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Abdullah M.S.P.,University of Malaya | Noordin M.I.,University of Malaya | Nyamathulla S.,University of Malaya | Ismail S.I.M.,Ain Medicare SDN. Bhd. | And 4 more authors.
Sains Malaysiana | Year: 2016

Growing needs, inadequate supply along with health and religious issues are reasons for the increase in the demand for an alternative source of gelatine in the food and pharmaceutical industries. This study was conducted to optimize the process for producing halal-compliant gelatine from chicken waste; chicken shank and toes (CST). Double extraction process employed produced gelatine which was vitreous, lightweight and gossamer in appearance. Gelatine yield was 9.52%(w/w) with a pH of 3.85, moisture content of 7.17%, total protein content of 93.77%, total fat content of 0.93% and total ash of 1.57%. The Bloom strength of the CST gelatine (148.33 ± 5.51) was found to be slightly lower than the commercially available bovine gelatine (BS) (169.33 ± 58.53) (P > 0.05). Amino acid analysis showed that the CST gelatine (91.38 ± 1.01%) was comparable to BS gelatine (90.65 ± 1.56%)(P > 0.05). Double extraction has been shown to successfully increase the surface area to volume ratio of CST waste resulting in increased yield in gelatine and protein with lower total fat content obtained. The test results obtained showed that the CST gelatine produced through this method complies with pharmaceutical standards.


Sathasivam H.P.,Sultan Ismail Hospital | Ismail S.,Sultan Abdul Halim Hospital | Ahmad A.R.,Tengku Ampuan Afzan Hospital | Basri N.N.,Hospital Raja Permaisuri Bainun | And 5 more authors.
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology | Year: 2016

Objectives: This study was performed to obtain the clinicodemographic data regarding patients with trigeminal neuralgia (TN) treated at oral-maxillofacial medicine clinics, as there is a paucity of such information in the Asian setting. Study Design: Retrospective multicenter study involving clinicodemographic information of 320 patients with TN diagnosed between 2001 and 2012 at eight regional oral-maxillofacial medicine clinics and followed up for at least 6 months. Statistical tests were performed to assess the associations among the clinicodemographic factors. Results: TN was mostly diagnosed during the seventh and sixth decades of life, with a median of 58.2 years (interquartile range = 13.0). Females were more commonly affected (61.6%). TN affected the right side more frequently, and the mandibular branch was most commonly involved (58.5%). Carbamazepine was the first-line drug of choice (87.5%). Conclusions: Asian patients with TN exhibited features similar to those in Caucasian patients except for the increased affliction of the mandibular division. © 2016 Elsevier Inc.


PubMed | Penang Health Services, Sultan Ismail Hospital, Raja Perempuan Zainab II Hospital, Hospital Raja Permaisuri Bainun and 4 more.
Type: Journal Article | Journal: Oral surgery, oral medicine, oral pathology and oral radiology | Year: 2016

This study was performed to obtain the clinicodemographic data regarding patients with trigeminal neuralgia (TN) treated at oral-maxillofacial medicine clinics, as there is a paucity of such information in the Asian setting.Retrospective multicenter study involving clinicodemographic information of 320 patients with TN diagnosed between 2001 and 2012 at eight regional oral-maxillofacial medicine clinics and followed up for at least 6months. Statistical tests were performed to assess the associations among the clinicodemographic factors.TN was mostly diagnosed during the seventh and sixth decades of life, with a median of 58.2years (interquartile range=13.0). Females were more commonly affected (61.6%). TN affected the right side more frequently, and the mandibular branch was most commonly involved (58.5%). Carbamazepine was the first-line drug of choice (87.5%).Asian patients with TN exhibited features similar to those in Caucasian patients except for the increased affliction of the mandibular division.


PubMed | Pulau Pinang Hospital and Raja Perempuan Zainab II Hospital
Type: Journal Article | Journal: Malaysian orthopaedic journal | Year: 2014

Primary sacral tumours are rare, therefore experience of managing their associated complications are very limited. Effective surgical treatment of pelvic chondrosarcoma remains a major challenge for orthopaedic surgeons, due to the complex anatomic structure of the pelvis, the lack of defined compartment borders, the close vicinity to vital structures, and the risk of jeopardizing pelvic structural stability. We report a rare case of a giant sacral chondrosarcoma (100cm x 80cm) in an elderly male who successfully underwent tumour resection with good functional outcome and recovery. Long term follow up is essential in view of the possibility of local tumour recurrence.Giant Chondrosarcoma, Sacrum, Surgery, Elderly Male.


Sze-How N.G.,Raja Perempuan Zainab II Hospital | Imisairi A.H.,Raja Perempuan Zainab II Hospital
World Journal of Endocrine Surgery | Year: 2012

To report a case of anaplastic thyroid carcinoma (ATC) with huge ulcer and to review our experience with these aggressive tumors in our hospital. We retrospectively reviewed the presentation, treatment and survival of all the patients who were diagnosed with ATC at Hospital Raja Perempuan Zainab II (HRPZ II), Kota Bharu, Malaysia from 2004 to 2010. A 63-year-old woman presented to outpatient clinic with history of anterior neck swelling for more than 10 years. She complained of rapid increase in size with huge ulcer and associated with hoarseness of voice and shortness of breath over 1 month period. She was investigated and the diagnosis of ATC was established. However, she refused for any surgical intervention and eventually succumbed during the palliative treatment 5 months later. ATC is a very rare thyroid cancer and usually presents at a very late stage with significant morbidity and mortality. Early detection, new therapeutic strategies and more studies especially based on molecular approaches may probably more helpful for better survival results in the future.


Rhendra Hardy M.Z.,Universiti Sains Malaysia | Zayuah M.S.,Universiti Sains Malaysia | Baharudin A.,Universiti Sains Malaysia | Wan Aasim W.A.,Universiti Sains Malaysia | And 3 more authors.
International Journal of Pediatric Otorhinolaryngology | Year: 2010

Introduction: Tonsillectomy is frequently associated with postoperative pain of considerable duration, which is usually accompanied by the substantial consumption of both opioid and non-opioid analgesic such as NSAIDs and local anaesthetics. Objective: The aim of this study was to evaluate the efficacy between 2% viscous lignocaine and sodium diclofenac based upon the visual analogue scores (VASs), consumption of pethidine 0.5 mg kg-1 as the rescue drug postoperatively and time taken to resume feeding. Methods: 130 patients aged between 5 and 12 years old were randomly allocated into 2 groups to be given either 2% viscous lignocaine 4 mg kg-1 body weight topically post-tonsillectomy or sodium diclofenac 1 mg kg-1 per-rectal post-induction of anaesthesia. Postoperatively visual analogues score was done for 24 h, the amount of pethidine given and time when the patient start taking oral feeding of clear fluid, soft diet and normal diet were documented. Results: There was no significant difference in the visual analogue scores in both groups, however the requirement of pethidine as the rescue drug postoperatively was significant 2 h post-tonsillectomy (p = 0.023) in viscous lignocaine group compared to sodium diclofenac. The time taken to resume oral feeding and soft diet was also significant in viscous lignocaine group (p = 0.016 and p = 0.007) whereas there was no significant in taking normal diet. Conclusion: We concluded that 2% viscous lignocaine applied topically post-tonsillectomy is comparable to sodium diclofenac per-rectal in providing analgesia and faster oral feeding. © 2010 Elsevier Ireland Ltd. All rights reserved.

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