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Hospital de Órbigo, Spain

Araujo-Fernandez S.,Hospital Povisa | Ahijon-Lana M.,Hospital Ramon y Cajal | Isenberg D.A.,University College London
Lupus | Year: 2014

Drug-induced lupus erythematosus is defined as a syndrome with clinical and serological features similar to systemic lupus erythematosus that is temporally related to continuous drug exposure and which resolves after discontinuation of this drug. More than 90 drugs, including biological modulators such as tumour necrosis factor-α inhibitors and interferons, have been identified as likely 'culprits'. While there are no standard diagnostic criteria for drug-induced lupus erythematosus, guidelines that can help to distinguish drug-induced lupus erythematosus from systemic lupus erythematosus have been proposed and several different patterns of drug-induced lupus erythematosus are emerging. Distinguishing drug-induced lupus erythematosus from systemic lupus erythematosus is important because the prognosis of drug-induced lupus erythematosus is usually good when the drug is withdrawn. This review discusses the differences between drug-induced lupus erythematosus and systemic lupus erythematosus, the mechanisms of action of drug-induced lupus erythematosus and drugs that are usually associated with drug-induced lupus erythematosus, with particular focus on the biological treatments. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav. Source


Antielevation syndrome as a complication of inferior oblique anterior transposition usually appears in the early postoperative period. A 29-year-old woman who had been operated on for right superior oblique palsy developed diplopia 10 years after surgery: motility examination was consistent with an antielevation syndrome. A right inferior oblique recession of 14 mm was performed on the previously transposed muscle; motility improved, and the patient has remained asymptomatic. © 2011 by the American Association for Pediatric Ophthalmology and Strabismus. Source


Forti Sampietro L.,Hospital Povisa | Forti Buratti M.A.,Imperial College London
Revista Espanola de Medicina Legal | Year: 2012

This review explores suicide risk factors in patients diagnosed with borderline personality disorder and proposes a comprehensive diagnostic assessment. A literature search in PubMed (since 2007) was performed, with the following key word search: "borderline personality disorder", "suicide", and "self-harming behaviour". With the selected articles, the following conclusions were drawn up: 1) self harming behaviors are different to lethal suicide attempts in terms of prognosis and personality traits; 2) there are controversial results, probably explained by the fact that borderline personality disorder is an heterogeneous category; and 3) the global risk of completed suicide in these patients is high and the current diagnostic criteria (DSM-IV-TR) do not take into account the associated risk factors (comorbidities, environment, personality traits). Lastly, a topographic assessment of personality, including those aspects not present in the DSM, is proposed. © 2012 Asociacion Nacional de Medicos Forenses. Publicado por Elsevier Espana, S.L. Todos los derechos reservados. Source


Suarez-Penaranda J.M.,University of Santiago de Compostela | Vieites B.,University of Seville | Del Rio E.,University of Santiago de Compostela | Ortiz-Rey J.A.,Hospital Xeral | Anton I.,Hospital Povisa
Journal of Cutaneous Pathology | Year: 2013

Background Paracentrotus lividus is the most common variety of sea urchin in the west coasts of Spain and has commercial value for the alimentary industry. Puncture with the spine of its rigid external skeleton may cause mechanical injury by skin penetration. It causes immediate local symptoms and, in some cases, a delayed reaction occurs in the site of injury, weeks to months later. In this case, persistent, firm, flesh-colored papules or nodules develop. Material and methods Twenty-four biopsies from 21 patients with the diagnosis of sea urchin granuloma were studied, as well the clinical data. Specimens were routinely processed and stained with hematoxylin-eosin and leucocyte common antigen, CD20, CD3, CD4, CD8, CD30, CD68, kappa and lambda. Results Patients presented with persistent, single or multiple, nodules or papules, usually located in the hands. They developed from 2 weeks to over 1 year after the injury. Histopathologically, granulomas were present in all but one case. Sarcoidal granulomas were more common than suppurative or necrobiotic granulomas. Immunohistochemistry showed a polymorphous lymphoid inflammatory infiltrate, with T leucocytes predominating in most cases. Conclusion Histopathological examination of sea urchin granulomas shows a non-specific granulomatous inflammation, in most cases of sarcoidal type. Being aware of the triggering event is necessary for the correct diagnosis. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Source


Valldeperas X.,Hospital Universitari Germans Trias | Lorenzo-Carrero J.,Hospital Povisa
BioMed Research International | Year: 2014

The use of endotamponade agents has gained a major role in the management of macular complications of high myopia. Myopic foveoschisis and macular hole are the main macular complication of pathologic myopia, this growing condition that is a main cause of visual loss, especially in patients at a younger age. We discuss the physical properties and advantages and disadvantages of the main ocular tamponade agents used in the treatment of these diseases. © 2014 X. Valldeperas and J. Lorenzo-Carrero. Source

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