Time filter

Source Type

Esplugues de Llobregat, Spain

Martinez-Biarge M.,Hospital Universitario La Paz | Madero R.,Hospital Universitario La Paz | Gonzlez A.,Hospital Universitario La Paz | Quero J.,Hospital Universitario La Paz | Garca-Alix A.,Hospital Sant Joan de Deu
American Journal of Obstetrics and Gynecology | Year: 2012

Objective: To examine perinatal morbidity and rate of hypoxic-ischemic encephalopathy in infants exposed to intrapartum sentinel events. Study Design: Retrospective cohort study from 2000-2005. Perinatal mortality, perinatal morbidity and rate of hypoxic-ischemic encephalopathy were compared in 3 groups of infants exposed to different risk factors for perinatal asphyxia (sentinel events, nonreassuring fetal status, elective cesarean section). Results: Five hundred eighty-six infants were studied. Perinatal mortality was 6% in the sentinel event group and 0.3% in the nonreassuring fetal status group (relative risk, 2.4; 95% confidence interval, 1.952.94). Perinatal morbidity was 2-6 times more frequent in infants exposed to sentinel events; the incidence of hypoxic-ischemic encephalopathy was 10%, compared with 2.5% in the nonreassuring fetal status group (relative risk, 1.93; 95% confidence interval, 1.492.52). No infant in the elective cesarean section group died, had perinatal morbidity, or developed encephalopathy. Conclusion: Intrapartum sentinel events are associated with a high incidence of perinatal morbidity and hypoxic-ischemic encephalopathy. © 2012 Mosby, Inc. All rights reserved. Source

Fernandez-Alvarez E.,Hospital Sant Joan de Deu
Journal of Pediatric Neurology | Year: 2015

Monosymptomatic, benign, sudden, and brief episodes of paroxysmal nonepileptic movements are quite common in infants. Their morphology is polymorphic. According to their predominant semiology, different terms are used. The most frequent are benign myoclonus of early infancy and shuddering attacks; other forms of these episodes have been reported with various denominations generating a confusing terminological scenario. We must consider two opposing arguments: we could think of these varied episodes as different processes or as different expressive varieties of the same process. This article supports the thesis that these phenomena are different expressions of the same nondisease condition and, moreover, proposes a new descriptive term for their identification: polymorphic, benign, nonepileptic, paroxysmal infantile movements or, alternatively, Fejerman condition (FC). Source

Hospital Sant Joan De Deu | Date: 2013-01-21

The present invention relates to the field of pediatric or childhood tumor therapy. More specifically, the invention relates to the use of the allosteric activator of the calcium sensor receptor, cinacalcet, for the preparation of a pharmaceutical product for the treatment of neuroblastic tumors, particularly for the treatment of neuroblastomas, ganglioneuroblastomas and ganglioneuromas.

Hospital Sant Joan De Deu | Date: 2014-02-20

The respiratory exercise device comprises means for detecting the respiration of a person and it is characterized in that said means for detecting the respiration of a person comprises a turbine whistle ( The method for respiratory exercise comprises the steps of obtaining data relating to the respiration of a person with the previous device, sending said data relating to the respiration to control means; and applying an algorithm to said data for calculating the values of the flows generated by the respiration. It allows respiratory exercise to be carried out in a simple manner, even for children.

Perez-Poyato M.S.,Hospital Sant Joan de Deu | Pineda M.,Hospital Sant Joan de Deu | Pineda M.,CIBER ISCIII
Current Pharmaceutical Biotechnology | Year: 2011

Niemann-Pick disease type C is an autosomal recessive disorder caused by mutations in either one of the two genes, NPC1 or NPC2, which encode proteins involved in the regulation of normal transport and/or processing of free cholesterol. Several types of lipids including free cholesterol (unesterified), sphingosine, sphingomyelin, phospholipids and glycosphingolipids (glucosylceramide and gangliosides GM2 and GM3) are accumulated in lysosomes and late endosomes of cells, with pronounced concentrations in the liver and the spleen. The key laboratory diagnostic test for NP-C is filliping staining of cultured skin fibroblasts from the patient, to demonstrate free cholesterol accumulation in lysosomes secondary to impaired intracellular cholesterol transport. The symptomatology and rate of disease progression are strongly influenced by age at disease onset and different clinical forms have been described on this basis: Perinatal,Early-infantile (EI), late-infantile (LI), juvenile and adult forms. Clinical symptoms include progressive neurological deterioration and visceral organomegaly. Nowadays there is no fully effective treatment, only supportive measures for relief of specific manifestations of the disease. The intervention to slow disease progression is the most promising therapy. A number of experimental disease - specific therapies, based on the molecular pathology of NP-C, have been tested in cell culture and animal models including neurosteroids, cholesterol - binding agents, curcumin and Miglustat. This paper summarizes the recent developments that have been investigated for the treatment in patients and animal models with NPC. Current therapeutic approaches have been classified based on the targeting of cellular function, the anti - apoptotic cellular mechanisms and the stem cells therapy. © 2011 Bentham Science Publishers Ltd. Source

Discover hidden collaborations