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Quanzhou, China

Zhao Y.,Hospital of Chinese PLA
Journal of Clinical Rehabilitative Tissue Engineering Research

BACKGROUND: Pelvic fractures are more common in clinic. There are various internal fixation methods for implantation that are difficult. If not treated properly, it can cause pelvic soft tissue injury, skin necrosis, infection, leading to clinical failure of internal fixation as one important reason. OBJECTIVE: To investigate the optimal internal fixation therapy for pelvic fractures and to evaluate its effect. METHODS: A computer-based online search of VIP database (2004-01/2011) was conducted to retrieve articles regarding screw and plate internal fixation of treatment of pelvic fractures using the keywords of "pelvic fracture, internal fixation, effect evaluation". RESULTS AND CONCLUSION: Pelvic fracture is a high-energy injury with high morbidity and high mortality, and the incidence is increased year by year in clinic. Relevant biomechanical studies are useful to explain the action mechanism and fracture type of pelvic fractures and play a very important role in the final choice of treatment. Anatomic reduction and solid fixation of pelvic fractures as well as screws and plate internal fixation are very important. To develop an implant with small wound, low infection rate, stable fixation and good compatibility is the current direction in the treatment of unstable pelvic fractures. Source

Yang B.,Chinese PLA General Hospital | Yu R.-l.,Chinese PLA General Hospital | Tuo S.,Hospital of Chinese PLA | Tuo C.-w.,Hospital of Chinese PLA | And 6 more authors.

Background: Human xenograft models, resulting from orthotopic transplantation (implantation into the anatomically correct site) of histologically intact tissue into animals, are important for investigating local tumor growth, vascular and lymphatic invasion at the primary tumor site and metastasis. Methodology/Principal Findings: We used surgical orthotopic transplantation to establish a nude mouse model of primary hepatic lymphoma (PHL), HLBL-0102. We performed orthotopic transfer of the HLBL-0102 tumor for 42 generations and characterized the tumor cells. The maintenance of PHL characteristics were supported by immunohistochemical and cytogenetic analysis. We also report the antitumor effect of Cantide, an antisense phosphorothioate oligonucleotide against hTERT, on the growth of HLBL-0102 tumors. We showed a significant, dose-dependent inhibition of tumor weight and serum LDH activity in the orthotopically transplanted animals by Cantide. Importantly, survival was prolonged in Cantide-treated HLBL-0102 tumor-bearing mice when compared to mock-treated mice. Conclusions/Significance: Our study provided the basis for the development of a clinical trial protocol to treat PHL. © 2012 Yang et al. Source

Wang M.-H.,Hospital of Chinese PLA | Xu J.-F.,Hospital of Chinese PLA
International Eye Science

AIM: To observe the changes of preoperative and postoperative tear film in the surgical treatment for pterygium by pterygium excision combined with autologous limbus epithelial transplantation, and analyse the influence of pterygium on the function of tear film. METHODS: A total of 24 cases (24 eyes) of pterygium underwent pterygium excision combined with autologous limbus epithelial transplantation. All patients were measured by Schirmer test and tear film break-up test (BUT) on 1 day before operation, 1 month and 2 months after operation respectively. RESULTS: The result of Schirmer test were 15.5±7.81 mm, 15.76±7.39 mm and 16.00±8.05 mm, and BUT were 8.15±3.611, 10.05±3.03, and 10.50±4.26 seconds on 1 day before operation, 1 month and 2 months after operation respectively. The difference of BUT had statistical significance between preoperation and postoperation (P<0.05), but there was no significant change in Schirmer test in different time (P >0.05). CONCLUSION: The form of the ocular surface and the stability of tear film were restored by pterygium excision combined with autologous limbus epithelial transplantation. Source

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