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Tours, France

Salhi H.,Hospital of Tours | Corcia P.,Hospital of Tours | Corcia P.,French Institute of Health and Medical Research | Remer S.,Hospital of Tours | And 2 more authors.
Journal of Clinical Neurophysiology | Year: 2014

PURPOSE:: Somatosensory evoked potentials (SEPs) offer complementary results to those of nerve conduction studies and contribute to the electrodiagnostic criteria of chronic inflammatory demyelinating polyradiculoneuropathy. METHODS:: We performed nerve conduction studies and SEPs in patients with symmetrical motor weakness, areflexia, and/or sensory disturbances lasting for at least 8 weeks. We determined two groups according to the electrodiagnostic criteria of the European Federation of Neurological Societies. Group 1 included patients who met the definite or probable electrodiagnostic criteria, and group 2 included patients who met the possible electrodiagnostic criteria. We also compared SEPs results with those of controls (group of healthy subjects). RESULTS:: Sixteen patients (14 men; mean age, 59 ± 17.3 years) were included in the study. The latencies of potentials N9, N13, N7, and N22 and the intervals N9-N13 and N7-N22 were significantly increased in patients compared with controls. The N9/iP14 amplitude ratio was significantly lower in patients. There was no significant difference in the latencies of SEPs between the two groups of patients. CONCLUSIONS:: We confirm the contribution of SEPs as complementary information to nerve conduction studies in chronic inflammatory demyelinating polyradiculoneuropathy diagnosis. In addition to the usual abnormalities, a decrease in the N9/iP14 amplitude ratio could potentially be used as an electrodiagnostic criterion. Copyright © 2014 by the American Clinical Neurophysiology Society. Source

Claudon M.,University of Lorraine | Durand E.,University of Strasbourg | Grenier N.,Interventional Imaging | Prigent A.,University Paris - Sud | And 53 more authors.
Radiology | Year: 2014

Purpose: To evaluate if measurement of split renal function (SRF) with dynamic contrast material-enhanced (DCE) magnetic resonance (MR) urography is equivalent to that with renal scintigraphy (RS) in patients suspected of having chronic urinary obstruction.Materials and Methods: The study protocol was approved by the institutional ethics committee of the coordinating center on behalf of all participating centers. Informed consent was obtained from all adult patients or both parents of children. This prospective, comparative study included 369 pediatric and adult patients from 14 university hospitals who were suspected of having chronic or intermittent urinary obstruction, and data from 295 patients with complete data wereused for analysis. SRF was measured by using the area under the curve and the Patlak-Rutland methods, including successive review by a senior and an expert reviewer and measurement of intra- and interobserver agreement for each technique. An equivalence test for mean SRF was conducted with an a of 5%.Results: Reproducibility was substantial to almost perfect for both methods. Equivalence of DCE MR urography and RS for measurement of SRF was shown in patients with moderately dilated kidneys (P < .001 with the Patlak-Rutland method). However, in severely dilated kidneys, the mean SRF measurement was underestimated by 4% when DCE MR urography was used compared with that when RS was used. Age and type of MR imaging device had no significant effect.Conclusion: For moderately dilated kidneys, equivalence of DCE MR urography to RS was shown, with a standard deviation of approximately 12% between the techniques, making substitution of DCE MR urography for RS acceptable. For severely dilated kidneys, a mean underestimation of SRF of 4% should be expected with DCE MR urography, making substitution questionable. © RSNA, 2014. Source

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