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Marine Coromoto Nava B.,Hospital Militar Dr. Carlos Arvelo | Analy Perez G.,Simon Bolivar University of Venezuela | Herrera H.A.,Simon Bolivar University of Venezuela | Rosa Armenia Hernandez H.,Simon Bolivar University of Venezuela
Revista Chilena de Nutricion | Year: 2011

Preschool Venezuelan children underwent a study that measures the relationship between anthropometric nutritional state, food habits and physical activity level (PAL). Methods: Using Frisancho's pattern as a reference, 173 children were studied, and anthropometric indicators such as height/age, weight/height and both lean and fat arm areas were measured. To assess food habits and PAL, a questionnaire was developed and applied. Results: For vegetables, fruits and fats the consumption patterns was low, and for cereals, meats, and dairy products was high. In 52% of the children the PAL was intense, and in the 27% was light. Among food habits, PAL and sedentary index (SI) an association was found. Conclusions: Results suggest implementing changes from the preschool stage to correct for inappropriate food habits, to encourage physical activity and to avoid a high SI, will relate to the appearance of adult chronic degenerative diseases. Source

Durnes G.,Hospital Militar Dr. Carlos Arvelo | Natalia F.M.,Laboratorio Elmor | Raul C.,Farmacologo Clinico. Investigador Independiente
Informe Medico | Year: 2013

Chronic bronchopulmonary diseases involving inflammation, hypersecretion and bronchial hyperreactivity, such as asthma, chronic bronchitis and chronic obstructive pulmonary disease (COPD) are common causes of medical consultation. Spirometry and nitric oxide assay (NO) in exhaled air (FENO) are non-invasive methods for clinically assessing those diseases. The main objective of this clinical study was to evaluate acebro-phylline efficacy on bronchopulmonary inflammation in volunteer patients, 12 to 50 years old, whose initial FENO values were greater than 20 ppb. Safety and tolerability of medication were also evaluated. Methods: Randomized, controlled, double blind, parallel, prospective design with rescue medication. Patients referred to the Allergy and Immunology Department, Military Hospital "Dr. Carlos Arvelo, Caracas, were previously treated according to GINA Guidelines. Patients received either acebrophylline (100 mg/mL) or identical placebo every 12 hours for 90 days. Salbutamol aerosol (100 mcg/dose) was allowed as rescue medication if necessary. On days 0 and 90 the following evaluations were done: 1. F ENO measurement with a non-invasive clinical technique (Ecomedics analyzer Model CLD88SP). 2. Respiratory volumes: FEV1, FVC, FEV1/FVC, PEF (Hillmed spirometer). 3. Hematology, blood chemical values and urinalysis. Research protocol was approved by Institutional Ethics Review Board and by the National Regulatory Agency. Results: One hundred patients who met inclusion/exclusion criteria were selected and signed the Informed Consent. Included patients were those with FENO and FEV1 values > 20 ppb and < 100%, respectively. Randomized code was open and the final sample distribution was: acebrophylline n=30 and placebo n=24. Although in 70% of acebrophylline treated patients FENO decreased, there was no statistically significant difference between the mean ± SEM before and after treatment in the whole group (77, 71 ± 9, 37 to 64, 78 ± 8, 11 ppb). At the end of treatment a reduced progression and severity of oxidative stress in the acebrofilin group was observed. Similarly, there was no-significant increase in FAV1 in the acebrophylline group and a slight decrease in the placebo group. There was no difference in tolerability between the two groups. Conclusions: Acebrophylline administration during 90 days in patients with inflammation, hypersecretion and airway hyperresponsiveness, showed a non-statistically significant oxidative stress reduction estimated by FENO. In 70% of treated patients the values of the inflammation marker decreased at the end of treatment. No adverse events were reported with acebrophylline. Source

Grinblat B.,University of Sao Paulo | Sanclemente G.,University of Antioquia | Lopez M.,Hospital Militar Dr. Carlos Arvelo | Alcala D.,Centro Dermatologico Dr Ladislao Of La Pascua | And 2 more authors.
Photodermatology Photoimmunology and Photomedicine | Year: 2016

Although conventional photodynamic therapy (c-PDT) using methyl aminolevulinate cream (MAL) is effective for the treatment of grade I-II facial and scalp actinic keratosis (AK), it is associated with treatment-related pain for some patients. Daylight-mediated PDT (DL-PDT) has shown similar efficacy to c-PDT, was nearly painless, and was well tolerated. Overall, DL-PDT effectively treats AK and offers a simpler and better tolerated treatment option than c-PDT. This consensus panel provided recommendations on the use of DL-PDT in Latin America (LATAM) for the treatment of actinic damage associated with few or multiple AKs. The panel was comprised of eight dermatologists from different LATAM countries who have experience using PDT for the treatment of actinic damage. The panel reviewed the relevant literature and provided personal expertise with regard to using DL-PDT for the treatment of photodamage with or without AK. The recommendations formulated by the expert panel provide evidence-based guidelines on all aspects of DL-PDT for the treatment of actinic damage associated with AK in different regions of LATAM. These recommendations provide guidance for dermatologists to ensure maintenance of efficacy and safety of DL-PDT when treating actinic damage, associated with few or multiple AKs in sun-exposed skin. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Source

Hernandez P.,Central University of Venezuela | Mata C.,Central University of Venezuela | Lares M.,Central University of Venezuela | Velazco Y.,Central University of Venezuela | Brito S.,Hospital Militar Dr. Carlos Arvelo
Anales Venezolanos de Nutricion | Year: 2013

The Glycemic Index (GI) and Glycemic Load (GL) are valid indicators of effect of foods on blood glucose response. This study aimed to assess the GI and GL of diets consumed by diabetics and nondiabetics adults, as indicators of diet quality and its relation to nutritional status. The study was carried out in the consultation of Endocrinology of the Military Hospital "Dr. Carlos Arvelo" during the period July 2010 - January 2011. This is a descriptive research, with a study group of 43 adult subjects, 23 diabetics (D) and 20 nondiabetics (ND). Nutritional anthropometric evaluation was applied and determined the GI and GL of diet. For comparison between means groups the test "t" of Student was conducted and for distributions between groups Chi2 was used. Was found a predominance of medium and high IG (70% ND and 88% in D), medium and high CG (75% in ND and 78.3% in D) and excess malnutrition (55% in ND and 70% D) in both groups. We conclude that GI and GL are alternative and valid indicators of quality of diet and may be considered useful in the assessment and dietary management of diabetics and in prevention of chronic diseases programs, aimed at the general population, without using isolated and unaware of their limitations. Source

Rosenthal V.D.,International Nosocomial Infection Control Consortium | Maki D.G.,University of Wisconsin - Medical School | Jamulitrat S.,Songklanagarind Hospital | Medeiros E.A.,Hospital Sao Paulo | And 22 more authors.
American Journal of Infection Control | Year: 2010

We report the results of the International Infection Control Consortium (INICC) surveillance study from January 2003 through December 2008 in 173 intensive care units (ICUs) in Latin America, Asia, Africa, and Europe. During the 6-year study, using Centers for Disease Control and Prevention (CDC) US National Healthcare Safety Network (NHSN; formerly the National Nosocomial Infection Surveillance system [NNIS]) definitions for device-associated health care-associated infection, we collected prospective data from 155,358 patients hospitalized in the consortium's hospital ICUs for an aggregate of 923,624 days. Although device utilization in the developing countries' ICUs was remarkably similar to that reported from US ICUs in the CDC's NHSN, rates of device-associated nosocomial infection were markedly higher in the ICUs of the INICC hospitals: the pooled rate of central venous catheter (CVC)-associated bloodstream infections (BSI) in the INICC ICUs, 7.6 per 1000 CVC-days, is nearly 3-fold higher than the 2.0 per 1000 CVC-days reported from comparable US ICUs, and the overall rate of ventilator-associated pneumonia (VAP) was also far higher, 13.6 versus 3.3 per 1000 ventilator-days, respectively, as was the rate of catheter-associated urinary tract infection (CAUTI), 6.3 versus 3.3 per 1000 catheter-days, respectively. Most strikingly, the frequencies of resistance of Staphylococcus aureus isolates to methicillin (MRSA) (84.1% vs 56.8%, respectively), Klebsiella pneumoniae to ceftazidime or ceftriaxone (76.1% vs 27.1%, respectively), Acinetobacter baumannii to imipenem (46.3% vs 29.2%, respectively), and Pseudomonas aeruginosa to piperacillin (78.0% vs 20.2%, respectively) were also far higher in the consortium's ICUs, and the crude unadjusted excess mortalities of device-related infections ranged from 23.6% (CVC-associated bloodstream infections) to 29.3% (VAP). © 2010 Association for Professionals in Infection Control and Epidemiology, Inc. Source

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