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PubMed | Instituto Nacional Of Salud, Mederi Hospital Universitario Mayor, University of California at Davis, Emory University and El Rosario University
Type: | Journal: Journal of autoimmunity | Year: 2017

We have focused on the epidemiology and immunobiology of Zika virus (ZIKV) infection and factors associated with the development of Guillain-Barr syndrome (GBS) and other neurological syndromes in Ccuta, the capital of North Santander department, Colombia. Data of patients with ZIKV disease reported to the national population-based surveillance system were used to calculate the basic reproduction number (R

Anaya J.-M.,El Rosario University | Anaya J.-M.,Mederi Hospital Universitario Mayor | Reyes B.,El Rosario University | Reyes B.,Mederi Hospital Universitario Mayor | And 4 more authors.
Clinical and Experimental Rheumatology | Year: 2015

This was a case study in which 3 patients with autoimmune/auto-inflammatory syndrome induced by adjuvants (ASIA) after quadrivalent human papillomavirus vaccination (HPV) were evaluated and described. All the patients were women. Diagnosis consisted of HLA-B27 enthesitis related arthritis, rheumatoid arthritis and systemic lupus erythematous, respectively. Our results highlight the risk of developing ASIA after HPV vaccination and may serve to increase the awareness of such a complication. Factors that are predictive of developing autoimmune diseases should be examined at the population level in order to establish preventive measures in at-risk individuals for whom healthcare should be personalised and participatory. © Clinical and Experimental Rheumatology 2015.

PubMed | Mederi Hospital Universitario Mayor and El Rosario University
Type: | Journal: Immunologic research | Year: 2016

Guillain-Barr syndrome (GBS) is a rapid-onset muscle weakness disease caused by the immune-mediated damage of the peripheral nervous system. Since there is an increase incidence of GBS cases in Latin America, particularly in Colombia, and most of them are currently preceded by Zika virus (ZIKV) infection, we aimed to assess the available evidence of the disease in Colombia through a systematic literature review. Out of 51 screened abstracts, only 16 corresponded to articles that met inclusion criteria, of which 15 were case reports or case series. A total of 796 cases of GBS were reported in the included articles. The majority of patients were males (66.8%) and younger than 50years old (94%). An infectious disease before the onset of GBS was registered in 31% of patients, with gastrointestinal or respiratory symptoms being the most frequently observed. In those cases in which electrodiagnostic tests were performed, the most common subphenotype was acute inflammatory demyelinating polyneuropathy (17%). Death was reported in 15% of patients. Data regarding GBS in Colombia is scant and heterogeneous. Taking into account the burden of the disease and the recent rise of GBS cases associated with ZIKV, a careful patient evaluation and a systematic collection of data are warranted. A form to data gathering is proposed.

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