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Pascual-Pedreno A.,Hospital General la Mancha Centro | Perez-Medina T.,Hospital Universitario Puerta Of Hierro | Brouard Urkiaga I.,Hospital de Cruces | Fernandez-Parra J.,Hospital Virgen de Las Nieves | Sobreviela-Laserrada M.,Hospital Universitario Lozano Blesa
European Journal of Obstetrics Gynecology and Reproductive Biology | Year: 2013

Objective: To evaluate the implementation of endoscopic gynecologic surgery in Spanish hospitals. Study design: In January 2011, a questionnaire was sent to 198 gynecology departments to determine the diffusion and acceptance of specific endoscopic procedures (hysteroscopy and laparoscopy) in each hospital. Results: The response rate was 52% (103/198). The practice of basic laparoscopy in Spain is high (90% of the hospitals surveyed reported that >50% of their specialists use this technique). Although advanced laparoscopic procedures are used in 83.4% of hospitals, 59.2% of these hospitals reported that <25% of gynecologists knew how to perform these techniques. In the case of adnexal masses, the approach used depends on the characteristics of the mass. Most hospitals (96.1%) reported routine use of a laparoscopic approach for benign adnexal masses measuring <10 cm, while 42% of hospitals reported routine use of a laparoscopic approach for masses that appear to be suspicious on ultrasound. Regarding hysterectomy, 38 hospitals (36.9%) reported that an abdominal approach was used in <25% of hysterectomies, 53 hospitals (51.5%) reported that a vaginal approach was used in 25-50% of hysterectomies, and 53 hospitals (52%) reported that a laparoscopic approach was used in <25% of hysterectomies. For the treatment of gynecological cancers, 53 hospitals (52%) reported that a laparoscopic approach was used in <25% of cases; this approach was reported more commonly by teaching hospitals (81.9% vs. 46.75; p < 0.001) and hospitals with >200 beds (84.3% vs. 45.5%; p < 0.001). In teaching hospitals, the concordance between what the respondents felt residents should be able to do, in terms of laparoscopic techniques, and what residents were actually able to do upon finishing their residency training was quite high, with the degree of concordance varying between 84.3% (adnexal mass approach) and 100% (diagnostic laparoscopy and tubal sterilization). Conclusions: More than 90% of the Spanish hospitals surveyed perform basic endoscopic techniques, and 83.4% are able to perform advanced endoscopic procedures. © 2013 Elsevier Ireland Ltd. All rights reserved.

Asin L.,University of Zaragoza | Ibarra M.R.,University of Zaragoza | Tres A.,Hospital Universitario Lozano Blesa | Goya G.F.,University of Zaragoza | Goya G.F.,Institute Nanociencia Of Aragon
Pharmaceutical Research | Year: 2012

Purpose: To investigate the effects of alternating magnetic fields (AMF) on the death rate of dendritic cells (DCs) loaded with magnetic nanoparticles (MNPs) as heating agents. AMF exposure time and amplitude as well as the MNPs concentration were screened to assess the best conditions for a controlled field-induced cell death. Methods: Human-monocyte-derived DCs were co-incubated with dextran-coated MNPs. The cells were exposed to AMF (f=260 kHz; 0

Rubio C. P.,Hospital Universitario Miguel Servet | Baquedano M. L.,Hospital Universitario Miguel Servet | Gil A. E.,Instituto Valenciano Of Infertilidad Ivi | Lapresta M. M.,Hospital Universitario Lozano Blesa
Revista Chilena de Obstetricia y Ginecologia | Year: 2012

Acute genital ulcer or Lipschütz ulcer is a rare and underdiagnosed, entity that usually presents an acute and painful ulcer in the vulva, lower vagina and/or perineum of nonvenereal origin. The etiology is unknown but the differential diagnosis must include sexually and nonsexually transmitted infections, autoimmune conditions, local manifestations of systemic illness and drug reactions. The lesions heal spontaneously and most patients have no recurrence and no long-term sequelae.

Bernal M.,University of Zaragoza | Bernal M.,Hospital Universitario Lozano Blesa | Souza D.L.B.,University of Zaragoza | Gomez G.J.,University of Zaragoza
Semergen | Year: 2013

Introduction and objective: Lung cancer has a high incidence in Aragon (Spain). Current measures, such as stopping smoking, may lead to a change in lung cancer trends. The objective of the study is to track the trends during the period of 15 years from 2008 to 2022. Participants and methods: The mortality from all causes and that specific to lung cancer in Aragon between 1998 and 2007 was analysed using the statistical program MIAMOD/PIAMOD to estimate incidence rates, prevalence, and mortality until 2022. Results: Projections between 2008 and 2022 in men: adjusted incidence rates per 100,000 will decline from 64.62 to 58.49. The mortality will decline from 57.41 to 51.95, and the prevalence of 94.13 cases per 100,000 inhabitants to 88.45. In women, the adjusted incidence rate will increase from 8.3 to 10.58, with a mortality of 7.21 to 9.18 and a prevalence from 14.78 to 18.75. Conclusions: These projections indicate that lung cancer incidence and mortality will remain a serious problem in the Aragon (Spain), and that a more intense primary prevention program is needed. © 2012 Sociedad Española de Médicos de Atención Primaria (SEMERGEN).

Asin L.,University of Zaragoza | Goya G.F.,University of Zaragoza | Tres A.,University of Zaragoza | Tres A.,Hospital Universitario Lozano Blesa | Ibarra M.R.,University of Zaragoza
Cell Death and Disease | Year: 2013

Magnetic hyperthermia (MH) is based on the use of magnetic nanoparticles (MNPs) to selectively increase the temperature of MNP-loaded target tissues when applying an alternating magnetic field (AMF) in the range of radiofrequency. To date, all MH research has focused on heat generation in an attempt to elucidate the mechanisms for the death of MNP-loaded cells submitted to AMF. However, recent in vitro studies have demonstrated the feasibility of inducing dramatic cell death without increasing the macroscopic temperature during AMF exposure. Here, we show that the cell death observed following AMF exposure, specifically that of MNP-loaded dendritic cells (DCs) in culture, was caused by the release of toxic agents into the cell culture supernatants and not due to a macroscopic temperature increase. We performed MH in vitro experiments to demonstrate that the supernatant of the cell culture following AMF exposure was highly toxic when added to control unloaded DCs, as this treatment led to nearly 100% cell death. Therefore, our results demonstrate that heat is not the only agent responsible for triggering cell death following MH treatment. This finding offers new perspectives for the use of DCs as the proverbial Trojan horse to vectorise MNPs to the target tumour area and these results further support the use of DCs as therapeutic agents against cancer when submitted to AMF. Furthermore, this discovery may help in understanding the mechanism of cell death mediated by exposure to AMF. © 2013 Macmillan Publishers Limited All rights reserved.

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