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Ding X.,Wuhan University | Yan D.,Hospital of Kunming Medical College | Long Q.,Wuhan University
Medical Journal of Wuhan University | Year: 2010

Objective: To investigate the effect of using the suspension of ferroso-ferric oxide granules and iodinated oil to embolize the artery of primary hepatic carcinoma. Methods, Ninety-eight cases with primary hepatic carcinoma who had accepted TACE were retrospectively studied and were divided into three groups according to the method of treatment as group A (suspension of iodinated oil embolism and chemotherapeutics), group B (suspension of iodinated oil embolism, chemotherapeutics, and the stem artery embolizing by spongia gelatinosa) , and group C (suspension of ferroso-ferric oxide granules iodinated oil and chemotherapeutics). Results, The nulli-recanalization rate of group B and group C were obviously higher than that of group A (both P< 0. 01), however, the part-recanalization rate and the all-recanalization rate of group A and B were lower (all P<0. 01). There was no statistical differences in recanalization between group B and group C (P>0. 05). Conclusion, After embolization, the revascularization results were different according to the embolizing method adopted. The method of using the suspension of ferroso-ferric oxide granules and iodinated oil is the more effective one. Source


Niu J.-K.,Hospital of Kunming Medical College | Miao Y.-L.,Hospital of Kunming Medical College
World Chinese Journal of Digestology | Year: 2011

Ulcerative colitis (UC), one of non-specific chronic inflammatory conditions of the gastrointestinal tract with unknown complex etiology, is a chronic inflammatory bowel disorder characterized by diffuse mucosal inflammation of the colorectum with exacerbations and remissions. Nowadays, the diagnosis of UC is based mainly on symptoms, endoscopic findings, and histopathologic grading of biopsy specimens. However, there is a lack of a gold standard for the diagnosis of UC. Endoscopy is the cornerstone for diagnosis and evaluation of UC and plays a significant role in diagnosis, evaluating disease activity, malignancy surveillance and treatment. Over recent decades, the emergence of new imaging techniques, including endoscopic ultraonography, chromoendoscopy, magnification endoscopy, narrow-band endoscopic imaging, and laser scanning confocal microendoscopy, has provided a great boost to endoscopic diagnosis and treatment of UC. In this article, we will review the recent advances in endoscopic diagnosis and treatment of UC. Source


Wang Y.,Hospital of Kunming Medical College | Liu L.,Hospital of Kunming Medical College | Tang H.,Hospital of Kunming Medical College | Zhang L.,Hospital of Kunming Medical College | He Q.,Hospital of Kunming Medical College
Journal of Leukemia and Lymphoma | Year: 2011

Objective To explore the p27 gene expression and clinical significance in acute leukemia (AL). Methods RT-PCR was used for testing the mRNA levels of p27 gene in bone marrow mononuclear cell of 65 cases of newly diagnosed AL patients and 41 controls. The correlation between the p27 gene expression positive rate and age, sex, peripheral blood white blood cell count and extramedullary infiltration were analyzed simultaneously in AL patients. Results The positive rate of p27 gene expression (36.9%, 24/65) was significantly lower in AL group than that in the control group (87.8%, 36/41) (P <0.05), and which was lower than the control group (P <0.05) in the AML group (34.2%, 13/38) and the ALL group (37.5%, 9/24). However, comparing AML group with ALL group, the difference was not statistically significant (P >0.05). At the same time, compared the p27 gene expression positive rate of > 14 years old group (52 cases) and <14 years old group (13 cases), and also compared in male group (34 cases) and in female group (31 cases), there was no statistically difference (P >0.05); Compared the p27 gene expression positive rate of peripheral blood white blood cell count >20×l09/L group (31 cases) and <20×l09/L group (34 cases), also compared with in extramedullary infiltration group (37 cases) and in no extramedullary infiltration group (28 cases), the relationship of p27 gene expression positive rate with peripheral blood white blood cell count as well as extramedullary infiltration was a negative correlation (r = -0.284, P < 0.05, r = -0.300, P < 0.05). Conclusion There is p27 mRNA expression deletion in AL patients, and the deletion is present in the AML and ALL at the same time. p27 mRNA expression is negatively correlated with peripheral blood white blood cell count or extramedullary infiltration, which might be one of the mechanisms of occurrence and development of AL. Source


Yang Z.,Hospital of Kunming Medical College | Jin C.,Hospital of Kunming Medical College | Chen T.,Hospital of Kunming Medical College | Sun H.,Hospital of Kunming Medical College | And 4 more authors.
Oncology Letters | Year: 2012

Brachytherapy is regarded as the most effective method in the treatment of metastatic spinal tumors since little damage is caused to surrounding healthy tissue. However, this method may cause radiation myelopathy if an overdose occurs. In the present study, we established a Banna mini-pig 125 I spinal cord implantation model to provide a tool for the study of how to reduce these types of side effects. Cell cycle alteration, apoptosis and necrosis of spinal cord neurons in the presence of various doses and durations of 125 I brachytherapy were also investigated. The pigs were randomly divided into four groups, A, B, C and D. In group A, four 125 I seeds (total radioactivity, 4.0 mCi) were implanted into the dura mater of the spinal canal at the level of T13. In groups B and C, eight 125 I sources (total radioactivity, 8.0 mCi) were inserted at the same location. Groups A and C were raised for up to 8 months and group B for only 2 months. Neurons from the swine spinal cord at the T13 level were collected and cell cycle analysis was performed. Apoptosis and necrosis were tested by a terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL) assay. The Banna mini-pig brachytherapy model was successfully established. Radiation myelopathy was closely associated with radiation dose and duration, more neurons were blocked in the G2 and S phases as dose and time increased, and an increase in apoptosis and necrosis was detected. Ratios of apoptosis and necrosis were reduced as lower doses and shorter durations of radiation were applied. Our results demonstrate that the Banna mini-pig is an ideal animal to study 125 I brachytherapy. Low-dose and short-term brachytherapy may effectively decrease apoptosis and necrosis in spinal cord cells in Banna mini-pigs. Source

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