitivity, only the "number of visits made to the health centre in the last 3 months" was significantly higher in the group of patients also with a diagnosis of any mental disorder in the medical record (5 vs. 2.77; p = 002). Conclusions: There is an important underdiagnosis of the mental disorders in our environment. More visits to the health centre are associated with this diagnosis. © 2017 Sociedad Española de Médicos de Atención Primaria (SEMERGEN).


PubMed | Hospitales Idcsalud, Hospital Universitario 12 Of Octubre, Hospital Clinico Universitario Lozano Blesa, Hospital San Pedro Of Alcantara and 15 more.
Type: Journal Article | Journal: Archivos de bronconeumologia | Year: 2016

The Thoracic Surgery and Thoracic Oncology groups of the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) have backed the publication of a handbook on recommendations for the diagnosis and treatment of non-small cell lung cancer. Due to the high incidence and mortality of this disease, the best scientific evidence must be constantly updated and made available for consultation by healthcare professionals. To draw up these recommendations, we called on a wide-ranging group of experts from the different specialties, who have prepared a comprehensive review, divided into 4 main sections. The first addresses disease prevention and screening, including risk factors, the role of smoking cessation, and screening programs for early diagnosis. The second section analyzes clinical presentation, imaging studies, and surgical risk, including cardiological risk and the evaluation of respiratory function. The third section addresses cytohistological confirmation and staging studies, and scrutinizes the TNM and histological classifications, non-invasive and minimally invasive sampling methods, and surgical techniques for diagnosis and staging. The fourth and final section looks at different therapeutic aspects, such as the role of surgery, chemotherapy, radiation therapy, a multidisciplinary approach according to disease stage, and other specifically targeted treatments, concluding with recommendations on the follow-up of lung cancer patients and surgical and endoscopic palliative interventions in advanced stages.


Haidar R.,American University of Beirut | Mhaidli H.,Hospital Universitario Of Gran Canaria | Musallam K.M.,American University of Beirut | Taher A.T.,American University of Beirut
Spine | Year: 2012

Study Design: Literature review. Objective: To present a comprehensive overview of spinal involvement in patients with β-thalassemia, aiming to orient the spinal surgeon to these potentially disabling complications. Summary of Background Data: β-thalassemia, an inherited disorder of hemoglobin synthesis, is the most common monogenetic disease worldwide. Patients with thalassemia major (TM) suffer a severe anemia that requires regular blood transfusions for survival and iron chelation therapy to control transfusional iron overload. Thalassemia intermedia is a phenotype of thalassemia with a milder course and anemia, wherein most patients remain transfusion independent. Spinal involvement related to disease course and treatment is common in patients with thalassemia syndromes, yet it has not been constructively reviewed in the literature. Methods: Potentially relevant studies were identified from an electronic search of MEDLINE (1966 to the second week of May 2010). Results: In patients with TM, genetic and acquired risk factors lead to osteoporosis, pathologic fractures of the spine, and back pain. Osteoporosis in TM patients is progressive; thus, early diagnosis and treatment are recommended. Bisphosphonates are relatively safe and effective in this patient population. Characteristic intervertebral disc degeneration is also seen in patients with TM who have evidence of severe iron overload or those who receive the subcutaneous iron chelator deferoxamine. Spinal asymmetry and overt scoliosis are common in patients with TM. The prognosis seems favorable, with many patients showing spontaneous resolution without the need for intervention. In patients with thalassemia intermedia, ineffective erythropoiesis drives extramedullary hematopoietic tissue formation, which is mostly evident on magnetic resonance imaging. Paraspinal involvement is of greatest concern because of the associated spinal cord compression. Several treatment options have been described, including transfusion therapy, laminectomy, radiotherapy, and the use of fetal hemoglobin-inducing agents that decrease the hematopoietic drive. Conclusion: Current knowledge supports that spinal involvement in patients with β-thalassemia is common and diverse yet still requires further prospective evaluation. Copyright © 2012 Lippincott Williams & Wilkins.


Martinez-Quintana E.,Complejo Hospitalario Universitario Insular Materno Infantil | Rodriguez-Gonzalez F.,Hospital Universitario Of Gran Canaria | Junquera-Rionda P.,Complejo Hospitalario Universitario Insular Materno Infantil
Pediatric Cardiology | Year: 2013

Hypertrophic cardiomyopathy is the disease with the largest heterogeneity in clinical cardiology. An underrecognized and incompletely described subgroup within this spectrum comprises patients with ventricular diverticulum, coronary myocardial bridging, and left ventricular crypts and crevices. This report presents the case of a Noonan syndrome patient with these four hypertrophic cardiomyopathy characteristics. © 2012 Springer Science+Business Media, LLC.


Esparragon F.R.,Hospital Universitario Of Gran Canaria | Esparragon F.R.,University of Las Palmas de Gran Canaria | Companioni O.,Hospital Universitario Of Gran Canaria | Bello M.G.,Hospital Universitario Of Gran Canaria | And 3 more authors.
Disease Markers | Year: 2012

Recent genome-wide single nucleotide polymorphism (SNP) association studies (GWAS) have identified a number of SNPs that were significantly associated with coronary artery disease (CAD) and myocardial infarction (MI). We tested for replication of the previously described association with CAD in our case-control datasets of SNPs variants located at 1p13.1, 2q33.1, 10q11.1, 9p21, and 21q22. We observed a small significant risk associated of the SNP rs10757274 with CAD in the PROCAGENE study. Besides, the multilocus combination rs10757274 and rs1333048 gave a near significant result. We confirmed that the SNP rs10757274 showed association with CAD in the PROCAGENE study, although after applying the Bonferroni correction was not longer significant. Independent replication studies in other populations are needed to unequivocally confirm the association. © 2012 - IOS Press and the authors. All rights reserved.


Haidar R.,American University of Beirut | Mhaidli H.,Hospital Universitario Of Gran Canaria | Taher A.T.,American University of Beirut
European Spine Journal | Year: 2010

Ineffective erythropoiesis in patients with thalassemia intermedia drives extramedullary hematopoietic tumor formation in several parts of the body. Paraspinal involvement has received increasing attention due to the associated morbidity secondary to spinal cord compression. Although the history and physical examination may help narrow the differential diagnosis, radiographic imaging remains essential to confirm the existence of hematopoietic tissue. Characteristic appearance has been observed mainly on magnetic resonance imaging. Several treatment options have been described, including transfusion therapy, laminectomy, radiotherapy, and the use of fetal hemoglobin inducing agents that decrease the hematopoietic drive. However, the ideal management scheme remains controversial. Until large prospective trials evaluate the efficacy and safety of the available treatment options, both in single and in combination therapy, an individualized approach should be entertained. © 2010 Springer-Verlag.


Mhaidli H.H.,Hospital Universitario Of Gran Canaria | Der-Boghossian A.H.,American University of Beirut | Haidar R.K.,American University of Beirut
Musculoskeletal Surgery | Year: 2013

Propionibacterium acnes detection in culture media was previously considered a contamination but recently its infectious role was discovered in post-spinal surgery infections. P. acnes might be introduced during surgery. Its diagnosis is based on non-specific clinical signs, image indications of infection, and the conclusive microbiological sign. Furthermore, its diagnosis is difficult because of slow growth rate and low virulence, delaying its presentation. Usually, the infection is manifested after a couple of months or years. Here, a 65-year-old man presented with drainage at the site of instrumented spinal surgery performed 13 years ago. P. acnes infection was confirmed by culture with extended incubation. Our review of the literature revealed only two other reported cases of delayed P. acnes infection presenting a decade following a spinal surgery with instrumentation. This article sheds light on such delayed infections and discusses their presentation and management. © 2012 Springer-Verlag.


Haidar R.K.,American University of Beirut | Kassak K.,American University of Beirut | Masrouha K.,University of Chicago | Ibrahim K.,University of Chicago | Mhaidli H.,Hospital Universitario Of Gran Canaria
Spine | Year: 2015

Study Design. Cross-sectional validation and reliability assessment study of Arabic version of Scoliosis Research Society-22 (SRS-22r) Questionnaire. Objective. To develop and validate the Arabic version of the SRS-22r questionnaire. Summary of Background Data. The diagnosis and treatment of adolescent idiopathic scoliosis may influence patient quality of life. SRS-22r is an internationally validated questionnaire used to assess function/activity, pain, self-image, and mental health of patients with scoliosis. It has been translated into several languages but not into Arabic language. Therefore, a valid health-related quality-of-life outcome questionnaire for patients with spinal deformity is still lacking in Arabic language. Methods. The English version of SRS-22r questionnaire was translated, back-translated, and culturally adapted to Arabic language. Then, 81 patients with idiopathic adolescent scoliosis were allocated randomly into either the reliability testing group (group 1) or the validity testing group (group 2). Group 1 patients completed Arabic version of SRS-22r questionnaire twice with 1-week interval in-between. Cronbach α and intraclass correlation coefficient were measured to determine internal consistency and temporal reliability. Group 2 patients completed the Arabic version of SRS-22r questionnaire and the previously validated Arabic version of 36-Item Short Form Health Survey (Short Form-36) questionnaire concurrently, and Pearson correlation coefficient was obtained to assess validity. Results. Content analysis, internal consistency reliability, test/retest reproducibility (intraclass correlation coefficient range: 0.82-0.90), and test of concurrent validity showed satisfactory results. Function/activity and satisfaction with management domains had a lower Cronbach α (0.58 and 0.44, respectively, vs. 0.71-0.85 range for others). Self-image/appearance and satisfaction with management had a lower correlation with domains of the 36-Item Short Form Health Survey. Conclusion. An Arabic version of the SRS-22r questionnaire has been developed and validated. This questionnaire will aid health care workers and researchers in evaluation of patient perception of the deformity, satisfaction with treatment, and quality of life in Arabic-speaking populations. © 2015, Wolters Kluwer Health, Inc.


PubMed | Hospital Universitario Of Gran Canaria
Type: Case Reports | Journal: Musculoskeletal surgery | Year: 2013

Propionibacterium acnes detection in culture media was previously considered a contamination but recently its infectious role was discovered in post-spinal surgery infections. P. acnes might be introduced during surgery. Its diagnosis is based on non-specific clinical signs, image indications of infection, and the conclusive microbiological sign. Furthermore, its diagnosis is difficult because of slow growth rate and low virulence, delaying its presentation. Usually, the infection is manifested after a couple of months or years. Here, a 65-year-old man presented with drainage at the site of instrumented spinal surgery performed 13 years ago. P. acnes infection was confirmed by culture with extended incubation. Our review of the literature revealed only two other reported cases of delayed P. acnes infection presenting a decade following a spinal surgery with instrumentation. This article sheds light on such delayed infections and discusses their presentation and management.

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