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Cai X.B.,Shanghai JiaoTong University | Dai Y.M.,Hospital of Traditional Chinese Medicine | Wan X.J.,Shanghai JiaoTong University | Zeng Y.,Shanghai JiaoTong University | And 3 more authors.
Digestive Diseases and Sciences | Year: 2013

Background: Intrasphincteric injection of botulinum toxin (BTX) and removable self-expanding metal stents (SEMS) have both been used for the treatment of achalasia. Aim: To compare the effectiveness and long-term outcome of SEMS placement and BTX injection in patients with achalasia. Methods: A total of 110 patients with newly diagnosed achalasia were enrolled in the study between July 2003 and December 2009. The patients received either BTX injection (n = 51) or SEMS placement (n = 59). Clinical symptoms, objective parameters, and long-term clinical outcomes were evaluated after 7 and 30 days and then every 6 months until withdrawal from the study. The mean duration of follow-up was 28 months (range 10-36 months). Results: Improvements in global symptom and dysphagia scores and in basal lower esophageal sphincter pressure were significantly more marked in the SEMS group than in the BTX group (all P < 0.05). After 12 months, the remission rate in the SEMS group (81.28 %) was statistically significantly higher than that in the BTX group (64.58; P < 0.05). At 36 months, the remission rates in the two groups were 49.1 and. 4.2 %, respectively (P < 0.01). The symptom-free interval was 831 ± 46 days in the SEMS group and 522 ± 42 days in the BTX group (P < 0.01). No side effects were reported with BTX treatment. In the SEMS group there were 13 episodes of chest pain, nine cases of regurgitation, and four stent migrations. No serious complications occurred. Conclusion: Removable SEMS was associated with better long-term outcomes than BTX injection in patients with achalasia. © 2013 Springer Science+Business Media New York.

Wang Y.,Hospital of Traditional Chinese Medicine
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban | Year: 2013

To study effects of Xinfeng Capsule (XFC, a Chinese herbal compound for benefiting qi, invigorating Pi, and dredging col laterals) on myocardial fibrosis in adjuvant arthritis (AA) rats and its mechanism study. Sixty male Wistar rats were randomly divided into the normal control (NC) group (n = 12) and the model control (MC) group (n =48). Except rats in the NC group, Freund's complete adjuvant (0. 1 mL) was intracutaneously injected from the right hind limb to prepare the AA rat model. On the 19th day of inflammation rats in the AA model group were randomly divided into four groups, i.e., the XFC group, the methotrexate (MTX) group, the Tripterygium wilfordii polycoride Tablet (TPT) group, and the MC group, 12 in each group. Rats were sacrificed after 30-day medication. The myocardial ultrastructure was observed under transmission electron microscope. The mRNA and protein expression levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) were detected using RT-PCR and Western blot respectively. (1) Results under electron microscope showed obvious hyperplasia of collagen fibers in myocardial cells of AA rats, which indicated the trend of myocardial fibrosis. The myocardial ultrastructural changes could be effectively improved in the MTX group, the TPT group, and the XFC group. The morphology of myocardial cells in the XFC group was contact, with clear nucleus, and little collagen fibers, which was better than the other groups. (2) Compared with the NC group, the mRNA and protein expression levels of MMP-9 in the myocardial tissue of the MC group were obviously up-regulated, while the mRNA and protein expression levels of TIMP-1 were obviously down-regulated (P <0. 01). The mRNA and protein expression levels of MMP-9 decreased, and the mRNA and protein expression levels of TIMP-1 obviously increased in the XFC group, showing statistical difference when compared with the MC group (P < 0. 5, P < 0. 01). XFC could effectively inhibit the myocardial fibrosis of AA rats.lts mechanisms might be correlated with inhibiting the mRNA and protein expression levels of MMP-9, improving the mRNA and protein expression levels of TIMP-1, adjusting the balance of MMP-9/TIMP-1 ,and improving the metabolism of myocardial extracellular matrix.

Zhang Y.-M.,Hospital of Traditional Chinese Medicine | Huang Q.-F.,Meridian
Journal of Acupuncture and Tuina Science | Year: 2014

In review of acupuncture literature from 1949 to 2010, in accordance with the data in 'Traditional Chinese Medical Acupuncture-moxibustion Information Databank', the accounting analysis was used for comprehensive analysis and regularity summery of acupuncture therapy for apoplexy sequelae. The results showed that Hegu (LI 4), Zusanli (ST 36), Quchi (LI 11), Jianyu (LI 15), Sanyinjiao (SP 6), Yanglingquan (GB 34), Lianquan (CV 23), and Waiguan (TE 5) were used at the highest frequency. In the therapeutic methods, acupuncture was used at the highest frequency, followed by scalp acupuncture, and simultaneous application of acupuncture and herbal medicine. © 2014 Shanghai Research Institute of Acupuncture and Meridian and Springer-Verlag Berlin Heidelberg.

Gao X.,Chongqing Technology and Business University | Guo H.,Chongqing Institute of Forensic Science | Du Y.,Hospital of Traditional Chinese Medicine | Gu C.,EnerVault
Journal of Analytical Toxicology | Year: 2015

Xylazine as veterinary medicine for sedation, but intoxication cases in humans were identified in the last few years. A highly sensitive method is required for analyzing xylazine and its metabolites in human blood and urine. This article presents an ultra high performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry (UHPLC-QTOF) study for simultaneous determination of xylazine and 2,6-dimethylaniline (DMA) in human blood and urine. The samples were extracted and cleaned up by Oasis MCX solid-phase extraction. The analysis is performed using an UHPLCQTOF. Analysis precision, accuracy, sensitivity, linear range, limit of detection (LOD) and limit of quantification (LOQ) were validated for the proposed method. In the blood and urine samples, the linear calibration curves with high linearity are obtained over the range of 2.0- 1,000.0 ng/mL. The LOD for xylazine and DMA in blood are 0.2 and 0.1 ng/mL, in urine are 0.4 and 0.2 ng/mL; the LOQ for xylazine and DMA in blood are 0.6 and 0.3 ng/mL, in urine are 1.0 and 0.6 ng/mL, respectively. The intra- and interday precision is better than 8.6 and 11.9%. In conclusion, the proposed method is highly sensitive and reproducible, thus suitable for accurate quantification of xylazine and its metabolites in blood and urine. © The Author 2015.

Zhang L.J.,Hospital of Traditional Chinese Medicine
Zhongguo gu shang = China journal of orthopaedics and traumatology | Year: 2012

To study the application of stress X-ray of knee joint for the diagnosis ot medial collateral ligament injury. From January 2008 to June 2011, 46 patients with medial collateral ligament injury were reviewed. Among the patients, 32 patients were male and 14 patients were female, ranging in age from 28 to 72 years, with an average of (49.46 +/- 22.54) years. Left knee joint injuries occurred in 22 patients, and 24 patients had injuries in right knee joint. Thirty-one patients were treated with surgical method, and 15 patients were treated with conservative method including 1 patient finally received operation after 3 months treatment with conservative method without effect. The injury side and normal side were observed by X-ray under stress and non-stress, as well as MRI. Operation was used to treat patients with medial gap markedly widen and the deep layer of medial collateral ligament injury in MRI. A line (line A) was drawn from medial condyle to lateral condyle of tibia platform. The line A was translated to the inner margin of condylus medialis femoris, which was line B. The perpendicular distance was measured, which was line C. The ration of space difference (R) was calculated by (space at stress force of injured side-space at non-stress force of injured side)/(space at stress force of normal side-space at non-stress force of normal side). The relationship between R and ligament injury type were investigated. There were 17 patients with injuries of superficial lamella, 21 patients with injuries of deep lamella. Eight patients had associated injuries of articular capsule and posterior cruciate ligament. When R value was between 1.51 to 5.24, the injury of superficial ligament was found in 15 patients, actual injuries were found in 17 patients. When R value between 5.28 and 13.85, the injuries of bathypelagic ligament were found in 19 patients, actual injuries were found in 21 patients. When R value was between 15.61 and 26.25, the associated injuries of articular capsule and posterior cruciate ligament were found in 7 patients, actual injuries were found in 8 patients. Using the specific value as the standard of measurement can provide the quantizatily fractionation of the medial collateral ligament injury.

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