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Camara-Lemarroy C.R.,Autonomous University of Nuevo Leon | Guzman-de la Garza F.J.,Autonomous University of Nuevo Leon | Alarcon-Galvan G.,Hospital Universitario Jose Eleuterio Gonzalez | Cordero-Perez P.,Autonomous University of Nuevo Leon | And 3 more authors.
Archives of Medical Research | Year: 2014

Background and Aims: Temporal occlusion of the hepatoduodenal ligament (HDL) is often used during liver surgeries in order to reduce blood loss, resulting in ischemia/reperfusion injury (I/R). The aim of the study was to investigate the effects of atorvastatin (ATOR) on hepatic I/R injury and on serum levels of tumor necrosis factor-alpha (TNF-α), endothelin-1 (ET-1), antithrombin III (ATIII) and intracellular adhesion molecule-1 (ICAM-1). Methods: Liver ischemia was induced in Wistar rats by clamping the HDL for 60 min, followed by either 60 or 180 min reperfusion. Rats received either vehicle or 10 mg/kg ATOR before hepatic I/R. Control group received sham surgery. Livers were examined for histological damage and serum AST, ALT, TNF-α, ET-1, ATIII and ICAM-1 concentrations were measured. Results: After I/R, AST and ALT were significantly elevated, ATIII levels were significantly depleted, both TNF-α and ICAM-1 levels increased and ET-1 was significantly elevated (at 180 min). ATOR pretreatment attenuated these alterations and diminished histological injury scores. Conclusions: Our results show that ATOR protects the liver from I/R injury. © 2014 IMSS.


Pelaez-Ballestas I.,Hospital General de Mexico | Sanin L.H.,Autonomous University of Chihuahua | Moreno-Montoya J.,Hospital General de Mexico | Burgos-Vargas R.,National Autonomous University of Mexico | And 6 more authors.
Journal of Rheumatology | Year: 2011

To estimate the prevalence of musculoskeletal (MSK) disorders and to describe predicting variables associated with rheumatic diseases in 5 regions of México. Methods: This was a cross-sectional, community-based study performed in 5 regions in México. The methodology followed the guidelines proposed by the Community Oriented Program for the Control of the Rheumatic Diseases (COPCORD). A standardized methodology was used at all sites, with trained personnel following a common protocol of interviewing adult subjects in their household. A "positive case" was defined as an individual with nontraumatic MSK pain of > 1 on a visual analog pain scale (0 to 10) during the last 7 days. All positive cases were referred to internists or rheumatologists for further clinical evaluation, diagnosis, and proper treatment. Results: The study included 19,213 individuals; 11,602 (68.8%) were female, and their mean age was 42.8 (SD 17.9) years. The prevalence of MSK pain was 25.5%, but significant variations (7.1% to 43.5%) across geographical regions occurred. The prevalence of osteoarthritis was 10.5%, back pain 5.8%, rheumatic regional pain syndromes 3.8%, rheumatoid arthritis 1.6%, fibromyalgia 0.7%, and gout 0.3%. The prevalence of MSK manifestations was associated with older age and female gender. Conclusion: The prevalence of MSK pain in our study was 25.5%. Geographic variations in the prevalence of MSK pain and specific diagnoses suggested a role for geographic factors in the prevalence of rheumatic diseases.


Barbosa-Alanis H.J.,Sociedad de Dermatologia de Nuevo Leon | Barbosa-Moreno L.,Hospital Universitario Jose Eleuterio Gonzalez
Dermatologia Revista Mexicana | Year: 2016

This is a short review concerning the history of medicine in the northeast of Mexico, particularly in Monterrey, Nuevo Leon, dating since the 16th century to present day. As well, the foundation of the Department of Dermatology at the University Hospital and the Dermatology Society of Nuevo Leon, AC.


Barbosa-Alanis H.J.,Sociedad de Dermatologia de Nuevo Leon | Gonzalez-Cabello D.,Monterrey | Barbosa-Moreno L.,Hospital Universitario Jose Eleuterio Gonzalez
Dermatologia Revista Mexicana | Year: 2016

Vulva diseases have not been of much interest among dermatologists. The main goal of this review is to raise awareness of these frequent illnesses that are poorly cared for. There is not much information available for treating these diseases, and since there is no clear division between specialties for treating the vulvar pathology, it has lead to its relegation. This review exposes the most frequent inflammatory dermatoses of the vulva, based on histopathologic patterns according to a classification of the International Society for the Stu dy of the Vulvar Diseases (ISSVD).


Guzman-De La Garza F.J.,Autonomous University of Nuevo Leon | Camara-Lemarroy C.R.,Autonomous University of Nuevo Leon | Ballesteros-Elizondo R.G.,Autonomous University of Nuevo Leon | Alarcon-Galvan G.,Hospital Universitario Jose Eleuterio Gonzalez | And 2 more authors.
Surgery Today | Year: 2010

Purpose: Intestinal ischemia reperfusion (I/R) induces severe injury and significant mortality. New therapeutic interventions are needed; ketamine is an anesthetic with anti-inflammatory properties, which has shown protective effects on I/R in various organs. This study investigated effects of ketamine on intestinal I/R injury. Methods: Male Wistar rats underwent either sham surgery or 30 min of intestinal ischemia followed by 60 min reperfusion. Ketamine pretreatment was administered by intraperitoneal injections at doses of 100, 50, 12.5, or 6.25 mg/kg. The intestinal morphology, mucosal damage, leukocyte infiltration, serum P-selectin, serum intracellular adhesion molecule-1 (ICAM-1), serum antithrombin-III (ATIII), and myenteric ganglion cell structure were evaluated. Results: Intestinal I/R led to severe mucosal damage, leukocyte (especially neutrophil) infiltration, P-selectin and ICAM-1 elevations, ATIII depletion, and myenteric ganglion cell morphological alterations. The ketamine dose dependently diminished these alterations (except for ICAM-1 serum levels), reaching statistical significance at 100, 50, and 12.5 mg/kg. Conclusions: Ketamine protects the intestine against I/R injury. Ketamine anesthesia has been recommended for clinical situations of sepsis and hemodynamic instability, both frequent during intestinal I/R. The clinical application of ketamine in situations of intestinal I/R warrants consideration. © 2010 Springer.

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