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Mar del Plata, Argentina

Secchi M.A.,Hospital Italiano Garibaldi and Medical School IUNIR | Pettinari R.,Hospital Regional | Mercapide C.,Hospital Artemides Zatti | Bracco R.,Hospital Interzonal | And 10 more authors.
Liver International | Year: 2010

Background: The management of hydatid liver disease (HLD) includes various nonsurgical and surgical treatment options. Methods: The purpose of the present longitudinal study was to report the changes in surgical management and the consequent outcome of HLD patients in 10 referral surgical centres in Argentina from 1975 to 2007. The study result analysis was divided into two study periods (1975-1990 and 1991-2007). Results: A total of 1412 patients underwent radical (Group 1: 396 patients), conservative (Group 2: 748 patients) or combined (Group 3: 536 interventions in 268 patients) surgical procedures. The overall mortality and complication rate (Clavien I-IV) was 1.8 and 39% respectively. The complication rate was significantly lower in Group 1 (26%) compared with Group 2 (45%) and Group 3 (42%) There was a significant decrease in mortality (2.3 vs. 1%), complication (42 vs. 34%) and early reoperation (12 vs. 6%) rates between the first study part (918 patients) and the second study part (494 patients). During a median follow-up of 7 years, there was a significant decrease in the first part of this study in the late reoperation rate (8.4-3%) and in disease recurrence (9-1.6%). Conclusion: This large national observational multicentre series shows a significant improvement in surgical management of HLD in Argentina, with a decrease in mortality, morbidity, early and late reoperation and recurrence rates. A recent trend was observed in favour of an earlier diagnosis, less complicated clinical presentation and recent use of minimally invasive approaches. © 2009 John Wiley & Sons A/S.

Haye Salinas M.J.,Hospital Privado Centro Medico de Cordoba S.A. | Retamozo S.,Hospital Privado Centro Medico de Cordoba S.A. | Alvarez A.C.,Hospital Privado Centro Medico de Cordoba S.A. | Maldonado Ficco H.,Institute Rehabilitacion Psicofisica | And 23 more authors.
Rheumatology International | Year: 2015

Our objective was to analyze the effects of cigarette smoking on disease activity, functional capacity, radiographic damage, serology and presence of extraarticular manifestations in patients with rheumatoid arthritis and undifferentiated arthritis. This is a cross-sectional study of 1,305 patients (729 with rheumatoid arthritis and 576 with undifferentiated arthritis) from CONAART, the Argentine Consortium for Early Arthritis that includes patients older than 16 years with <2 years of disease. Sociodemographic data, clinical characteristics of the disease and smoking history were collected. In patients with rheumatoid arthritis the disease activity score of 28 joints was 5.4 ± 1.3 in current smokers, 5.2 ± 1.4 in former smokers and 5.1 ± 1.4 in never smokers (p = 0.011). The simple erosion narrowing score was higher in current smokers and former smokers than in never smokers (M 14.0, RQ 6.0–21.0; M 15.0, RQ 7.0–24.0; M 10.0, RQ 5.0–17.0; p = 0.006). Current smokers had higher rheumatoid factor titer (M 160.0, RQ 80.0–341.0) than former smokers (M 146.8, RQ 6.03–255.5) and never smokers (M 15.0, RQ 9.0–80.0) (p = 0.004). The variable independently associated with tobacco exposure was simple erosion narrowing score (OR = 1.03, 95 % CI 1.00–1.05; p = 0.012). In patients with undifferentiated arthritis, an association between smoking status and parameters of activity or radiographic damage was not observed. Neither was tobacco exposure related to the presence of extraarticular manifestations or to the degree of disability in any of the two groups of patients. No relation was found between disease activity and severity, and number of packs smoked per year. Tobacco. © 2014, Springer-Verlag Berlin Heidelberg.

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