Hospital Quiron Of Valencia

Valencia de Alcántara, Spain

Hospital Quiron Of Valencia

Valencia de Alcántara, Spain
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Thompson A.J.,Duke University | Patel K.,Duke University | Chuang W.-L.,Kaohsiung Medical University | Lawitz E.J.,Alamo Medical Research | And 15 more authors.
Gut | Year: 2012

Objectives: Genotype-specific associations between hepatitis C virus (HCV) and insulin resistance (IR) have been described, but a causal relationship remains unclear. This study investigated the association between a sustained virological response (SVR) and IR after chronic HCV therapy. Methods: 2255 treatment-naive patients with chronic HCV genotype 1 or 2/3 were enrolled in two phase 3 trials of albinterferon alpha-2b versus pegylated interferon alpha-2a for 48 or 24 weeks, respectively. IR was measured before treatment and 12 weeks after treatment using homeostasis model assessment (HOMA)-IR. Results: Paired HOMA-IR measurements were available in 1038 non-diabetic patients (497 with genotype 1; 541 with genotype 2/3). At baseline the prevalence of HOMA-IR >3 was greater in patients with genotype 1 than 2/3 (33% vs 27%; p=0.048). There was a significant reduction in the prevalence of IR in patients with genotype 1 achieving SVR (δ 10%; p<0.001), but not in genotype 1 non-responders or those with genotype 2/3. Multivariate analysis indicated that SVR was associated with a significant reduction in mean HOMA-IR in patients with genotype 1 (p=0.004), but not in those with genotype 2/3, which was independent of body mass index, alanine transaminase, γ-glutamyl transpeptidase and lipid level changes. Conclusions: SVR is associated with a reduction in HOMA-IR in patients with HCV genotype 1 but not in those with genotype 2/3. Genotype 1 may have a direct effect on the development of IR, independent of host metabolic factors, and may be partially reversed by viral eradication.


Alberich-Bayarri A.,Hospital Quiron Of Valencia | Marti-Bonmati L.,Hospital Quiron Of Valencia | Marti-Bonmati L.,University of Valencia | Sanz-Requena R.,Hospital Quiron Of Valencia | And 5 more authors.
Radiologia | Year: 2014

Objective We used an animal model to analyze the reproducibility and accuracy of certain biomarkers of bone image quality in comparison to a gold standard of computed microtomography (μCT). Material and methods We used magnetic resonance (MR) imaging and μCT to study the metaphyses of 5 sheep tibiae. The MR images (3 Teslas) were acquired with a T1-weighted gradient echo sequence and an isotropic spatial resolution of 180 μm. The μCT images were acquired using a scanner with a spatial resolution of 7.5 μm isotropic voxels. In the preparation of the images, we applied equalization, interpolation, and thresholding algorithms. In the quantitative analysis, we calculated the percentage of bone volume (BV/TV), the trabecular thickness (Tb.Th), the trabecular separation (Tb.Sp), the trabecular index (Tb.N), the 2 D fractal dimension (D2D), the 3 D fractal dimension (D3D), and the elastic module in the three spatial directions (Ex, Ey and Ez). Results The morphometric and mechanical quantification of trabecular bone by MR was very reproducible, with percentages of variation below 9% for all the parameters. Its accuracy compared to the gold standard (μCT) was high, with errors less than 15% for BV/TV, D2D, D3D, and E appx, Eappy and Eappz. Conclusions Our experimental results in animals confirm that the parameters of BV/TV, D 2D, D3D, and Eappx, Eappy and E appz obtained by MR have excellent reproducibility and accuracy and can be used as imaging biomarkers for the quality of trabecular bone. © 2011 SERAM. Published by Elsevier Espana, S.L. All rights reserved.


PubMed | Philips, University of Valencia, España University and Hospital Quiron Of Valencia
Type: Journal Article | Journal: Radiologia | Year: 2014

We used an animal model to analyze the reproducibility and accuracy of certain biomarkers of bone image quality in comparison to a gold standard of computed microtomography (CT).We used magnetic resonance (MR) imaging and CT to study the metaphyses of 5 sheep tibiae. The MR images (3 Teslas) were acquired with a T1-weighted gradient echo sequence and an isotropic spatial resolution of 180m. The CT images were acquired using a scanner with a spatial resolution of 7.5m isotropic voxels. In the preparation of the images, we applied equalization, interpolation, and thresholding algorithms. In the quantitative analysis, we calculated the percentage of bone volume (BV/TV), the trabecular thickness (Tb.Th), the trabecular separation (Tb.Sp), the trabecular index (Tb.N), the 2D fractal dimension (D(2D)), the 3D fractal dimension (D(3D)), and the elastic module in the three spatial directions (Ex, Ey and Ez).The morphometric and mechanical quantification of trabecular bone by MR was very reproducible, with percentages of variation below 9% for all the parameters. Its accuracy compared to the gold standard (CT) was high, with errors less than 15% for BV/TV, D(2D), D(3D), and E(app)x, E(app)y and E(app)z.Our experimental results in animals confirm that the parameters of BV/TV, D(2D), D(3D), and E(app)x, E(app)y and E(app)z obtained by MR have excellent reproducibility and accuracy and can be used as imaging biomarkers for the quality of trabecular bone.


Mari Cotino J.F.,Universitario Of Valencia | Mari Cotino J.F.,Hospital Quiron Of Valencia | Suriano M.M.,Universitario Of Valencia | De La Cruz Aguilo R.I.,Universitario Of Valencia | Vila-Arteaga J.,Universitario Of Valencia
British Journal of Ophthalmology | Year: 2013

Purpose: To describe clinically, a case series of central toxic keratopathy (CTK), and contribute with one possible aetiology of this entity. Methods: A retrospective observational case series, which included 12 eyes diagnosed with CTK after undergoing laser refractive surgery in situ keratomileusis (LASIK). Results: From a total of 28 eyes that underwent LASIK in the same week, 12 develop CTK. The mean time of the diagnostic was 4 days after surgery. The resolution time had an interval between 1, 3 and 9 months, and an average of 4.6 months. The occurrence of CTK cases coincided with the change of the brand of surgical gloves, and no further cases were found after their replacement. Conclusions: The CTK clinical findings are well described, but with a yet unknown origin. It seems clear that it does not require specific treatment. It is possible that there might be a relationship between a substance of the gloves and CTK. Further studies are needed to know all the details of this process.


Lopez Castillo V.,Hospital Quiron Of Valencia | Ricart J.M.,Hospital Quiron Of Valencia
Medicina Cutanea Ibero-Latino-Americana | Year: 2012

Koebner phenomenon was first described in 1877 as the appearance of psoriatic lesions in the uninvolved skin of psoriatic patients as a consequence of trauma. We report a 33-year-old woman referred to our department for evaluation of multiple psoriasiform skin lesions appearing after sclerotherapy for varicose veins of the legs.

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