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Ramos S.,Hospital Universitario Of Coimbra Praceta Mota Pinto | Pinheiro S.,Hospital Universitario Of Coimbra Praceta Mota Pinto | Diogo C.,Hospital Universitario Of Coimbra Praceta Mota Pinto | BernarDo J.,Hospital Universitario Of Coimbra | Freire Dos Santos M.J.,Hospital Universitario Of Coimbra Praceta Mota Pinto
Cirugia Plastica Ibero-Latinoamericana | Year: 2011

Thoracic reconstruction represents a surgical challenge. Often, the deffects are not only large, but also complex, involving all layers of the thoracic wall. The authors reviewed the medical records of the patients who underwent thoracic reconstruction, operated in cooperation with the Cardiothoracic Surgery Department, between 1998 and 2008, in Coimbra University Hospital, Portugal. Source

Trindade F.,Hospital de Cascais Dr. Jose de Almeida | Torrelo A.,Hospital Infantil Universitario Nino Jesus | Requena L.,Fundacion Jimenez Diaz | Tellechea O.,Hospital Universitario Of Coimbra | And 6 more authors.
Journal of Cutaneous Pathology | Year: 2013

Background According to the International Society for the study of vascular Anomalies, vascular anomalies are classified as vascular neoplasms and vascular malformations. In some vascular lesions, categorization as a neoplasm or malformation has not been established with confidence so far. In order to further clarify the nosology of verrucous hemangioma, we studied 13 cases. Objective To analyze immunohistochemical characteristics of verrucous hemangiomas in order to gain further insight in its histogenesis. Methods We carried out a retrospective review. Immunohistochemical expression for Wilms tumor 1 (WT1), Glut-1 and D2-40 was performed in 13 cases. Results Immunohistochemistry performed with Glut-1 and WT1 showed positive staining in all lesions. All verrucous hemangiomas lacked D2-40 immunostaining. Conclusions This is the first report in the literature investigating WT1 in verrucous hemangioma in order to further clarify the nosology of this vascular anomaly. Despite the clinical features of verrucous hemangioma, which are similar to those seen in vascular malformations, verrucous hemangioma exhibited an immunoprofile similar to vascular neoplasms, according to WT1 and Glut-1 positivity. © 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd. Source

Sanabria M.R.,University of Valladolid | Fernandez I.,University of Valladolid | Fernandez I.,CIBER ISCIII | Sala-Puigdollers A.,University of Valladolid | And 13 more authors.
European Journal of Ophthalmology | Year: 2012

Purpose. To identify the indications and differences in outcomes for adding a scleral buckle (SB) to pars plana vitrectomy (PPV) in a prospective series of rhegmatogenous retinal detachment (RD) by using propensity score matching (PSM) to analyze causal effects in observational studies. Methods. Data were collected from the Retina 1 Project, a prospective, interventional, nonrandomized study of consecutive RDs. Case selection was based upon treatment with PPV or PPV+SB. Surgeons followed personal criteria for the inclusion of SB in the PPV. Propensity score matching corrected for selection biases. Outcomes were assessed by anatomic and visual criteria and the development of proliferative vitreoretinopathy. Results. Of 523 patients analyzed, 251 had PPV and 272 had PPV+SB. Surgeons used PPV+SB more frequently in younger patients with RD, in those with posterior or unidentified breaks, in phakic eyes, in eyes with the posterior vitreous attached, and for more extended RDs. Overall single surgery anatomic success rate was 86.4%. Based on PSM, there were no difference in reattachment rates of the PPV group, 86.9%, and the PPV+SB group, 85.93%. The incidence of PVR was similar in both groups, with 8.5% in the PPV group and 10.5% in the PPV+SB group. Conclusions. Data from the Retina 1 Project established the indications for adding SB to PPV in treating primary RD in this series. No anatomic or visual differences between PPV and PPV+SB were found. © 2011 Wichtig Editore. Source

Trindade F.,Hospital de Cascais Dr. Jose de Almeida | Kutzner H.,Dermatohistopathologische Gemeinschaftslabor | Tellechea O.,Hospital Universitario Of Coimbra | Requena L.,Fundacion Jimenez Diaz | Colmenero I.,Hospital Infantil Universitario Nino Jesus
Journal of the American Academy of Dermatology | Year: 2012

Background: Hobnail hemangioma (HH) is currently classified as a benign vascular tumor, although it is not well understood whether this lesion differentiates toward blood or lymphatic endothelial cells. Immunostaining with the endothelial marker Wilms tumor 1 (WT1) helps distinguish between vascular neoplasms and malformations, being positive in the former and negative in the latter. Objective: We sought to investigate WT1, human herpesvirus 8 latent nuclear antigen, D2-40, and Ki-67 immunoprofile in HH, to gain further insight into its histogenesis. Methods: We evaluated 52 HHs collected in Dermatohistopathologische Gemeinschaftslabor, Friedrichshafen, Germany. Immunohistochemical expression of WT1 was performed in all cases. Ten of 52 lesions were also studied for D2-40 and Ki-67 staining and 12 lesions were stained for human herpesvirus 8 latent nuclear antigen. Results: All 52 HHs were completely negative for WT1 immunostaining. Immunohistochemistry performed in 10 HHs showed diffuse and strong positive staining for D2-40 in 8 lesions and focal positivity in two. All cases tested showed negative staining for Ki-67 and human herpesvirus 8 latent nuclear antigen. Limitations: There are no limitations. Conclusions: Although the exact histogenesis of HH is unknown, most of the performed immunohistochemical studies support a lymphatic line of differentiation. However, on the basis of the WT1 negativity, we believe that HH is better considered as a lymphatic malformation rather than a lymphatic neoplasm. © 2010 by the American Academy of Dermatology, Inc. Source

Trindade F.,Hospital de Cascais Dr. Jose de Almeida | Tellechea O.,Hospital Universitario Of Coimbra | Torrelo A.,Hospital Infantil Universitario Nino Jesus | Requena L.,Fundacion Jimenez Diaz | Colmenero I.,Hospital Infantil Universitario Nino Jesus
American Journal of Dermatopathology | Year: 2011

Background: Wilms tumor 1 (WT1) protein is expressed during angiogenesis and malignant transformation of endothelial cells and can be helpful to distinguish between proliferative and malformative vascular lesions. Methods: We evaluated retrospectively 117 vascular neoplasms and 50 vascular malformations. Vascular neoplasms included infantile hemangioma (n = 87), noninvoluting congenital hemangioma (n = 5), rapidly involuting congenital hemangioma (n = 3), tufted angioma (n = 8), pyogenic granuloma (n = 13), and spindle cell hemangioma (n = 1). Vascular malformations were lymphatic malformations (n = 28), venous malformations (n = 16), capillary malformation (n = 1), and stage II arteriovenous malformations (n = 5). Immunohistochemical stains for WT1 and GLUT1 were performed in all lesions. Results: All 117 vascular neoplasms showed positive expression of WT1, whereas all vascular malformations in our study were completely negative for WT1 except in arteriovenous malformations, where WT1 expression was positive. Conclusions: The comparison between vascular neoplasms and vascular malformations showed that GLUT1 expression is positive only in infantile hemangiomas, whereas WT1 positivity is found in all vascular neoplasms and in arteriovenous malformations. WT1 antibody is an ancillary test that can be helpful to differentiate vascular neoplasms from most vascular malformations. Copyright © 2011 by Lippincott Williams & Wilkins. Source

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